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hydroxysteroid_dehydrogenase

Euk-Vir

Lymphocystis_disease_virus_4

hydroxysteroid_dehydrogenase__YP_010087882__Lymphocystis_disease_virus_4__2704413

Identity

Accession:
YP_010087882 ↗
Protein ID:
hydroxysteroid_dehydrogenase
Kingdom:
euk

Quality

85.7 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Iridoviridae› Lymphocystivirus› Lymphocystis_disease_virus_4

TaxID: 2704413

Cluster

View cluster (4 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-175_211-244_310-317
PDB
Domain cluster: rep: 3-beta_hydroxysteroid_dehydrogenase_isomerase_family__YP_009342125__Lymphocystis_disease_virus_Sa__1898060__D2-175_211-244_309-317
Pfam (6)
AccessionNameScoreE-valueQ covHMM cov
PF01370.28 best Epimerase 57.7 1.70e-15 86.1% 71.2%
PF01073.26 3Beta_HSD 107.9 6.90e-31 80.1% 65.0%
PF07993.19 NAD_binding_4 33.4 3.70e-08 73.2% 47.7%
PF13460.13 NAD_binding_10 33.7 4.80e-08 71.8% 69.6%
PF02719.22 Polysacc_synt_2 36.2 5.70e-09 51.4% 42.3%
PF01073.26 3Beta_HSD 22.1 9.70e-05 21.3% 12.5%
D2 high residues 182-208_246-308_324-337
PDB
Domain cluster: representative
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4wpgA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.70 50.0 5.57e-01 98.1% 98.7%
3e48B02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.64 54.0 5.48e-01 99.0% 93.3%
2b69A02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.64 44.0 4.85e-01 100.0% 91.3%
1bsvA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.63 49.0 5.11e-01 100.0% 91.5%
4lw8A02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.63 46.0 4.94e-01 100.0% 94.1%
4e5yD02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.62 49.0 5.02e-01 100.0% 88.0%
2zskA02 3.40.50.1860 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.58 41.0 4.10e-01 74.0% 84.5%
1qydA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 40.0 3.28e-01 70.2% 65.4%
1mv8A03 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.58 42.0 3.41e-01 76.0% 65.8%
2derB01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.57 44.0 3.54e-01 81.7% 93.1%
6dntA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.57 49.0 4.85e-01 100.0% 91.7%
3eheA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.56 43.0 4.51e-01 100.0% 90.6%
6bwlA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.56 48.0 4.84e-01 100.0% 93.4%
4as2A01 3.40.50.1000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HAD superfamily/HAD-like 0.56 43.0 3.46e-01 84.6% 96.4%
3lf2A01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 38.0 2.92e-01 71.2% 69.3%
3bzcA03 3.30.420.140 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › YqgF/RNase H-like domain 0.55 40.0 3.78e-01 76.9% 71.1%
2xr1A03 3.60.15.10 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 0.54 38.0 2.85e-01 72.1% 81.5%
6wjaA02 3.90.25.10 Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 0.54 46.0 4.64e-01 99.0% 96.2%
4chgA00 3.40.50.1010 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease 0.51 38.0 3.53e-01 78.8% 70.7%
2qjcA00 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.50 37.0 2.95e-01 77.9% 80.2%
ECOD (19)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3912183 2003.1.1.11 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › 3Beta_HSD 0.86 80.0 5.29e-01 100.0% 43.9%
3972535 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.72 65.0 4.62e-01 100.0% 45.8%
3616435 2003.1.1.67 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NAD_binding_10 0.65 57.0 3.94e-01 100.0% 43.3%
5022022 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.62 55.0 4.05e-01 100.0% 49.8%
4997731 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.61 44.0 3.74e-01 75.0% 64.7%
3839301 2006.1.1.6 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Acid_phosphat_B 0.60 46.0 3.61e-01 81.7% 80.0%
3443018 2003.1.1.53 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › NmrA 0.57 39.0 3.18e-01 71.2% 68.6%
3943513 2484.1.1.74 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Tex_YqgF 0.56 41.0 3.67e-01 76.9% 59.3%
4536847 2005.1.1.23 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › tRNA_Me_trans 0.56 41.0 3.32e-01 78.8% 83.7%
3181781 2003.1.1.20 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › Epimerase 0.55 47.0 3.47e-01 100.0% 42.2%
5000570 2003.4.1.1 ↗ a/b three-layered sandwiches › Rossmann-like › Tryptophan synthase beta subunit-like PLP-dependent enzymes › Tryptophan synthase beta subunit-like PLP-dependent enzymes › PALP 0.54 41.0 3.41e-01 79.8% 71.9%
None — 0.53 39.0 3.20e-01 78.8% 86.8%
3286968 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.53 41.0 3.18e-01 86.5% 72.7%
4991588 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.52 39.0 3.38e-01 80.8% 86.9%
3957330 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.52 40.0 2.97e-01 82.7% 81.4%
4032928 2004.1.1.73 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 0.52 44.0 3.35e-01 100.0% 87.1%
5057914 2484.1.1.330 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › DUF460 0.52 37.0 3.23e-01 77.9% 48.1%
3560032 2006.1.1.62 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › Hydrolase, Hydrolase_like, Hydrolase_6 0.50 43.0 3.75e-01 96.2% 97.0%
4996416 7512.1.1.0 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.50 41.0 3.45e-01 91.3% 97.4%