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hypothetical_protein_HhV6Bgp013

Euk-Vir

Human_betaherpesvirus_6B

hypothetical_protein_HhV6Bgp013__NP_050187__Human_betaherpesvirus_6B__32604

Identity

Accession:: NP_050187 ↗
Protein ID:: hypothetical_protein_HhV6Bgp013
Kingdom:: euk

Quality

65.1 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Human_betaherpesvirus_6B

TaxID: 32604

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 55-174

PDB

Domain cluster: rep: gp3__YP_007417792__Caviid_betaherpesvirus_2__33706__D377-544

D2 high residues 189-325

PDB

D3 high residues 505-686

PDB

Domain cluster: rep: protein_UL27__YP_004940053__Aotine_betaherpesvirus_1__50290__D178-261_284-374

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF05999.17 best	Herpes_U5	323.0	5.10e-96	100.0%	43.4%

D4 medium residues 368-407

PDB

D5 medium residues 408-504_689-786

PDB

Domain cluster: rep: protein_UL27__YP_002608241__Human_herpesvirus_5__10359__D150-198_411-491_534-560

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF05999.17 best	Herpes_U5	168.2	4.60e-49	50.3%	21.3%
PF05999.17	Herpes_U5	61.7	8.60e-17	23.1%	8.8%

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2iaiA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.59	35.0	4.08e-01	79.0%	81.6%
5iduC03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.57	33.0	3.66e-01	70.3%	69.8%
2nwbA02	1.20.58.480	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.57	40.0	3.79e-01	71.8%	90.7%
1w99A01	1.20.190.10	Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain	0.56	44.0	4.66e-01	88.7%	91.3%
2i10B02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.55	31.0	3.81e-01	74.4%	85.6%
4ie5A02	1.20.58.1470	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › FTO C-terminal domain	0.55	36.0	4.29e-01	75.4%	97.0%
2rldA00	1.20.1440.60	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence	0.54	32.0	4.04e-01	73.8%	97.4%
3chtA00	1.10.620.20	Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A	0.54	42.0	3.60e-01	81.0%	86.4%
5jpoD02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.53	32.0	3.80e-01	88.7%	87.2%
4xvxA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.53	36.0	4.13e-01	77.4%	91.8%
2gfnA00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.53	41.0	4.16e-01	85.1%	82.8%
3qqaA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.52	33.0	3.79e-01	79.0%	85.8%
2w2dD01	1.20.1120.10	Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain"	0.52	38.0	3.06e-01	75.4%	97.5%
8fnyA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.51	36.0	3.53e-01	79.5%	66.0%
1r2jA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	36.0	4.14e-01	76.9%	95.8%
2pg0A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	35.0	4.04e-01	77.4%	92.6%
3m0fB02	1.20.1050.10	Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 ›	0.51	32.0	3.96e-01	84.6%	99.2%
3hd6A00	1.10.3430.10	Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains	0.50	42.0	3.33e-01	89.2%	73.9%

ECOD (29)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4350232	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.65	55.0	4.77e-01	89.7%	94.9%
5043455	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.63	53.0	4.71e-01	89.7%	94.6%
3600308	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.63	51.0	4.77e-01	85.6%	88.3%
4539519	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.63	53.0	4.69e-01	89.7%	98.9%
3350768	5069.1.1.4 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Ferric_reduct	0.62	57.0	4.82e-01	100.0%	73.8%
5061391	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.62	52.0	4.49e-01	89.2%	97.3%
4977753	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.62	51.0	4.54e-01	88.7%	96.1%
5001888	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.61	51.0	4.44e-01	89.7%	95.7%
3289222	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.61	51.0	4.40e-01	89.2%	97.0%
3932573	633.10.1.0 ↗	alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like	0.60	36.0	4.23e-01	74.9%	82.9%
4020994	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.58	42.0	4.81e-01	80.5%	99.3%
3724557	5069.1.1.0 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes	0.56	44.0	4.52e-01	81.5%	96.8%
4014281	5001.1.1.0 ↗	alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like	0.56	43.0	3.87e-01	79.0%	84.4%
4668781	191.1.1.28 ↗	alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › TetR_C_26	0.56	34.0	3.97e-01	78.5%	83.5%
3408006	5069.1.1.7 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_B561	0.55	49.0	4.73e-01	94.4%	86.5%
5067000	633.6.1.1 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1	0.55	35.0	3.94e-01	71.8%	81.3%
4989482	141.1.1.3 ↗	alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases › UbiA	0.55	46.0	4.21e-01	88.7%	99.2%
4979964	3896.1.1.0 ↗	alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase	0.55	42.0	3.77e-01	78.5%	78.9%
3266913	604.5.1.46 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › TPR_SYVN1_N	0.54	42.0	3.95e-01	78.5%	95.7%
4350358	109.4.1.179 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nro1	0.54	44.0	3.47e-01	86.7%	71.4%
3321540	5069.1.1.7 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Cytochrom_B561	0.54	48.0	4.58e-01	95.4%	90.0%
3720162	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.53	38.0	3.29e-01	70.8%	49.3%
3290903	2498.1.1.6 ↗	mixed a+b and a/b › Zincin-like › "Metalloproteases (""zincins"") catalytic domain" › "Metalloproteases (""zincins"") catalytic domain" › Peptidase_M3	0.53	43.0	2.98e-01	84.1%	68.7%
4005538	5058.1.1.14 ↗	alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MscS_TM	0.53	47.0	4.16e-01	97.4%	93.9%
3498332	633.21.1.0 ↗	alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107	0.53	33.0	3.74e-01	73.3%	79.3%
3598799	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.52	39.0	4.28e-01	80.5%	94.8%
3631036	5069.1.1.38 ↗	alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Frag1	0.52	40.0	4.18e-01	85.1%	86.7%
3345554	611.7.1.0 ↗	alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain	0.52	35.0	3.83e-01	74.4%	82.5%
4941161	1075.5.1.2 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › MurJ	0.51	38.0	3.56e-01	76.9%	82.0%

D6 medium residues 787-848

PDB