←Back to structures
hypothetical_protein_VARVgp122
Euk-VirVariola_virus
hypothetical_protein_VARVgp122__NP_042166__Variola_virus__10255
Identity
- Accession:
- NP_042166 ↗
- Protein ID:
- hypothetical_protein_VARVgp122
- Kingdom:
- euk
Quality
82.2
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Orthopoxvirus›
Variola_virus
TaxID: 10255
Cluster
View cluster (178 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 259-465
Domain cluster:
rep: MK064563__AZI75768.1__SBFV2-gp01__00001__D223-383
D2
medium
residues 1-52
Domain cluster:
rep: 110R__NP_938365__Yaba_monkey_tumor_virus__38804__D1-54
D3
medium
residues 95-132_210-254
Domain cluster:
representative
CATH (37)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7t85A01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.74 | 59.0 | 4.68e-01 | 84.3% | 70.8% |
| 3v4rA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.74 | 68.0 | 4.75e-01 | 100.0% | 91.5% |
| 1kgdA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.73 | 51.0 | 4.55e-01 | 89.2% | 52.2% |
| 3dmqA04 | 3.40.50.10810 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Tandem AAA-ATPase domain | 0.72 | 65.0 | 4.41e-01 | 100.0% | 86.4% |
| 1a5tA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.72 | 66.0 | 5.18e-01 | 100.0% | 92.2% |
| 1svmA03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.71 | 64.0 | 5.24e-01 | 100.0% | 94.1% |
| 2yogA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.71 | 58.0 | 4.42e-01 | 89.2% | 67.0% |
| 2qorA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.69 | 51.0 | 4.37e-01 | 89.2% | 50.0% |
| 1c4oA03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.64 | 57.0 | 4.52e-01 | 100.0% | 50.9% |
| 6i1dA02 | 3.40.50.10890 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.64 | 57.0 | 4.40e-01 | 100.0% | 94.1% |
| 5ywwA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.63 | 55.0 | 4.32e-01 | 100.0% | 65.2% |
| 1c4oA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.62 | 56.0 | 4.53e-01 | 97.6% | 88.9% |
| 6fcxA01 | 3.20.20.220 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › | 0.61 | 48.0 | 3.47e-01 | 90.4% | 99.3% |
| 2g5gX01 | 3.40.50.11550 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.61 | 54.0 | 4.13e-01 | 100.0% | 85.7% |
| 1xtiA02 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.60 | 54.0 | 4.34e-01 | 100.0% | 68.3% |
| 3eafA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.60 | 51.0 | 4.08e-01 | 98.8% | 71.2% |
| 1b1cA00 | 3.40.50.360 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain | 0.60 | 44.0 | 3.61e-01 | 80.7% | 75.9% |
| 4nqrA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.59 | 50.0 | 4.20e-01 | 98.8% | 67.7% |
| 3cu5B00 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.59 | 40.0 | 3.48e-01 | 91.6% | 45.0% |
| 2wjwA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.59 | 50.0 | 4.14e-01 | 98.8% | 63.8% |
| 4q6bA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 50.0 | 4.37e-01 | 100.0% | 82.1% |
| 3qi7A02 | 3.40.50.11390 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.58 | 50.0 | 4.06e-01 | 98.8% | 67.7% |
| 4wzzA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 51.0 | 4.12e-01 | 100.0% | 50.9% |
| 2b4yA01 | 3.40.50.1220 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › TPP-binding domain | 0.58 | 49.0 | 4.15e-01 | 100.0% | 92.8% |
| 2bn4A01 | 3.40.50.360 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain | 0.57 | 45.0 | 3.55e-01 | 85.5% | 73.8% |
| 4h2dA00 | 3.40.50.360 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Flavodoxin domain | 0.57 | 44.0 | 3.63e-01 | 85.5% | 80.4% |
| 1eamA00 | 3.40.50.150 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 | 0.56 | 50.0 | 3.43e-01 | 100.0% | 32.6% |
| 4c6rA00 | 3.40.50.10140 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Toll/interleukin-1 receptor homology (TIR) domain | 0.56 | 43.0 | 3.58e-01 | 86.7% | 86.4% |
| 3brsA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.55 | 46.0 | 4.11e-01 | 100.0% | 88.8% |
| 2xciC01 | 3.40.50.11720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 3-Deoxy-D-manno-octulosonic-acid transferase, N-terminal domain | 0.54 | 41.0 | 3.43e-01 | 85.5% | 72.1% |
| 3om0A02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.54 | 46.0 | 3.81e-01 | 98.8% | 60.6% |
| 5oomK00 | 3.90.1180.10 | Alpha Beta › Alpha-Beta Complex › Ribosomal Protein L13p; Chain: A; › Ribosomal protein L13 | 0.54 | 48.0 | 3.78e-01 | 100.0% | 66.7% |
| 6efrA01 | 3.40.190.120 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Osmoprotection protein (prox); domain 2 | 0.54 | 40.0 | 3.87e-01 | 98.8% | 69.1% |
| 2jjmA02 | 3.40.50.2000 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; | 0.54 | 42.0 | 3.35e-01 | 85.5% | 68.7% |
| 4i6kA00 | 3.20.20.140 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases | 0.53 | 46.0 | 3.28e-01 | 98.8% | 73.8% |
| 6i3mE02 | 3.40.50.10470 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Translation initiation factor eif-2b; domain 2 | 0.51 | 45.0 | 3.41e-01 | 100.0% | 44.0% |
| 3a04A01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.50 | 42.0 | 3.14e-01 | 100.0% | 88.8% |
ECOD (30)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3627729 | 2004.1.1.120 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ResIII | 0.76 | 71.0 | 4.69e-01 | 100.0% | 68.0% |
| 3929018 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.76 | 70.0 | 4.76e-01 | 100.0% | 73.3% |
| 5058934 | 2004.1.1.1221 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF27431 | 0.75 | 69.0 | 4.55e-01 | 100.0% | 93.4% |
| 4179762 | 2004.1.1.233 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Cas3-like_C_2 | 0.75 | 67.0 | 3.99e-01 | 100.0% | 40.3% |
| 5048316 | 2004.1.1.1221 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PF27431 | 0.74 | 69.0 | 4.30e-01 | 100.0% | 94.8% |
| 3388291 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.73 | 66.0 | 5.73e-01 | 100.0% | 93.6% |
| 4868966 | 2004.1.1.29 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD | 0.66 | 59.0 | 4.76e-01 | 100.0% | 66.5% |
| 3881870 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.65 | 58.0 | 4.89e-01 | 100.0% | 76.4% |
| 4118384 | 2004.1.1.414 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › GTP_EFTU, MMR_HSR1 | 0.65 | 54.0 | 3.83e-01 | 89.2% | 50.6% |
| 4828865 | 2004.1.1.23 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SNF2-rel_dom | 0.62 | 53.0 | 3.83e-01 | 100.0% | 46.4% |
| 3587801 | 2004.1.1.554 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrB_inter | 0.60 | 52.0 | 3.45e-01 | 100.0% | 73.1% |
| 3193070 | 2007.2.3.3 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Syja_N | 0.60 | 54.0 | 3.55e-01 | 100.0% | 58.5% |
| 3642856 | 2003.1.5.47 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › PRMT5 | 0.60 | 47.0 | 4.56e-01 | 100.0% | 75.8% |
| 3731197 | 2007.2.3.8 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase3 | 0.59 | 50.0 | 3.56e-01 | 100.0% | 78.6% |
| 3711265 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.59 | 51.0 | 4.25e-01 | 100.0% | 74.2% |
| 5029279 | 2007.2.2.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Phosphotyrosine protein phosphatases I-like | 0.58 | 49.0 | 4.37e-01 | 97.6% | 65.0% |
| 4890134 | 2007.1.2.4 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor | 0.58 | 50.0 | 3.90e-01 | 100.0% | 79.3% |
| 4188766 | 2004.1.1.159 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Mur_ligase_M | 0.58 | 46.0 | 3.60e-01 | 89.2% | 60.0% |
| 3947275 | 2005.1.1.3 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp | 0.56 | 46.0 | 3.94e-01 | 92.8% | 98.6% |
| 3829770 | 2005.1.1.43 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CHX17_2nd | 0.56 | 49.0 | 3.86e-01 | 98.8% | 78.3% |
| 3988213 | 2007.1.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Response_reg | 0.54 | 44.0 | 3.70e-01 | 89.2% | 56.6% |
| 4096365 | 2484.1.1.40 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RuvX | 0.53 | 43.0 | 3.56e-01 | 89.2% | 70.7% |
| 4998336 | 2008.1.1.107 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › NERD | 0.53 | 38.0 | 3.21e-01 | 77.1% | 86.2% |
| 5015825 | 7523.1.1.27 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › NMT1_2 | 0.52 | 44.0 | 3.95e-01 | 100.0% | 63.8% |
| 3731558 | 2007.2.1.3 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › Flavoproteins › FMN_red | 0.52 | 37.0 | 2.83e-01 | 75.9% | 77.8% |
| 4065153 | 2007.1.6.2 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Aminoacid dehydrogenase-like, N-terminal domain › THF_DHG_CYH | 0.51 | 42.0 | 3.72e-01 | 95.2% | 85.4% |
| 3193579 | 7502.1.1.0 ↗ | a/b three-layered sandwiches › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS › Anticodon-binding domain of Class II aaRS | 0.51 | 40.0 | 3.17e-01 | 88.0% | 60.0% |
| 5030368 | 7512.1.1.12 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyco_tran_28_C | 0.51 | 39.0 | 3.16e-01 | 86.7% | 61.7% |
| 4996411 | 7512.1.1.3 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glycos_transf_1 | 0.50 | 38.0 | 3.02e-01 | 85.5% | 63.0% |
| 4962917 | 2005.1.1.3 ↗ | a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp | 0.50 | 43.0 | 3.65e-01 | 98.8% | 77.9% |
D4
medium
residues 133-209
Domain cluster:
rep: DNA_helicase,_transcritional_elongation__NP_659682__Sheeppox_virus__10266__D145-204