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hydroxysteroid_dehydrogenase

Euk-Vir

Pigeonpox_virus

hydroxysteroid_dehydrogenase__YP_009046283__Pigeonpox_virus__10264

Identity

Accession:
YP_009046283 ↗
Protein ID:
hydroxysteroid_dehydrogenase
Kingdom:
euk

Quality

90.3 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Avipoxvirus› Pigeonpox_virus

TaxID: 10264

Cluster

View cluster (115 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 4-191_225-257
PDB
Domain cluster: rep: 3-beta_hydroxysteroid_dehydrogenase_isomerase_family__YP_009342125__Lymphocystis_disease_virus_Sa__1898060__D2-175_211-244_309-317
Pfam (6)
AccessionNameScoreE-valueQ covHMM cov
PF01370.28 best Epimerase 74.1 1.60e-20 95.5% 70.8%
PF01073.26 3Beta_HSD 234.6 1.60e-69 84.2% 64.6%
PF07993.19 NAD_binding_4 51.6 1.00e-13 84.2% 76.0%
PF02719.22 Polysacc_synt_2 54.7 1.30e-14 82.3% 45.4%
PF16363.12 GDP_Man_Dehyd 39.1 9.20e-10 77.8% 48.2%
PF01073.26 3Beta_HSD 36.3 4.70e-09 15.8% 12.1%
D2 high residues 196-221_261-329_348-361
PDB
Domain cluster: rep: hydroxysteroid_dehydrogenase__YP_010087882__Lymphocystis_disease_virus_4__2704413__D182-208_246-308_324-337
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3i6iA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.64 58.0 5.70e-01 99.1% 97.4%
1bsvA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.61 46.0 4.94e-01 100.0% 93.6%
3k9cA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.55 40.0 3.70e-01 75.2% 89.4%
4e3zB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 38.0 3.05e-01 71.6% 77.2%
1yb1B01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 38.0 3.01e-01 71.6% 71.9%
2ew8B00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.54 37.0 2.98e-01 71.6% 72.4%
5ktkA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 41.0 2.80e-01 84.4% 50.2%
3qivA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 37.0 3.08e-01 72.5% 78.9%
3ksuB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 39.0 3.13e-01 77.1% 77.1%
4iuyA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.53 39.0 2.99e-01 77.1% 70.4%
3oidC00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 39.0 3.06e-01 79.8% 71.4%
3ausA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 38.0 2.91e-01 77.1% 67.9%
3s55E00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 39.0 2.98e-01 79.8% 70.7%
3wtbC00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 39.0 3.05e-01 79.8% 72.4%
4iiuC00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 39.0 3.05e-01 79.8% 74.2%
3m1aJ00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 40.0 3.02e-01 83.5% 79.8%
1g0nB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 40.0 3.17e-01 87.2% 83.1%
5g4kA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 40.0 3.14e-01 87.2% 83.3%
5epoA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 39.0 2.98e-01 80.7% 69.0%
4r75A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 37.0 3.33e-01 77.1% 98.8%
3i3oG00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 41.0 3.18e-01 87.2% 81.6%
4yxfB00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 39.0 3.14e-01 83.5% 86.3%
5jc8C00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 40.0 3.10e-01 85.3% 71.8%
3tndA00 3.40.50.1010 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease 0.51 35.0 3.30e-01 70.6% 71.2%
1snyA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.50 40.0 3.12e-01 86.2% 86.7%
3h7aA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.50 39.0 3.15e-01 82.6% 86.3%
3rkrA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.50 40.0 3.22e-01 87.2% 99.5%
ECOD (51)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3542046 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.96 92.0 6.09e-01 100.0% 45.8%
None — 0.95 92.0 6.08e-01 100.0% 45.8%
3912183 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.88 83.0 5.54e-01 100.0% 44.9%
3845323 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.86 80.0 5.31e-01 100.0% 41.8%
3654643 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.84 78.0 6.20e-01 100.0% 81.0%
3257145 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.83 76.0 5.25e-01 100.0% 47.0%
3869053 2003.1.1.160 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD, NmrA 0.82 76.0 5.12e-01 100.0% 44.8%
3503100 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.81 72.0 4.93e-01 96.3% 45.8%
None — 0.81 75.0 5.07e-01 100.0% 45.9%
3534810 2003.1.1.160 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD, NmrA 0.81 74.0 5.14e-01 100.0% 47.0%
4487437 2003.1.1.160 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD, NmrA 0.81 74.0 5.11e-01 98.2% 47.6%
3834581 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.80 73.0 4.92e-01 100.0% 42.3%
3983616 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.80 74.0 5.08e-01 100.0% 45.8%
3286127 2003.1.1.160 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD, NmrA 0.79 72.0 5.00e-01 100.0% 46.7%
None — 0.79 72.0 4.98e-01 100.0% 44.9%
None — 0.77 75.0 5.05e-01 100.0% 95.5%
3423243 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.76 69.0 4.62e-01 100.0% 42.3%
5046403 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.74 65.0 4.62e-01 96.3% 46.8%
4978097 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.73 66.0 4.65e-01 100.0% 46.6%
4613677 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.73 66.0 4.68e-01 100.0% 46.7%
3597018 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.73 66.0 4.55e-01 100.0% 45.3%
3924456 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.73 65.0 4.51e-01 100.0% 45.6%
3982773 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.70 63.0 4.53e-01 100.0% 50.0%
4480522 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.67 60.0 4.29e-01 100.0% 43.8%
3972492 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.66 60.0 4.28e-01 100.0% 45.4%
4014179 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.66 59.0 4.22e-01 100.0% 48.8%
3205647 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.65 58.0 4.19e-01 99.1% 49.8%
4017152 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.63 55.0 3.98e-01 98.2% 53.2%
5022022 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.61 55.0 4.06e-01 100.0% 51.2%
4167131 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.55 41.0 2.93e-01 79.8% 67.9%
5007658 2484.1.1.66 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DDE_3 0.55 39.0 3.64e-01 72.5% 65.2%
3276940 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.55 41.0 3.05e-01 80.7% 68.1%
1155156 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.54 38.0 3.22e-01 72.5% 88.0%
3685167 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.54 42.0 3.02e-01 83.5% 79.1%
3288328 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.53 42.0 3.19e-01 86.2% 78.9%
3631090 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.53 41.0 3.03e-01 83.5% 76.3%
3403683 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.53 42.0 3.20e-01 87.2% 78.5%
3257090 2003.1.1.4 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.52 40.0 3.22e-01 84.4% 84.2%
4140368 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.52 41.0 3.16e-01 83.5% 81.6%
3285218 2003.1.1.69 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short_C2 0.52 41.0 3.19e-01 87.2% 85.8%
3998911 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.52 41.0 2.95e-01 87.2% 62.4%
3955827 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.52 41.0 3.03e-01 87.2% 67.9%
5039733 7592.1.1.0 ↗ a/b three-layered sandwiches › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains › CARF (CRISPR-associated Rossmann fold) domains 0.51 37.0 3.56e-01 80.7% 63.8%
5048385 2005.1.1.18 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › NAD_synthase 0.51 41.0 3.04e-01 87.2% 62.0%
3096936 2003.1.1.69 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short_C2 0.51 41.0 3.21e-01 87.2% 86.4%
3945070 2003.1.1.69 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short_C2 0.51 38.0 2.98e-01 79.8% 73.2%
3955044 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.51 40.0 3.06e-01 86.2% 79.2%
3960340 2003.1.1.0 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains 0.50 39.0 3.11e-01 85.3% 85.9%
3279826 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.50 40.0 2.97e-01 86.2% 77.6%
145518 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.50 40.0 3.22e-01 87.2% 99.5%
3688006 2003.1.1.69 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short_C2 0.50 38.0 2.90e-01 80.7% 66.4%