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large_T_antigen

Euk-Vir

Sea_otter_polyomavirus_1

large_T_antigen__YP_009091977__Sea_otter_polyomavirus_1__1552409

Identity

Accession:
YP_009091977 ↗
Protein ID:
large_T_antigen
Kingdom:
euk

Quality

84.5 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Sepolyvirales› Polyomaviridae› Sea_otter_polyomavirus_1

TaxID: 1552409

Cluster

View cluster (129 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 7-75
PDB
Domain cluster: rep: small_T_antigen__YP_007346980__Betapolyomavirus_ptedavyi__1891773__D7-77
D2 high residues 141-250
PDB
Domain cluster: rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02217.23 best T_Ag_DNA_bind 112.0 2.50e-32 80.0% 93.6%
D3 high residues 269-353
PDB
Domain cluster: rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 116.8 1.60e-33 100.0% 19.9%
D4 medium residues 383-446_493-517_543-626
PDB
Domain cluster: rep: large_T_antigen__YP_007195293__Alphapolyomavirus_septipanos__1891739__D391-454_582-665
Pfam (3)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 109.0 3.90e-31 50.3% 19.9%
PF06431.17 Polyoma_lg_T_C 100.2 1.80e-28 37.6% 15.1%
PF06431.17 Polyoma_lg_T_C 36.5 3.80e-09 16.2% 6.0%
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1svmA02 1.20.1050.70 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Large T antigen, SV40, domain 3 1.00 51.0 6.34e-01 98.3% 76.3%
1tueD00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.66 50.0 4.75e-01 77.5% 93.1%
1u0jA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.66 47.0 4.46e-01 73.4% 87.4%
D5 medium residues 447-492_518-542
PDB
Domain cluster: representative
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 62.4 5.20e-17 64.8% 11.5%
PF06431.17 Polyoma_lg_T_C 27.2 2.50e-06 35.2% 5.5%
CATH (44)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1m53A01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.66 57.0 3.60e-01 100.0% 37.4%
1g5aA02 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.65 57.0 3.61e-01 100.0% 34.3%
2gl5A02 3.20.20.120 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain 0.65 56.0 3.87e-01 100.0% 51.1%
7xsyA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.65 56.0 3.56e-01 100.0% 54.8%
1gjwA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.63 52.0 3.12e-01 95.8% 22.2%
5z2xA00 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.62 53.0 3.46e-01 100.0% 76.0%
3ssmC02 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.62 54.0 3.90e-01 100.0% 71.6%
1s3lA00 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.62 53.0 4.14e-01 100.0% 46.1%
6y9tB01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.60 50.0 3.22e-01 97.2% 45.6%
3o63A00 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.60 52.0 3.77e-01 100.0% 48.6%
2aaaA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.60 51.0 3.31e-01 100.0% 46.5%
4aefA03 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.60 51.0 3.29e-01 100.0% 50.8%
3lkbA02 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.59 51.0 3.99e-01 100.0% 70.7%
3dhuA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.59 50.0 3.29e-01 100.0% 48.4%
2qr6A02 3.20.20.70 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I 0.59 51.0 3.31e-01 100.0% 38.9%
2qgzA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.59 51.0 3.87e-01 100.0% 49.7%
4hxfB02 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.59 50.0 3.46e-01 100.0% 70.4%
3ih5A00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.58 43.0 3.10e-01 78.9% 80.5%
5bt8A02 3.40.50.1260 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Phosphoglycerate kinase, N-terminal domain 0.58 48.0 3.55e-01 100.0% 83.6%
1wlsA02 3.40.50.40 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.57 48.0 4.07e-01 100.0% 88.5%
3zssA03 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.57 48.0 3.14e-01 100.0% 51.2%
1igrA03 3.80.20.20 Alpha Beta › Alpha-Beta Horseshoe › 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A › Receptor L-domain 0.57 48.0 3.75e-01 100.0% 68.6%
6d2xA01 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.57 47.0 3.19e-01 98.6% 25.4%
2f62A00 3.40.50.450 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.57 47.0 3.82e-01 100.0% 82.9%
3h05B00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.57 41.0 3.23e-01 78.9% 38.7%
3k32B00 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.57 40.0 2.99e-01 78.9% 27.6%
7drdG01 3.20.20.150 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Divalent-metal-dependent TIM barrel enzymes 0.56 47.0 3.31e-01 100.0% 48.3%
2jaxA02 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.56 40.0 3.31e-01 77.5% 96.3%
1o2dA01 3.40.50.1970 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 47.0 3.66e-01 100.0% 78.6%
1eswA00 3.20.20.80 Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases 0.56 46.0 2.89e-01 100.0% 66.4%
1xm7A00 3.60.21.10 Alpha Beta › 4-Layer Sandwich › Purple Acid Phosphatase; chain A, domain 2 › Metallo-dependent phosphatases 0.55 47.0 3.58e-01 100.0% 48.9%
4ceiB01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.55 46.0 3.58e-01 100.0% 80.0%
3ojoB02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 46.0 3.46e-01 95.8% 55.6%
6c49A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.55 43.0 3.51e-01 93.0% 42.5%
1yzyA01 3.40.50.10840 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Putative sugar-binding, N-terminal domain 0.54 46.0 3.31e-01 100.0% 81.6%
3g1pA00 3.60.15.10 Alpha Beta › 4-Layer Sandwich › Metallo-beta-lactamase; Chain A › Ribonuclease Z/Hydroxyacylglutathione hydrolase-like 0.54 45.0 3.23e-01 100.0% 33.7%
2csuA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.54 46.0 3.88e-01 100.0% 90.6%
1lycA02 1.10.420.10 Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 2 › Peroxidase, domain 2 0.52 43.0 3.48e-01 98.6% 91.4%
3dcmX00 3.40.1280.10 Alpha Beta › 3-Layer(aba) Sandwich › Alpha/beta knot › SPOUT methyltransferase, trefoil knot domain 0.52 36.0 2.80e-01 77.5% 44.1%
2iu4A01 3.40.50.10440 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Dihydroxyacetone kinase; domain 1 0.51 44.0 3.41e-01 100.0% 76.0%
5kzkA02 3.40.1280.10 Alpha Beta › 3-Layer(aba) Sandwich › Alpha/beta knot › SPOUT methyltransferase, trefoil knot domain 0.51 37.0 2.95e-01 78.9% 38.5%
1vhvA02 3.30.950.10 Alpha Beta › 2-Layer Sandwich › Methyltransferase, Cobalt-precorrin-4 Transmethylase; Domain 2 › Tetrapyrrole methylase, C-terminal domain 0.50 42.0 3.50e-01 98.6% 79.1%
1to0D00 3.40.1280.10 Alpha Beta › 3-Layer(aba) Sandwich › Alpha/beta knot › SPOUT methyltransferase, trefoil knot domain 0.50 37.0 2.97e-01 80.3% 79.3%
3t37A01 3.50.50.60 Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain 0.50 36.0 2.58e-01 78.9% 51.6%
ECOD (30)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4979883 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.61 45.0 3.64e-01 78.9% 49.3%
3835401 2007.9.1.1 ↗ a/b three-layered sandwiches › Flavodoxin-like › Toll/Interleukin receptor TIR domain › Toll/Interleukin receptor TIR domain › TIR 0.61 52.0 4.23e-01 100.0% 76.6%
5040846 2005.1.1.0 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains 0.60 43.0 3.58e-01 77.5% 49.6%
4961979 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.60 44.0 3.57e-01 78.9% 49.3%
4219821 2002.1.1.35 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › DAHP_synth_1 0.59 49.0 3.45e-01 100.0% 39.6%
3406190 7579.1.1.0 ↗ a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases 0.59 49.0 3.32e-01 100.0% 55.1%
4271370 2004.1.1.164 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Roc 0.59 50.0 3.81e-01 100.0% 74.6%
4448185 2002.1.1.9 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › OMPdecase 0.58 49.0 3.67e-01 100.0% 48.5%
3451675 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.58 43.0 3.32e-01 78.9% 91.3%
4030842 2004.1.1.29 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD 0.58 48.0 3.70e-01 100.0% 70.0%
3292397 2004.1.1.135 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PIF1 0.57 49.0 3.43e-01 100.0% 38.5%
5001827 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.57 42.0 3.30e-01 78.9% 75.9%
2877581 2484.1.1.95 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Terminase-T7_RNaseH-like 0.57 41.0 2.86e-01 78.9% 33.8%
5026879 2006.1.2.1 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › DHH phosphoesterases › DHH 0.57 46.0 3.40e-01 93.0% 37.6%
4961978 2005.1.1.3 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › Usp 0.56 40.0 3.37e-01 77.5% 54.8%
5016401 109.4.1.210 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_19 0.56 47.0 2.95e-01 98.6% 30.7%
5035892 2006.1.1.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like 0.56 41.0 3.20e-01 78.9% 85.0%
3363794 2004.1.1.30 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C 0.56 37.0 3.40e-01 73.2% 50.5%
3196141 2003.1.11.1 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Formate/glycerate dehydrogenase catalytic domain-like › 2-Hacid_dh 0.55 47.0 3.75e-01 100.0% 94.1%
3441883 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.55 46.0 3.86e-01 100.0% 71.9%
3726827 2003.1.1.5 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ADH_zinc_N 0.54 43.0 3.38e-01 94.4% 37.2%
3958559 2003.1.3.73 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › Nucleotide-binding domain › CoA_transf_3 0.54 40.0 3.24e-01 81.7% 79.3%
3257930 2002.1.1.30 ↗ a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Glyco_hydro_18 0.53 45.0 3.18e-01 100.0% 47.2%
5025480 7512.1.1.0 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.53 44.0 3.34e-01 100.0% 94.9%
3376161 7512.1.1.0 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.52 44.0 3.10e-01 100.0% 90.6%
3593213 7512.1.1.0 ↗ a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase 0.52 44.0 3.30e-01 100.0% 63.0%
3449783 2488.1.1.1 ↗ a/b three-layered sandwiches › alpha/beta knot › alpha/beta knot › alpha/beta knot › SpoU_methylase 0.52 40.0 2.80e-01 85.9% 71.0%
3666922 207.1.1.95 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › LRR_14 0.51 43.0 3.15e-01 100.0% 36.9%
3959900 323.1.1.3 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › AMP-binding 0.51 34.0 2.94e-01 71.8% 43.2%
3396442 2007.1.2.30 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › IR75A_N 0.50 42.0 3.22e-01 100.0% 51.9%