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large_T_antigen
Euk-VirSparus_aurata_polyomavirus_1
large_T_antigen__YP_009272697__Sparus_aurata_polyomavirus_1__1885927
Identity
- Accession:
- YP_009272697 ↗
- Protein ID:
- large_T_antigen
- Kingdom:
- euk
Quality
68.9
mean pLDDT
Taxonomy
Shotokuvirae›
Cossaviricota›
Papovaviricetes›
Sepolyvirales›
Polyomaviridae›
Thetapolyomavirus›
Sparus_aurata_polyomavirus_1
TaxID: 1885927
Cluster
View cluster (129 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 1-67
Domain cluster:
rep: sLT__YP_009110678__Black_sea_bass_polyomavirus_1__1572341__D7-71
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1zkeA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 58.0 | 5.43e-01 | 100.0% | 77.8% |
| 3fghA00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.67 | 45.0 | 4.58e-01 | 70.1% | 94.0% |
| 1v64A00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.67 | 46.0 | 3.91e-01 | 71.6% | 60.2% |
| 3whjA00 | 6.10.140.1710 | Special › Helix non-globular › Helix Hairpins › | 0.66 | 57.0 | 4.78e-01 | 94.0% | 74.8% |
| 2rkkA01 | 1.25.40.270 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Vacuolar protein sorting-associated protein vta1 | 0.66 | 50.0 | 3.84e-01 | 82.1% | 47.4% |
| 1x3kA01 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.61 | 50.0 | 3.89e-01 | 91.0% | 94.6% |
| 1t3dA01 | 1.10.3130.10 | Mainly Alpha › Orthogonal Bundle › serine acetyltransferase, domain 1 › serine acetyltransferase, domain 1 | 0.57 | 41.0 | 3.33e-01 | 77.6% | 65.0% |
| 4by6A01 | 1.25.40.790 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.57 | 48.0 | 3.27e-01 | 100.0% | 47.7% |
| 6cgvM01 | 1.20.120.1500 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pre-hexon-linking protein IIIa | 0.57 | 39.0 | 3.18e-01 | 73.1% | 37.3% |
| 7r8bB01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 42.0 | 2.77e-01 | 79.1% | 33.5% |
| 2lyyA00 | 1.10.287.3020 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.54 | 38.0 | 3.42e-01 | 74.6% | 79.2% |
| 2zcuA02 | 3.90.25.10 | Alpha Beta › Alpha-Beta Complex › UDP-galactose 4-epimerase; domain 1 › UDP-galactose 4-epimerase, domain 1 | 0.53 | 42.0 | 3.58e-01 | 89.6% | 85.2% |
| 1gt0D00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.51 | 42.0 | 3.97e-01 | 88.1% | 78.5% |
| 1sqgA01 | 1.10.940.10 | Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like | 0.50 | 39.0 | 3.19e-01 | 89.6% | 78.0% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3738479 | 1128.1.1.1 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein › Complex1_LYR | 0.76 | 48.0 | 4.42e-01 | 73.1% | 50.6% |
| 3595202 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.72 | 62.0 | 4.33e-01 | 97.0% | 40.5% |
| 4587007 | 3718.1.1.0 ↗ | alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT | 0.70 | 56.0 | 4.92e-01 | 88.1% | 73.0% |
| 3267852 | 1128.1.1.1 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein › Complex1_LYR | 0.68 | 46.0 | 4.40e-01 | 71.6% | 60.0% |
| 3740089 | 1134.1.1.7 ↗ | alpha bundles › C-terminal helical domain of alanine-tRNA ligase › C-terminal helical domain of alanine-tRNA ligase › Eukaryotic C-Ala helical domain › ALA1 | 0.67 | 53.0 | 5.46e-01 | 85.1% | 90.8% |
| 4966173 | 101.1.4.97 ↗ | alpha arrays › HTH › HTH › tetra-helical, lambda repressor-like › DrmE_C | 0.65 | 57.0 | 4.68e-01 | 100.0% | 87.2% |
| 3704696 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.64 | 56.0 | 5.05e-01 | 97.0% | 80.0% |
| 3597989 | 650.1.1.0 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain | 0.64 | 55.0 | 5.08e-01 | 95.5% | 85.9% |
| 3999694 | 109.26.1.12 ↗ | alpha superhelices › Repetitive alpha hairpins › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › TPR_Nup160_C, TPR_NUP160_120_M | 0.62 | 48.0 | 3.09e-01 | 85.1% | 20.6% |
| 5021020 | 632.7.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain | 0.60 | 50.0 | 4.50e-01 | 97.0% | 66.7% |
| 4070498 | 101.11.1.1 ↗ | alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › PNPase | 0.59 | 53.0 | 4.76e-01 | 98.5% | 84.4% |
| 3590445 | 316.2.1.0 ↗ | a+b three layers › Nucleotidyltransferase-like › Rv2827c C-terminal domain-like › Rv2827c C-terminal domain-like | 0.58 | 44.0 | 3.51e-01 | 83.6% | 67.1% |
| 3765803 | 4156.1.1.2 ↗ | alpha arrays › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › Sec63 N-terminal subdomain-like › HA2_N,HA2_C | 0.57 | 51.0 | 3.60e-01 | 98.5% | 52.2% |
| 5056632 | 2008.1.1.59 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_1 | 0.57 | 45.0 | 3.11e-01 | 86.6% | 28.3% |
| 3860830 | 2004.1.1.564 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › HA2_N, HA2_C | 0.57 | 50.0 | 2.93e-01 | 98.5% | 18.0% |
| 3736421 | 192.8.1.35 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › DUF6594 | 0.56 | 48.0 | 4.54e-01 | 100.0% | 88.2% |
| 3239957 | 2007.2.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II | 0.54 | 45.0 | 3.46e-01 | 95.5% | 52.9% |
| 3992404 | 190.1.1.1 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box | 0.54 | 48.0 | 4.39e-01 | 95.5% | 76.5% |
| 3200876 | 190.1.1.0 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box | 0.53 | 46.0 | 4.19e-01 | 95.5% | 88.9% |
| 4015915 | 190.1.1.3 ↗ | alpha arrays › HMG-box-like › HMG-box › HMG-box › HMG_box_2 | 0.51 | 44.0 | 4.13e-01 | 94.0% | 93.8% |
D2
high
residues 80-191
Domain cluster:
rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
D3
medium
residues 203-297
Domain cluster:
rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 34.1 | 2.10e-08 | 99.0% | 18.9% |
D4
medium
residues 298-355_495-572
Domain cluster:
representative
CATH (6)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1svmA02 | 1.20.1050.70 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Large T antigen, SV40, domain 3 | 0.74 | 59.0 | 6.33e-01 | 86.8% | 95.8% |
| 6vw7B03 | 1.20.1440.230 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain | 0.58 | 29.0 | 3.56e-01 | 77.2% | 76.2% |
| 3k1rA01 | 1.20.1160.20 | Mainly Alpha › Up-down Bundle › Paired amphipathic helix 2 (pah2 repeat) › | 0.54 | 25.0 | 3.22e-01 | 79.4% | 72.8% |
| 2gscC00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.53 | 32.0 | 3.50e-01 | 79.4% | 72.7% |
| 2mtqA00 | 1.20.58.130 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 29.0 | 3.81e-01 | 78.7% | 100.0% |
| 4ldsA00 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.52 | 39.0 | 2.85e-01 | 80.1% | 91.2% |
ECOD (6)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3601270 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.54 | 43.0 | 3.35e-01 | 85.3% | 76.1% |
| 3590536 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.52 | 37.0 | 3.15e-01 | 72.1% | 64.6% |
| 3783652 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 36.0 | 2.95e-01 | 71.3% | 66.4% |
| 3180241 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 36.0 | 3.19e-01 | 74.3% | 72.9% |
| 4108783 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 35.0 | 3.19e-01 | 71.3% | 74.6% |
| 3228203 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.50 | 36.0 | 3.11e-01 | 74.3% | 67.6% |