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hypothetical_protein_VARVgp168
Euk-VirVariola_virus
hypothetical_protein_VARVgp168__NP_042212__Variola_virus__10255
Identity
- Accession:
- NP_042212 ↗
- Protein ID:
- hypothetical_protein_VARVgp168
- Kingdom:
- euk
Quality
78.6
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Pokkesviricetes›
Chitovirales›
Poxviridae›
Orthopoxvirus›
Variola_virus
TaxID: 10255
Cluster
View cluster (116 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-73
Domain cluster:
rep: Mad1_20_16_scaffold_0_curated_closed_complete_start-adj_prodigal-single.1__X__X__00491__D28-102
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00625.28 best | Guanylate_kin | 59.3 | 5.70e-16 | 100.0% | 39.0% |
CATH (12)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3wp0A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.79 | 72.0 | 5.34e-01 | 100.0% | 76.8% |
| 4wsiB03 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.78 | 71.0 | 5.07e-01 | 100.0% | 38.1% |
| 6nuiA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.71 | 64.0 | 4.70e-01 | 100.0% | 41.2% |
| 4by6D02 | 1.25.40.800 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.52 | 44.0 | 3.26e-01 | 100.0% | 76.9% |
| 1yewB00 | 1.20.1450.10 | Mainly Alpha › Up-down Bundle › particulate methane monooxygenase, chain B › Ammonia/particulate methane monooxygenase, subunit A | 0.52 | 44.0 | 3.10e-01 | 94.5% | 45.8% |
| 1sy7A03 | 3.40.50.880 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Class I glutamine amidotransferase (GATase) domain | 0.52 | 44.0 | 3.31e-01 | 97.3% | 55.4% |
| 1jihA01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.52 | 42.0 | 3.24e-01 | 97.3% | 87.6% |
| 1pj5A03 | 3.30.1360.120 | Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › Probable tRNA modification gtpase trme; domain 1 | 0.51 | 39.0 | 3.00e-01 | 86.3% | 82.3% |
| 1cs3A00 | 3.30.710.10 | Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A | 0.50 | 42.0 | 3.76e-01 | 100.0% | 74.1% |
| 3jamK00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.50 | 37.0 | 3.52e-01 | 84.9% | 63.5% |
| 3hqiA02 | 3.30.710.10 | Alpha Beta › 2-Layer Sandwich › Potassium Channel Kv1.1; Chain A › Potassium Channel Kv1.1; Chain A | 0.50 | 42.0 | 3.54e-01 | 100.0% | 72.9% |
| 3gv5B01 | 3.30.70.270 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain | 0.50 | 39.0 | 3.39e-01 | 91.8% | 65.2% |
ECOD (68)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3481198 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.85 | 77.0 | 5.27e-01 | 100.0% | 30.9% |
| 3482144 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.84 | 78.0 | 5.48e-01 | 100.0% | 36.2% |
| 3519997 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.84 | 78.0 | 5.54e-01 | 100.0% | 38.0% |
| 3389805 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.84 | 78.0 | 5.29e-01 | 100.0% | 32.3% |
| 3397637 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.83 | 77.0 | 5.25e-01 | 100.0% | 32.8% |
| 3581577 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.83 | 62.0 | 5.09e-01 | 79.5% | 44.6% |
| 3789700 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.83 | 76.0 | 5.46e-01 | 100.0% | 39.0% |
| 3230470 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.82 | 77.0 | 5.39e-01 | 100.0% | 36.6% |
| 3623496 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.82 | 76.0 | 5.35e-01 | 100.0% | 37.1% |
| 4305751 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.82 | 75.0 | 5.40e-01 | 100.0% | 39.5% |
| 3931844 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.82 | 75.0 | 5.41e-01 | 100.0% | 40.0% |
| 3539257 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.81 | 75.0 | 5.26e-01 | 100.0% | 36.2% |
| 4269513 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.81 | 74.0 | 5.10e-01 | 100.0% | 32.3% |
| 3474707 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.81 | 74.0 | 5.27e-01 | 100.0% | 37.6% |
| 3894021 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.81 | 74.0 | 5.14e-01 | 100.0% | 34.1% |
| 3798314 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.80 | 73.0 | 5.07e-01 | 100.0% | 33.8% |
| 3492473 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.80 | 73.0 | 5.76e-01 | 100.0% | 68.3% |
| 3798014 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.80 | 73.0 | 5.01e-01 | 100.0% | 32.3% |
| 3580834 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.77 | 71.0 | 5.09e-01 | 100.0% | 72.0% |
| 3613625 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.77 | 71.0 | 4.89e-01 | 100.0% | 42.6% |
| 3798335 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.77 | 71.0 | 5.07e-01 | 100.0% | 72.0% |
| 3599128 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.77 | 70.0 | 5.05e-01 | 100.0% | 40.0% |
| 3479738 | 207.1.1.0 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats | 0.76 | 64.0 | 3.75e-01 | 91.8% | 11.9% |
| 4012507 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.76 | 70.0 | 5.07e-01 | 100.0% | 40.0% |
| 3910006 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.76 | 70.0 | 4.88e-01 | 100.0% | 78.2% |
| 3712406 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.76 | 69.0 | 4.95e-01 | 100.0% | 37.6% |
| 4190166 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.76 | 69.0 | 4.93e-01 | 100.0% | 38.5% |
| 4213537 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.75 | 68.0 | 4.99e-01 | 100.0% | 40.0% |
| 4678860 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.75 | 68.0 | 4.92e-01 | 100.0% | 74.7% |
| 4188216 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.75 | 68.0 | 4.86e-01 | 100.0% | 71.7% |
| None | — | 0.75 | 68.0 | 4.84e-01 | 100.0% | 69.8% | |
| 3920323 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.74 | 65.0 | 4.44e-01 | 97.3% | 29.4% |
| 3447908 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.74 | 64.0 | 4.62e-01 | 95.9% | 76.6% |
| 2393040 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.74 | 67.0 | 4.73e-01 | 100.0% | 36.6% |
| 4232099 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.74 | 67.0 | 4.70e-01 | 100.0% | 65.5% |
| 3485807 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.73 | 66.0 | 4.57e-01 | 100.0% | 30.8% |
| 165134 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.73 | 65.0 | 4.77e-01 | 100.0% | 39.8% |
| 4296001 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.73 | 64.0 | 4.70e-01 | 100.0% | 40.0% |
| 3588701 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.72 | 65.0 | 4.84e-01 | 100.0% | 42.2% |
| 4002879 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.72 | 60.0 | 4.43e-01 | 91.8% | 35.8% |
| 4364445 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.72 | 64.0 | 4.55e-01 | 100.0% | 68.2% |
| 3779005 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.72 | 63.0 | 3.72e-01 | 97.3% | 13.5% |
| 4660772 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.71 | 64.0 | 4.53e-01 | 100.0% | 66.5% |
| 3861664 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.71 | 59.0 | 4.43e-01 | 91.8% | 37.2% |
| 3193192 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.70 | 63.0 | 4.59e-01 | 100.0% | 42.5% |
| 3543629 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.70 | 58.0 | 4.35e-01 | 91.8% | 36.2% |
| 3965925 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.70 | 62.0 | 4.53e-01 | 100.0% | 71.5% |
| 3524949 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.69 | 57.0 | 4.29e-01 | 91.8% | 37.3% |
| 4297700 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.69 | 60.0 | 4.49e-01 | 100.0% | 38.9% |
| 4461479 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.69 | 60.0 | 4.53e-01 | 100.0% | 41.1% |
| 4515833 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.69 | 61.0 | 4.31e-01 | 100.0% | 33.8% |
| 3510416 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.68 | 58.0 | 4.31e-01 | 94.5% | 39.5% |
| 4239688 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.68 | 61.0 | 4.42e-01 | 100.0% | 36.2% |
| 4477375 | 2004.1.1.192 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_18 | 0.68 | 59.0 | 4.44e-01 | 100.0% | 38.6% |
| 5050242 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.68 | 58.0 | 4.30e-01 | 100.0% | 36.6% |
| 4055310 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.67 | 59.0 | 4.43e-01 | 100.0% | 38.8% |
| 4354223 | 2004.1.1.192 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_18 | 0.67 | 59.0 | 4.43e-01 | 100.0% | 75.1% |
| 4061553 | 2004.1.1.208 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_33 | 0.67 | 59.0 | 4.46e-01 | 100.0% | 73.9% |
| 4321081 | 2004.1.1.192 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_18 | 0.67 | 59.0 | 4.43e-01 | 100.0% | 78.3% |
| 4062874 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.67 | 59.0 | 4.36e-01 | 100.0% | 73.2% |
| 4510425 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.66 | 57.0 | 4.32e-01 | 100.0% | 39.4% |
| 4269138 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.66 | 58.0 | 4.30e-01 | 100.0% | 74.7% |
| 4256195 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.65 | 58.0 | 4.36e-01 | 100.0% | 77.2% |
| 4483715 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.65 | 55.0 | 4.19e-01 | 97.3% | 38.9% |
| 1537619 | 2004.1.1.50 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Guanylate_kin | 0.65 | 57.0 | 4.27e-01 | 100.0% | 70.1% |
| 5079074 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.54 | 39.0 | 3.43e-01 | 76.7% | 75.5% |
| 3171078 | 109.4.1.1932 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NopRA1, PF26140 | 0.53 | 45.0 | 2.48e-01 | 100.0% | 12.0% |
| 1298571 | 3207.1.1.1 ↗ | alpha bundles › PmoA › PmoA › PmoA › AMO | 0.50 | 42.0 | 2.97e-01 | 94.5% | 43.0% |
D2
medium
residues 74-151
Domain cluster:
rep: HSPV178b__ABH08289__Horsepox_virus__397342__D21-96
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00625.28 best | Guanylate_kin | 35.5 | 1.20e-08 | 89.7% | 35.7% |