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non-structural_protein_NS2a

Euk-Vir

Betacoronavirus_HKU24

non-structural_protein_NS2a__YP_009113023__Betacoronavirus_HKU24__1590370

Identity

Accession:
YP_009113023 ↗
Protein ID:
non-structural_protein_NS2a
Kingdom:
euk

Quality

70.0 mean pLDDT

Taxonomy

Orthornavirae› Pisuviricota› Pisoniviricetes› Nidovirales› Coronaviridae› Betacoronavirus› Betacoronavirus_HKU24

TaxID: 1590370

Cluster

View cluster (6 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 11-186
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF05213.19 best Corona_NS2A 184.9 2.80e-54 99.4% 65.2%
CATH (14)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
2vfkA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.79 74.0 7.00e-01 100.0% 95.6%
1iuhA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.78 73.0 7.24e-01 100.0% 95.6%
4qakA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.77 68.0 6.93e-01 100.0% 95.9%
1vdxA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.74 69.0 6.86e-01 100.0% 97.3%
4h7wA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.74 70.0 6.84e-01 100.0% 96.8%
1jh6A00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.72 65.0 6.48e-01 100.0% 93.9%
2d4gA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.72 62.0 6.42e-01 100.0% 98.2%
2fsqA00 3.90.1140.10 Alpha Beta › Alpha-Beta Complex › Cyclic Phosphodiesterase; Chain: A, › Cyclic phosphodiesterase 0.72 67.0 6.07e-01 100.0% 84.9%
1wojA00 3.90.1740.10 Alpha Beta › Alpha-Beta Complex › 2',3'-cyclic nucleotide 3'-phosphodiesterase fold › 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily 0.60 55.0 5.18e-01 97.7% 99.0%
2r41A00 3.10.450.150 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › enterococcus faecalis protein 0.54 30.0 3.65e-01 79.5% 86.4%
2it1A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.54 22.0 3.38e-01 88.1% 100.0%
1pfsA00 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 25.0 3.59e-01 99.4% 98.7%
1v43A03 2.40.50.140 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › Nucleic acid-binding proteins 0.53 22.0 3.28e-01 88.1% 96.9%
3fvqA03 2.40.50.470 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › 0.52 18.0 2.97e-01 96.0% 87.9%
ECOD (65)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1736491 264.1.1.2 ↗ beta barrels › LigT-like › LigT-related › LigT-related › Corona_NS2A 0.90 72.0 7.91e-01 91.5% 98.0%
1549209 264.1.1.2 ↗ beta barrels › LigT-like › LigT-related › LigT-related › Corona_NS2A 0.87 66.0 7.25e-01 100.0% 94.4%
1869530 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.79 75.0 6.99e-01 100.0% 92.9%
3698720 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.79 74.0 6.82e-01 100.0% 87.0%
3894760 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.79 75.0 7.20e-01 100.0% 95.9%
1117634 264.1.1.8 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS,AKAP7_RIRII_bdg 0.78 73.0 6.66e-01 100.0% 85.2%
5039548 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.78 73.0 7.31e-01 100.0% 97.2%
4982807 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.78 73.0 7.24e-01 100.0% 97.8%
4026533 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.78 73.0 7.02e-01 100.0% 96.0%
4020982 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.78 73.0 6.28e-01 100.0% 75.8%
4972305 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.77 72.0 7.22e-01 100.0% 97.2%
3531648 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.77 73.0 7.26e-01 100.0% 98.9%
4952280 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.77 72.0 7.23e-01 100.0% 98.9%
4937535 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.77 72.0 7.27e-01 100.0% 98.9%
3290691 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.77 72.0 6.74e-01 100.0% 83.6%
3253597 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.77 72.0 6.97e-01 100.0% 97.9%
5000045 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.77 72.0 7.12e-01 100.0% 96.2%
4972958 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.77 73.0 7.18e-01 100.0% 97.3%
3982264 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.77 68.0 6.89e-01 100.0% 95.4%
None — 0.77 72.0 7.10e-01 100.0% 96.7%
5062926 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.77 66.0 6.80e-01 100.0% 96.4%
4967857 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.76 71.0 7.05e-01 97.7% 97.2%
4453123 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.76 71.0 7.12e-01 100.0% 98.3%
3233020 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.76 71.0 6.96e-01 100.0% 97.4%
3730050 264.1.1.5 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2H-phosphodiest 0.76 71.0 6.48e-01 100.0% 90.8%
5019632 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.76 72.0 6.62e-01 100.0% 94.0%
1953031 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.76 67.0 6.79e-01 100.0% 94.9%
5026546 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.76 71.0 7.09e-01 100.0% 98.3%
None — 0.76 70.0 7.05e-01 100.0% 98.9%
None — 0.75 70.0 6.95e-01 100.0% 97.2%
5028063 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.75 67.0 6.73e-01 100.0% 96.0%
4948034 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.75 70.0 6.89e-01 100.0% 95.7%
5055911 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.75 69.0 6.91e-01 100.0% 97.2%
4942504 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.74 69.0 6.86e-01 100.0% 97.3%
5010662 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.74 69.0 6.84e-01 100.0% 95.7%
4965540 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.74 69.0 6.81e-01 100.0% 97.8%
4957217 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.74 68.0 6.80e-01 100.0% 96.7%
4949121 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.73 68.0 6.78e-01 100.0% 97.2%
4079239 264.1.1.4 ↗ beta barrels › LigT-like › LigT-related › LigT-related › CPDase 0.73 68.0 6.60e-01 100.0% 98.4%
2322578 264.1.1.6 ↗ beta barrels › LigT-like › LigT-related › LigT-related › HVSL 0.73 68.0 6.72e-01 100.0% 96.2%
3690734 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.73 63.0 6.51e-01 100.0% 98.2%
5058094 264.1.1.1 ↗ beta barrels › LigT-like › LigT-related › LigT-related › LigT_PEase 0.73 67.0 6.72e-01 100.0% 98.3%
4932664 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.72 68.0 6.72e-01 100.0% 96.2%
3479830 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.72 68.0 6.55e-01 100.0% 94.4%
3397353 264.1.1.6 ↗ beta barrels › LigT-like › LigT-related › LigT-related › HVSL 0.72 68.0 6.72e-01 100.0% 96.2%
4046553 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.72 63.0 6.42e-01 100.0% 96.5%
3270425 264.1.1.6 ↗ beta barrels › LigT-like › LigT-related › LigT-related › HVSL 0.72 67.0 6.49e-01 100.0% 97.9%
3990131 264.1.1.5 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2H-phosphodiest 0.72 66.0 6.21e-01 98.9% 92.9%
4968059 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.71 66.0 6.60e-01 100.0% 97.2%
4951894 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.71 64.0 6.23e-01 100.0% 87.2%
5011802 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.71 65.0 6.19e-01 100.0% 84.4%
3744563 264.1.1.4 ↗ beta barrels › LigT-like › LigT-related › LigT-related › CPDase 0.69 64.0 6.41e-01 100.0% 98.3%
4031839 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.69 60.0 6.19e-01 100.0% 97.6%
4951796 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.69 64.0 6.18e-01 100.0% 98.0%
4423124 264.1.1.15 ↗ beta barrels › LigT-like › LigT-related › LigT-related › DUF1045 0.66 60.0 5.52e-01 100.0% 98.7%
3304264 264.1.1.7 ↗ beta barrels › LigT-like › LigT-related › LigT-related › AKAP7_NLS 0.66 48.0 5.48e-01 94.9% 98.5%
3181856 264.1.1.9 ↗ beta barrels › LigT-like › LigT-related › LigT-related › 2_5_RNA_ligase2 0.66 60.0 5.56e-01 100.0% 96.4%
3608079 264.1.1.10 ↗ beta barrels › LigT-like › LigT-related › LigT-related › tRNA_lig_CPD 0.64 48.0 5.36e-01 97.2% 98.6%
3709497 264.1.1.10 ↗ beta barrels › LigT-like › LigT-related › LigT-related › tRNA_lig_CPD 0.63 49.0 5.34e-01 98.3% 96.6%
3611297 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.63 49.0 5.35e-01 96.6% 97.9%
3594510 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.60 54.0 5.13e-01 97.2% 100.0%
3497100 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.60 55.0 4.87e-01 98.3% 98.0%
3480974 264.1.1.3 ↗ beta barrels › LigT-like › LigT-related › LigT-related › CNPase 0.59 54.0 4.88e-01 98.3% 99.6%
3591493 264.1.1.0 ↗ beta barrels › LigT-like › LigT-related › LigT-related 0.59 45.0 4.93e-01 98.3% 97.9%
3744887 264.1.1.10 ↗ beta barrels › LigT-like › LigT-related › LigT-related › tRNA_lig_CPD 0.58 49.0 5.04e-01 88.6% 99.4%
D2 high residues 198-265
PDB