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hypothetical_protein_pv_179
Euk-VirPithovirus_sibericum
hypothetical_protein_pv_179__YP_009001081__Pithovirus_sibericum__1450746
Identity
- Accession:
- YP_009001081 ↗
- Protein ID:
- hypothetical_protein_pv_179
- Kingdom:
- euk
Quality
70.1
mean pLDDT
Taxonomy
Bamfordvirae›
Nucleocytoviricota›
Megaviricetes›
Pimascovirales›
Pithoviridae›
Alphapithovirus›
Pithovirus_sibericum
TaxID: 1450746
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 32-84
Domain cluster:
representative
CATH (64)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2nn4A00 | 1.10.287.760 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YqgQ-like | 0.79 | 58.0 | 5.55e-01 | 86.8% | 67.7% |
| 1tj7A01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.77 | 60.0 | 4.81e-01 | 94.3% | 43.8% |
| 2hh7A00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.75 | 68.0 | 5.77e-01 | 100.0% | 68.2% |
| 1b3qA01 | 1.10.287.560 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Histidine kinase CheA-like, homodimeric domain | 0.75 | 62.0 | 5.90e-01 | 94.3% | 77.4% |
| 1vx7301 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.75 | 67.0 | 5.94e-01 | 98.1% | 83.8% |
| 6o9aA01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.75 | 55.0 | 3.88e-01 | 77.4% | 31.1% |
| 3gg7A00 | 3.20.20.140 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Metal-dependent hydrolases | 0.74 | 59.0 | 3.78e-01 | 86.8% | 51.4% |
| 3ehfD01 | 1.20.5.1930 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.74 | 66.0 | 6.28e-01 | 100.0% | 84.1% |
| 1cxzB00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.74 | 66.0 | 5.60e-01 | 100.0% | 62.8% |
| 2c5iT00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.74 | 65.0 | 5.39e-01 | 100.0% | 59.6% |
| 1x0tA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.74 | 57.0 | 5.45e-01 | 83.0% | 72.1% |
| 1zkeA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.73 | 64.0 | 5.58e-01 | 100.0% | 96.3% |
| 2mpnA00 | 6.10.140.1340 | Special › Helix non-globular › Helix Hairpins › | 0.72 | 62.0 | 5.80e-01 | 100.0% | 80.9% |
| 6zhiB02 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.72 | 56.0 | 4.90e-01 | 100.0% | 55.4% |
| 2gtsA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.72 | 63.0 | 5.55e-01 | 100.0% | 67.5% |
| 1u9pA00 | 1.10.1220.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant › Met repressor-like | 0.71 | 53.0 | 4.31e-01 | 79.2% | 49.0% |
| 3c57B00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.71 | 51.0 | 5.32e-01 | 88.7% | 83.7% |
| 2qkdA02 | 2.60.120.1040 | Mainly Beta › Sandwich › Jelly Rolls › ZPR1, A/B domain | 0.69 | 58.0 | 4.22e-01 | 92.5% | 55.7% |
| 2o8xA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.69 | 53.0 | 5.12e-01 | 84.9% | 93.4% |
| 3hugA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.68 | 57.0 | 5.05e-01 | 96.2% | 73.8% |
| 1rsoB00 | 1.10.287.650 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › L27 domain | 0.68 | 53.0 | 5.28e-01 | 94.3% | 82.1% |
| 2cazD00 | 6.10.140.820 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 59.0 | 5.68e-01 | 98.1% | 100.0% |
| 2y39A00 | 1.20.120.1490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.68 | 58.0 | 4.66e-01 | 100.0% | 52.7% |
| 4nqwA02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.67 | 54.0 | 5.15e-01 | 90.6% | 87.5% |
| 5fgmA00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.67 | 57.0 | 5.45e-01 | 100.0% | 98.5% |
| 3onqA03 | 1.10.10.2840 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › PucR C-terminal helix-turn-helix domain | 0.67 | 52.0 | 3.91e-01 | 83.0% | 44.3% |
| 2kw6A00 | 6.10.140.1300 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 55.0 | 5.17e-01 | 90.6% | 84.6% |
| 1ucuA01 | 6.10.280.190 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 55.0 | 5.11e-01 | 92.5% | 100.0% |
| 3rq9A00 | 1.10.287.2500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.67 | 56.0 | 4.94e-01 | 94.3% | 76.9% |
| 3fd9A03 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.67 | 57.0 | 5.23e-01 | 100.0% | 76.7% |
| 1ij5A01 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 57.0 | 5.12e-01 | 100.0% | 86.8% |
| 4iv6B01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.67 | 46.0 | 3.64e-01 | 100.0% | 33.6% |
| 2fb5A01 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.67 | 58.0 | 5.28e-01 | 100.0% | 76.4% |
| 1fc3B00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.66 | 56.0 | 4.53e-01 | 94.3% | 70.3% |
| 4v1gA00 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.66 | 57.0 | 4.97e-01 | 100.0% | 70.6% |
| 3t0yA02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.66 | 51.0 | 4.96e-01 | 84.9% | 95.0% |
| 2w7nA00 | 1.10.10.2690 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.66 | 57.0 | 4.81e-01 | 100.0% | 70.2% |
| 6tkvA01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.66 | 58.0 | 5.39e-01 | 100.0% | 83.8% |
| 1jalA03 | 1.10.150.300 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Obg-related GTPase Ych/YyaF, coiled-coil domain | 0.66 | 50.0 | 4.39e-01 | 94.3% | 54.3% |
| 4b6xA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 56.0 | 5.23e-01 | 100.0% | 82.6% |
| 4k7cA01 | 3.90.70.10 | Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases | 0.66 | 54.0 | 3.21e-01 | 92.5% | 29.9% |
| 4go1A01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.65 | 47.0 | 4.72e-01 | 75.5% | 77.8% |
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 57.0 | 4.92e-01 | 100.0% | 62.4% |
| 7ymiZ01 | 1.10.287.740 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre | 0.65 | 51.0 | 5.06e-01 | 94.3% | 86.2% |
| 2cobA01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.64 | 41.0 | 4.36e-01 | 71.7% | 77.3% |
| 5f64A02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.64 | 50.0 | 4.42e-01 | 83.0% | 72.0% |
| 3vfzB00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.64 | 55.0 | 5.23e-01 | 94.3% | 96.8% |
| 3n5lA03 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 53.0 | 5.24e-01 | 100.0% | 98.2% |
| 1rr7A01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.64 | 43.0 | 4.49e-01 | 73.6% | 80.4% |
| 2de2A01 | 3.40.190.10 | Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II | 0.63 | 50.0 | 3.44e-01 | 90.6% | 44.3% |
| 1bhaA00 | 1.10.287.170 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 51.0 | 4.76e-01 | 92.5% | 88.1% |
| 1z0pA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 52.0 | 4.76e-01 | 100.0% | 78.1% |
| 3r84A00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 50.0 | 4.51e-01 | 100.0% | 67.9% |
| 1pixA03 | 3.90.226.10 | Alpha Beta › Alpha-Beta Complex › 2-enoyl-CoA Hydratase; Chain A, domain 1 › 2-enoyl-CoA Hydratase; Chain A, domain 1 | 0.61 | 53.0 | 3.34e-01 | 100.0% | 29.1% |
| 1kyoF00 | 1.10.287.20 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Ubiquinol-cytochrome C reductase hinge domain | 0.61 | 52.0 | 4.72e-01 | 100.0% | 77.0% |
| 3g2bA00 | 1.10.10.1150 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Coenzyme PQQ synthesis protein D (PqqD) | 0.59 | 47.0 | 3.99e-01 | 88.7% | 61.1% |
| 5z4zC00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.59 | 49.0 | 4.22e-01 | 96.2% | 95.5% |
| 7ymiD01 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.58 | 47.0 | 3.43e-01 | 100.0% | 61.1% |
| 1wp7A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.58 | 47.0 | 4.53e-01 | 100.0% | 87.5% |
| 3h4cA02 | 1.10.472.110 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › | 0.57 | 44.0 | 3.57e-01 | 88.7% | 65.5% |
| 1tfeA02 | 1.10.286.20 | Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › | 0.55 | 39.0 | 4.16e-01 | 83.0% | 91.1% |
| 1h3lB00 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.55 | 43.0 | 3.88e-01 | 94.3% | 60.3% |
| 5hxgB00 | 1.10.4000.10 | Mainly Alpha › Orthogonal Bundle › Flagellar transcriptional activator fold › Flagellar transcriptional activator FlhD | 0.54 | 44.0 | 4.15e-01 | 92.5% | 73.8% |
| 1ojlA03 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.54 | 39.0 | 4.14e-01 | 88.7% | 89.4% |
ECOD (24)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4189586 | 192.29.1.264 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › COX4_pro | 0.83 | 71.0 | 5.73e-01 | 100.0% | 51.6% |
| 5006936 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.79 | 69.0 | 6.45e-01 | 100.0% | 78.5% |
| 3974470 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.78 | 65.0 | 5.91e-01 | 100.0% | 70.0% |
| 3287592 | 3443.1.1.0 ↗ | alpha duplicates or obligate multimers › Get5 carboxyl domain › Get5 carboxyl domain › Get5 carboxyl domain | 0.76 | 66.0 | 6.83e-01 | 94.3% | 100.0% |
| 3652032 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.75 | 59.0 | 5.31e-01 | 88.7% | 61.3% |
| 3539738 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.75 | 60.0 | 3.92e-01 | 96.2% | 20.9% |
| 1164229 | 605.1.1.4 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA_3 | 0.75 | 67.0 | 6.23e-01 | 100.0% | 80.3% |
| 3278996 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.74 | 57.0 | 4.61e-01 | 83.0% | 58.0% |
| 3735470 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.73 | 53.0 | 5.00e-01 | 79.2% | 70.8% |
| 5076400 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.73 | 62.0 | 5.13e-01 | 100.0% | 53.7% |
| 4458464 | 2004.1.1.5 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran | 0.71 | 57.0 | 3.49e-01 | 100.0% | 13.7% |
| 4964259 | 5055.1.1.0 ↗ | extended segments › Small-conductance potassium channel › Small-conductance potassium channel › Small-conductance potassium channel | 0.71 | 60.0 | 5.99e-01 | 94.3% | 90.9% |
| 3741234 | 605.2.1.3 ↗ | alpha duplicates or obligate multimers › ROP-like › Hypothetical protein D-63 › Hypothetical protein D-63 › Seryl_tRNA_N | 0.70 | 62.0 | 4.79e-01 | 100.0% | 47.8% |
| 3691750 | 376.1.1.8 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › U-box | 0.69 | 60.0 | 4.37e-01 | 100.0% | 35.6% |
| 3282520 | 325.1.7.0 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif | 0.67 | 55.0 | 5.03e-01 | 92.5% | 77.1% |
| 3607406 | 6026.1.1.0 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain | 0.67 | 55.0 | 4.85e-01 | 100.0% | 61.3% |
| 3189978 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.67 | 56.0 | 4.43e-01 | 100.0% | 44.3% |
| 2448404 | 101.1.1.31 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › Sigma70_r4 | 0.66 | 55.0 | 5.39e-01 | 96.2% | 95.0% |
| 3988447 | 5043.1.1.0 ↗ | extended segments › Sensor proteins transmembrane domains › Htr2 transmembrane domain-like › Htr2 transmembrane domain-like | 0.65 | 53.0 | 5.25e-01 | 96.2% | 89.1% |
| 4994798 | 3646.1.1.0 ↗ | alpha complex topology › T-component of energy-coupling factor (ECF) transporters › T-component of energy-coupling factor (ECF) transporters › T-component of energy-coupling factor (ECF) transporters | 0.65 | 55.0 | 3.79e-01 | 100.0% | 86.5% |
| 3723174 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.62 | 52.0 | 4.76e-01 | 100.0% | 76.0% |
| 3973870 | 223.1.1.0 ↗ | a+b three layers › Profilin-like › sensor domains › sensor domains | 0.62 | 49.0 | 3.25e-01 | 100.0% | 19.6% |
| 3357244 | 4106.1.1.1 ↗ | few secondary structure elements › Zinc hairpin stack › Zinc hairpin stack › Zinc hairpin stack › DHHC | 0.58 | 48.0 | 3.91e-01 | 96.2% | 49.5% |
| 3404418 | 101.1.1.24 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › CENP-B_N | 0.52 | 39.0 | 3.66e-01 | 83.0% | 62.9% |