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large_T_antigen

Euk-Vir

Betapolyomavirus_secuchlopygerythrus

large_T_antigen__YP_009111364__Betapolyomavirus_secuchlopygerythrus__1891758

Identity

Accession:
YP_009111364 ↗
Protein ID:
large_T_antigen
Kingdom:
euk

Quality

80.0 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Sepolyvirales› Polyomaviridae› Betapolyomavirus› Betapolyomavirus_secuchlopygerythrus

TaxID: 1891758

Cluster

View cluster (129 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 7-98
PDB
Domain cluster: representative
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1fafA00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.90 62.0 6.70e-01 70.7% 82.3%
1gh6A01 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.83 58.0 5.60e-01 72.8% 65.3%
4w8pA02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.63 53.0 4.70e-01 91.3% 78.5%
3m9vA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.62 47.0 3.96e-01 80.4% 57.3%
2jlnA00 1.10.4160.10 Mainly Alpha › Orthogonal Bundle › Hydantoin permease › Hydantoin permease 0.62 44.0 2.84e-01 75.0% 35.9%
1zzpA00 1.20.120.330 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 0.60 49.0 4.69e-01 89.1% 82.6%
1j8yF01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.56 40.0 4.16e-01 91.3% 82.6%
4gkfA00 1.10.520.30 Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › AF1862-like domain 0.54 37.0 3.23e-01 71.7% 99.3%
2yxlA01 1.10.940.10 Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like 0.52 42.0 3.62e-01 96.7% 53.9%
2vpzC00 1.20.1630.10 Mainly Alpha › Up-down Bundle › Formate dehydrogenase/DMSO reductase fold › Formate dehydrogenase/DMSO reductase domain 0.52 46.0 3.38e-01 98.9% 88.0%
1a22A00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.52 42.0 3.45e-01 91.3% 91.7%
3q1xA01 1.10.3130.10 Mainly Alpha › Orthogonal Bundle › serine acetyltransferase, domain 1 › serine acetyltransferase, domain 1 0.51 40.0 3.60e-01 88.0% 75.5%
2itbB00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.51 43.0 3.43e-01 95.7% 75.3%
ECOD (29)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3692 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.90 62.0 6.70e-01 70.7% 82.3%
3709866 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.81 57.0 6.07e-01 73.9% 83.7%
3470995 109.4.1.470 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › INTS2 0.65 45.0 2.88e-01 70.7% 16.2%
5035115 601.4.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains 0.63 49.0 4.14e-01 83.7% 85.0%
5036796 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.63 53.0 4.61e-01 92.4% 82.1%
3619083 5057.1.1.0 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore 0.62 52.0 4.58e-01 91.3% 82.2%
3199524 109.4.1.148 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › EST1_DNA_bind,EST1 0.62 43.0 2.71e-01 72.8% 23.7%
3648060 611.9.1.4 ↗ alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N 0.61 47.0 4.16e-01 82.6% 68.9%
4221264 109.4.1.777 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.60 49.0 3.24e-01 90.2% 43.7%
3693618 109.4.1.356 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans 0.60 48.0 3.08e-01 88.0% 81.2%
3562464 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.59 46.0 3.03e-01 88.0% 42.2%
3184415 109.4.1.681 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 0.59 45.0 2.97e-01 82.6% 83.2%
3435307 3684.1.1.0 ↗ alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like 0.58 47.0 3.90e-01 90.2% 57.6%
3935590 109.4.1.1127 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › ARM_Cnot1 0.58 42.0 3.20e-01 77.2% 52.9%
3170784 206.1.1.28 ↗ a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Haspin_kinase 0.57 46.0 3.31e-01 91.3% 57.0%
3935505 198.1.1.0 ↗ alpha arrays › Saposin-like › Saposin-like › Saposin-like 0.57 42.0 4.40e-01 97.8% 87.1%
3874338 150.3.1.22 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › PRF 0.57 47.0 3.74e-01 90.2% 91.8%
3268562 3651.1.1.1 ↗ alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › IF-2B 0.56 47.0 4.07e-01 93.5% 76.0%
3794774 603.1.1.17 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › SNARE 0.56 42.0 3.51e-01 81.5% 72.4%
3796452 109.4.1.414 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MMS19_N 0.56 38.0 2.61e-01 70.7% 39.7%
3231735 106.1.1.1 ↗ alpha arrays › Globin-like › Globin-like › Globin-like › Globin 0.54 40.0 3.23e-01 77.2% 58.9%
4672230 3579.1.1.0 ↗ extended segments › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J › NADH-quinone oxidoreductase subunit J 0.54 38.0 3.24e-01 71.7% 91.0%
3622876 3651.1.1.0 ↗ alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain 0.54 45.0 4.01e-01 92.4% 71.9%
4600685 195.1.1.1 ↗ alpha complex topology › NusB-like › NusB-like › NusB-like › NusB 0.53 44.0 3.86e-01 96.7% 60.7%
3171048 603.1.1.205 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF29691 0.52 38.0 3.52e-01 77.2% 66.7%
3484245 101.1.1.0 ↗ alpha arrays › HTH › HTH › Three-helical HTH 0.52 41.0 4.17e-01 100.0% 87.8%
3299605 191.1.1.62 ↗ alpha bundles › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › Tetracyclin repressor-like, C-terminal domain › DUF4378 0.51 43.0 4.05e-01 93.5% 86.1%
5001109 5051.1.1.10 ↗ alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › AA_permease_2 0.51 45.0 2.93e-01 98.9% 42.2%
3655051 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.51 45.0 3.47e-01 100.0% 66.7%
D2 high residues 142-258
PDB
Domain cluster: rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF02217.23 best T_Ag_DNA_bind 126.8 5.90e-37 76.9% 94.7%
D3 high residues 272-356
PDB
Domain cluster: rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 173.7 8.40e-51 100.0% 20.4%
D4 medium residues 366-422_551-631
PDB
Domain cluster: rep: large_T_antigen__YP_007195293__Alphapolyomavirus_septipanos__1891739__D391-454_582-665
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 155.1 3.70e-45 60.1% 19.4%
PF06431.17 Polyoma_lg_T_C 112.3 3.70e-32 42.0% 13.7%
D5 medium residues 423-550
PDB
Domain cluster: rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 287.5 2.40e-85 100.0% 30.7%