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non-structural_protein_NS2a
Euk-VirYellow_fever_virus
non-structural_protein_NS2a__NP_776003__Yellow_fever_virus__11089
Identity
- Accession:
- NP_776003 ↗
- Protein ID:
- non-structural_protein_NS2a
- Kingdom:
- euk
Quality
71.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Yellow_fever_virus
TaxID: 11089
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 8-119
Domain cluster:
rep: nonstructural_protein_NS2A__NP_733808__dengue_virus_type_I__11053__D7-117
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01005.25 best | Flavi_NS2A | 185.7 | 1.50e-54 | 99.1% | 58.6% |
CATH (5)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1ujnA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.54 | 41.0 | 3.65e-01 | 82.1% | 91.1% |
| 2z1qB04 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.53 | 38.0 | 3.54e-01 | 73.2% | 90.4% |
| 2gruA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.53 | 38.0 | 3.24e-01 | 76.8% | 93.4% |
| 3clhA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.52 | 39.0 | 3.61e-01 | 80.4% | 89.3% |
| 3qbeA02 | 1.20.1090.10 | Mainly Alpha › Up-down Bundle › Dehydroquinate synthase-like, alpha domain › Dehydroquinate synthase-like - alpha domain | 0.52 | 39.0 | 3.41e-01 | 81.2% | 90.2% |
ECOD (3)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4957735 | 601.1.2.151 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › DUF4386 | 0.52 | 45.0 | 3.74e-01 | 98.2% | 92.4% |
| 4932787 | 4095.1.1.1 ↗ | alpha bundles › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › ATP-dependent DNA ligase DNA-binding domain › DNA_ligase_A_N | 0.52 | 43.0 | 3.49e-01 | 91.1% | 68.4% |
| 3185802 | 7015.1.1.0 ↗ | alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain | 0.50 | 37.0 | 3.53e-01 | 77.7% | 91.1% |
D2
medium
residues 120-222
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01005.25 best | Flavi_NS2A | 130.6 | 1.10e-37 | 72.8% | 34.9% |
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1w53A00 | 1.10.1240.30 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain | 0.72 | 51.0 | 5.57e-01 | 87.4% | 90.5% |
| 2paqA00 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.69 | 53.0 | 4.43e-01 | 81.6% | 61.6% |
| 5ux1D00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.67 | 51.0 | 4.14e-01 | 81.6% | 77.2% |
| 1q6aA00 | 1.10.1240.30 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain | 0.66 | 51.0 | 5.04e-01 | 94.2% | 78.5% |
| 3owaA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.61 | 43.0 | 3.63e-01 | 72.8% | 82.5% |
| 2hz8A00 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.59 | 45.0 | 4.42e-01 | 81.6% | 82.6% |
| 4dyqA01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.58 | 42.0 | 4.30e-01 | 76.7% | 89.3% |
| 1zvzA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.58 | 46.0 | 4.34e-01 | 84.5% | 95.2% |
| 5dkoA02 | 1.10.3900.10 | Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like | 0.56 | 46.0 | 3.91e-01 | 88.3% | 98.8% |
| 3juiA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.56 | 48.0 | 4.07e-01 | 96.1% | 74.1% |
| 7ae2A01 | 1.20.120.580 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like | 0.55 | 44.0 | 4.02e-01 | 87.4% | 92.0% |
| 1sqmA04 | 1.25.40.320 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain | 0.54 | 50.0 | 4.36e-01 | 99.0% | 79.9% |
| 3htaC00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.52 | 46.0 | 3.83e-01 | 100.0% | 66.7% |
| 4gyoA02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.52 | 40.0 | 3.19e-01 | 83.5% | 95.5% |
| 3ezhA00 | 1.20.120.960 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase NarX, sensor domain | 0.51 | 40.0 | 3.90e-01 | 84.5% | 79.8% |
| 6wb9201 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.50 | 40.0 | 2.94e-01 | 86.4% | 42.2% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4949687 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.60 | 43.0 | 3.69e-01 | 75.7% | 63.4% |
| 383331 | 101.31.1.1 ↗ | alpha arrays › HTH › Bacteriophage Sf6 terminase small subunit › Bacteriophage Sf6 terminase small subunit › Sf6_terminase | 0.57 | 41.0 | 3.87e-01 | 75.7% | 71.5% |
| 3420055 | 109.4.1.883 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 | 0.57 | 43.0 | 3.66e-01 | 79.6% | 61.8% |
| 4956171 | 5069.1.3.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits | 0.56 | 43.0 | 4.45e-01 | 82.5% | 87.4% |
| 3297097 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.56 | 39.0 | 3.96e-01 | 73.8% | 92.4% |
| 3422731 | 109.4.1.1767 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_1, E_motif | 0.55 | 44.0 | 3.89e-01 | 100.0% | 58.8% |
| 3464245 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.55 | 44.0 | 4.26e-01 | 84.5% | 78.3% |
| 4272021 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.54 | 44.0 | 4.52e-01 | 85.4% | 89.0% |
| 4254477 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.54 | 42.0 | 4.34e-01 | 82.5% | 87.0% |
| 3346105 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.53 | 42.0 | 4.01e-01 | 100.0% | 72.5% |
| 4304767 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.52 | 40.0 | 4.11e-01 | 81.6% | 87.0% |
| 4435642 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.52 | 42.0 | 4.27e-01 | 84.5% | 91.0% |
| 4403319 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.52 | 40.0 | 4.00e-01 | 80.6% | 88.6% |
| 3302659 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.52 | 39.0 | 3.78e-01 | 79.6% | 87.0% |
| 3469136 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.51 | 39.0 | 3.51e-01 | 81.6% | 93.1% |
| 3714252 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.51 | 46.0 | 3.42e-01 | 100.0% | 67.2% |
| 3803012 | 109.4.1.3476 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3, PPR_long, Mtf2, TPR_24 | 0.51 | 39.0 | 2.36e-01 | 84.5% | 12.9% |
| 3931278 | 601.4.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains | 0.50 | 40.0 | 3.96e-01 | 84.5% | 81.5% |
| 3481292 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.50 | 39.0 | 3.53e-01 | 82.5% | 75.0% |
| 3362073 | 109.4.1.883 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 | 0.50 | 37.0 | 3.38e-01 | 98.1% | 58.5% |