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non-structural_protein_NS3
Euk-VirTick-borne_encephalitis_virus
non-structural_protein_NS3__NP_775507__Tick-borne_encephalitis_virus__11084
Identity
- Accession:
- NP_775507 ↗
- Protein ID:
- non-structural_protein_NS3
- Kingdom:
- euk
Quality
87.3
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Tick-borne_encephalitis_virus
TaxID: 11084
Cluster
View cluster (28 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-87
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00949.28 best | Peptidase_S7 | 42.6 | 7.30e-11 | 81.4% | 52.7% |
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2o8mB01 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.83 | 54.0 | 6.18e-01 | 74.4% | 87.9% |
| 2wv9A01 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.80 | 73.0 | 5.61e-01 | 95.3% | 51.2% |
| 4m9fA00 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.80 | 74.0 | 5.39e-01 | 96.5% | 54.5% |
| 1l1jA01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.74 | 52.0 | 4.67e-01 | 73.3% | 79.7% |
| 4ic6C01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.73 | 51.0 | 4.70e-01 | 73.3% | 74.5% |
| 5y2dA01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.72 | 53.0 | 4.70e-01 | 76.7% | 74.2% |
| 3k6yA01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.71 | 50.0 | 4.90e-01 | 73.3% | 75.0% |
| 4rqyA01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.71 | 52.0 | 4.57e-01 | 76.7% | 78.9% |
| 4yo1A01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.70 | 49.0 | 4.93e-01 | 73.3% | 78.7% |
| 5hmaA01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.70 | 52.0 | 5.19e-01 | 76.7% | 93.1% |
| 2z9iC01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.70 | 49.0 | 4.85e-01 | 73.3% | 79.3% |
| 6ku8A02 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.68 | 47.0 | 5.15e-01 | 70.9% | 91.3% |
| 3qzqA02 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.66 | 46.0 | 5.04e-01 | 70.9% | 91.3% |
| 4b6eB01 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.64 | 59.0 | 4.46e-01 | 100.0% | 82.7% |
| 3su0A01 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.64 | 59.0 | 5.40e-01 | 100.0% | 91.1% |
| 4zgnB00 | 2.40.30.10 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors | 0.59 | 40.0 | 3.85e-01 | 70.9% | 90.3% |
| 4mypA00 | 2.60.40.1850 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.59 | 42.0 | 3.76e-01 | 74.4% | 62.8% |
| 3qugA00 | 2.60.40.1850 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.58 | 40.0 | 3.73e-01 | 73.3% | 62.8% |
| 3sz6A00 | 2.60.40.1850 | Mainly Beta › Sandwich › Immunoglobulin-like › | 0.57 | 40.0 | 3.72e-01 | 74.4% | 66.4% |
| 2pp6A02 | 2.40.10.210 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Phage tail proteins (gpFII-like) | 0.57 | 39.0 | 4.32e-01 | 96.5% | 95.2% |
| 4ri0A01 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.55 | 45.0 | 3.61e-01 | 95.3% | 85.4% |
| 2ijd101 | 2.40.10.120 | Mainly Beta › Beta Barrel › Thrombin, subunit H › | 0.55 | 45.0 | 3.69e-01 | 96.5% | 95.0% |
| 4kbxA01 | 2.40.37.30 | Mainly Beta › Beta Barrel › Lyase, Ornithine Decarboxylase; Chain A, domain 1 › | 0.54 | 45.0 | 3.40e-01 | 94.2% | 79.9% |
| 2npiA03 | 2.40.30.330 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Pre-mRNA cleavage complex subunit Clp1, C-terminal domain | 0.54 | 40.0 | 3.82e-01 | 79.1% | 79.6% |
| 3hnmA00 | 2.60.120.260 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding domain-like | 0.54 | 38.0 | 3.17e-01 | 75.6% | 88.6% |
| 2zu2A01 | 2.40.10.10 | Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases | 0.52 | 36.0 | 3.55e-01 | 74.4% | 82.7% |
| 3gs9A01 | 6.20.110.10 | Special › Other non-globular › Thrombin, subunit H › | 0.52 | 43.0 | 4.47e-01 | 95.3% | 100.0% |
| 1ep3B01 | 2.40.30.10 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Translation factors | 0.51 | 39.0 | 3.77e-01 | 93.0% | 70.7% |
| 4ohvA03 | 2.40.30.330 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Pre-mRNA cleavage complex subunit Clp1, C-terminal domain | 0.51 | 37.0 | 3.70e-01 | 75.6% | 74.2% |
| 4dooA01 | 3.50.70.10 | Alpha Beta › 3-Layer(bba) Sandwich › Chalcone isomerase › | 0.51 | 36.0 | 3.07e-01 | 74.4% | 84.6% |
ECOD (22)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 169988 | 1.1.5.6 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S7 | 0.94 | 76.0 | 5.78e-01 | 84.9% | 41.6% |
| None | — | 0.93 | 74.0 | 5.74e-01 | 83.7% | 42.8% | |
| 3407091 | 1.1.17.1 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin | 0.76 | 56.0 | 3.85e-01 | 76.7% | 87.8% |
| 1311889 | 1.1.5.7 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.73 | 65.0 | 4.64e-01 | 96.5% | 60.0% |
| 3392280 | 1.1.17.1 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 › Trypsin | 0.72 | 53.0 | 3.68e-01 | 76.7% | 87.8% |
| 4092486 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.68 | 50.0 | 3.91e-01 | 77.9% | 87.2% |
| 4487049 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.67 | 50.0 | 3.93e-01 | 77.9% | 87.4% |
| 5057020 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.67 | 49.0 | 4.35e-01 | 76.7% | 92.0% |
| 1161323 | 1.1.5.14 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_S29 | 0.65 | 60.0 | 4.63e-01 | 100.0% | 94.5% |
| 3961015 | 10.12.1.0 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix | 0.59 | 32.0 | 3.31e-01 | 76.7% | 51.8% |
| 5023947 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.58 | 49.0 | 3.97e-01 | 94.2% | 84.1% |
| 4974463 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.57 | 46.0 | 3.90e-01 | 93.0% | 91.4% |
| 5018347 | 1.1.17.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel 2 | 0.57 | 47.0 | 4.00e-01 | 94.2% | 95.5% |
| 1099000 | 1.1.5.19 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel › Peptidase_C30 | 0.55 | 47.0 | 3.78e-01 | 100.0% | 95.1% |
| 3675857 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.55 | 38.0 | 3.04e-01 | 73.3% | 44.3% |
| 4014424 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.54 | 40.0 | 3.63e-01 | 91.9% | 58.3% |
| 3252646 | 1.1.9.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › PUA domain | 0.54 | 39.0 | 3.28e-01 | 74.4% | 82.1% |
| 4256596 | 10.2.1.5 ↗ | beta sandwiches › jelly-roll › Nucleoplasmin-like/VP (viral coat and capsid proteins) › Nucleoplasmin-like/VP (viral coat and capsid proteins) › TGFb_propeptide | 0.53 | 41.0 | 3.25e-01 | 83.7% | 53.7% |
| 4216957 | 3796.1.1.0 ↗ | alpha arrays › Iron-regulated surface determinant protein H linker domain › Iron-regulated surface determinant protein H linker domain › Iron-regulated surface determinant protein H linker domain | 0.51 | 44.0 | 3.45e-01 | 93.0% | 73.3% |
| 109 | 1.1.7.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C | 0.51 | 39.0 | 3.75e-01 | 93.0% | 69.3% |
| 3839891 | 1.1.5.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › FMN-binding split barrel | 0.51 | 36.0 | 3.49e-01 | 74.4% | 72.0% |
| 4952455 | 1.1.8.4 ↗ | beta barrels › cradle loop barrel › RIFT-related › Aminomethyltransferase beta-barrel domain › eIF2_C | 0.51 | 36.0 | 3.61e-01 | 75.6% | 83.1% |
D2
high
residues 107-174
Domain cluster:
rep: nonstructural_protein_NS3__NP_740299__Langat_virus__11085__D113-168
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00949.28 best | Peptidase_S7 | 43.4 | 4.30e-11 | 92.7% | 36.6% |
D3
high
residues 181-327
Domain cluster:
rep: LD_Run2_08_scaffold_35_prodigal-single.1__X__X__00177__D121-323
Pfam (3)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00270.36 best | DEAD | 30.7 | 3.50e-07 | 98.0% | 89.2% |
| PF04851.22 | ResIII | 28.3 | 2.20e-06 | 96.6% | 84.2% |
| PF07652.21 | Flavi_DEAD | 233.3 | 1.50e-69 | 94.6% | 93.2% |
D4
high
residues 337-476
Domain cluster:
rep: B962L__YP_009703129__African_swine_fever_virus__10497__D237-425
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00271.38 best | Helicase_C | 26.8 | 7.20e-06 | 82.1% | 85.5% |
D5
medium
residues 522-618
Domain cluster:
rep: non-structural_protein_NS3__NP_776005__Yellow_fever_virus__11089__D541-620
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF20907.3 best | Flav_NS3-hel_C | 65.2 | 7.90e-18 | 100.0% | 66.0% |