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large_T_antigen
Euk-VirBetapolyomavirus_ptedavyi
large_T_antigen__YP_007346979__Betapolyomavirus_ptedavyi__1891773
Identity
- Accession:
- YP_007346979 ↗
- Protein ID:
- large_T_antigen
- Kingdom:
- euk
Quality
83.9
mean pLDDT
Taxonomy
Shotokuvirae›
Cossaviricota›
Papovaviricetes›
Sepolyvirales›
Polyomaviridae›
Betapolyomavirus›
Betapolyomavirus_ptedavyi
TaxID: 1891773
Cluster
View cluster (129 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 143-257
Domain cluster:
rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02217.23 best | T_Ag_DNA_bind | 105.2 | 3.30e-30 | 79.1% | 94.7% |
D2
high
residues 275-359
Domain cluster:
rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 110.5 | 1.30e-31 | 100.0% | 20.1% |
D3
medium
residues 1-68
Domain cluster:
rep: small_T_antigen__YP_007346980__Betapolyomavirus_ptedavyi__1891773__D7-77
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00226.37 best | DnaJ | 28.4 | 2.00e-06 | 82.3% | 63.5% |
D4
medium
residues 386-403_554-631
Domain cluster:
rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D403-422_572-647
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 69.8 | 2.90e-19 | 82.3% | 18.7% |
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1svmA02 | 1.20.1050.70 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Large T antigen, SV40, domain 3 | 0.98 | 92.0 | 8.46e-01 | 99.0% | 78.8% |
| 3lvyE01 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.62 | 53.0 | 4.50e-01 | 95.8% | 67.9% |
| 6l3tA01 | 1.20.1440.80 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Gap junction channel protein cysteine-rich domain | 0.56 | 42.0 | 3.43e-01 | 83.3% | 57.8% |
| 4wjg400 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.54 | 43.0 | 3.21e-01 | 88.5% | 74.3% |
| 3tuiA00 | 1.10.3720.10 | Mainly Alpha › Orthogonal Bundle › MetI-like fold › MetI-like | 0.52 | 38.0 | 2.97e-01 | 77.1% | 69.4% |
| 1z72A00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.52 | 41.0 | 3.20e-01 | 86.5% | 91.7% |
| 1miwA03 | 1.20.58.560 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 38.0 | 3.80e-01 | 84.4% | 77.0% |
| 4c0nA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.50 | 36.0 | 3.21e-01 | 82.3% | 49.3% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3455048 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.54 | 44.0 | 3.96e-01 | 92.7% | 76.6% |
| 3396797 | 601.1.1.43 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Serendipity_A | 0.52 | 37.0 | 3.59e-01 | 89.6% | 66.4% |
D5
medium
residues 404-553
Domain cluster:
rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 271.3 | 2.00e-80 | 100.0% | 35.5% |
| PF00519.24 | PPV_E1_C | 28.2 | 1.50e-06 | 96.0% | 39.8% |