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helicase_primase_subunit_complex_protein

Euk-Vir

Murine_roseolovirus

helicase_primase_subunit_complex_protein__YP_009344923__Murine_roseolovirus__1940555

Identity

Accession:
YP_009344923 ↗
Protein ID:
helicase_primase_subunit_complex_protein
Kingdom:
euk

Quality

81.1 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 307-372_747-823
PDB
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 113.2 1.40e-32 55.2% 9.4%
PF02689.21 Herpes_Helicase 88.2 5.20e-25 46.9% 7.9%
D2 high residues 375-458_718-745
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 75.8 2.80e-21 76.8% 9.7%
D3 medium residues 6-38_91-160
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 78.8 3.60e-22 69.9% 8.0%
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6ketA01 3.20.20.30 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Luciferase-like domain 0.57 44.0 3.11e-01 84.5% 73.0%
2p8bA02 3.20.20.120 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain 0.54 40.0 3.17e-01 79.6% 55.7%
1zowA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.52 35.0 3.22e-01 70.9% 61.9%
1u6eA02 3.40.47.10 Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase 0.52 35.0 3.13e-01 70.9% 58.0%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3934257 2006.1.1.0 a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like 0.50 35.0 3.03e-01 72.8% 50.0%
D4 medium residues 77-90_161-306
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 201.7 2.50e-59 91.2% 19.6%
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
7br2D01 3.40.50.1110 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › SGNH hydrolase 0.54 34.0 3.08e-01 86.3% 44.7%
4c6sA00 3.40.50.10140 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Toll/interleukin-1 receptor homology (TIR) domain 0.53 30.0 3.23e-01 78.1% 59.9%
6hswA01 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.53 44.0 3.29e-01 88.7% 80.9%
2jbyA00 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.52 36.0 4.00e-01 85.6% 90.6%
4b3fX01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 47.0 3.66e-01 96.9% 85.5%
1nnwB00 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.51 34.0 2.98e-01 79.4% 43.0%
1zoyA04 4.10.80.40 Few Secondary Structures › Irregular › Rhinovirus 14, subunit 4 › succinate dehydrogenase protein domain 0.51 20.0 3.11e-01 91.3% 89.2%
2yv4A00 3.40.50.11030 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Threonylcarbamoyl-AMP synthase, C-terminal domain 0.51 32.0 3.93e-01 93.8% 100.0%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3742535 59.1.1.2 beta complex topology › triple barrel › triple barrel › Rap30/74 interaction domains-like › RNA_pol_Rpc4 0.54 21.0 2.92e-01 81.2% 70.7%
3947564 605.1.1.4 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 0.52 19.0 3.10e-01 73.1% 86.2%
D5 medium residues 468-496_627-688
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 45.0 6.10e-12 69.2% 7.2%
D6 medium residues 497-543_587-626
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02689.21 best Herpes_Helicase 28.9 4.30e-07 55.2% 5.7%
CATH (36)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2qffA00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.72 58.0 6.22e-01 100.0% 100.0%
3d2eA06 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.72 62.0 5.71e-01 100.0% 72.6%
2qnlA00 1.20.120.450 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain 0.72 63.0 5.22e-01 100.0% 97.5%
4nqfA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.66 60.0 5.03e-01 100.0% 74.5%
1qdbA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.65 58.0 4.93e-01 100.0% 63.6%
2c5iT00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.65 41.0 4.04e-01 72.4% 59.6%
2f22A00 1.20.120.450 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain 0.65 58.0 4.91e-01 98.9% 89.4%
2hsbA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.64 57.0 5.08e-01 100.0% 78.6%
2q00B00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.62 55.0 4.94e-01 100.0% 85.2%
1h6gA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.61 54.0 4.85e-01 100.0% 78.2%
1wolA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.61 54.0 4.85e-01 98.9% 78.7%
1yjgA00 1.20.120.240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 0.60 52.0 4.40e-01 100.0% 65.0%
1o3uA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.60 54.0 4.85e-01 100.0% 82.5%
3pe0A02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 41.0 3.92e-01 73.6% 59.4%
2jokA01 1.10.4120.10 Mainly Alpha › Orthogonal Bundle › SopE-like GEF fold › SopE-like, GEF domain 0.59 52.0 4.18e-01 98.9% 81.1%
3swhA01 1.10.357.50 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.59 38.0 3.14e-01 73.6% 34.5%
3u9jA00 1.20.120.520 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like 0.59 52.0 4.33e-01 100.0% 64.3%
2m6uA00 1.20.81.20 Mainly Alpha › Up-down Bundle › Receptor-associated Protein › 0.59 47.0 4.83e-01 92.0% 91.5%
6g4bA01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.58 49.0 4.03e-01 96.6% 59.6%
1l8dA00 1.10.287.510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.58 41.0 3.87e-01 73.6% 82.5%
2ieqA00 1.20.5.300 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.58 40.0 4.08e-01 73.6% 88.6%
3ezhA00 1.20.120.960 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase NarX, sensor domain 0.57 48.0 4.45e-01 97.7% 71.9%
5nl6B01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.57 37.0 3.36e-01 75.9% 47.9%
3fxhA00 1.20.120.600 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Crystal structure from the mobile metagenome of halifax harbour sewage outfall 0.57 40.0 3.70e-01 73.6% 99.1%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.56 37.0 3.45e-01 70.1% 53.6%
1js3A03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.56 46.0 4.52e-01 92.0% 95.9%
3kxaA02 1.10.260.40 Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains 0.56 33.0 3.76e-01 80.5% 78.8%
2ce7B03 1.20.58.760 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Peptidase M41 0.55 38.0 3.10e-01 72.4% 40.5%
8b70A01 1.20.1740.10 Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I 0.54 47.0 3.07e-01 96.6% 78.7%
4e1oA03 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.54 45.0 4.41e-01 93.1% 94.9%
7craA02 1.20.58.1480 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 50.0 4.90e-01 100.0% 98.9%
1w23A02 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.54 48.0 4.55e-01 100.0% 98.1%
2e8gA01 1.20.1440.150 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.54 45.0 4.08e-01 95.4% 67.7%
3ay5A01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.53 48.0 4.16e-01 100.0% 66.2%
1dtoA01 1.10.287.30 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 0.52 41.0 3.96e-01 86.2% 76.5%
2dr1A01 3.90.1150.10 Alpha Beta › Alpha-Beta Complex › Aspartate Aminotransferase, domain 1 › Aspartate Aminotransferase, domain 1 0.52 46.0 3.99e-01 98.9% 72.6%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3882152 601.20.1.0 alpha bundles › Four-helical up-and-down bundle › Apolipophorin-III › Apolipophorin-III 0.75 50.0 4.08e-01 100.0% 38.1%
3863109 4044.1.1.16 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › AMH_N 0.75 57.0 5.84e-01 98.9% 82.4%
5074957 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.71 52.0 5.72e-01 97.7% 95.7%
3575635 4044.1.1.0 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins 0.69 57.0 5.65e-01 98.9% 87.8%
3009331 4044.1.1.1 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Prismane 0.68 54.0 5.59e-01 98.9% 90.4%
3804215 1025.1.1.0 alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain 0.67 59.0 5.68e-01 97.7% 92.0%
4939027 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.66 55.0 4.98e-01 92.0% 75.8%
3227678 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.66 59.0 5.68e-01 98.9% 86.0%
5027823 601.7.1.2 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.65 59.0 4.68e-01 98.9% 64.7%
4956714 3567.1.1.0 a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer 0.65 57.0 5.58e-01 100.0% 89.5%
3443676 192.29.1.0 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.65 57.0 5.53e-01 100.0% 94.0%
5079372 601.7.1.2 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.63 56.0 5.08e-01 100.0% 86.6%
5050149 601.7.1.2 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.63 56.0 4.92e-01 100.0% 80.0%
3981044 867.1.1.1 a+b three layers › Coproporphyrinogen III oxidase › Coproporphyrinogen III oxidase › Coproporphyrinogen III oxidase › Coprogen_oxidas 0.62 54.0 3.88e-01 100.0% 70.1%
5076440 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.62 54.0 5.18e-01 98.9% 90.0%
3593494 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.61 54.0 5.21e-01 100.0% 89.0%
3706202 1128.1.1.0 alpha bundles › LYR protein › LYR protein › LYR protein 0.61 54.0 5.11e-01 100.0% 84.8%
5039337 601.7.1.2 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HEPN 0.61 54.0 4.70e-01 98.9% 82.2%
3248081 601.7.1.0 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.61 50.0 4.54e-01 100.0% 65.8%
5059791 601.7.1.0 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.61 54.0 5.10e-01 100.0% 87.6%
4953123 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.59 50.0 3.24e-01 94.3% 41.7%
3516178 5086.1.1.171 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › LMBR1 0.59 40.0 3.26e-01 98.9% 36.5%
3705963 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.58 41.0 3.84e-01 72.4% 66.7%
4607020 192.2.1.3 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Rad50_zn_hook 0.57 40.0 3.45e-01 72.4% 47.4%
3281890 601.4.1.2 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › NIT 0.57 48.0 4.10e-01 96.6% 65.3%
3602143 3755.3.1.305 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Rad50_zn_hook 0.56 39.0 2.85e-01 72.4% 95.0%
4988993 5086.1.1.231 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Rad50_zn_hook 0.56 39.0 3.30e-01 73.6% 75.3%
5005708 3755.3.1.127 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › NFACT_N 0.56 39.0 3.11e-01 73.6% 52.2%
3438244 3755.3.1.121 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Sin3_corepress 0.55 38.0 3.47e-01 71.3% 74.2%
3253767 192.2.1.0 alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.55 38.0 3.24e-01 73.6% 51.6%
3948847 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.55 38.0 3.63e-01 71.3% 65.0%
5006471 5079.1.1.1 alpha duplicates or obligate multimers › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › Magnesium transporter MgtE membrane domain › MgtE 0.54 47.0 3.83e-01 98.9% 96.5%
3582116 1147.1.1.1 alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL 0.53 36.0 3.27e-01 74.7% 50.8%
4947769 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.53 40.0 3.41e-01 80.5% 60.0%
3692753 5086.1.1.12 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › Uds1 0.51 35.0 2.99e-01 72.4% 74.0%
3632592 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.51 43.0 3.85e-01 97.7% 75.4%
3205253 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.50 48.0 3.71e-01 100.0% 72.9%