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mRNA-capping_enzyme

Euk-Vir

Pithovirus_sibericum

mRNA-capping_enzyme__YP_009001355__Pithovirus_sibericum__1450746

Identity

Accession:: YP_009001355 ↗
Protein ID:: mRNA-capping_enzyme
Kingdom:: euk

Quality

63.4 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Pimascovirales› Pithoviridae› Alphapithovirus› Pithovirus_sibericum

TaxID: 1450746

Cluster

View cluster (8 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 574-714_770-811

PDB

Domain cluster: rep: IMGVR_UViG_3300005095_000540-3300005095-Ga0072504_10167229__D19-209

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03291.23 best	mRNA_G-N7_MeTrfase	30.2	3.50e-07	94.0%	45.4%
PF08241.19	Methyltransf_11	27.1	7.40e-06	59.6%	100.0%
PF13649.13	Methyltransf_25	28.6	2.70e-06	57.9%	99.0%

D2 medium residues 28-60_142-153_179-201

PDB

D3 medium residues 61-141_154-178

PDB

Domain cluster: representative

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5a67A00	2.40.320.10	Mainly Beta › Beta Barrel › Hypothetical Protein Pfu-838710-001 › Hypothetical Protein Pfu-838710-001	0.70	65.0	5.12e-01	100.0%	68.9%
3cnwA00	3.30.530.20	Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain	0.54	36.0	3.25e-01	99.1%	51.1%
3cloC01	3.30.450.20	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain	0.53	38.0	3.08e-01	90.6%	40.4%

ECOD (3)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1674584	868.1.1.1 ↗	a+b complex topology › mRNA triphosphatase CET1-related › mRNA triphosphatase CET1-related › mRNA triphosphatase CET1-related › CYTH	0.70	65.0	5.12e-01	100.0%	68.9%
3389726	868.1.1.5 ↗	a+b complex topology › mRNA triphosphatase CET1-related › mRNA triphosphatase CET1-related › mRNA triphosphatase CET1-related › Med18	0.62	56.0	4.49e-01	100.0%	64.9%
3389090	3775.1.1.1 ↗	beta barrels › Lysosome membrane protein 2 lumenal domain › Lysosome membrane protein 2 lumenal domain › Lysosome membrane protein 2 lumenal domain › CD36	0.51	36.0	2.47e-01	72.6%	81.2%

D4 medium residues 216-244_274-391

PDB

Domain cluster: rep: Adenylation_DNA_ligase_like_superfamily_domain__YP_008437195__Pandoravirus_salinus__1349410__D92-124_182-237_296-354

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01331.26 best	mRNA_cap_enzyme	32.8	7.10e-08	74.2%	39.2%

CATH (6)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1ckmA01	3.30.470.30	Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme	0.74	71.0	6.96e-01	100.0%	98.1%
3vnnA00	3.30.470.30	Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme	0.69	53.0	5.77e-01	80.3%	96.0%
3l2pA03	3.30.470.30	Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme	0.68	50.0	5.54e-01	76.2%	100.0%
4ckbA01	3.30.470.140	Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 ›	0.64	52.0	4.87e-01	100.0%	70.2%
3qwuA02	3.30.470.30	Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › DNA ligase/mRNA capping enzyme	0.57	47.0	4.39e-01	87.8%	74.4%
3hoiA00	3.40.109.10	Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase	0.51	46.0	4.21e-01	98.6%	95.9%

ECOD (15)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3310146	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.77	73.0	5.29e-01	100.0%	51.0%
3610835	206.1.3.4 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › mRNA_cap_enzyme	0.76	72.0	5.60e-01	100.0%	66.6%
4027847	206.1.3.4 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › mRNA_cap_enzyme	0.76	72.0	6.15e-01	100.0%	75.9%
3240894	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.72	64.0	5.18e-01	93.9%	64.5%
3492438	206.1.3.30 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › SPN1_m3Gcap_bd	0.69	60.0	5.00e-01	91.8%	65.7%
3550572	206.1.3.30 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › SPN1_m3Gcap_bd	0.69	62.0	5.02e-01	94.6%	65.0%
3894770	206.1.3.4 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › mRNA_cap_enzyme	0.68	62.0	5.13e-01	96.6%	62.4%
3997608	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.68	61.0	4.88e-01	95.9%	59.0%
3578637	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.68	60.0	4.70e-01	93.9%	54.8%
3939998	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.67	60.0	4.92e-01	95.9%	63.9%
3709083	206.1.3.70 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › DUF7920	0.57	52.0	3.96e-01	100.0%	67.0%
3682212	206.1.3.0 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp	0.53	43.0	3.32e-01	93.9%	39.2%
4995028	227.1.1.6 ↗	a+b two layers › DNA clamp › DNA clamp › DNA clamp › PCNA_C	0.52	34.0	3.62e-01	77.6%	75.2%
4838796	304.103.1.1 ↗	a+b two layers › Alpha-beta plaits › FMN-dependent nitroreductase-like › FMN-dependent nitroreductase-like › Nitroreductase	0.51	45.0	4.16e-01	98.0%	95.8%
3198426	4.1.1.0 ↗	beta barrels › SH3 › SH3 › SH3	0.50	31.0	3.75e-01	77.6%	100.0%

D5 medium residues 245-273_392-456

PDB

Domain cluster: representative

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1b04A02	3.30.1490.70	Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 ›	0.66	57.0	5.69e-01	95.7%	97.0%
1dgsA02	3.30.1490.70	Alpha Beta › 2-Layer Sandwich › Dna Ligase; domain 1 ›	0.65	55.0	5.56e-01	93.6%	100.0%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5067098	898.1.1.1 ↗	a+b two layers › a+b domain in Ribosomal protein L1 › a+b domain in Ribosomal protein L1 › a+b domain in Ribosomal protein L1 › Ribosomal_L1	0.54	45.0	4.16e-01	91.5%	94.2%

D6 medium residues 457-504_522-547

PDB

Domain cluster: representative

CATH (7)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3mlqH00	2.40.10.170	Mainly Beta › Beta Barrel › Thrombin, subunit H ›	0.59	30.0	3.59e-01	93.2%	78.6%
2derA03	2.40.30.10	Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors	0.58	32.0	3.10e-01	93.2%	46.0%
1v9kA00	3.30.2350.10	Alpha Beta › 2-Layer Sandwich › Pseudouridine synthase › Pseudouridine synthase	0.57	40.0	2.85e-01	94.6%	23.8%
1gydB00	2.115.10.20	Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43	0.53	40.0	2.74e-01	85.1%	90.2%
3hi2B00	3.30.2310.40	Alpha Beta › 2-Layer Sandwich › YaeB-like fold ›	0.51	29.0	2.69e-01	94.6%	40.2%
3jtzA00	3.30.160.390	Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › Integrase, DNA-binding domain	0.51	31.0	3.07e-01	81.1%	57.1%
5c7qB00	3.90.79.10	Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase	0.51	39.0	2.97e-01	83.8%	56.7%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3197575	2.1.1.1 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › Ribosom_S12_S23	0.59	34.0	3.20e-01	83.8%	45.6%
3251601	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.56	48.0	4.87e-01	94.6%	98.7%
3757181	304.102.1.1 ↗	a+b two layers › Alpha-beta plaits › Pseudouridine synthase › Pseudouridine synthase › PseudoU_synth_2	0.53	45.0	3.05e-01	94.6%	25.0%
3481723	214.1.1.1 ↗	a+b two layers › SH2 › SH2 › SH2 › SH2	0.52	42.0	3.64e-01	87.8%	96.5%
3497892	206.1.1.1 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase	0.52	38.0	2.35e-01	78.4%	43.8%
3224710	389.1.1.0 ↗	few secondary structure elements › EGF-like › EGF-related › EGF/Laminin	0.52	39.0	3.97e-01	82.4%	100.0%
3390155	1.1.8.5 ↗	beta barrels › cradle loop barrel › RIFT-related › Aminomethyltransferase beta-barrel domain › tRNA_Me_trans_C	0.52	31.0	3.02e-01	95.9%	49.4%
4012257	2.1.1.0 ↗	beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein	0.52	36.0	3.17e-01	74.3%	65.8%
4943963	11.1.1.0 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like	0.51	38.0	3.44e-01	90.5%	59.0%

D7 medium residues 715-769

PDB

D8 medium residues 871-1002

PDB