←Back to structures
large_T_antigen
Euk-VirMastomys_natalensis_polyomavirus_2
large_T_antigen__YP_010087541__Mastomys_natalensis_polyomavirus_2__2182467
Identity
- Accession:
- YP_010087541 ↗
- Protein ID:
- large_T_antigen
- Kingdom:
- euk
Quality
79.0
mean pLDDT
Taxonomy
Shotokuvirae›
Cossaviricota›
Papovaviricetes›
Sepolyvirales›
Polyomaviridae›
Alphapolyomavirus›
Mastomys_natalensis_polyomavirus_2
TaxID: 2182467
Cluster
View cluster (129 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 261-378
Domain cluster:
rep: large_T_antigen__YP_009115503__Adelie_penguin_polyomavirus__1590650__D167-268
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02217.23 best | T_Ag_DNA_bind | 110.8 | 5.80e-32 | 76.3% | 94.7% |
D2
high
residues 390-473
Domain cluster:
rep: ORF01L__YP_009252373__Marbled_eel_polyomavirus__1662286__D415-505
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 70.5 | 1.80e-19 | 100.0% | 19.4% |
D3
medium
residues 1-68_91-112
Domain cluster:
rep: small_T_antigen__YP_007346980__Betapolyomavirus_ptedavyi__1891773__D7-77
D4
medium
residues 474-515_669-747
Domain cluster:
rep: large_T_antigen__YP_007195293__Alphapolyomavirus_septipanos__1891739__D391-454_582-665
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 32.8 | 5.20e-08 | 64.5% | 17.0% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1svmA02 | 1.20.1050.70 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › Large T antigen, SV40, domain 3 | 0.95 | 87.0 | 8.89e-01 | 94.2% | 100.0% |
| 3kcuD00 | 1.20.1080.10 | Mainly Alpha › Up-down Bundle › Glycerol uptake facilitator protein › Glycerol uptake facilitator protein. | 0.57 | 49.0 | 3.89e-01 | 95.0% | 87.1% |
| 4g12A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 47.0 | 4.37e-01 | 97.5% | 92.6% |
| 8sbeA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.51 | 36.0 | 3.06e-01 | 71.9% | 69.9% |
| 3frrA00 | 1.20.1260.60 | Mainly Alpha › Up-down Bundle › Ferritin › Vacuolar protein sorting-associated protein Ist1 | 0.50 | 40.0 | 3.46e-01 | 84.3% | 55.4% |
ECOD (15)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3874897 | 320.4.1.5 ↗ | a+b two layers › R3H domain-like › PUB domain › PUB domain › Gasdermin_C | 0.59 | 43.0 | 3.70e-01 | 76.0% | 100.0% |
| 3032082 | 320.4.1.2 ↗ | a+b two layers › R3H domain-like › PUB domain › PUB domain › Orthopox_A47 | 0.57 | 42.0 | 3.58e-01 | 77.7% | 93.2% |
| 4423562 | 7524.1.1.1 ↗ | a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh | 0.55 | 40.0 | 3.14e-01 | 75.2% | 92.9% |
| 3608820 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 38.0 | 3.15e-01 | 71.9% | 64.2% |
| 3944659 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.54 | 38.0 | 3.29e-01 | 73.6% | 73.3% |
| 4995211 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 38.0 | 3.20e-01 | 72.7% | 70.5% |
| 3914182 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 37.0 | 3.15e-01 | 72.7% | 68.8% |
| 5076868 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 38.0 | 3.24e-01 | 73.6% | 70.0% |
| 3655727 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 38.0 | 3.17e-01 | 73.6% | 68.3% |
| 4023948 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 38.0 | 3.19e-01 | 77.7% | 66.1% |
| 4314734 | 7524.1.1.1 ↗ | a/b three-layered sandwiches › ALDH-like › ALDH-like › ALDH-like › Aldedh | 0.52 | 39.0 | 2.96e-01 | 77.7% | 91.4% |
| 4934758 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 36.0 | 3.19e-01 | 71.9% | 76.1% |
| 3759091 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 37.0 | 3.04e-01 | 74.4% | 64.5% |
| 5010974 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 36.0 | 3.08e-01 | 73.6% | 69.8% |
| 5014403 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.50 | 36.0 | 3.14e-01 | 73.6% | 75.7% |
D5
medium
residues 516-668
Domain cluster:
rep: MN062720.1__QDP45567.1__SEA_FUZZBUSTER_83__00083__D568-722_747-764
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF06431.17 best | Polyoma_lg_T_C | 214.9 | 2.60e-63 | 99.4% | 35.0% |
| PF00519.24 | PPV_E1_C | 33.3 | 4.10e-08 | 98.7% | 40.5% |
| PF01057.24 | Parvo_NS1 | 21.7 | 1.30e-04 | 49.0% | 13.3% |