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interleukin-10
Euk-VirAnguillid_herpesvirus_1
interleukin-10__YP_006355432__Anguillid_herpesvirus_1__150286
Identity
- Accession:
- YP_006355432 ↗
- Protein ID:
- interleukin-10
- Kingdom:
- euk
Quality
74.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Alloherpesviridae›
Cyvirus›
Anguillid_herpesvirus_1
TaxID: 150286
Cluster
View cluster (22 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 58-165
Domain cluster:
representative
CATH (37)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1lk3A00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.82 | 75.0 | 6.92e-01 | 100.0% | 77.9% |
| 1n1fA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.79 | 73.0 | 6.45e-01 | 99.1% | 71.2% |
| 2oc5A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.76 | 66.0 | 5.26e-01 | 94.4% | 55.3% |
| 1rtwB00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.74 | 67.0 | 5.36e-01 | 100.0% | 68.3% |
| 1b5lA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.73 | 65.0 | 5.79e-01 | 98.1% | 75.0% |
| 3qhbA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.72 | 65.0 | 5.50e-01 | 100.0% | 81.0% |
| 1tj7A01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.66 | 46.0 | 4.68e-01 | 94.4% | 73.3% |
| 3r2kA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.66 | 57.0 | 5.04e-01 | 94.4% | 74.7% |
| 4etrB00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.65 | 55.0 | 5.27e-01 | 95.4% | 80.3% |
| 1lb3A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.63 | 53.0 | 4.66e-01 | 94.4% | 72.5% |
| 2p61A00 | 1.20.120.490 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hypothetical protein TM1646-like domain | 0.62 | 44.0 | 4.33e-01 | 95.4% | 68.4% |
| 3ripA02 | 1.20.120.1900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain | 0.62 | 49.0 | 3.64e-01 | 84.3% | 94.3% |
| 3caxA01 | 1.20.120.520 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like | 0.61 | 45.0 | 3.55e-01 | 76.9% | 70.5% |
| 1jalA03 | 1.10.150.300 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Obg-related GTPase Ych/YyaF, coiled-coil domain | 0.60 | 41.0 | 4.63e-01 | 89.8% | 91.4% |
| 3rguB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.60 | 43.0 | 4.74e-01 | 81.5% | 92.0% |
| 4nwpD00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.59 | 52.0 | 4.62e-01 | 93.5% | 78.5% |
| 5cy5B00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.59 | 51.0 | 4.56e-01 | 92.6% | 81.2% |
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.59 | 51.0 | 5.30e-01 | 92.6% | 100.0% |
| 3dbyL00 | 1.20.1260.120 | Mainly Alpha › Up-down Bundle › Ferritin › Protein of unknown function DUF2935 | 0.58 | 50.0 | 3.80e-01 | 94.4% | 95.4% |
| 2v0oB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.57 | 40.0 | 3.04e-01 | 74.1% | 77.1% |
| 2etnB01 | 1.10.287.180 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Transcription elongation factor, GreA/GreB, N-terminal domain | 0.56 | 35.0 | 4.10e-01 | 95.4% | 90.8% |
| 4oe8C00 | 1.10.8.1170 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.56 | 40.0 | 4.35e-01 | 74.1% | 97.7% |
| 2p7vA00 | 1.20.120.1370 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Regulator of RNA polymerase sigma(70) subunit, domain 4 | 0.55 | 46.0 | 4.12e-01 | 100.0% | 64.2% |
| 4btfA01 | 1.20.930.20 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain | 0.55 | 44.0 | 4.57e-01 | 88.9% | 100.0% |
| 1q0gA00 | 1.20.120.400 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase | 0.54 | 39.0 | 3.82e-01 | 74.1% | 78.6% |
| 4wpeA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.54 | 44.0 | 3.25e-01 | 86.1% | 80.4% |
| 3m9vA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.54 | 46.0 | 4.10e-01 | 94.4% | 84.7% |
| 3lssA01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.54 | 36.0 | 3.63e-01 | 94.4% | 67.0% |
| 2j6lA01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.54 | 48.0 | 3.52e-01 | 100.0% | 76.3% |
| 3rosA01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.53 | 48.0 | 3.62e-01 | 100.0% | 85.1% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.53 | 45.0 | 4.41e-01 | 94.4% | 95.7% |
| 1x04A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.53 | 44.0 | 3.52e-01 | 88.0% | 79.0% |
| 1t90A01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.52 | 47.0 | 3.48e-01 | 99.1% | 93.9% |
| 6fjxA01 | 3.40.605.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aldehyde Dehydrogenase; Chain A, domain 1 › Aldehyde Dehydrogenase; Chain A, domain 1 | 0.51 | 47.0 | 3.47e-01 | 100.0% | 93.7% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.51 | 42.0 | 4.07e-01 | 100.0% | 77.4% |
| 1gqeA01 | 1.20.58.410 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Release factor | 0.51 | 37.0 | 3.66e-01 | 75.0% | 100.0% |
| 4gycA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.50 | 44.0 | 3.52e-01 | 97.2% | 82.3% |
ECOD (31)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3900667 | 150.3.1.6 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › IL10 | 0.90 | 86.0 | 7.42e-01 | 100.0% | 71.0% |
| 4038790 | 150.3.1.6 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › IL10 | 0.85 | 81.0 | 7.04e-01 | 100.0% | 71.2% |
| 4264893 | 150.3.1.6 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › IL10 | 0.83 | 78.0 | 6.70e-01 | 100.0% | 67.5% |
| 1821875 | 4970.1.1.1 ↗ | alpha bundles › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › fingers domain in bacteriophage RB69-like DNA polymerase I › DNA_pol_B | 0.75 | 41.0 | 5.43e-01 | 92.6% | 98.3% |
| 3722554 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.71 | 61.0 | 4.59e-01 | 94.4% | 94.0% |
| 4002308 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.70 | 61.0 | 4.99e-01 | 97.2% | 88.2% |
| 3791628 | 1203.1.2.0 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 | 0.69 | 48.0 | 4.36e-01 | 71.3% | 74.5% |
| 56672 | 150.3.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine | 0.69 | 64.0 | 5.69e-01 | 98.1% | 76.0% |
| 3513342 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.69 | 59.0 | 4.84e-01 | 95.4% | 82.4% |
| 5014995 | 150.1.1.3 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Rubrerythrin | 0.68 | 61.0 | 5.51e-01 | 97.2% | 84.8% |
| 3404404 | 5050.1.1.2 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PTR2 | 0.63 | 53.0 | 4.33e-01 | 93.5% | 96.7% |
| 3714029 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.61 | 41.0 | 3.40e-01 | 99.1% | 39.5% |
| 3908126 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.61 | 53.0 | 4.86e-01 | 95.4% | 97.9% |
| 3262781 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.60 | 52.0 | 4.64e-01 | 94.4% | 91.0% |
| 3644115 | 603.1.1.177 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF641 | 0.60 | 41.0 | 3.92e-01 | 70.4% | 69.2% |
| 4033046 | 632.19.1.3 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Choline binding protein A › Choline binding protein A › DUF1542 | 0.60 | 38.0 | 4.44e-01 | 82.4% | 90.7% |
| 3782067 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.60 | 53.0 | 4.74e-01 | 97.2% | 100.0% |
| 3248423 | 109.42.1.1 ↗ | alpha superhelices › Repetitive alpha hairpins › E3 ubiquitin-protein ligase SHPRH first helical domain › E3 ubiquitin-protein ligase SHPRH first helical domain › SHPRH_helical-1st | 0.58 | 50.0 | 4.05e-01 | 93.5% | 93.7% |
| 3606983 | 1189.1.1.2 ↗ | alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG_B | 0.58 | 49.0 | 3.49e-01 | 92.6% | 80.9% |
| 4974664 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.58 | 39.0 | 3.81e-01 | 90.7% | 62.5% |
| 3221996 | 3684.1.1.0 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like | 0.58 | 47.0 | 4.15e-01 | 85.2% | 84.0% |
| 3919997 | 3615.1.1.0 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain | 0.58 | 50.0 | 4.83e-01 | 94.4% | 88.3% |
| 3599032 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.58 | 40.0 | 3.13e-01 | 71.3% | 81.7% |
| 3447801 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.55 | 45.0 | 4.28e-01 | 92.6% | 95.4% |
| 3617266 | 632.1.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain | 0.54 | 42.0 | 4.09e-01 | 81.5% | 80.8% |
| 4141759 | 5045.1.1.1 ↗ | alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › ATP-synt_A | 0.54 | 38.0 | 3.09e-01 | 75.0% | 91.3% |
| 4547023 | 5045.1.1.1 ↗ | alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › ATP-synt_A | 0.52 | 37.0 | 3.04e-01 | 75.0% | 93.7% |
| 3701651 | 601.18.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 | 0.52 | 42.0 | 4.45e-01 | 88.9% | 94.9% |
| 3948656 | 601.4.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › NIT | 0.52 | 40.0 | 3.62e-01 | 84.3% | 70.3% |
| 4346157 | 3684.1.1.28 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PF26154 | 0.51 | 42.0 | 4.06e-01 | 90.7% | 80.0% |
| 3250598 | 633.6.1.2 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX | 0.50 | 45.0 | 3.92e-01 | 100.0% | 71.6% |