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multifunctional_expression_regulator
Euk-VirAotine_betaherpesvirus_1
multifunctional_expression_regulator__YP_004940085__Aotine_betaherpesvirus_1__50290
Identity
- Accession:
- YP_004940085 ↗
- Protein ID:
- multifunctional_expression_regulator
- Kingdom:
- euk
Quality
66.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Cytomegalovirus›
Aotine_betaherpesvirus_1
TaxID: 50290
Cluster
View cluster (9 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 268-441
Domain cluster:
rep: multifunctional_expression_regulator__NP_944380__Psittacid_alphaherpesvirus_1__50294__D475-625
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05459.19 best | Herpes_UL69 | 151.6 | 3.50e-44 | 100.0% | 75.2% |
CATH (24)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.71 | 44.0 | 5.28e-01 | 97.7% | 93.8% |
| 2kbbA00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.66 | 46.0 | 4.67e-01 | 96.6% | 70.7% |
| 2hujA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.66 | 44.0 | 5.13e-01 | 98.3% | 94.4% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.66 | 44.0 | 5.15e-01 | 90.2% | 99.1% |
| 2z1qB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.65 | 37.0 | 4.18e-01 | 84.5% | 70.6% |
| 6adqG01 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.64 | 48.0 | 4.83e-01 | 90.2% | 75.3% |
| 3nb2A04 | 1.10.4140.10 | Mainly Alpha › Orthogonal Bundle › effector protein (NleL) fold › effector protein (NleL) | 0.61 | 36.0 | 3.61e-01 | 89.7% | 55.9% |
| 3pwxA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.61 | 42.0 | 4.21e-01 | 96.0% | 66.8% |
| 6nmnA02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.60 | 39.0 | 4.41e-01 | 90.8% | 86.7% |
| 3ejnA03 | 1.20.120.840 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SusD-like, tetratrico peptide repeats domain | 0.60 | 34.0 | 4.05e-01 | 90.2% | 82.9% |
| 3rh3A01 | 1.20.120.930 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Uncharacterised protein PF12889, N-terminal DUF3829 | 0.59 | 38.0 | 4.28e-01 | 96.0% | 83.5% |
| 4hkrA00 | 1.20.140.140 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Calcium release-activated calcium channel protein Orai | 0.58 | 39.0 | 4.06e-01 | 81.6% | 72.1% |
| 4hr1A00 | 1.20.1270.410 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.57 | 36.0 | 4.13e-01 | 85.1% | 89.8% |
| 1aepA00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.57 | 41.0 | 4.36e-01 | 98.9% | 84.3% |
| 1ks9A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.57 | 33.0 | 3.79e-01 | 96.6% | 78.0% |
| 2cfqA02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.55 | 42.0 | 3.95e-01 | 98.3% | 65.1% |
| 2vxxA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.55 | 37.0 | 3.72e-01 | 96.6% | 67.4% |
| 5ziyA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.55 | 45.0 | 4.41e-01 | 96.0% | 79.4% |
| 5tj5E00 | 1.20.120.610 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase | 0.54 | 34.0 | 3.79e-01 | 77.6% | 77.5% |
| 2zy9A03 | 1.10.357.20 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › SLC41 divalent cation transporters, integral membrane domain | 0.53 | 32.0 | 3.25e-01 | 75.9% | 56.9% |
| 3o10C00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.52 | 39.0 | 4.28e-01 | 90.8% | 97.8% |
| 6whpA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.52 | 37.0 | 3.21e-01 | 73.6% | 75.8% |
| 1dlcA01 | 1.20.190.10 | Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain | 0.51 | 46.0 | 4.24e-01 | 100.0% | 93.0% |
| 4ocqA01 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.51 | 38.0 | 3.39e-01 | 76.4% | 75.4% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1562404 | 3977.1.1.1 ↗ | alpha duplicates or obligate multimers › ICP27 homology domain › ICP27 homology domain › ICP27 homology domain › Herpes_UL69 | 0.78 | 64.0 | 5.46e-01 | 100.0% | 56.0% |
| 4220561 | 601.1.1.5 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › CAS_C | 0.69 | 45.0 | 5.14e-01 | 90.2% | 88.4% |
| 3676140 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 44.0 | 5.12e-01 | 94.8% | 90.4% |
| 4509435 | 601.1.1.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › TLN1-like_RS | 0.67 | 44.0 | 4.59e-01 | 89.7% | 70.6% |
| 3765 | 601.26.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › YppE-like › YppE-like › DUF1798 | 0.66 | 44.0 | 5.24e-01 | 98.3% | 98.3% |
| 4205410 | 601.1.3.5 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › TLN1-like_RS | 0.65 | 43.0 | 4.53e-01 | 89.7% | 73.5% |
| 3251840 | 601.1.3.6 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › Talin_IBS2B | 0.64 | 43.0 | 4.47e-01 | 92.0% | 73.1% |
| 3688918 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.63 | 45.0 | 4.95e-01 | 96.0% | 90.0% |
| 5013099 | 601.3.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain | 0.62 | 42.0 | 4.69e-01 | 92.0% | 88.1% |
| 3692941 | 601.14.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin › Hemerythrin | 0.62 | 48.0 | 4.71e-01 | 100.0% | 75.1% |
| 3817156 | 601.14.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin | 0.60 | 48.0 | 4.70e-01 | 100.0% | 79.5% |
| 3446288 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.59 | 41.0 | 4.51e-01 | 96.0% | 87.1% |
| 4929492 | 601.1.3.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 | 0.59 | 43.0 | 4.66e-01 | 98.3% | 92.1% |
| 3723563 | 3567.1.1.0 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer | 0.56 | 44.0 | 4.13e-01 | 82.2% | 95.8% |
| 3248447 | 5054.1.1.9 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › PKD_channel | 0.56 | 46.0 | 3.64e-01 | 90.8% | 44.5% |
| 3182950 | 192.29.1.148 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF3433 | 0.56 | 51.0 | 4.95e-01 | 99.4% | 100.0% |
| 3644901 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 41.0 | 4.21e-01 | 99.4% | 81.0% |
| 3727075 | 109.4.1.111 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PUL | 0.55 | 41.0 | 3.34e-01 | 77.6% | 79.3% |
| 3694780 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 38.0 | 3.71e-01 | 96.0% | 63.1% |
| 3651197 | 150.1.1.110 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › DUF7358 | 0.54 | 43.0 | 3.84e-01 | 83.9% | 60.0% |
| 5026989 | 604.5.1.1 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU_div | 0.54 | 39.0 | 3.64e-01 | 92.0% | 58.2% |
| 3270616 | 1188.1.1.1 ↗ | alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip | 0.54 | 42.0 | 3.70e-01 | 83.3% | 91.5% |
| 3715565 | 604.5.1.0 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) | 0.52 | 44.0 | 4.07e-01 | 90.8% | 99.1% |
| 4023035 | 1065.1.1.1 ↗ | alpha bundles › SPX domain › SPX domain › SPX domain › SPX | 0.51 | 39.0 | 3.67e-01 | 78.7% | 91.0% |
| 4955023 | 5051.1.1.10 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › AA_permease_2 | 0.51 | 43.0 | 3.05e-01 | 92.5% | 84.0% |
| 3723852 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.50 | 33.0 | 3.73e-01 | 72.4% | 85.2% |
| 5030388 | 129.1.1.5 ↗ | alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › Ferric_reduct | 0.50 | 42.0 | 4.06e-01 | 100.0% | 78.0% |
| 3707826 | 1075.1.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › ABCG5/ABCG8 transmembrane domain › ABC2_membrane | 0.50 | 43.0 | 3.69e-01 | 94.3% | 60.7% |
D2
medium
residues 194-267