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hypothetical_protein_VARVgp131

Euk-Vir

Variola_virus

hypothetical_protein_VARVgp131__NP_042175__Variola_virus__10255

Identity

Accession:
NP_042175 ↗
Protein ID:
hypothetical_protein_VARVgp131
Kingdom:
euk

Quality

73.3 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-55
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF04508.18 best Pox_A_type_inc 38.7 7.80e-10 41.8% 95.7%
PF04508.18 Pox_A_type_inc 34.7 1.50e-08 40.0% 95.7%
CATH (64)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1z0jB00 4.10.860.20 Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain 0.91 76.0 7.95e-01 94.5% 96.1%
1nt2B02 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.91 84.0 7.82e-01 100.0% 98.5%
4a17U01 1.10.287.310 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.90 82.0 7.16e-01 96.4% 77.9%
3vkgB03 1.20.58.1120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dynein motor heavy chain, linker domain, subdomain 4 0.90 78.0 5.44e-01 100.0% 32.7%
6gy8A01 1.20.1170.10 Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › 0.89 83.0 4.95e-01 100.0% 17.2%
4u1cA01 4.10.860.10 Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › UVR domain 0.89 71.0 7.32e-01 94.5% 90.4%
6h9xA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.89 76.0 6.02e-01 100.0% 49.0%
2etnB01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.89 82.0 7.23e-01 100.0% 75.0%
1p49A02 1.10.287.550 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.89 81.0 7.97e-01 100.0% 100.0%
2gv9A05 1.10.287.690 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain 0.88 73.0 7.09e-01 100.0% 81.4%
4b6xA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.88 80.0 7.38e-01 100.0% 78.3%
4abmD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.88 79.0 6.95e-01 100.0% 68.8%
7ymiZ01 1.10.287.740 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre 0.88 77.0 7.61e-01 94.5% 100.0%
2gd5A00 6.10.140.1230 Special › Helix non-globular › Helix Hairpins › 0.87 79.0 5.66e-01 100.0% 38.0%
6ygiB01 1.10.4090.10 Mainly Alpha › Orthogonal Bundle › Hepatitis B viral capsid (hbcag) fold › Viral capsid, core domain supefamily, Hepatitis B virus 0.86 77.0 5.57e-01 100.0% 39.7%
3r84B00 6.10.280.160 Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 0.85 78.0 6.83e-01 100.0% 85.0%
3ehfD01 1.20.5.1930 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.85 77.0 7.34e-01 100.0% 85.7%
2hh7A00 1.20.58.1000 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer 0.85 77.0 6.63e-01 100.0% 64.7%
4q20A01 1.10.287.130 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain 0.85 73.0 6.28e-01 100.0% 62.2%
4nb5B02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.85 75.0 7.08e-01 100.0% 82.8%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.84 76.0 6.09e-01 100.0% 52.9%
4dylA02 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.84 77.0 6.36e-01 100.0% 60.6%
3k29A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.84 77.0 5.38e-01 100.0% 34.2%
2qffA00 1.20.1270.10 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.84 68.0 6.11e-01 94.5% 64.9%
1z0pA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.84 76.0 6.85e-01 100.0% 78.1%
1pd3A00 1.10.287.230 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.83 71.0 7.17e-01 100.0% 94.4%
4errB00 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.83 65.0 5.68e-01 98.2% 56.6%
2a2cA03 1.20.1440.340 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.83 69.0 5.05e-01 90.9% 36.2%
2kw6A00 6.10.140.1300 Special › Helix non-globular › Helix Hairpins › 0.83 62.0 5.87e-01 100.0% 67.7%
4cqiA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.82 65.0 5.14e-01 89.1% 43.9%
1wa8A00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.82 72.0 5.95e-01 100.0% 64.6%
2p4vA01 1.10.287.180 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain 0.82 74.0 6.63e-01 100.0% 75.0%
3agtA00 1.20.120.50 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like 0.82 64.0 4.71e-01 83.6% 42.1%
2gtsA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.81 72.0 6.44e-01 100.0% 94.8%
3l1nA01 6.10.140.790 Special › Helix non-globular › Helix Hairpins › 0.81 68.0 7.00e-01 92.7% 100.0%
4e4eA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.80 65.0 5.93e-01 100.0% 67.6%
1ku9A02 1.10.287.450 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.79 66.0 6.31e-01 100.0% 78.1%
1vcsA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.79 69.0 5.68e-01 100.0% 54.9%
1kfdA02 1.20.1060.10 Mainly Alpha › Up-down Bundle › Taq DNA Polymerase; Chain T, domain 4 › Taq DNA Polymerase; Chain T, domain 4 0.79 71.0 6.52e-01 100.0% 85.9%
1ma1A01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.78 69.0 6.59e-01 100.0% 87.5%
6tkvA01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.78 68.0 6.37e-01 100.0% 85.3%
1b3qA01 1.10.287.560 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Histidine kinase CheA-like, homodimeric domain 0.75 63.0 6.05e-01 100.0% 82.3%
3b2eF00 1.10.287.660 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.75 64.0 6.21e-01 100.0% 100.0%
2bduA02 1.10.150.340 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain 0.75 56.0 5.13e-01 100.0% 60.8%
2pmsC00 6.10.140.920 Special › Helix non-globular › Helix Hairpins › 0.75 63.0 5.18e-01 100.0% 55.0%
3favD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.74 63.0 5.73e-01 100.0% 98.7%
4l0rB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.74 63.0 5.84e-01 100.0% 98.6%
3ns4A00 1.10.357.110 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Vacuolar protein sorting-associated protein 53, C-terminus 0.74 57.0 3.76e-01 81.8% 39.0%
1hr5A00 1.20.5.420 Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C 0.73 56.0 5.87e-01 92.7% 100.0%
3hwcA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.73 61.0 4.21e-01 100.0% 32.9%
3caxA01 1.20.120.520 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like 0.72 60.0 4.10e-01 100.0% 71.4%
3etvA01 1.10.287.3290 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.72 59.0 5.26e-01 96.4% 64.3%
4v1gA00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.72 62.0 5.46e-01 100.0% 76.5%
2bdeA03 1.20.58.1160 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.72 60.0 5.49e-01 100.0% 84.4%
6f1eA01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.71 57.0 4.32e-01 94.5% 36.7%
2xokP00 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.71 60.0 5.51e-01 100.0% 77.0%
1dd5A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.69 61.0 4.78e-01 96.4% 77.1%
2psmA00 1.20.1250.70 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interleukin-15/Interleukin-21 0.69 54.0 4.31e-01 94.5% 41.9%
2odmA00 1.10.287.750 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like 0.68 56.0 5.12e-01 100.0% 68.4%
6ynwH01 1.20.20.10 Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C 0.64 57.0 5.20e-01 100.0% 75.7%
1luwA01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.64 53.0 5.15e-01 100.0% 90.6%
3dmqA08 6.10.140.1500 Special › Helix non-globular › Helix Hairpins › 0.63 48.0 4.45e-01 92.7% 65.0%
2x6hA03 1.10.1070.11 Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5 › Phosphatidylinositol 3-/4-kinase, catalytic domain 0.53 42.0 3.07e-01 100.0% 27.5%
2ds2D01 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.53 41.0 4.13e-01 87.3% 91.2%
ECOD (43)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4193568 605.1.1.4 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 0.96 91.0 7.77e-01 100.0% 72.5%
4942772 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.95 90.0 8.39e-01 100.0% 84.6%
3218879 605.1.1.0 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase 0.94 85.0 8.28e-01 96.4% 100.0%
4405928 5086.1.1.196 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_YknX 0.93 88.0 7.96e-01 100.0% 91.4%
4977416 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.93 88.0 5.52e-01 100.0% 39.7%
3391706 192.5.1.0 alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat 0.92 87.0 6.35e-01 100.0% 49.2%
4028552 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.92 86.0 5.40e-01 100.0% 34.7%
3511919 3560.1.1.1 a+b complex topology › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Med8 0.92 85.0 5.96e-01 100.0% 35.5%
4984327 192.7.1.2 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N 0.92 86.0 6.71e-01 100.0% 61.0%
5035167 2004.1.1.87 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.91 85.0 4.94e-01 100.0% 15.8%
3615907 3560.1.1.1 a+b complex topology › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Med8 0.91 84.0 5.57e-01 100.0% 33.8%
4174713 192.1.1.2 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › GreA_GreB_N 0.91 85.0 7.38e-01 100.0% 72.5%
3794775 3826.1.1.0 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) 0.91 83.0 7.75e-01 100.0% 81.5%
3408094 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.91 84.0 6.11e-01 100.0% 42.2%
3641527 192.8.1.353 alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › Med10 0.91 85.0 7.34e-01 100.0% 68.8%
3350539 192.23.1.6 alpha bundles › Long alpha-hairpin › DUF683 › DUF683 › Med10 0.90 85.0 7.14e-01 100.0% 64.7%
3908132 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.90 83.0 5.21e-01 100.0% 25.2%
3697208 604.7.1.0 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.90 83.0 6.22e-01 100.0% 45.6%
3997689 5001.1.1.1 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_1 0.90 83.0 4.94e-01 100.0% 24.9%
3544617 1008.1.1.0 alpha bundles › BRCC36 C-terminal helical domain › BRCC36 C-terminal helical domain › BRCC36 C-terminal helical domain 0.90 82.0 7.43e-01 100.0% 75.7%
5012794 4333.1.1.0 a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain 0.90 78.0 4.56e-01 100.0% 14.1%
3348910 192.1.1.46 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › DUF3475 0.89 82.0 5.39e-01 100.0% 28.8%
3971706 5071.3.1.1 alpha bundles › cytochrome bc1 complex 11 kDa protein-like › DUF465 › DUF465 › DUF465 0.88 82.0 7.45e-01 100.0% 78.6%
3614068 5055.1.1.0 extended segments › Small-conductance potassium channel › Small-conductance potassium channel › Small-conductance potassium channel 0.88 75.0 6.50e-01 100.0% 62.5%
60297 192.1.1.0 alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain 0.88 81.0 7.24e-01 100.0% 76.0%
3215306 3826.1.1.0 alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) 0.88 79.0 6.80e-01 100.0% 67.1%
3297107 4006.1.1.0 alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain 0.88 80.0 6.56e-01 100.0% 57.9%
3916825 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.87 80.0 5.68e-01 100.0% 52.0%
3170876 192.7.1.30 alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › CUX1_N 0.86 77.0 6.01e-01 100.0% 55.7%
3385950 5086.1.1.0 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.86 76.0 7.01e-01 98.2% 100.0%
3798984 3560.1.1.0 a+b complex topology › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 › Mediator of RNA polymerase II transcription subunit 8 0.85 77.0 5.15e-01 100.0% 33.8%
5018636 605.1.1.3 alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_2 0.84 76.0 7.00e-01 100.0% 81.4%
3246566 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.84 74.0 5.06e-01 100.0% 30.0%
5057329 3755.3.1.0 alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.84 76.0 5.50e-01 100.0% 53.8%
4110261 3748.1.1.2 extended segments › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › 26S proteasome regulatory subunit RPN8/RPN11 C-terminal domain › CSN5_C 0.84 74.0 6.43e-01 100.0% 76.5%
3681259 5058.1.1.57 alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › V-SNARE 0.84 74.0 6.41e-01 100.0% 72.9%
4025 150.5.1.1 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like › WXG100 0.82 72.0 5.95e-01 100.0% 64.6%
3443076 207.1.1.0 beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.82 74.0 4.23e-01 100.0% 11.6%
3794795 603.1.1.3 alpha bundles › STAT-like › t-snare proteins › t-snare proteins › V-SNARE 0.79 69.0 5.72e-01 100.0% 64.0%
3611416 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.76 65.0 4.19e-01 100.0% 21.2%
149872 3291.1.1.1 alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Snf7 0.75 63.0 5.74e-01 100.0% 77.2%
3349325 5086.1.1.135 alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › DUF7615 0.75 63.0 5.69e-01 100.0% 88.7%
3197800 221.13.1.2 a+b two layers › beta-Grasp › Mitochondrial calcium uniporter N-terminal domain › Mitochondrial calcium uniporter N-terminal domain › RRG1_C 0.73 59.0 4.24e-01 100.0% 30.3%
D2 medium residues 56-108
PDB
Domain cluster: representative
D3 medium residues 109-194
PDB