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multifunctional_expression_regulator
Euk-VirElephant_endotheliotropic_herpesvirus_5
multifunctional_expression_regulator__YP_009052022__Elephant_endotheliotropic_herpesvirus_5__768738
Identity
- Accession:
- YP_009052022 ↗
- Protein ID:
- multifunctional_expression_regulator
- Kingdom:
- euk
Quality
53.2
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Proboscivirus›
Elephant_endotheliotropic_herpesvirus_5
TaxID: 768738
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 158-229
Domain cluster:
representative
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4rg8A04 | 1.10.287.1240 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 34.0 | 3.65e-01 | 70.8% | 66.1% |
| 2rreA00 | 1.10.10.2010 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.54 | 36.0 | 3.63e-01 | 70.8% | 90.5% |
| 6ia6A01 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.51 | 44.0 | 3.02e-01 | 95.8% | 34.3% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3712373 | 650.1.1.0 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain | 0.67 | 35.0 | 3.43e-01 | 84.7% | 43.8% |
| 5010025 | 331.3.1.0 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like | 0.60 | 41.0 | 3.53e-01 | 72.2% | 83.3% |
| 4440636 | 4959.1.1.1 ↗ | a+b complex topology › first helical domain in RNA-polymerase beta-prime subunit › first helical domain in RNA-polymerase beta-prime subunit › first helical domain in RNA-polymerase beta-prime subunit › RNA_pol_Rpb1_3 | 0.53 | 40.0 | 3.19e-01 | 79.2% | 92.1% |
D2
medium
residues 230-313_332-435
Domain cluster:
rep: multifunctional_expression_regulator__NP_944380__Psittacid_alphaherpesvirus_1__50294__D475-625
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF05459.19 best | Herpes_UL69 | 98.4 | 6.60e-28 | 100.0% | 74.3% |
CATH (22)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2etsA00 | 1.20.120.440 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like | 0.65 | 38.0 | 4.67e-01 | 96.3% | 91.3% |
| 6xz3A01 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.64 | 39.0 | 4.78e-01 | 88.8% | 96.6% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.62 | 40.0 | 4.72e-01 | 90.4% | 95.2% |
| 1sj7C00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.62 | 38.0 | 3.99e-01 | 87.8% | 66.9% |
| 4g80T00 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.61 | 40.0 | 4.51e-01 | 89.9% | 88.5% |
| 1ivhA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.59 | 35.0 | 3.98e-01 | 88.8% | 77.3% |
| 5h5mA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.59 | 39.0 | 4.59e-01 | 90.4% | 97.7% |
| 4dxwB01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.58 | 33.0 | 4.17e-01 | 97.9% | 95.4% |
| 3ck6C02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.57 | 32.0 | 3.96e-01 | 72.3% | 86.6% |
| 2pg0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.57 | 34.0 | 3.79e-01 | 88.8% | 73.2% |
| 5af7B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.57 | 34.0 | 3.74e-01 | 88.3% | 73.0% |
| 3nvoB02 | 1.20.58.340 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region | 0.57 | 32.0 | 3.98e-01 | 72.3% | 88.8% |
| 3axjB01 | 1.20.58.190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 | 0.56 | 30.0 | 3.29e-01 | 77.1% | 60.0% |
| 1rx0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 34.0 | 3.73e-01 | 88.8% | 71.6% |
| 1wolA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.55 | 35.0 | 4.16e-01 | 95.7% | 96.7% |
| 3o7pA01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.53 | 40.0 | 3.86e-01 | 96.8% | 67.4% |
| 3qc1A01 | 1.25.40.540 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › TAP42-like family | 0.52 | 34.0 | 3.77e-01 | 87.8% | 81.5% |
| 2c0uA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.52 | 35.0 | 3.69e-01 | 87.8% | 74.0% |
| 1zk8B02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 30.0 | 3.43e-01 | 91.0% | 77.3% |
| 5iduC03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.51 | 33.0 | 3.60e-01 | 88.3% | 75.5% |
| 7p3rA01 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.50 | 40.0 | 3.27e-01 | 81.4% | 86.8% |
| 3crdA00 | 1.10.533.10 | Mainly Alpha › Orthogonal Bundle › Death Domain, Fas › Death Domain, Fas | 0.50 | 23.0 | 3.15e-01 | 85.1% | 82.0% |
ECOD (32)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1548122 | 601.43.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Biofilm formation modulator YmoB › Biofilm formation modulator YmoB › YbaJ | 0.68 | 41.0 | 4.92e-01 | 98.9% | 91.0% |
| 3446288 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.64 | 41.0 | 4.70e-01 | 94.7% | 85.7% |
| 3638493 | 601.16.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase | 0.62 | 45.0 | 4.81e-01 | 99.5% | 87.5% |
| 3236795 | 601.16.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › Focal_AT | 0.61 | 40.0 | 4.54e-01 | 92.0% | 87.9% |
| 4489112 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.60 | 40.0 | 4.23e-01 | 88.8% | 74.1% |
| 3823764 | 3684.1.1.2 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 | 0.60 | 43.0 | 3.98e-01 | 72.9% | 78.3% |
| 4929492 | 601.1.3.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 | 0.60 | 41.0 | 4.67e-01 | 98.4% | 93.6% |
| 3745002 | 601.1.1.98 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › PF27524 | 0.59 | 35.0 | 3.82e-01 | 97.9% | 69.7% |
| 4506271 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.58 | 40.0 | 4.42e-01 | 96.8% | 89.0% |
| 3249529 | 601.1.2.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) | 0.58 | 39.0 | 4.46e-01 | 94.1% | 94.1% |
| 4071531 | 1188.1.1.3 ↗ | alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Mntp | 0.57 | 36.0 | 3.65e-01 | 89.4% | 62.2% |
| 3957096 | 601.14.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Hemerythrin › Hemerythrin › Hemerythrin | 0.57 | 46.0 | 4.67e-01 | 99.5% | 87.0% |
| 3286769 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.56 | 42.0 | 4.60e-01 | 88.8% | 97.3% |
| 3236655 | 109.4.1.1839 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Otopetrin | 0.56 | 37.0 | 3.57e-01 | 86.2% | 56.4% |
| 3736715 | 601.1.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin | 0.56 | 37.0 | 3.82e-01 | 96.3% | 68.9% |
| 3637538 | 601.1.2.63 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › HIP1R | 0.55 | 37.0 | 3.76e-01 | 96.3% | 65.8% |
| 3610403 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.55 | 39.0 | 4.24e-01 | 92.6% | 86.1% |
| 3740475 | 604.5.1.8 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ArAE_2 | 0.54 | 38.0 | 3.61e-01 | 90.4% | 59.5% |
| 3343651 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.54 | 35.0 | 3.60e-01 | 85.6% | 64.9% |
| 4023423 | 5057.1.1.0 ↗ | alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore | 0.54 | 42.0 | 4.31e-01 | 99.5% | 83.9% |
| 4602450 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.54 | 37.0 | 3.54e-01 | 98.4% | 58.2% |
| 3713349 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 35.0 | 3.40e-01 | 92.6% | 57.6% |
| 3723912 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.53 | 39.0 | 3.70e-01 | 95.7% | 63.2% |
| 3795144 | 3615.1.1.9 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › TMEM72 | 0.53 | 33.0 | 3.85e-01 | 86.2% | 88.5% |
| 3187666 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 36.0 | 3.22e-01 | 95.2% | 46.5% |
| 5073100 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.53 | 34.0 | 3.19e-01 | 86.7% | 51.1% |
| 3668007 | 601.51.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-helical domain in phase 1 flagellin › alpha-helical domain in phase 1 flagellin | 0.52 | 43.0 | 3.82e-01 | 85.1% | 65.4% |
| 3239575 | 5054.1.1.0 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels | 0.52 | 36.0 | 3.12e-01 | 98.9% | 43.0% |
| 3489229 | 5050.1.1.22 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1_like | 0.52 | 35.0 | 3.20e-01 | 88.8% | 49.0% |
| 3838924 | 101.1.1.140 ↗ | alpha arrays › HTH › HTH › Three-helical HTH › DUF1294 | 0.52 | 29.0 | 3.55e-01 | 70.7% | 88.2% |
| 3194834 | 601.1.2.72 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › SesA | 0.51 | 34.0 | 3.64e-01 | 87.8% | 75.2% |
| 3317793 | 611.9.1.4 ↗ | alpha bundles › N-cbl like › Resistance protein (Rx) N-terminal domain › Resistance protein (Rx) N-terminal domain › Rx_N | 0.50 | 34.0 | 3.79e-01 | 80.3% | 86.0% |