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membrane_protein_US16
Euk-VirHuman_herpesvirus_5
membrane_protein_US16__YP_002608318__Human_herpesvirus_5__10359
Identity
- Accession:
- YP_002608318 ↗
- Protein ID:
- membrane_protein_US16
- Kingdom:
- euk
Quality
73.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Cytomegalovirus›
Human_betaherpesvirus_5
TaxID: 10359
Cluster
View cluster (68 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 87-111_127-277
Domain cluster:
representative
CATH (29)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.86 | 42.0 | 4.99e-01 | 97.2% | 66.9% |
| 7q37A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.69 | 55.0 | 5.20e-01 | 85.2% | 100.0% |
| 7sk7A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.66 | 52.0 | 4.57e-01 | 82.4% | 100.0% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.63 | 42.0 | 5.01e-01 | 72.7% | 98.3% |
| 1uurA01 | 1.20.58.240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › STAT; domain 1 | 0.63 | 36.0 | 4.59e-01 | 93.2% | 90.9% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.63 | 40.0 | 4.42e-01 | 98.9% | 77.6% |
| 6nsjA00 | 1.25.40.600 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › AmiS/UreI transporter | 0.62 | 44.0 | 4.39e-01 | 71.6% | 97.8% |
| 1xwjA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 45.0 | 5.17e-01 | 75.6% | 100.0% |
| 5ts9B00 | 1.20.59.10 | Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase | 0.62 | 43.0 | 4.51e-01 | 71.0% | 99.4% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.61 | 39.0 | 4.85e-01 | 94.9% | 99.1% |
| 3rzeA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.61 | 49.0 | 4.25e-01 | 84.7% | 97.8% |
| 7yu4A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.60 | 49.0 | 4.35e-01 | 85.8% | 93.8% |
| 4l6rA02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.60 | 48.0 | 4.10e-01 | 85.8% | 89.4% |
| 1hm7B00 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.59 | 44.0 | 3.69e-01 | 76.7% | 92.1% |
| 3caxA01 | 1.20.120.520 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like | 0.59 | 41.0 | 3.86e-01 | 71.6% | 87.1% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.59 | 34.0 | 4.44e-01 | 83.5% | 100.0% |
| 5h5mA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.57 | 39.0 | 4.50e-01 | 71.6% | 93.8% |
| 1sziA02 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.57 | 37.0 | 4.15e-01 | 100.0% | 83.9% |
| 6nmnA02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.56 | 34.0 | 3.94e-01 | 98.9% | 82.0% |
| 2zy9A03 | 1.10.357.20 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain | 0.56 | 43.0 | 4.40e-01 | 80.7% | 88.5% |
| 1qkrB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.56 | 44.0 | 4.43e-01 | 82.4% | 86.7% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.55 | 38.0 | 4.10e-01 | 71.6% | 80.4% |
| 4wpeA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.54 | 38.0 | 3.31e-01 | 72.2% | 81.8% |
| 4c3eM00 | 1.20.120.1350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain | 0.53 | 28.0 | 2.94e-01 | 70.5% | 53.5% |
| 5xnyA02 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.53 | 43.0 | 3.87e-01 | 85.8% | 95.1% |
| 1lm3B00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.53 | 32.0 | 4.01e-01 | 94.3% | 100.0% |
| 2hsbA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.52 | 35.0 | 4.09e-01 | 94.9% | 96.8% |
| 6rv2A00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 38.0 | 3.39e-01 | 76.1% | 95.7% |
| 3l39A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.50 | 46.0 | 4.45e-01 | 100.0% | 97.5% |
ECOD (41)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3478015 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.74 | 71.0 | 6.37e-01 | 100.0% | 82.5% |
| 3401837 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.74 | 67.0 | 6.16e-01 | 96.6% | 80.9% |
| 3577761 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.71 | 52.0 | 5.86e-01 | 98.9% | 93.6% |
| 3486791 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.71 | 64.0 | 6.58e-01 | 95.5% | 100.0% |
| 3169936 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.71 | 66.0 | 6.02e-01 | 97.2% | 83.2% |
| 3327396 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.71 | 66.0 | 6.09e-01 | 97.7% | 82.8% |
| 3478731 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.70 | 64.0 | 6.32e-01 | 97.2% | 96.8% |
| 3849233 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.70 | 65.0 | 6.02e-01 | 98.3% | 80.8% |
| 3740175 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 66.0 | 6.04e-01 | 99.4% | 79.5% |
| 3390912 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.69 | 63.0 | 5.77e-01 | 96.0% | 79.6% |
| 4346691 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.69 | 30.0 | 2.65e-01 | 100.0% | 30.2% |
| 3980685 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 62.0 | 5.73e-01 | 94.3% | 82.8% |
| 3694381 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 64.0 | 5.95e-01 | 98.3% | 80.8% |
| 3964581 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 63.0 | 5.89e-01 | 97.2% | 85.7% |
| 4017167 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.68 | 57.0 | 4.85e-01 | 88.6% | 96.8% |
| 3498465 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.68 | 34.0 | 4.10e-01 | 91.5% | 70.4% |
| 5083715 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 63.0 | 5.85e-01 | 97.7% | 81.9% |
| 3471323 | 3890.1.1.0 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins | 0.68 | 63.0 | 5.84e-01 | 99.4% | 82.7% |
| 3800644 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 61.0 | 5.74e-01 | 95.5% | 83.3% |
| 4011437 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.67 | 54.0 | 4.84e-01 | 85.8% | 95.9% |
| 3386740 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 61.0 | 5.54e-01 | 97.2% | 76.1% |
| 3725315 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.66 | 54.0 | 4.63e-01 | 85.8% | 94.2% |
| 5060571 | 1076.1.1.0 ↗ | alpha bundles › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related › Intramembrane protease Rce1-related | 0.65 | 46.0 | 4.24e-01 | 71.6% | 57.8% |
| 3725075 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.64 | 54.0 | 4.67e-01 | 88.6% | 97.8% |
| 3240810 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.64 | 41.0 | 4.65e-01 | 70.5% | 81.4% |
| 3735641 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.64 | 52.0 | 4.47e-01 | 85.8% | 95.4% |
| 4010929 | 5001.1.1.85 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Fung_rhodopsin | 0.62 | 45.0 | 4.12e-01 | 73.3% | 98.7% |
| 3171851 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.62 | 44.0 | 4.62e-01 | 71.0% | 81.9% |
| 4988202 | 1075.5.1.4 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter › Polysacc_synt | 0.62 | 49.0 | 4.59e-01 | 81.8% | 79.1% |
| 3315159 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.62 | 41.0 | 4.30e-01 | 99.4% | 73.1% |
| 3253931 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.58 | 47.0 | 5.01e-01 | 84.1% | 98.1% |
| 3845241 | 5001.1.1.3 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_2 | 0.58 | 47.0 | 3.92e-01 | 85.8% | 91.5% |
| 3502146 | 5001.1.1.3 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7tm_2 | 0.57 | 46.0 | 3.95e-01 | 85.8% | 91.4% |
| 4929461 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.57 | 43.0 | 4.19e-01 | 78.4% | 81.4% |
| 4013341 | 3755.4.1.3 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Helo_like_N | 0.56 | 33.0 | 3.85e-01 | 80.7% | 80.0% |
| 3249529 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.56 | 39.0 | 4.41e-01 | 71.6% | 98.5% |
| 5016355 | 601.30.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Helical bundle domain in hypothetical protein PH1320 › Helical bundle domain in hypothetical protein PH1320 › NOG1_N | 0.54 | 37.0 | 4.18e-01 | 71.0% | 91.1% |
| 3938853 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.54 | 38.0 | 3.51e-01 | 71.6% | 55.7% |
| 3277600 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.53 | 43.0 | 3.51e-01 | 85.2% | 80.6% |
| 4424083 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.51 | 40.0 | 3.60e-01 | 100.0% | 60.4% |
| 3276862 | 3758.1.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Bacterial hemolysins › Bacterial hemolysins | 0.50 | 40.0 | 3.77e-01 | 100.0% | 68.4% |
D2
medium
residues 18-86
Domain cluster:
representative