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hypothetical_protein_pv_203

Euk-Vir

Pithovirus_sibericum

hypothetical_protein_pv_203__YP_009001105__Pithovirus_sibericum__1450746

Identity

Accession:
YP_009001105 ↗
Protein ID:
hypothetical_protein_pv_203
Kingdom:
euk

Quality

83.6 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Pithoviridae› Alphapithovirus› Pithovirus_sibericum

TaxID: 1450746

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-95
PDB
Domain cluster: representative
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5jnbA01 1.10.1410.10 Mainly Alpha › Orthogonal Bundle › Poly(a)-polymerase, middle domain › 0.54 40.0 3.16e-01 78.9% 79.6%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3377590 101.1.10.7 ↗ alpha arrays › HTH › HTH › Cyclin-like › Cyclin_C 0.66 47.0 4.40e-01 73.7% 64.3%
3832993 109.4.1.1335 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, PPR_2, E_motif 0.55 40.0 3.30e-01 77.9% 66.5%
D2 medium residues 96-219
PDB
Domain cluster: rep: hypothetical_protein_pv_205__YP_009001107__Pithovirus_sibericum__1450746__D98-189
D3 medium residues 220-277
PDB
Domain cluster: representative
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3l8rA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.73 57.0 4.76e-01 86.2% 86.3%
1uouA01 1.20.970.10 Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 0.68 53.0 5.14e-01 89.7% 82.4%
4wz9A04 1.25.50.20 Mainly Alpha › Alpha Horseshoe › Zincin-like fold › 0.66 55.0 3.51e-01 100.0% 25.2%
2b6cA01 1.20.1660.10 Mainly Alpha › Up-down Bundle › ARM repeat fold › Hypothetical protein (EF3068) 0.66 55.0 4.52e-01 98.3% 60.3%
1yozA00 1.10.3200.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af0941 › AF0941-like 0.65 48.0 3.87e-01 79.3% 90.3%
2p58C00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.64 48.0 4.03e-01 86.2% 45.5%
2dsjA01 1.20.970.10 Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C 0.62 49.0 4.78e-01 91.4% 82.1%
4kzsA02 6.10.140.1870 Special › Helix non-globular › Helix Hairpins › 0.62 48.0 4.56e-01 86.2% 91.4%
2x64A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.61 51.0 4.25e-01 100.0% 88.5%
3ay5A01 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.59 43.0 3.45e-01 82.8% 60.9%
2gsvA00 6.10.140.40 Special › Helix non-globular › Helix Hairpins › 0.58 42.0 4.05e-01 79.3% 98.5%
1vqrD00 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.58 47.0 3.20e-01 100.0% 39.5%
2imgA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.57 46.0 3.55e-01 94.8% 93.3%
2kmfA01 1.20.58.810 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 0.57 45.0 3.85e-01 91.4% 71.6%
1b5lA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.56 40.0 3.04e-01 77.6% 56.6%
1aa7A02 1.10.10.180 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Influenza matrix protein M1, N-terminal subdomain 2 0.56 46.0 4.31e-01 100.0% 85.9%
3cm0A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.56 47.0 3.42e-01 100.0% 51.1%
1mkiA02 1.10.1500.10 Mainly Alpha › Orthogonal Bundle › Probable Glutaminase Ybgj; Chain: A, domain 2 › 0.56 45.0 3.44e-01 89.7% 71.7%
5hayA02 1.25.40.440 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Nucleoporin, helical domain, central subdomain 0.56 45.0 4.25e-01 100.0% 82.3%
1vj7B01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.56 47.0 3.47e-01 100.0% 54.3%
2l6jA00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.55 43.0 3.70e-01 96.6% 64.9%
1qs1A01 3.90.176.10 Alpha Beta › Alpha-Beta Complex › Toxin ADP-ribosyltransferase; Chain A, domain 1 › Toxin ADP-ribosyltransferase; Chain A, domain 1 0.53 35.0 2.51e-01 70.7% 67.5%
5afdA00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.53 43.0 2.83e-01 98.3% 26.7%
1vw4L02 1.10.246.170 Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › 0.52 40.0 3.72e-01 91.4% 94.1%
2r11D00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.50 41.0 2.70e-01 96.6% 68.4%
5domA00 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.50 41.0 3.70e-01 100.0% 97.8%
4gytA00 1.20.120.740 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YgfB uncharacterised protein family PF03695 0.50 41.0 3.04e-01 98.3% 77.4%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3735100 109.3.1.2 ↗ alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2 0.74 62.0 4.40e-01 100.0% 53.8%
3726318 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.72 54.0 3.61e-01 81.0% 21.3%
3988387 604.10.1.1 ↗ alpha bundles › Spectrin repeat-like › Enzyme IIa from lactose specific PTS, IIa-lac › Enzyme IIa from lactose specific PTS, IIa-lac › PTS_IIA 0.71 58.0 4.85e-01 91.4% 88.0%
5064973 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.68 47.0 4.48e-01 74.1% 82.9%
3743518 109.4.1.257 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PDS5 0.67 58.0 3.64e-01 100.0% 43.6%
3232906 109.4.1.144 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Ints3_N 0.66 55.0 4.08e-01 100.0% 45.1%
4990095 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.64 48.0 4.37e-01 84.5% 83.5%
3505450 109.4.1.276 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EDC4_C 0.63 54.0 4.22e-01 100.0% 68.9%
5057676 192.4.1.1 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) › Ribosomal_L29 0.63 43.0 3.95e-01 70.7% 76.0%
3841191 604.3.1.22 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain › PF31030 0.62 51.0 4.48e-01 94.8% 80.0%
4929703 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.61 43.0 3.95e-01 75.9% 98.8%
3753752 109.60.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › RPAP3 C-terminal domain-like › RPAP3 C-terminal domain-like › RPAP3_C 0.59 48.0 3.81e-01 98.3% 54.3%
3486453 310.2.1.0 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF 0.59 43.0 3.66e-01 82.8% 83.8%
4874242 150.3.1.8 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › EPO_TPO 0.57 43.0 3.32e-01 86.2% 74.3%
4245358 109.1.1.1 ↗ alpha superhelices › Repetitive alpha hairpins › Glutathione S-transferase (GST)-C › Glutathione S-transferase (GST)-C › GST_C 0.57 46.0 3.76e-01 100.0% 78.5%
3304870 5059.1.1.24 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › PUNUT 0.56 40.0 2.56e-01 79.3% 80.0%
3984796 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.56 48.0 3.43e-01 100.0% 49.5%
3998931 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 43.0 3.63e-01 87.9% 76.2%
3828248 5050.1.1.15 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nodulin-like 0.55 46.0 3.06e-01 96.6% 48.4%
5022257 4156.1.1.6 ↗ alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Helicase_dom4_arc 0.55 43.0 3.35e-01 94.8% 97.3%
3857249 1134.1.1.10 ↗ alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain › NTP_transf_7 0.54 43.0 3.53e-01 94.8% 85.6%
3534852 109.4.1.1182 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › NTP_transf_7 0.54 43.0 3.51e-01 94.8% 85.6%
4934877 604.12.1.0 ↗ alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.54 45.0 3.38e-01 98.3% 82.4%
4609007 101.1.17.0 ↗ alpha arrays › HTH › HTH › FF domain 0.54 39.0 4.19e-01 79.3% 100.0%
3577412 5054.1.1.83 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Tcp11 0.53 38.0 2.79e-01 79.3% 27.2%
3506989 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.53 37.0 3.90e-01 77.6% 92.0%
3639846 206.1.1.7 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › PI3_PI4_kinase 0.52 43.0 2.72e-01 100.0% 60.3%
3554793 592.1.1.0 ↗ alpha arrays › PWI domain-like › PWI domain › PWI domain 0.51 36.0 3.44e-01 79.3% 64.0%
D4 medium residues 278-371
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2i2xB01 1.10.1240.10 Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain 0.63 44.0 4.38e-01 74.5% 85.0%
2odmA00 1.10.287.750 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like 0.55 39.0 4.19e-01 98.9% 87.3%
6xpdA01 1.20.1510.10 Mainly Alpha › Up-down Bundle › Alpha-lytic protease prodomain-like › Cation efflux protein transmembrane domain 0.50 37.0 2.94e-01 77.7% 65.8%
4cemA00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.50 42.0 3.08e-01 100.0% 34.2%
ECOD (8)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4234683 7014.1.1.1 ↗ alpha bundles › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › Undecaprenyl pyrophosphate phosphatase (UppP) transmembrane domain › BacA 0.64 44.0 4.02e-01 71.3% 80.0%
3262295 1203.1.2.9 ↗ alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › TMEM128 0.57 32.0 2.89e-01 87.2% 38.3%
3712828 6155.1.1.2 ↗ alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop 0.56 38.0 3.49e-01 70.2% 68.0%
184859 192.15.1.3 ↗ alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Vps23_core 0.55 33.0 2.68e-01 80.9% 34.5%
3756667 109.25.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › GPCR-autoproteolysis inducing domain subdomain A › GPCR-autoproteolysis inducing domain subdomain A 0.54 45.0 3.74e-01 90.4% 68.2%
4032384 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.54 38.0 4.06e-01 98.9% 85.0%
3543876 604.1.1.1 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin 0.54 37.0 3.52e-01 70.2% 87.3%
4224289 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 36.0 3.04e-01 72.3% 55.6%
D5 medium residues 372-475
PDB
Domain cluster: rep: hypothetical_protein_pv_199__YP_009001101__Pithovirus_sibericum__1450746__D366-451