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hypothetical_protein_VARVgp053

Euk-Vir

Variola_virus

hypothetical_protein_VARVgp053__NP_042097__Variola_virus__10255

Identity

Accession:
NP_042097 ↗
Protein ID:
hypothetical_protein_VARVgp053
Kingdom:
euk

Quality

70.3 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Chitovirales› Poxviridae› Orthopoxvirus› Variola_virus

TaxID: 10255

Cluster

View cluster (22 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 351-408
PDB
Domain cluster: rep: hypothetical_protein_DpV83gp050__YP_227425__Deerpox_virus_W-848-83__305674__D350-406
D2 high residues 477-663
PDB
D3 medium residues 1-54
PDB
Domain cluster: representative
CATH (5)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
7jgsG01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.59 46.0 3.29e-01 85.2% 64.8%
2ynqB00 1.25.40.680 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Type VII secretion system EssB, C-terminal-like domain 0.58 46.0 3.47e-01 92.6% 60.3%
1t5jA00 1.10.4080.10 Mainly Alpha › Orthogonal Bundle › ADP-ribosylglycohydrolase fold › ADP-ribosylation/Crystallin J1 0.56 44.0 2.91e-01 100.0% 24.3%
3zriA01 1.10.1780.10 Mainly Alpha › Orthogonal Bundle › Double Clp-N motif › Clp, N-terminal domain 0.56 45.0 3.44e-01 98.1% 87.7%
2vqgA00 1.10.10.1280 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Alpha-helical porin B/porin C 0.55 40.0 3.69e-01 81.5% 90.8%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3444757 130.1.1.0 ↗ alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif 0.64 45.0 4.51e-01 74.1% 83.3%
3286911 101.1.2.0 ↗ alpha arrays › HTH › HTH › winged helix domain 0.62 46.0 4.26e-01 81.5% 94.3%
1108191 604.17.1.1 ↗ alpha bundles › Spectrin repeat-like › MTH_863 C-terminal domain-like › MTH_863 C-terminal domain-like › DUF447_C 0.58 42.0 3.95e-01 77.8% 85.1%
3725825 7000.1.1.2 ↗ alpha arrays › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS › inserted region in the C-terminal domain of the archeal LeuRS › RBD_LARS1 0.56 40.0 3.80e-01 77.8% 82.9%
4441922 6102.1.1.1 ↗ alpha arrays › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA › N-terminal domain of segregation and condensation protein A, ScpA › SMC_ScpA 0.56 37.0 3.01e-01 70.4% 80.8%
5009841 2006.1.4.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › PIN domain-like › PIN 0.52 37.0 2.96e-01 81.5% 34.6%
D4 medium residues 55-126
PDB
Domain cluster: rep: Iev_morphogenesis_protein__YP_010377057__Monkeypox_virus__10244__D56-119
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF04497.19 best Pox_E2-like 33.4 2.80e-08 100.0% 9.2%
D5 medium residues 127-202
PDB
Domain cluster: representative
CATH (15)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2yvyA01 1.25.60.10 Mainly Alpha › Alpha Horseshoe › MgtE N-terminal fold › MgtE N-terminal domain-like 0.69 59.0 5.09e-01 97.4% 99.2%
8gpvA01 1.25.60.10 Mainly Alpha › Alpha Horseshoe › MgtE N-terminal fold › MgtE N-terminal domain-like 0.69 59.0 5.00e-01 96.1% 89.1%
8gpsA01 1.25.60.10 Mainly Alpha › Alpha Horseshoe › MgtE N-terminal fold › MgtE N-terminal domain-like 0.65 55.0 5.00e-01 96.1% 86.7%
4hreA03 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.64 44.0 4.22e-01 71.1% 92.0%
1bc0A03 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.63 43.0 4.15e-01 71.1% 94.2%
1yz5B00 1.20.190.20 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › 14-3-3 domain 0.62 52.0 3.81e-01 96.1% 61.6%
3ivrA00 3.40.50.12780 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ANL, N-terminal domain 0.61 51.0 3.29e-01 94.7% 22.6%
1he8A03 1.25.40.70 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) 0.61 50.0 4.54e-01 94.7% 95.5%
3nyqA01 3.40.50.12780 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › ANL, N-terminal domain 0.60 49.0 3.23e-01 94.7% 31.3%
4mduA02 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.59 41.0 4.02e-01 72.4% 98.8%
4epzA00 1.25.40.810 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › UpxZ 0.56 46.0 3.80e-01 94.7% 68.2%
2guhB00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.56 42.0 3.26e-01 81.6% 73.6%
8hi7B01 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.55 46.0 3.27e-01 100.0% 46.3%
3u0hA00 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.51 42.0 3.02e-01 100.0% 43.7%
1aowA02 1.10.220.10 Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Annexin 0.50 39.0 4.00e-01 88.2% 100.0%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3735378 109.3.1.233 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › DUF7104 0.66 58.0 4.17e-01 100.0% 62.7%
3208161 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.64 43.0 4.22e-01 71.1% 94.1%
3940240 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.63 48.0 4.36e-01 82.9% 70.5%
3471675 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.63 48.0 4.48e-01 82.9% 81.1%
3931796 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.62 43.0 4.01e-01 73.7% 80.0%
3803313 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.62 47.0 4.14e-01 84.2% 73.3%
1609341 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.62 49.0 3.99e-01 88.2% 44.7%
3739754 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.61 47.0 4.39e-01 82.9% 83.2%
1874011 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.61 42.0 3.86e-01 72.4% 73.5%
3994159 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.61 53.0 3.68e-01 98.7% 37.4%
3723725 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.60 41.0 4.00e-01 71.1% 88.2%
3447407 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.60 41.0 4.05e-01 73.7% 94.1%
3234962 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.60 50.0 4.77e-01 100.0% 81.1%
3993727 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.60 42.0 3.99e-01 73.7% 82.2%
3619338 3371.1.1.0 ↗ few secondary structure elements › Regulator of transcription protein Rtr1 › Regulator of transcription protein Rtr1 › Regulator of transcription protein Rtr1 0.59 41.0 3.68e-01 72.4% 71.8%
3443239 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.59 42.0 4.01e-01 75.0% 94.4%
3321577 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.57 44.0 4.29e-01 82.9% 95.3%
3901709 176.1.1.0 ↗ alpha arrays › Annexin › Annexin › Annexin 0.57 41.0 4.05e-01 75.0% 97.5%
3959451 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.57 46.0 3.76e-01 94.7% 65.0%
4001181 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.57 48.0 4.36e-01 100.0% 71.8%
3562126 145.1.1.2 ↗ alpha arrays › F-box domain › F-box domain › F-box domain › Elongin_A 0.56 45.0 4.14e-01 100.0% 67.6%
3906995 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.55 39.0 3.99e-01 76.3% 100.0%
3489224 176.1.1.0 ↗ alpha arrays › Annexin › Annexin › Annexin 0.54 38.0 3.76e-01 76.3% 96.5%
3390327 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.54 38.0 3.90e-01 76.3% 98.7%
4678741 101.1.4.3 ↗ alpha arrays › HTH › HTH › tetra-helical, lambda repressor-like › HTH_3 0.54 31.0 3.21e-01 88.2% 57.3%
1872973 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.54 39.0 3.91e-01 77.6% 98.7%
3479797 176.1.1.0 ↗ alpha arrays › Annexin › Annexin › Annexin 0.53 40.0 3.93e-01 82.9% 97.6%
3559767 176.1.1.1 ↗ alpha arrays › Annexin › Annexin › Annexin › Annexin 0.53 39.0 3.98e-01 80.3% 100.0%
D6 medium residues 418-476
PDB