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large_T_antigen

Euk-Vir

Bat_polyomavirus

large_T_antigen__YP_009552118__Bat_polyomavirus__1221637

Identity

Accession:
YP_009552118 ↗
Protein ID:
large_T_antigen
Kingdom:
euk

Quality

76.2 mean pLDDT

Taxonomy

Shotokuvirae› Cossaviricota› Papovaviricetes› Sepolyvirales› Polyomaviridae› Bat_polyomavirus

TaxID: 1221637

Cluster

View cluster (129 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 11-81
PDB
Domain cluster: representative
CATH (31)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1fafA00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.78 66.0 6.40e-01 98.6% 82.3%
2ctqA01 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.76 59.0 5.34e-01 81.7% 64.9%
2bvlA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.74 53.0 5.01e-01 76.1% 69.8%
4dmvA01 1.20.58.1190 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.73 52.0 4.95e-01 76.1% 70.6%
2p58C00 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.70 43.0 3.70e-01 74.6% 39.3%
2kw6A00 6.10.140.1300 Special › Helix non-globular › Helix Hairpins › 0.68 46.0 4.85e-01 71.8% 76.9%
1bgcA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.67 48.0 3.74e-01 76.1% 67.1%
4it4A02 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.66 47.0 4.40e-01 76.1% 72.5%
2lsgA00 1.20.58.1280 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › DNA repair protein Rev1, C-terminal domain 0.66 48.0 4.34e-01 77.5% 57.7%
2o36A01 1.20.1050.40 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Endopeptidase. Chain P; domain 1 0.66 47.0 3.92e-01 76.1% 60.9%
1aj3A00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.64 47.0 4.24e-01 77.5% 87.8%
8fnyA01 1.25.40.10 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain 0.64 46.0 3.29e-01 76.1% 27.7%
3c5wA00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.63 47.0 3.30e-01 80.3% 53.9%
2n1rA00 1.10.150.90 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Immunodeficiency lentiviruses, gag gene matrix protein p17 0.62 54.0 4.45e-01 100.0% 56.0%
3ag7A00 1.10.287.110 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain 0.61 51.0 4.64e-01 98.6% 81.9%
3wozB00 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.61 46.0 3.21e-01 81.7% 38.0%
3fhnA04 1.20.58.670 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain D 0.60 42.0 3.45e-01 73.2% 50.4%
2xheA03 3.90.830.10 Alpha Beta › Alpha-Beta Complex › Syntaxin Binding Protein 1; Chain A, domain 2 › Sec1/Munc18 (SM) protein, domain 3a 0.59 51.0 4.35e-01 100.0% 66.9%
4c9bB00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.57 50.0 3.33e-01 95.8% 54.2%
8h6rA01 1.20.930.10 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 0.57 44.0 4.15e-01 81.7% 97.6%
3afgA02 3.40.50.200 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain 0.56 44.0 2.93e-01 87.3% 64.1%
4i2zA02 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.56 46.0 2.97e-01 93.0% 29.9%
1q2lA04 3.30.830.10 Alpha Beta › 2-Layer Sandwich › Cytochrome Bc1 Complex; Chain A, domain 1 › Metalloenzyme, LuxS/M16 peptidase-like 0.56 48.0 3.42e-01 100.0% 58.8%
3otgA01 3.40.50.2000 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Glycogen Phosphorylase B; 0.55 40.0 2.82e-01 77.5% 33.5%
6n2nA01 3.40.920.10 Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate-ferredoxin Oxidoreductase; domain 3 › Pyruvate-ferredoxin oxidoreductase, PFOR, domain III 0.54 43.0 3.30e-01 91.5% 47.8%
1e6bA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.53 38.0 3.38e-01 78.9% 54.1%
2ds2D01 1.10.110.10 Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins 0.52 37.0 3.98e-01 80.3% 96.5%
3bbyA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 45.0 3.82e-01 95.8% 59.0%
3phuA01 3.90.70.80 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › 0.51 38.0 3.08e-01 83.1% 40.3%
4xrpA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.51 44.0 3.59e-01 98.6% 87.8%
2jlnA00 1.10.4160.10 Mainly Alpha › Orthogonal Bundle › Hydantoin permease › Hydantoin permease 0.50 44.0 2.69e-01 98.6% 53.3%
ECOD (23)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3610628 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.86 65.0 6.62e-01 91.5% 81.4%
3392375 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.80 67.0 6.76e-01 98.6% 91.4%
3612725 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.78 62.0 5.82e-01 84.5% 70.6%
3594784 650.1.1.0 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain 0.78 67.0 6.07e-01 94.4% 72.6%
3530765 192.29.1.203 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › IQUB 0.78 54.0 4.52e-01 74.6% 44.3%
3849025 601.1.1.145 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › IQUB 0.78 54.0 4.52e-01 76.1% 44.3%
4357455 650.1.1.1 ↗ alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ 0.76 69.0 6.51e-01 100.0% 87.1%
3196101 109.27.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › BACK domain › BACK domain 0.74 46.0 4.63e-01 100.0% 62.9%
3615280 109.4.1.109 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sel1 0.72 51.0 3.11e-01 74.6% 21.6%
3448742 109.7.1.4 ↗ alpha superhelices › Repetitive alpha hairpins › Cytochrome c oxidase subunit E › Cytochrome c oxidase subunit E › SNAP 0.72 52.0 5.28e-01 76.1% 85.7%
4976398 622.1.1.0 ↗ alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain 0.67 52.0 4.59e-01 83.1% 83.5%
3996406 604.6.1.0 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain 0.66 47.0 4.74e-01 74.6% 75.7%
3285443 5051.1.1.9 ↗ alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Transp_cyt_pur 0.66 55.0 3.37e-01 94.4% 61.1%
3229971 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.64 45.0 3.19e-01 73.2% 32.6%
3484662 109.4.1.1413 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF28415 0.64 53.0 3.47e-01 91.5% 31.5%
3880516 109.4.1.109 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Sel1 0.63 44.0 3.09e-01 73.2% 26.4%
5057187 2004.1.1.76 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF87 0.60 47.0 3.05e-01 88.7% 22.1%
4196088 150.1.1.175 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › BREX_BrxC_helical 0.60 48.0 4.29e-01 90.1% 74.3%
3940544 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.58 37.0 3.22e-01 84.5% 43.8%
3736843 109.4.1.681 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Fungal_trans_2 0.55 47.0 3.07e-01 100.0% 56.2%
3657925 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.54 40.0 3.87e-01 78.9% 96.2%
5012559 6028.1.1.0 ↗ alpha bundles › Ribosome modulation factor › Ribosome modulation factor › Ribosome modulation factor 0.54 41.0 4.05e-01 81.7% 90.7%
3742733 610.4.1.1 ↗ alpha arrays › ERP29 C domain-like › YqeY domain › YqeY domain › YqeY 0.53 43.0 4.02e-01 98.6% 72.4%
D2 high residues 109-214
PDB
D3 high residues 227-317
PDB
Domain cluster: rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
CATH (8)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1svmA01 1.10.10.510 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Zinc finger, large T-antigen D1 domain 0.93 83.0 8.39e-01 100.0% 94.4%
2gxaE01 1.10.10.510 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Zinc finger, large T-antigen D1 domain 0.88 59.0 6.57e-01 100.0% 86.3%
3lnnB03 1.10.287.470 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.62 31.0 3.60e-01 98.9% 65.7%
3vwaA03 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.55 34.0 2.37e-01 98.9% 18.5%
3f4mA00 1.20.1440.160 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like 0.54 39.0 3.36e-01 78.0% 98.1%
3b77B02 1.10.287.210 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.53 31.0 3.18e-01 92.3% 59.8%
4huqS00 1.10.1760.20 Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › 0.51 46.0 3.79e-01 100.0% 79.9%
3onqA03 1.10.10.2840 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › PucR C-terminal helix-turn-helix domain 0.51 37.0 3.31e-01 76.9% 61.1%
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3506727 142.1.1.0 ↗ alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors 0.67 35.0 3.17e-01 85.7% 36.7%
5017266 5058.1.1.0 ↗ alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region 0.54 35.0 3.75e-01 87.9% 76.2%
3623208 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.51 33.0 3.35e-01 76.9% 66.7%
3584217 632.7.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.50 35.0 3.34e-01 74.7% 67.0%
D4 medium residues 335-357_507-575
PDB
Domain cluster: representative
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1svmA02 1.20.1050.70 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Large T antigen, SV40, domain 3 0.74 67.0 6.18e-01 100.0% 85.6%
2nyxB01 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.56 41.0 3.55e-01 75.0% 71.1%
6e1kA01 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.56 40.0 3.78e-01 73.9% 86.6%
4g9yA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.56 40.0 3.56e-01 75.0% 75.7%
4dxwA02 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.55 39.0 3.71e-01 75.0% 83.9%
3tjmA02 1.10.1470.20 Mainly Alpha › Orthogonal Bundle › Protein Yjbj; Chain: A; › Fatty acid synthase; domain 2 0.55 33.0 3.39e-01 100.0% 61.1%
2iu1A00 1.25.40.180 Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › 0.55 37.0 3.03e-01 93.5% 36.0%
2ig3A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.54 38.0 3.51e-01 80.4% 54.3%
4zqeA03 1.10.1740.10 Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif 0.53 43.0 4.27e-01 96.7% 83.3%
2fbhA00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 38.0 3.34e-01 75.0% 73.0%
3s2wG00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.53 39.0 3.47e-01 78.3% 75.9%
3ljxA01 1.10.3210.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 0.51 41.0 3.13e-01 89.1% 47.6%
1zylA03 1.20.1270.170 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 35.0 3.42e-01 84.8% 64.1%
3rvyA01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.50 34.0 3.23e-01 70.7% 55.3%
ECOD (6)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3950333 632.1.1.23 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain › DUF2516 0.61 43.0 4.51e-01 83.7% 82.4%
3394007 7111.1.1.1 ↗ alpha bundles › Ubiquinol-cytochrome C chaperone, C-terminal domain › Ubiquinol-cytochrome C chaperone, C-terminal domain › Ubiquinol-cytochrome C chaperone, C-terminal domain › Ubiq_cyt_C_chap 0.55 46.0 3.78e-01 95.7% 76.2%
5059305 5050.1.1.9 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 37.0 3.01e-01 98.9% 38.4%
3389097 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.51 38.0 3.01e-01 98.9% 36.1%
3401500 5054.1.1.0 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels 0.51 35.0 3.15e-01 72.8% 73.6%
3748236 5050.1.1.9 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 37.0 2.92e-01 93.5% 35.9%
D5 medium residues 358-506
PDB
Domain cluster: rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF06431.17 best Polyoma_lg_T_C 139.3 2.40e-40 98.0% 31.6%
PF00519.24 PPV_E1_C 34.4 1.90e-08 91.3% 37.7%