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membrane_protein_US19
Euk-VirHuman_herpesvirus_5
membrane_protein_US19__YP_002608321__Human_herpesvirus_5__10359
Identity
- Accession:
- YP_002608321 ↗
- Protein ID:
- membrane_protein_US19
- Kingdom:
- euk
Quality
70.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Cytomegalovirus›
Human_betaherpesvirus_5
TaxID: 10359
Cluster
View cluster (68 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 66-124
Domain cluster:
representative
CATH (47)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2cazC00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.75 | 59.0 | 5.81e-01 | 88.1% | 81.2% |
| 4wpeA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.75 | 61.0 | 3.94e-01 | 91.5% | 21.1% |
| 4h63H01 | 1.20.58.1710 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.73 | 62.0 | 5.83e-01 | 96.6% | 88.9% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.73 | 63.0 | 5.00e-01 | 100.0% | 53.6% |
| 2np9A01 | 1.20.58.1300 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.73 | 64.0 | 4.93e-01 | 100.0% | 46.3% |
| 2yfaB01 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.71 | 61.0 | 4.96e-01 | 100.0% | 51.3% |
| 3r84B00 | 6.10.280.160 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Mediator of RNA polymerase II transcription subunit 22 | 0.71 | 57.0 | 5.22e-01 | 91.5% | 85.0% |
| 2rbdA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.71 | 60.0 | 4.59e-01 | 100.0% | 78.0% |
| 7w9wA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.70 | 56.0 | 3.71e-01 | 91.5% | 33.2% |
| 4fvmA06 | 1.10.287.690 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › B family DNA polymerase, finger domain | 0.70 | 51.0 | 5.45e-01 | 79.7% | 97.9% |
| 4id0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.69 | 60.0 | 4.94e-01 | 100.0% | 80.4% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.69 | 56.0 | 4.93e-01 | 91.5% | 63.3% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 54.0 | 5.16e-01 | 91.5% | 79.5% |
| 1zpyA00 | 6.10.140.1960 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 58.0 | 5.12e-01 | 100.0% | 70.3% |
| 2e9xA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 57.0 | 4.52e-01 | 96.6% | 69.5% |
| 4w4kA00 | 1.10.287.850 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain | 0.68 | 54.0 | 4.96e-01 | 91.5% | 92.7% |
| 4mk3A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.68 | 59.0 | 4.78e-01 | 100.0% | 80.9% |
| 1w9cA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.67 | 57.0 | 3.65e-01 | 100.0% | 44.9% |
| 3m0fB02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.67 | 57.0 | 4.60e-01 | 100.0% | 78.9% |
| 2e5yA02 | 1.20.5.440 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain | 0.67 | 46.0 | 5.00e-01 | 89.8% | 95.6% |
| 2c2aA01 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.67 | 55.0 | 4.85e-01 | 94.9% | 71.1% |
| 3m7gA02 | 1.10.8.1010 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.67 | 54.0 | 4.67e-01 | 91.5% | 56.8% |
| 7eu3E01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.66 | 54.0 | 4.78e-01 | 91.5% | 64.4% |
| 3r2qA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.66 | 56.0 | 4.66e-01 | 100.0% | 84.1% |
| 2qf9A01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.66 | 54.0 | 4.15e-01 | 100.0% | 84.0% |
| 1z0jB00 | 4.10.860.20 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain | 0.65 | 48.0 | 5.05e-01 | 91.5% | 96.1% |
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 53.0 | 5.13e-01 | 89.8% | 81.8% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.65 | 54.0 | 5.38e-01 | 98.3% | 96.7% |
| 2btqB03 | 1.10.287.600 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.65 | 49.0 | 5.13e-01 | 83.1% | 100.0% |
| 5wp3B00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.64 | 54.0 | 4.65e-01 | 100.0% | 71.6% |
| 4cybD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.64 | 54.0 | 3.97e-01 | 98.3% | 38.0% |
| 2mpkA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.64 | 49.0 | 4.65e-01 | 88.1% | 82.4% |
| 2honA02 | 1.20.1250.30 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.64 | 47.0 | 3.55e-01 | 79.7% | 57.5% |
| 1b04A03 | 1.10.287.610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.63 | 48.0 | 4.76e-01 | 89.8% | 80.6% |
| 4hwdD00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.63 | 49.0 | 4.36e-01 | 88.1% | 60.0% |
| 4a17U01 | 1.10.287.310 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 51.0 | 4.71e-01 | 91.5% | 70.1% |
| 5b1aC01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.63 | 51.0 | 4.94e-01 | 93.2% | 80.9% |
| 4jgiA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.63 | 47.0 | 4.36e-01 | 86.4% | 62.5% |
| 2a26B01 | 4.10.860.10 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › UVR domain | 0.63 | 43.0 | 4.66e-01 | 76.3% | 100.0% |
| 3h6pC00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.62 | 49.0 | 5.06e-01 | 89.8% | 98.2% |
| 2pvqA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.62 | 54.0 | 4.50e-01 | 100.0% | 83.0% |
| 3lphC00 | 6.10.140.630 | Special › Helix non-globular › Helix Hairpins › | 0.62 | 49.0 | 4.95e-01 | 89.8% | 94.8% |
| 2q83A02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.62 | 48.0 | 3.33e-01 | 89.8% | 23.2% |
| 3qc1A01 | 1.25.40.540 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family | 0.61 | 50.0 | 3.88e-01 | 96.6% | 69.5% |
| 4q5qA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.59 | 49.0 | 4.20e-01 | 100.0% | 91.4% |
| 1jb0K00 | 1.20.860.20 | Mainly Alpha › Up-down Bundle › Alpha-t-alpha › Photosystem I PsaK, reaction centre | 0.57 | 38.0 | 4.17e-01 | 79.7% | 91.3% |
| 2k9pA00 | 1.10.287.920 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Pheromone alpha factor receptor. | 0.51 | 42.0 | 3.91e-01 | 96.6% | 71.2% |
ECOD (47)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3952753 | 150.7.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › PE › PE › PE | 0.77 | 61.0 | 5.66e-01 | 86.4% | 84.0% |
| 4999123 | 604.12.1.135 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › Oxidored_q2 | 0.75 | 60.0 | 4.92e-01 | 89.8% | 48.6% |
| 3990854 | 192.7.1.0 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm | 0.75 | 60.0 | 5.32e-01 | 91.5% | 95.6% |
| 3510163 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.74 | 59.0 | 4.89e-01 | 89.8% | 52.7% |
| 5035291 | 101.1.2.0 ↗ | alpha arrays › HTH › HTH › winged helix domain | 0.73 | 57.0 | 4.42e-01 | 88.1% | 44.4% |
| 3699638 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.72 | 58.0 | 3.27e-01 | 89.8% | 19.1% |
| 3237324 | 3710.1.1.1 ↗ | alpha bundles › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › Golgi to ER traffic protein 1 cytosolic domain › CHD5 | 0.72 | 59.0 | 5.91e-01 | 93.2% | 91.7% |
| 4397604 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.71 | 59.0 | 4.56e-01 | 91.5% | 42.3% |
| 3509749 | 604.1.1.175 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_Dys-1 | 0.71 | 57.0 | 5.06e-01 | 91.5% | 62.2% |
| 3507250 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.71 | 61.0 | 5.16e-01 | 100.0% | 63.8% |
| 3355429 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.71 | 58.0 | 5.63e-01 | 91.5% | 89.2% |
| 4806319 | 3755.1.1.2 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › YscO-like | 0.71 | 58.0 | 5.22e-01 | 91.5% | 78.3% |
| 3079196 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.71 | 57.0 | 4.98e-01 | 91.5% | 58.5% |
| 3599922 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.71 | 56.0 | 3.50e-01 | 89.8% | 37.1% |
| 3509024 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.71 | 56.0 | 4.75e-01 | 91.5% | 66.7% |
| 5002349 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.70 | 56.0 | 5.52e-01 | 91.5% | 89.2% |
| 3512471 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.70 | 58.0 | 5.01e-01 | 98.3% | 68.0% |
| 2394365 | 1189.1.1.0 ↗ | alpha bundles › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor › VSG (variant surface glycoprotein) N-terminal domain and haptoglobin-hemoglobin receptor | 0.70 | 56.0 | 5.17e-01 | 91.5% | 73.1% |
| 3962847 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.70 | 60.0 | 5.29e-01 | 100.0% | 71.1% |
| 5024001 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.69 | 55.0 | 4.73e-01 | 91.5% | 55.0% |
| 375927 | 150.1.1.14 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › EncFtn-like | 0.69 | 58.0 | 5.12e-01 | 100.0% | 69.6% |
| 3902140 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.69 | 54.0 | 4.76e-01 | 91.5% | 58.9% |
| 4671536 | 3718.1.1.1 ↗ | alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › FliT | 0.68 | 56.0 | 4.86e-01 | 98.3% | 57.9% |
| 4393704 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.68 | 55.0 | 3.32e-01 | 94.9% | 64.1% |
| 5047384 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.68 | 54.0 | 5.30e-01 | 89.8% | 89.2% |
| 4939305 | 7577.1.1.13 ↗ | a/b three-layered sandwiches › PLP-dependent transferases › PLP-dependent transferases › PLP-dependent transferases › SepSecS | 0.68 | 52.0 | 3.22e-01 | 86.4% | 14.7% |
| 4628639 | 150.1.1.59 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Coat_F | 0.68 | 58.0 | 5.02e-01 | 98.3% | 61.1% |
| 3925160 | 9.26.1.0 ↗ | beta barrels › Lipocalins/Streptavidin | 0.68 | 53.0 | 3.71e-01 | 86.4% | 27.9% |
| 4890998 | 148.1.3.28 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AAA_lid_11 | 0.68 | 54.0 | 3.49e-01 | 91.5% | 18.1% |
| 4936497 | 150.1.1.14 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › EncFtn-like | 0.68 | 57.0 | 5.10e-01 | 100.0% | 73.9% |
| 3701020 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.67 | 51.0 | 4.66e-01 | 91.5% | 62.5% |
| 3776400 | 192.5.1.1 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1 | 0.67 | 53.0 | 4.90e-01 | 91.5% | 72.5% |
| 3754265 | 603.1.1.187 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DNA_repr_REX1B | 0.67 | 57.0 | 5.05e-01 | 100.0% | 88.9% |
| 4105677 | 150.1.1.59 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Coat_F | 0.67 | 58.0 | 5.06e-01 | 98.3% | 64.4% |
| 3504312 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.67 | 56.0 | 4.83e-01 | 100.0% | 71.0% |
| 3742115 | 9.26.1.0 ↗ | beta barrels › Lipocalins/Streptavidin | 0.67 | 52.0 | 3.69e-01 | 88.1% | 28.4% |
| 5035107 | 3922.1.1.358 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › PF26119 | 0.66 | 52.0 | 4.34e-01 | 91.5% | 62.3% |
| 3845070 | 632.11.1.2 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like › DOCK_N | 0.66 | 50.0 | 4.32e-01 | 91.5% | 51.0% |
| 4419515 | 150.1.1.59 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Coat_F | 0.65 | 56.0 | 5.12e-01 | 100.0% | 77.5% |
| 3820045 | 603.1.1.118 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF7610 | 0.65 | 55.0 | 4.95e-01 | 100.0% | 76.5% |
| 4293828 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.64 | 49.0 | 3.90e-01 | 93.2% | 40.0% |
| 3704499 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 55.0 | 3.83e-01 | 100.0% | 58.0% |
| 3459313 | 616.1.1.1 ↗ | alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › Ribosomal_S15 | 0.63 | 54.0 | 4.78e-01 | 100.0% | 75.6% |
| 3471396 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.61 | 52.0 | 4.48e-01 | 98.3% | 71.6% |
| 4296465 | 206.1.3.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp | 0.58 | 48.0 | 2.99e-01 | 98.3% | 16.8% |
| 4432215 | 206.1.3.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp | 0.58 | 45.0 | 2.83e-01 | 88.1% | 16.1% |
| 4218967 | 206.1.3.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp | 0.54 | 46.0 | 2.93e-01 | 100.0% | 19.1% |
D2
medium
residues 125-240
Domain cluster:
rep: membrane_protein_US17__YP_004936127__Cercopithecine_betaherpesvirus_5__50292__D117-239
CATH (64)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2qffA00 | 1.20.1270.10 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.73 | 41.0 | 5.02e-01 | 93.1% | 86.5% |
| 4hkrA00 | 1.20.140.140 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Calcium release-activated calcium channel protein Orai | 0.73 | 54.0 | 4.77e-01 | 93.1% | 54.5% |
| 1k04A02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.72 | 56.0 | 5.91e-01 | 89.7% | 90.4% |
| 3cazB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.72 | 50.0 | 4.09e-01 | 71.6% | 79.5% |
| 3ug9A02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.71 | 65.0 | 5.18e-01 | 100.0% | 88.4% |
| 4iggB02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.70 | 63.0 | 6.22e-01 | 100.0% | 93.4% |
| 1qv9A02 | 6.10.140.120 | Special › Helix non-globular › Helix Hairpins › | 0.69 | 51.0 | 5.34e-01 | 98.3% | 85.4% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.69 | 43.0 | 4.56e-01 | 91.4% | 70.6% |
| 3dyjA01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.69 | 62.0 | 5.51e-01 | 100.0% | 74.7% |
| 1yo7A00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.69 | 45.0 | 4.47e-01 | 88.8% | 64.2% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.69 | 48.0 | 4.48e-01 | 92.2% | 57.1% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.68 | 50.0 | 5.08e-01 | 87.9% | 76.7% |
| 1uruA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.68 | 57.0 | 4.62e-01 | 88.8% | 85.2% |
| 3rh3A01 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.67 | 58.0 | 5.56e-01 | 100.0% | 80.5% |
| 2l10A00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.66 | 61.0 | 5.45e-01 | 100.0% | 72.8% |
| 4btfA01 | 1.20.930.20 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain | 0.66 | 43.0 | 4.59e-01 | 90.5% | 76.0% |
| 1h6gA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 59.0 | 5.91e-01 | 100.0% | 98.3% |
| 3caxA01 | 1.20.120.520 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › nmb1532 protein domain like | 0.65 | 59.0 | 4.79e-01 | 100.0% | 62.7% |
| 4p9tA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.65 | 58.0 | 5.81e-01 | 100.0% | 97.5% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.65 | 53.0 | 5.36e-01 | 99.1% | 88.5% |
| 6gy8A01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.65 | 60.0 | 4.24e-01 | 100.0% | 78.9% |
| 1m56C02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.64 | 59.0 | 4.91e-01 | 100.0% | 67.3% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.64 | 46.0 | 4.16e-01 | 73.3% | 83.8% |
| 1ezvC00 | 1.20.810.10 | Mainly Alpha › Up-down Bundle › Cytochrome Bc1 Complex; Chain C › Cytochrome Bc1 Complex; Chain C | 0.64 | 49.0 | 3.41e-01 | 80.2% | 77.1% |
| 3i9wA00 | 1.20.58.920 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 58.0 | 4.40e-01 | 100.0% | 91.5% |
| 1xwjA01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.63 | 58.0 | 5.59e-01 | 99.1% | 90.8% |
| 6t0bc02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.63 | 57.0 | 4.82e-01 | 100.0% | 68.6% |
| 2okuA00 | 1.20.120.470 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Acyl-CoA dehydrogenase, C-terminal domain | 0.63 | 52.0 | 5.19e-01 | 89.7% | 84.4% |
| 2ap3A00 | 1.20.120.570 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YkyA-like | 0.62 | 55.0 | 4.65e-01 | 96.6% | 80.7% |
| 2yevA03 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.62 | 56.0 | 4.82e-01 | 99.1% | 71.2% |
| 2x0cA01 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.62 | 56.0 | 4.87e-01 | 100.0% | 77.0% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 53.0 | 5.36e-01 | 94.0% | 100.0% |
| 6adqG01 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.62 | 55.0 | 4.79e-01 | 98.3% | 71.3% |
| 4kc9A02 | 1.20.120.1750 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.62 | 56.0 | 4.53e-01 | 100.0% | 68.3% |
| 5h5mA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 55.0 | 5.35e-01 | 100.0% | 95.4% |
| 2jswA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.61 | 52.0 | 4.40e-01 | 91.4% | 72.0% |
| 4m70I00 | 1.20.5.4130 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.61 | 50.0 | 5.18e-01 | 96.6% | 93.5% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.61 | 55.0 | 5.12e-01 | 100.0% | 87.0% |
| 5c4yA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.61 | 51.0 | 4.87e-01 | 92.2% | 81.6% |
| 2qkwA00 | 1.20.1270.140 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AvrPto | 0.61 | 46.0 | 4.90e-01 | 94.8% | 91.1% |
| 4w8pA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.60 | 54.0 | 5.25e-01 | 100.0% | 90.0% |
| 4wpeA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.60 | 50.0 | 3.81e-01 | 91.4% | 79.3% |
| 4al0A00 | 1.20.120.550 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Membrane associated eicosanoid/glutathione metabolism-like domain | 0.60 | 52.0 | 4.81e-01 | 93.1% | 87.7% |
| 2hfiA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.59 | 53.0 | 5.25e-01 | 100.0% | 93.5% |
| 2wb7A03 | 1.20.120.870 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › pT26-6p, five-helical bundle domain | 0.58 | 51.0 | 4.84e-01 | 94.8% | 83.1% |
| 3pltA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.58 | 47.0 | 3.88e-01 | 87.9% | 76.2% |
| 3t6gB00 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.58 | 52.0 | 5.00e-01 | 100.0% | 92.5% |
| 3gi8C00 | 1.20.1740.10 | Mainly Alpha › Up-down Bundle › Amino acid/polyamine transporter I › Amino acid/polyamine transporter I | 0.58 | 50.0 | 3.49e-01 | 99.1% | 69.0% |
| 3ieeA02 | 1.20.58.820 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Uncharacterised protein PF12889, C-terminal DUF3829 | 0.58 | 46.0 | 4.83e-01 | 87.9% | 95.1% |
| 4mt0A01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.58 | 45.0 | 3.22e-01 | 83.6% | 54.9% |
| 2q12A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.57 | 51.0 | 4.04e-01 | 98.3% | 71.9% |
| 5k3hB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 44.0 | 4.26e-01 | 89.7% | 73.7% |
| 2ddhA04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 43.0 | 4.18e-01 | 89.7% | 73.5% |
| 4ackB00 | 1.25.40.590 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Type IV / VI secretion system, DotU | 0.55 | 48.0 | 4.33e-01 | 92.2% | 93.5% |
| 2v0oB00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.55 | 45.0 | 3.42e-01 | 87.9% | 76.4% |
| 4yonA01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.53 | 44.0 | 3.65e-01 | 94.0% | 48.6% |
| 4pdyA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.53 | 45.0 | 3.62e-01 | 93.1% | 73.8% |
| 1xg2B00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.53 | 46.0 | 4.27e-01 | 96.6% | 74.2% |
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.53 | 48.0 | 4.28e-01 | 100.0% | 82.5% |
| 1qqtA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.52 | 42.0 | 4.07e-01 | 89.7% | 79.0% |
| 3dxpA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.52 | 42.0 | 3.39e-01 | 87.9% | 74.2% |
| 6l3tA01 | 1.20.1440.80 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Gap junction channel protein cysteine-rich domain | 0.52 | 44.0 | 3.73e-01 | 94.8% | 62.8% |
| 2rd3D00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.52 | 45.0 | 3.76e-01 | 100.0% | 83.9% |
| 1uddA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.51 | 43.0 | 3.59e-01 | 95.7% | 86.5% |
ECOD (74)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5065764 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.75 | 60.0 | 6.31e-01 | 100.0% | 92.4% |
| 3453619 | 601.4.1.12 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › DNA_repr_REX1B | 0.73 | 66.0 | 5.90e-01 | 96.6% | 80.0% |
| 3436259 | 632.15.1.5 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) › Rx_N | 0.72 | 50.0 | 4.96e-01 | 94.0% | 68.3% |
| 4959549 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.71 | 63.0 | 5.36e-01 | 100.0% | 60.0% |
| 3277432 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.71 | 63.0 | 5.39e-01 | 94.8% | 74.4% |
| 4001485 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.71 | 65.0 | 6.04e-01 | 100.0% | 80.7% |
| 3851394 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.70 | 62.0 | 5.97e-01 | 99.1% | 86.2% |
| 3577761 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.69 | 64.0 | 5.97e-01 | 99.1% | 80.7% |
| 3446288 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.69 | 60.0 | 5.61e-01 | 100.0% | 77.9% |
| 3500075 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.69 | 61.0 | 6.08e-01 | 99.1% | 93.3% |
| 3445405 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 57.0 | 5.73e-01 | 100.0% | 88.3% |
| 3740175 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 64.0 | 5.05e-01 | 100.0% | 52.7% |
| 3272925 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.67 | 61.0 | 6.02e-01 | 100.0% | 92.0% |
| 3276574 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 64.0 | 5.04e-01 | 100.0% | 55.3% |
| 3910430 | 611.8.1.1 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › Ariadne | 0.67 | 56.0 | 4.92e-01 | 92.2% | 61.8% |
| 3694381 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 63.0 | 4.98e-01 | 99.1% | 53.3% |
| 3626961 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.67 | 63.0 | 4.91e-01 | 100.0% | 50.4% |
| 4124285 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.67 | 60.0 | 5.52e-01 | 99.1% | 76.6% |
| 5075952 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.67 | 62.0 | 6.01e-01 | 100.0% | 90.6% |
| 3466334 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.66 | 47.0 | 4.56e-01 | 90.5% | 65.4% |
| 3849233 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.66 | 61.0 | 4.87e-01 | 100.0% | 53.1% |
| 5010954 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.66 | 56.0 | 5.77e-01 | 98.3% | 95.5% |
| 3255241 | 601.1.2.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Talin_IBS2B | 0.66 | 59.0 | 5.92e-01 | 99.1% | 96.5% |
| 3452617 | 5059.1.1.24 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › PUNUT | 0.65 | 58.0 | 4.14e-01 | 96.6% | 57.0% |
| 3666345 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.65 | 48.0 | 4.45e-01 | 89.7% | 60.0% |
| 3474226 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.65 | 59.0 | 5.51e-01 | 96.6% | 88.6% |
| 3488340 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.65 | 58.0 | 5.87e-01 | 99.1% | 99.1% |
| 3457663 | 192.29.1.178 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF28703 | 0.65 | 52.0 | 5.44e-01 | 95.7% | 95.2% |
| None | — | 0.65 | 50.0 | 3.49e-01 | 81.0% | 80.0% | |
| 3539994 | 5059.1.1.33 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA, SLC35F | 0.64 | 57.0 | 4.14e-01 | 97.4% | 56.5% |
| 3594775 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.64 | 54.0 | 3.92e-01 | 90.5% | 38.7% |
| 3653618 | 5069.1.3.69 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › ETR1_N | 0.63 | 47.0 | 5.21e-01 | 85.3% | 94.7% |
| 3762384 | 601.16.1.9 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › PF31076 | 0.63 | 58.0 | 5.36e-01 | 100.0% | 81.4% |
| 5038569 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.63 | 53.0 | 5.15e-01 | 90.5% | 92.3% |
| 3685068 | 5059.1.1.16 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › SLC35F | 0.63 | 54.0 | 3.95e-01 | 94.8% | 91.9% |
| 5009683 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.62 | 56.0 | 5.29e-01 | 99.1% | 80.7% |
| 3966166 | 601.4.1.4 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › PilJ | 0.62 | 56.0 | 5.40e-01 | 100.0% | 92.3% |
| 5010536 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.62 | 52.0 | 4.53e-01 | 92.2% | 67.0% |
| 3224747 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.62 | 56.0 | 4.86e-01 | 96.6% | 70.6% |
| 5073911 | 5039.1.1.0 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like | 0.62 | 57.0 | 5.50e-01 | 100.0% | 98.5% |
| 3502904 | 611.8.1.0 ↗ | alpha bundles › N-cbl like › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 › C-terminal domain of E3 ubiquitin-protein ligase ARIH1 | 0.62 | 54.0 | 4.99e-01 | 93.1% | 89.0% |
| 4664275 | 5039.1.1.1 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 | 0.62 | 56.0 | 4.64e-01 | 100.0% | 65.4% |
| 3371270 | 633.10.1.0 ↗ | alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like | 0.62 | 44.0 | 4.19e-01 | 90.5% | 61.4% |
| 3975942 | 601.4.1.6 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TorS_sensor_domain | 0.62 | 55.0 | 5.31e-01 | 100.0% | 88.5% |
| 3730903 | 601.18.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 | 0.62 | 56.0 | 5.13e-01 | 100.0% | 96.0% |
| 3434876 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.62 | 53.0 | 5.26e-01 | 93.1% | 87.5% |
| 3442785 | 611.7.1.11 ↗ | alpha bundles › N-cbl like › Mixed lineage kinase domain-like (MLKL) N-terminal domain › Mixed lineage kinase domain-like (MLKL) N-terminal domain › DUF7032 | 0.62 | 53.0 | 4.98e-01 | 91.4% | 79.3% |
| 3239452 | 601.1.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Vinculin | 0.62 | 55.0 | 5.02e-01 | 100.0% | 90.3% |
| 3619004 | 601.1.1.7 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Talin_IBS2B | 0.61 | 55.0 | 5.49e-01 | 100.0% | 95.0% |
| 3889629 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.61 | 55.0 | 4.66e-01 | 100.0% | 61.5% |
| 3970945 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.61 | 55.0 | 5.56e-01 | 99.1% | 97.4% |
| 4944946 | 1075.1.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain | 0.61 | 54.0 | 4.06e-01 | 95.7% | 64.0% |
| 3721384 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.61 | 55.0 | 4.83e-01 | 100.0% | 93.1% |
| 2396196 | 601.1.2.1 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Vinculin | 0.61 | 55.0 | 5.26e-01 | 100.0% | 90.2% |
| 3442186 | 3755.4.1.17 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N | 0.60 | 51.0 | 4.93e-01 | 92.2% | 92.3% |
| 3340986 | 601.51.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin | 0.60 | 54.0 | 4.55e-01 | 100.0% | 82.5% |
| 3370777 | 192.29.1.251 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › UbiA | 0.60 | 53.0 | 4.51e-01 | 100.0% | 65.6% |
| 3309205 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.59 | 43.0 | 3.99e-01 | 89.7% | 60.0% |
| 3630464 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.58 | 48.0 | 4.96e-01 | 86.2% | 93.6% |
| 3485215 | 5059.1.1.5 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › UAA | 0.58 | 52.0 | 3.73e-01 | 97.4% | 51.8% |
| 3179413 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.58 | 45.0 | 3.14e-01 | 81.0% | 68.2% |
| 4390628 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.57 | 46.0 | 4.08e-01 | 83.6% | 78.1% |
| 3709600 | 622.4.1.0 ↗ | alpha bundles › YvfG-like › Mite allergen Der p 5-related › Mite allergen Der p 5-related | 0.57 | 39.0 | 4.01e-01 | 70.7% | 78.3% |
| 3943034 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.57 | 51.0 | 5.03e-01 | 100.0% | 93.6% |
| 3789965 | 109.3.1.167 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ion_trans, TRPM2 | 0.57 | 52.0 | 3.24e-01 | 100.0% | 40.6% |
| 3634474 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.56 | 47.0 | 4.73e-01 | 87.1% | 93.0% |
| 3199087 | 5038.2.1.1 ↗ | alpha superhelices › Cytochrome c oxidase subunit I-like › MAPEG domain-like › MAPEG domain-like › MAPEG | 0.56 | 47.0 | 4.45e-01 | 91.4% | 95.0% |
| 3291574 | 192.29.1.248 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PF27150 | 0.56 | 48.0 | 4.75e-01 | 94.0% | 90.4% |
| 1180574 | 4177.1.1.6 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR_3_WASP_bdg | 0.55 | 49.0 | 4.06e-01 | 98.3% | 83.2% |
| 3803172 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.54 | 47.0 | 4.26e-01 | 96.6% | 69.4% |
| 3701568 | 601.1.1.99 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Got1 | 0.53 | 45.0 | 4.33e-01 | 100.0% | 80.7% |
| 3204386 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 42.0 | 4.23e-01 | 87.9% | 94.2% |
| 3748949 | 544.1.1.0 ↗ | alpha bundles › Functional domain of the splicing factor Prp18 › Functional domain of the splicing factor Prp18 › Functional domain of the splicing factor Prp18 | 0.51 | 40.0 | 4.18e-01 | 85.3% | 100.0% |
| 3350509 | 5068.1.1.1 ↗ | alpha bundles › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) › Cytochrom_B_C | 0.51 | 39.0 | 3.47e-01 | 81.0% | 77.6% |