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membrane_protein_US15
Euk-VirHuman_betaherpesvirus_5
membrane_protein_US15__YP_081600__Human_betaherpesvirus_5__10359
Identity
- Accession:
- YP_081600 ↗
- Protein ID:
- membrane_protein_US15
- Kingdom:
- euk
Quality
85.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Cytomegalovirus›
Human_betaherpesvirus_5
TaxID: 10359
Cluster
View cluster (3 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 73-253
Domain cluster:
rep: membrane_protein_US16__YP_002608318__Human_herpesvirus_5__10359__D87-111_127-277
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01027.27 best | Bax1-I | 46.8 | 4.40e-12 | 97.8% | 81.2% |
CATH (21)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 6d5xA00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.68 | 45.0 | 4.86e-01 | 94.5% | 78.8% |
| 1qv9A02 | 6.10.140.120 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 37.0 | 4.85e-01 | 79.0% | 93.2% |
| 1vcsA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.64 | 32.0 | 4.28e-01 | 88.4% | 86.3% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.61 | 30.0 | 4.05e-01 | 88.4% | 88.8% |
| 3agtA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.60 | 39.0 | 4.47e-01 | 96.1% | 88.0% |
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.60 | 41.0 | 4.88e-01 | 96.7% | 96.9% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.59 | 37.0 | 4.59e-01 | 97.2% | 98.3% |
| 2i0mA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.58 | 30.0 | 3.92e-01 | 86.7% | 86.8% |
| 6t0bc02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.57 | 45.0 | 4.44e-01 | 81.8% | 99.5% |
| 1sziA02 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.57 | 38.0 | 4.29e-01 | 99.4% | 88.3% |
| 2mgxA00 | 1.20.940.10 | Mainly Alpha › Up-down Bundle › RNA Binding Protein, Prp18; Chain A › Functional domain of the splicing factor Prp18 | 0.56 | 30.0 | 3.44e-01 | 95.0% | 69.5% |
| 2jx0A00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.56 | 39.0 | 4.53e-01 | 100.0% | 98.5% |
| 7nmqA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.56 | 45.0 | 3.62e-01 | 84.5% | 74.9% |
| 8gr7A01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.55 | 43.0 | 3.55e-01 | 80.7% | 58.9% |
| 1jm6B02 | 1.20.140.20 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain | 0.54 | 38.0 | 4.09e-01 | 98.3% | 82.8% |
| 2y44A00 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.54 | 34.0 | 3.44e-01 | 99.4% | 62.0% |
| 5xnyA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.54 | 42.0 | 3.85e-01 | 82.3% | 95.1% |
| 1st6A02 | 1.20.120.810 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vinculin, Vh2 four-helix bundle | 0.54 | 36.0 | 3.36e-01 | 100.0% | 51.7% |
| 2cmrA00 | 1.20.58.1860 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 41.0 | 4.05e-01 | 79.6% | 94.3% |
| 6adqB01 | 1.20.810.10 | Mainly Alpha › Up-down Bundle › Cytochrome Bc1 Complex; Chain C › Cytochrome Bc1 Complex; Chain C | 0.53 | 37.0 | 2.84e-01 | 70.2% | 78.6% |
| 2ptqA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.51 | 40.0 | 3.46e-01 | 80.7% | 87.1% |
ECOD (49)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5063587 | 611.9.1.0 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain | 0.73 | 34.0 | 5.19e-01 | 70.2% | 98.8% |
| 3478015 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.72 | 67.0 | 6.19e-01 | 100.0% | 83.8% |
| 3486791 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.72 | 63.0 | 6.57e-01 | 92.8% | 100.0% |
| 3725075 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.71 | 57.0 | 4.94e-01 | 83.4% | 97.0% |
| 4017167 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.70 | 57.0 | 4.84e-01 | 83.4% | 96.8% |
| 3478731 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.70 | 65.0 | 6.52e-01 | 98.3% | 99.5% |
| 3213626 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.70 | 64.0 | 5.89e-01 | 97.2% | 80.0% |
| 3397602 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.70 | 65.0 | 6.01e-01 | 99.4% | 84.0% |
| 3735641 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.69 | 55.0 | 4.74e-01 | 82.9% | 95.4% |
| 3415929 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 65.0 | 6.13e-01 | 99.4% | 84.7% |
| 3411573 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.69 | 66.0 | 6.00e-01 | 100.0% | 83.0% |
| 3939603 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 65.0 | 6.02e-01 | 98.9% | 85.5% |
| 3725315 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.69 | 55.0 | 4.72e-01 | 82.3% | 93.1% |
| 3849233 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 65.0 | 6.11e-01 | 100.0% | 84.0% |
| 3403648 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.69 | 65.0 | 6.08e-01 | 100.0% | 86.5% |
| 3414049 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.69 | 63.0 | 5.96e-01 | 96.7% | 85.2% |
| 3740175 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 64.0 | 5.98e-01 | 100.0% | 81.8% |
| 3471382 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.68 | 63.0 | 5.86e-01 | 98.9% | 84.4% |
| 3500534 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 62.0 | 5.89e-01 | 98.3% | 83.8% |
| 3540947 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 63.0 | 5.89e-01 | 99.4% | 84.1% |
| 3481708 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.67 | 63.0 | 5.77e-01 | 100.0% | 83.0% |
| 3487803 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.67 | 62.0 | 5.73e-01 | 98.9% | 81.6% |
| 3169936 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 63.0 | 5.86e-01 | 99.4% | 86.4% |
| 3448448 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 62.0 | 5.84e-01 | 97.8% | 85.4% |
| 3626734 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 62.0 | 5.89e-01 | 100.0% | 84.5% |
| 3327396 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 62.0 | 5.84e-01 | 98.3% | 85.6% |
| 3694381 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 63.0 | 5.88e-01 | 100.0% | 84.1% |
| 3392422 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 62.0 | 5.80e-01 | 98.3% | 86.5% |
| 3476662 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.65 | 61.0 | 5.68e-01 | 99.4% | 83.9% |
| 4027411 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.65 | 61.0 | 5.70e-01 | 98.3% | 87.0% |
| 3610437 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.65 | 59.0 | 5.68e-01 | 96.7% | 86.8% |
| 4011437 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.65 | 51.0 | 4.65e-01 | 83.4% | 96.3% |
| 3964581 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.64 | 61.0 | 5.76e-01 | 99.4% | 88.1% |
| 3923749 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.64 | 50.0 | 4.28e-01 | 82.3% | 91.2% |
| 3178615 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.62 | 49.0 | 4.30e-01 | 82.3% | 99.6% |
| 3600308 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.61 | 48.0 | 4.35e-01 | 81.2% | 96.2% |
| 3623750 | 1188.1.1.1 ↗ | alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip | 0.61 | 42.0 | 3.77e-01 | 70.2% | 78.0% |
| 3253931 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.60 | 47.0 | 5.05e-01 | 81.2% | 96.8% |
| 4927494 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.59 | 52.0 | 4.66e-01 | 96.7% | 96.9% |
| 4003422 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.58 | 31.0 | 3.27e-01 | 81.2% | 55.2% |
| 3845241 | 5001.1.1.3 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_2 | 0.58 | 46.0 | 3.89e-01 | 82.9% | 90.8% |
| 3397343 | 601.16.1.3 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › GIT1_C | 0.56 | 39.0 | 4.52e-01 | 97.8% | 98.5% |
| 5050456 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.55 | 46.0 | 3.88e-01 | 88.4% | 60.3% |
| 5062722 | 1075.5.1.8 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt_3 | 0.55 | 43.0 | 3.70e-01 | 80.7% | 64.2% |
| 5018993 | 601.30.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N | 0.55 | 36.0 | 4.32e-01 | 100.0% | 96.8% |
| 3776957 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.54 | 37.0 | 4.21e-01 | 98.9% | 92.6% |
| 3910430 | 611.8.1.1 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne | 0.53 | 40.0 | 4.21e-01 | 76.8% | 86.7% |
| 5004943 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.53 | 39.0 | 4.11e-01 | 80.1% | 85.6% |
| 3920499 | 611.8.1.1 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne | 0.53 | 40.0 | 4.17e-01 | 97.8% | 84.1% |
D2
medium
residues 19-72
Domain cluster:
representative