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large_T_antigen
Euk-VirBat_polyomavirus_6d
large_T_antigen__YP_009129300__Bat_polyomavirus_6d__1623686
Identity
- Accession:
- YP_009129300 ↗
- Protein ID:
- large_T_antigen
- Kingdom:
- euk
Quality
84.8
mean pLDDT
Taxonomy
TaxID: 1623686
Cluster
View cluster (129 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 151-270
Domain cluster:
rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02217.23 best | T_Ag_DNA_bind | 89.7 | 2.30e-25 | 77.5% | 93.6% |
D2
medium
residues 1-67
Domain cluster:
rep: small_T_antigen__YP_007346980__Betapolyomavirus_ptedavyi__1891773__D7-77
D3
medium
residues 294-393
Domain cluster:
rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 126.3 | 2.10e-36 | 100.0% | 23.5% |
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1svmA01 | 1.10.10.510 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Zinc finger, large T-antigen D1 domain | 0.98 | 72.0 | 7.63e-01 | 75.0% | 83.3% |
| 2rekA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.58 | 36.0 | 3.03e-01 | 77.0% | 35.5% |
| 4i9oA00 | 1.10.246.20 | Mainly Alpha › Orthogonal Bundle › Serum Albumin; Chain A, Domain 1 › Coactivator CBP, KIX domain | 0.58 | 33.0 | 3.71e-01 | 90.0% | 71.8% |
| 2elcA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.55 | 26.0 | 3.13e-01 | 100.0% | 64.2% |
| 2gsqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.55 | 34.0 | 3.39e-01 | 91.0% | 57.4% |
| 2pnqA00 | 3.60.40.10 | Alpha Beta › 4-Layer Sandwich › Phosphatase 2c; domain 1 › PPM-type phosphatase domain | 0.52 | 40.0 | 2.73e-01 | 83.0% | 25.4% |
| 3n00A00 | 1.10.565.10 | Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor | 0.51 | 44.0 | 3.66e-01 | 96.0% | 65.8% |
| 3iqcA00 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.51 | 33.0 | 3.18e-01 | 100.0% | 54.6% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4882224 | 8001.1.1.2 ↗ | alpha arrays › N-terminal domain of large tumor antigen › N-terminal domain of large tumor antigen › N-terminal domain of large tumor antigen › Polyoma_lg_T_C | 0.97 | 77.0 | 7.88e-01 | 81.0% | 84.4% |
| 3783238 | 5041.1.1.15 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › Tmemb_170 | 0.55 | 35.0 | 3.39e-01 | 89.0% | 55.7% |
| 3528706 | 192.29.1.11 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › FerA | 0.52 | 37.0 | 3.44e-01 | 100.0% | 58.4% |
| 3330826 | 6155.1.1.1 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › MtN3_slv | 0.52 | 36.0 | 3.80e-01 | 100.0% | 80.0% |
D4
medium
residues 394-437_559-645
Domain cluster:
rep: large_T_antigen__YP_007195293__Alphapolyomavirus_septipanos__1891739__D391-454_582-665
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 36.0 | 5.40e-09 | 66.4% | 18.7% |
| PF06431.17 | Polyoma_lg_T_C | 40.4 | 2.50e-10 | 42.0% | 10.3% |
D5
medium
residues 438-558
Domain cluster:
rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 211.5 | 3.00e-62 | 100.0% | 29.0% |