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major_DNA_binding_protein

Euk-Vir

Human_betaherpesvirus_6A

major_DNA_binding_protein__NP_042934__Human_betaherpesvirus_6A__32603

Identity

Accession:: NP_042934 ↗
Protein ID:: major_DNA_binding_protein
Kingdom:: euk

Quality

80.7 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Roseolovirus› Human_betaherpesvirus_6A

TaxID: 32603

Cluster

View cluster (33 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 1005-1084

PDB

Domain cluster: rep: major_DNA_binding_protein__NP_050222__Human_betaherpesvirus_6B__32604__D1005-1084

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	74.8	3.40e-21	100.0%	7.3%

D2 medium residues 1-185

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	252.0	1.10e-74	100.0%	16.8%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3s1tA02	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.56	25.0	3.68e-01	92.4%	96.2%
1z2zA02	3.30.70.3160	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.53	23.0	3.08e-01	92.4%	76.7%
3p96A02	3.30.70.260	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › ACT domain	0.50	23.0	3.22e-01	91.9%	90.5%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7679	4174.1.1.1 ↗	a+b complex topology › N-terminal domain in viral ssDNA binding protein › N-terminal domain in viral ssDNA binding protein › N-terminal domain in viral ssDNA binding protein › Viral_DNA_bp	0.91	85.0	7.23e-01	96.8%	66.4%
4028969	304.9.1.1 ↗	a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD › RRM_1	0.56	27.0	3.43e-01	92.4%	76.4%
3229098	329.1.1.0 ↗	a+b two layers › Prokaryotic AspRS, insert domain › Prokaryotic AspRS, insert domain › Prokaryotic AspRS, insert domain	0.52	27.0	3.35e-01	89.2%	80.0%
5043867	304.126.1.0 ↗	a+b two layers › Alpha-beta plaits › ferredoxin-like domain in vacuolar ATP synthase subunit C › ferredoxin-like domain in vacuolar ATP synthase subunit C	0.51	21.0	3.09e-01	91.9%	88.0%

D3 medium residues 217-426_621-688

PDB

Domain cluster: representative

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	281.5	1.40e-83	76.3%	18.8%
PF00747.23	Viral_DNA_bp	92.1	2.10e-26	24.8%	6.0%

CATH (3)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2pv4A00	1.10.3440.10	Mainly Alpha › Orthogonal Bundle › Sama2622-like fold › Sama2622-like	0.59	29.0	3.92e-01	98.9%	87.6%
2w0gA00	1.20.58.610	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Cdc37, Hsp90 binding domain	0.52	22.0	3.14e-01	95.3%	81.4%
1zp2A02	1.10.472.10	Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › Cyclin-like	0.50	22.0	3.40e-01	74.5%	100.0%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3391293	101.1.10.13 ↗	alpha arrays › HTH › HTH › Cyclin-like › DUF3452	0.52	23.0	3.51e-01	100.0%	95.8%

D4 medium residues 427-498

PDB

Domain cluster: rep: major_DNA_binding_protein__NP_050222__Human_betaherpesvirus_6B__32604__D414-501

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	87.9	4.00e-25	100.0%	6.5%

D5 medium residues 499-519_603-620_729-743_860-874_910-1004

PDB

D6 medium residues 537-602_766-859

PDB

Domain cluster: rep: single-stranded_DNA-binding_protein__YP_073781__Human_betaherpesvirus_7__10372__D539-623_810-829_841-855

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	135.1	2.20e-39	61.3%	8.1%
PF00747.23	Viral_DNA_bp	59.8	1.20e-16	41.9%	6.1%

D7 medium residues 690-728

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00747.23 best	Viral_DNA_bp	29.0	2.40e-07	100.0%	3.5%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5mteA00	3.90.45.10	Alpha Beta › Alpha-Beta Complex › Peptide Deformylase › Peptide deformylase	0.54	39.0	2.76e-01	76.9%	31.4%
5f3bD00	2.10.90.10	Mainly Beta › Ribbon › Cystine Knot Cytokines, subunit B › Cystine-knot cytokines	0.54	42.0	3.21e-01	92.3%	92.2%
8ciwA02	2.40.110.10	Mainly Beta › Beta Barrel › Butyryl-CoA Dehydrogenase, subunit A; domain 2 › Butyryl-CoA Dehydrogenase, subunit A, domain 2	0.54	41.0	2.95e-01	89.7%	29.3%
4mtmA01	2.60.40.3940	Mainly Beta › Sandwich › Immunoglobulin-like ›	0.52	38.0	3.12e-01	92.3%	100.0%
4zg5A00	3.40.1210.10	Alpha Beta › 3-Layer(aba) Sandwich › Stationary-phase Survival Protein Sure Homolog; Chain: A, › Survival protein SurE-like phosphatase/nucleotidase	0.50	36.0	2.36e-01	87.2%	75.3%

ECOD (3)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3597952	4261.1.1.0 ↗	a+b two layers › TrkA C-terminal domain-like › TrkA C-terminal domain-like › TrkA C-terminal domain-like	0.55	39.0	3.37e-01	82.1%	56.0%
3614911	11.1.1.0 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like	0.54	43.0	2.60e-01	100.0%	27.4%
3484523	5.1.5.4 ↗	beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › DPPIV_N	0.54	43.0	2.61e-01	100.0%	19.7%