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large_T_antigen

Euk-Vir

STL_polyomavirus

large_T_antigen__YP_007354885__STL_polyomavirus__1277649

Identity

Accession:: YP_007354885 ↗
Protein ID:: large_T_antigen
Kingdom:: euk

Quality

86.2 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Sepolyvirales› Polyomaviridae› Deltapolyomavirus› STL_polyomavirus

TaxID: 1277649

Cluster

View cluster (129 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 7-69

PDB

Domain cluster: rep: small_T_antigen__YP_007346980__Betapolyomavirus_ptedavyi__1891773__D7-77

D2 high residues 151-264

PDB

Domain cluster: rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02217.23 best	T_Ag_DNA_bind	99.3	2.10e-28	79.0%	94.7%

D3 medium residues 288-363

PDB

Domain cluster: rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06431.17 best	Polyoma_lg_T_C	81.1	1.10e-22	100.0%	17.3%

CATH (13)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1svmA01	1.10.10.510	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Zinc finger, large T-antigen D1 domain	0.98	94.0	8.76e-01	100.0%	85.6%
2zxqA06	1.20.1270.70	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle	0.61	33.0	3.56e-01	100.0%	60.6%
3t46A00	1.20.1270.10	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.60	32.0	3.31e-01	96.1%	54.7%
1bgwA03	1.10.268.10	Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3	0.59	50.0	4.56e-01	100.0%	90.0%
2icwG02	1.10.10.530	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › mam-mhc complex, Chain D, Domain 2	0.58	41.0	3.90e-01	96.1%	62.9%
6me6B02	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.58	40.0	2.68e-01	72.4%	34.6%
2w02B01	1.10.150.640	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › AcsD, thumb domain, helical bundle	0.57	42.0	4.32e-01	100.0%	81.1%
7e4gA01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.57	48.0	3.55e-01	93.4%	81.7%
1ltlA01	3.30.1640.10	Alpha Beta › 2-Layer Sandwich › mini-chromosome maintenance (MCM) complex, chain A, domain 1 › mini-chromosome maintenance (MCM) complex, chain A, domain 1	0.54	40.0	3.86e-01	94.7%	68.9%
2w53B00	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.53	43.0	3.40e-01	93.4%	66.5%
3ucaA00	1.10.600.10	Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase	0.53	39.0	2.72e-01	80.3%	38.0%
4fx0A00	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.52	45.0	3.92e-01	100.0%	67.2%
1gt0D00	1.10.30.10	Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain	0.51	40.0	3.97e-01	97.4%	83.5%

ECOD (5)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4882224	8001.1.1.2 ↗	alpha arrays › N-terminal domain of large tumor antigen › N-terminal domain of large tumor antigen › N-terminal domain of large tumor antigen › Polyoma_lg_T_C	0.96	92.0	8.32e-01	100.0%	80.2%
3925604	109.32.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Alkylsulfatase SdsA1 linker domain › Alkylsulfatase SdsA1 linker domain	0.71	38.0	3.29e-01	94.7%	34.8%
3303117	605.4.1.0 ↗	alpha duplicates or obligate multimers › ROP-like › ROP protein › ROP protein	0.65	40.0	3.86e-01	100.0%	55.3%
3230949	103.4.1.1 ↗	alpha arrays › RuvA-C › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein › Elongation factor TFIIS domain 2/ Kix domain of creb binding protein › KIX	0.65	41.0	4.14e-01	89.5%	65.3%
3510536	138.1.1.5 ↗	alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA_pol3_gamma3	0.60	47.0	4.12e-01	86.8%	81.7%

D4 medium residues 405-561

PDB

Domain cluster: rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06431.17 best	Polyoma_lg_T_C	246.2	8.40e-73	100.0%	37.2%
PF00519.24	PPV_E1_C	27.1	3.10e-06	96.8%	38.8%

D5 medium residues 562-638

PDB

Domain cluster: rep: large_T_antigen__YP_007195273__Alphapolyomavirus_apaniscus__1236391__D601-612_625-670

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF06431.17 best	Polyoma_lg_T_C	54.4	1.50e-14	97.4%	16.3%