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hydrophobic_tubular_protein_NS1

Euk-Vir

Changuinola_virus

hydrophobic_tubular_protein_NS1__YP_008719922__Changuinola_virus__40052

Identity

Accession:
YP_008719922 ↗
Protein ID:
hydrophobic_tubular_protein_NS1
Kingdom:
euk

Quality

84.5 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 1-95
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01718.24 best Orbi_NS1 122.7 2.10e-35 100.0% 17.8%
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3tdvA02 3.90.1200.10 Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe 0.61 47.0 3.64e-01 82.1% 71.8%
3t46A00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.60 44.0 4.82e-01 83.2% 96.0%
2qffA00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 41.0 4.45e-01 83.2% 94.6%
1g4uS01 1.20.120.260 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Virulence factor YopE uncharacterised domain 0.56 45.0 4.08e-01 86.3% 78.0%
4i9oA00 1.10.246.20 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Coactivator CBP, KIX domain 0.56 35.0 3.81e-01 80.0% 76.9%
1on2A02 1.10.60.10 Mainly Alpha › Orthogonal Bundle › Diphtheria Toxin Repressor; domain 2 › Iron dependent repressor, metal binding and dimerisation domain 0.55 36.0 4.19e-01 90.5% 98.4%
4lqkA00 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.55 42.0 3.86e-01 84.2% 93.9%
7miqA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 37.0 3.60e-01 71.6% 95.5%
6ianC01 1.10.418.70 Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Intraflagellar transport protein 81, N-terminal domain 0.53 44.0 4.11e-01 91.6% 76.7%
7ae2A01 1.20.120.580 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like 0.53 43.0 3.89e-01 90.5% 75.9%
2lmgA00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.53 39.0 4.31e-01 85.3% 100.0%
3pwxA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.52 41.0 3.34e-01 84.2% 58.7%
2uxwA01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 41.0 3.34e-01 86.3% 61.3%
3anwB00 1.20.58.2050 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 36.0 3.02e-01 71.6% 87.0%
2wyhB04 1.20.1270.50 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain 0.51 42.0 4.12e-01 89.5% 89.1%
ECOD (9)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4601603 632.15.1.4 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › HSP70 0.59 43.0 4.61e-01 82.1% 91.3%
3880261 5000.3.1.0 alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death 0.58 46.0 3.72e-01 86.3% 97.9%
4194678 632.7.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.57 42.0 4.50e-01 81.1% 91.3%
5031855 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.56 44.0 4.69e-01 86.3% 98.8%
3701062 109.4.1.1202 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DGF-1_C 0.55 43.0 2.97e-01 84.2% 94.7%
3711237 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.55 42.0 4.55e-01 86.3% 98.8%
4055723 632.7.1.1 alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 0.52 41.0 4.11e-01 85.3% 85.3%
3588371 148.1.3.278 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › Bac_RepA_C 0.52 40.0 3.69e-01 84.2% 82.4%
3868831 174.1.1.43 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › CD20 0.50 42.0 3.56e-01 92.6% 70.3%
D2 medium residues 130-253
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01718.24 best Orbi_NS1 126.4 1.60e-36 100.0% 23.8%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1z1bA01 3.30.160.60 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Classic Zinc Finger 0.51 22.0 3.15e-01 96.0% 86.0%
1ny8A00 3.30.300.90 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › BolA-like 0.50 33.0 3.59e-01 80.6% 82.5%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4941465 327.7.1.0 a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like 0.54 24.0 3.26e-01 90.3% 85.5%
4975459 2008.1.1.0 a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like 0.51 37.0 3.50e-01 76.6% 69.7%
3289927 5073.1.1.4 alpha bundles › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain-related › Calcium ATPase transmembrane domain M › Cation_ATPase_C,Cation_ATPase_N 0.50 40.0 2.88e-01 86.3% 77.0%
D3 medium residues 254-347
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01718.24 best Orbi_NS1 83.1 2.00e-23 100.0% 17.4%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5ci5B02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.52 37.0 2.92e-01 73.4% 79.8%
4ryaA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 36.0 2.83e-01 73.4% 77.8%
4ed9A01 3.40.50.10540 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Crotonobetainyl-coa:carnitine coa-transferase; domain 1 0.51 39.0 2.93e-01 88.3% 54.2%
ECOD (1)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3593469 103.1.1.0 alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain 0.62 38.0 4.38e-01 73.4% 96.6%
D4 medium residues 348-415
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01718.24 best Orbi_NS1 72.3 4.00e-20 100.0% 13.0%
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4q63A00 2.40.10.430 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.62 42.0 3.77e-01 97.1% 51.6%
5gt8D02 3.30.2130.10 Alpha Beta › 2-Layer Sandwich › VC0802-like › VC0802-like 0.59 45.0 3.83e-01 85.3% 92.6%
3aqoA01 3.30.70.3400 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.57 33.0 3.18e-01 92.6% 47.5%
6tznA01 3.30.70.330 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › RRM (RNA recognition motif) domain 0.57 39.0 3.42e-01 97.1% 46.3%
2cocA01 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.55 41.0 3.70e-01 82.4% 95.0%
3od1A01 3.30.930.10 Alpha Beta › 2-Layer Sandwich › BirA Bifunctional Protein; domain 2 › Bira Bifunctional Protein; Domain 2 0.54 42.0 2.83e-01 89.7% 87.2%
2bhoA00 3.30.1460.10 Alpha Beta › 2-Layer Sandwich › Yope Regulator; Chain: A, › 0.54 39.0 3.44e-01 88.2% 49.1%
3thxB04 1.10.1420.10 Mainly Alpha › Orthogonal Bundle › MutS, DNA mismatch repair protein; Chain A, domain 3 › 0.54 37.0 3.05e-01 86.8% 38.3%
1c4kA04 3.90.100.10 Alpha Beta › Alpha-Beta Complex › Ornithine Decarboxylase; Chain A, domain 4 › Orn/Lys/Arg decarboxylase, C-terminal domain 0.54 39.0 3.26e-01 79.4% 72.1%
2p4bB02 3.30.200.100 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › MucB/RseB, C-terminal domain 0.53 43.0 3.94e-01 97.1% 94.9%
2gmlA02 3.30.70.1560 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Alpha-L RNA-binding motif 0.52 33.0 3.32e-01 95.6% 59.5%
8egxA04 2.60.40.60 Mainly Beta › Sandwich › Immunoglobulin-like › Cadherins 0.52 41.0 3.67e-01 88.2% 64.4%
2r15A01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 37.0 3.26e-01 86.8% 49.5%
4nswA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.51 39.0 3.41e-01 85.3% 89.0%
5nqdA01 3.30.200.200 Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › 0.51 43.0 3.30e-01 100.0% 57.0%
ECOD (14)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3597863 622.4.1.0 alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related 0.69 43.0 3.23e-01 88.2% 27.7%
3290436 304.3.1.0 a+b two layers › Alpha-beta plaits › HMA-related › HMA, heavy metal-associated domain 0.61 37.0 3.83e-01 79.4% 63.1%
3311966 304.9.1.47 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › DUF4283 0.61 38.0 3.68e-01 95.6% 56.0%
4958791 304.4.1.0 a+b two layers › Alpha-beta plaits › Dimeric alpha+beta barrel › Dimeric alpha+beta barrel 0.58 32.0 3.40e-01 82.4% 58.3%
4946346 327.11.2.0 a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Eukaryotic type KH-domain (KH-domain type I) 0.57 41.0 3.61e-01 85.3% 48.2%
3928061 601.23.1.1 alpha bundles › Four-helical up-and-down bundle › DNA repair protein MutS, domain III › DNA repair protein MutS, domain III › MutS_III 0.57 38.0 2.52e-01 86.8% 14.5%
4456185 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.56 39.0 3.85e-01 76.5% 68.0%
3852303 220.1.1.1 beta barrels › PH domain-like › PH domain-like › PH domain-like › PH 0.54 42.0 3.41e-01 85.3% 75.4%
3855878 304.9.1.21 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRP7,RRM_Rrp7 0.53 40.0 2.89e-01 86.8% 37.3%
5044181 304.117.1.0 a+b two layers › Alpha-beta plaits › Ferredoxin-like domain in YebC › Ferredoxin-like domain in YebC 0.52 33.0 3.26e-01 95.6% 58.7%
3199775 3008.1.1.0 a+b three layers › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › A subdomain in the anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.50 40.0 3.64e-01 92.6% 87.0%
3983826 1154.1.1.1 beta duplicates or obligate multimers › VirG insertion domain (VID) › VirG insertion domain (VID) › VirG insertion domain (VID) › VID 0.50 38.0 3.86e-01 85.3% 81.4%
3825215 387.1.5.7 few secondary structure elements › omega toxin-like › omega toxin-related › Scorpion toxin-like › SCRL 0.50 32.0 3.45e-01 86.8% 80.0%
3931394 220.1.1.1 beta barrels › PH domain-like › PH domain-like › PH domain-like › PH 0.50 40.0 3.05e-01 89.7% 69.7%
D5 medium residues 416-529
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01718.24 best Orbi_NS1 116.7 1.30e-33 93.0% 20.0%
CATH (12)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3a11B01 1.20.120.420 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 0.60 45.0 4.41e-01 87.7% 71.2%
2mtqA00 1.20.58.130 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 35.0 4.21e-01 100.0% 90.4%
1dk8A02 1.10.167.10 Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 0.57 41.0 4.65e-01 82.5% 98.8%
7utzR02 1.20.1070.10 Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins 0.57 48.0 3.73e-01 94.7% 88.3%
1x8zB00 1.20.140.40 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein 0.57 36.0 3.33e-01 86.8% 49.7%
6qumA04 1.10.1140.10 Mainly Alpha › Orthogonal Bundle › Bovine Mitochondrial F1-ATPase, ATP Synthase Beta Chain; Chain D, domain3 › Bovine Mitochondrial F1-atpase; Atp Synthase Beta Chain; Chain D, domain 3 0.54 37.0 3.40e-01 100.0% 53.7%
6wh0A01 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.54 36.0 3.29e-01 85.1% 50.7%
2fp1B00 1.20.59.10 Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase 0.54 37.0 3.32e-01 70.2% 90.9%
2g3kA00 1.20.120.1130 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vps28 C-terminal domain 0.53 40.0 4.38e-01 91.2% 97.9%
3q9dB01 1.20.58.1050 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 31.0 3.46e-01 85.1% 73.0%
1wtyA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.52 44.0 4.40e-01 92.1% 99.1%
1oxjA02 1.25.40.170 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Smaug, PHAT domain 0.50 36.0 3.69e-01 82.5% 77.1%
ECOD (15)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3250588 109.4.1.791 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_17 0.62 33.0 3.61e-01 94.7% 60.0%
4011331 3651.1.1.0 alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain 0.60 41.0 4.10e-01 70.2% 69.2%
5029451 601.7.1.0 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.59 49.0 4.52e-01 90.4% 81.3%
3248081 601.7.1.0 alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain 0.59 47.0 4.69e-01 86.8% 100.0%
3805763 7015.1.1.0 alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.57 44.0 4.00e-01 94.7% 61.3%
3798260 196.1.1.0 alpha bundles › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS 0.56 43.0 3.48e-01 84.2% 42.2%
3704187 601.28.1.1 alpha bundles › Four-helical up-and-down bundle › VPS28 C-terminal domain-like › VPS28 C-terminal domain-like › VPS28 0.55 43.0 4.45e-01 83.3% 90.0%
3583791 196.1.1.1 alpha bundles › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › RGS 0.54 41.0 3.89e-01 85.1% 65.9%
3264751 4044.1.1.0 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins 0.53 42.0 3.89e-01 84.2% 80.7%
3515234 109.3.1.0 alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat 0.53 47.0 4.29e-01 100.0% 74.5%
4976469 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.52 44.0 3.36e-01 95.6% 70.5%
3278587 191.1.1.1 alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_1 0.52 37.0 3.37e-01 73.7% 91.0%
3961148 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.52 32.0 3.23e-01 83.3% 60.0%
4342803 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.51 35.0 3.61e-01 95.6% 73.6%
3364492 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.51 42.0 3.83e-01 95.6% 67.3%