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non-structural_protein_NS4a
Euk-VirPowassan_virus
non-structural_protein_NS4a__NP_775521__Powassan_virus__11083
Identity
- Accession:
- NP_775521 ↗
- Protein ID:
- non-structural_protein_NS4a
- Kingdom:
- euk
Quality
83.8
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Powassan_virus
TaxID: 11083
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-76
Domain cluster:
rep: NS4A__YP_009553734__Kampung_Karu_virus__2045186__D2-69
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 30.5 | 4.40e-07 | 94.7% | 47.9% |
CATH (46)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1vp7A00 | 1.10.287.1040 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Exonuclease VII, small subunit | 0.78 | 58.0 | 6.08e-01 | 77.6% | 94.1% |
| 1cxzB00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.74 | 51.0 | 4.93e-01 | 73.7% | 64.0% |
| 3lnnB03 | 1.10.287.470 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.72 | 48.0 | 5.12e-01 | 85.5% | 77.6% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 52.0 | 5.23e-01 | 85.5% | 75.0% |
| 3txsC01 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.71 | 48.0 | 4.90e-01 | 75.0% | 70.7% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.69 | 50.0 | 4.46e-01 | 76.3% | 85.0% |
| 4l0rB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.69 | 52.0 | 5.36e-01 | 80.3% | 84.9% |
| 4okvE00 | 6.10.140.1890 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 43.0 | 4.70e-01 | 84.2% | 75.4% |
| 1orsC00 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.68 | 54.0 | 4.52e-01 | 88.2% | 50.0% |
| 2efkA01 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.68 | 52.0 | 3.58e-01 | 84.2% | 24.0% |
| 2lm9A00 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.68 | 47.0 | 4.35e-01 | 84.2% | 57.3% |
| 1ailA00 | 1.10.287.10 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding | 0.67 | 46.0 | 4.81e-01 | 72.4% | 77.1% |
| 1br0A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 53.0 | 4.60e-01 | 88.2% | 55.0% |
| 3ok8A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.67 | 47.0 | 3.43e-01 | 75.0% | 30.1% |
| 1ykhA00 | 6.10.140.200 | Special › Helix non-globular › Helix Hairpins › | 0.66 | 51.0 | 4.76e-01 | 84.2% | 78.9% |
| 1t72A01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.65 | 50.0 | 4.31e-01 | 81.6% | 73.5% |
| 1zpyA00 | 6.10.140.1960 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 51.0 | 4.84e-01 | 85.5% | 79.1% |
| 1wpaA01 | 6.10.140.340 | Special › Helix non-globular › Helix Hairpins › | 0.65 | 48.0 | 4.42e-01 | 78.9% | 96.0% |
| 1vf7A03 | 1.10.287.470 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.64 | 44.0 | 4.90e-01 | 72.4% | 100.0% |
| 1tjlA00 | 1.20.120.910 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › DksA, coiled-coil domain | 0.64 | 54.0 | 4.32e-01 | 92.1% | 69.7% |
| 3behB01 | 1.20.120.540 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels | 0.63 | 49.0 | 4.24e-01 | 84.2% | 53.8% |
| 2zgyA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.63 | 48.0 | 3.95e-01 | 81.6% | 71.4% |
| 2rkhA02 | 1.20.1280.20 | Mainly Alpha › Up-down Bundle › Monooxygenase › HscB, C-terminal domain | 0.63 | 44.0 | 4.47e-01 | 73.7% | 72.4% |
| 3fxdB00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 41.0 | 4.59e-01 | 84.2% | 86.2% |
| 1xqrA00 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.63 | 44.0 | 3.00e-01 | 72.4% | 34.8% |
| 4iggA01 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.63 | 45.0 | 4.75e-01 | 77.6% | 85.1% |
| 4nb5B02 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.63 | 45.0 | 4.85e-01 | 77.6% | 90.6% |
| 1yq1A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.62 | 47.0 | 4.19e-01 | 81.6% | 96.4% |
| 1hs7A00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.62 | 43.0 | 3.95e-01 | 71.1% | 77.3% |
| 4h63K00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.62 | 48.0 | 4.47e-01 | 84.2% | 65.3% |
| 3cwzB01 | 1.20.58.900 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › RUN domain | 0.62 | 51.0 | 4.18e-01 | 92.1% | 70.5% |
| 1vctA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.61 | 48.0 | 4.26e-01 | 90.8% | 58.7% |
| 4aflA00 | 6.10.140.1740 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 53.0 | 4.79e-01 | 94.7% | 97.1% |
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.61 | 38.0 | 4.59e-01 | 72.4% | 98.0% |
| 1rq0A01 | 6.10.140.160 | Special › Helix non-globular › Helix Hairpins › | 0.61 | 46.0 | 4.53e-01 | 82.9% | 75.9% |
| 3qweA00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.60 | 51.0 | 3.58e-01 | 96.1% | 51.5% |
| 1j1jA02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.60 | 42.0 | 4.13e-01 | 76.3% | 67.1% |
| 4e6nA02 | 6.10.140.1010 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 45.0 | 4.73e-01 | 81.6% | 97.0% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.58 | 43.0 | 4.65e-01 | 85.5% | 100.0% |
| 2jqqA00 | 1.20.58.1240 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 46.0 | 3.82e-01 | 92.1% | 76.6% |
| 1kmiZ02 | 1.10.287.500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.57 | 42.0 | 3.57e-01 | 84.2% | 45.5% |
| 6yz2A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.57 | 48.0 | 4.20e-01 | 96.1% | 100.0% |
| 5z7qA00 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.56 | 48.0 | 3.79e-01 | 98.7% | 99.4% |
| 3dxpA02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.56 | 46.0 | 3.28e-01 | 90.8% | 92.4% |
| 2bnlC00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.56 | 41.0 | 3.46e-01 | 78.9% | 100.0% |
| 4i5sB03 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.56 | 47.0 | 4.79e-01 | 93.4% | 100.0% |
ECOD (50)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3098420 | 4006.1.1.1 ↗ | alpha bundles › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › Release factor (Pfam 00472) N-terminal alpha helical domain › PCRF | 0.79 | 69.0 | 6.07e-01 | 94.7% | 67.0% |
| 4883924 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.76 | 53.0 | 5.20e-01 | 73.7% | 68.8% |
| 4977429 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.74 | 55.0 | 4.46e-01 | 86.8% | 42.9% |
| 3178900 | 192.2.1.30 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Uds1 | 0.73 | 53.0 | 4.26e-01 | 76.3% | 47.6% |
| 3286637 | 2484.1.1.124 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › OrfB_IS605 | 0.71 | 53.0 | 4.11e-01 | 86.8% | 36.4% |
| 3620978 | 2003.1.2.18 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain | 0.71 | 51.0 | 3.32e-01 | 75.0% | 18.1% |
| 4259224 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.71 | 51.0 | 3.98e-01 | 75.0% | 37.4% |
| 4994040 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.71 | 53.0 | 4.86e-01 | 80.3% | 61.0% |
| 3215465 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.70 | 50.0 | 4.20e-01 | 75.0% | 45.4% |
| 3598168 | 3755.1.1.0 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related | 0.70 | 52.0 | 3.99e-01 | 78.9% | 35.8% |
| 3944501 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.70 | 51.0 | 5.04e-01 | 84.2% | 72.5% |
| 3962991 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.70 | 55.0 | 4.05e-01 | 84.2% | 33.8% |
| 3277923 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.70 | 49.0 | 4.80e-01 | 73.7% | 67.5% |
| 3940784 | 604.1.1.1 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin | 0.69 | 50.0 | 4.38e-01 | 75.0% | 51.8% |
| 3665862 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.69 | 62.0 | 5.29e-01 | 98.7% | 93.3% |
| 3671258 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.69 | 53.0 | 4.40e-01 | 84.2% | 47.7% |
| 4581983 | 5086.1.1.13 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › T3SSipB | 0.69 | 54.0 | 4.39e-01 | 84.2% | 47.1% |
| 4028999 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.68 | 47.0 | 5.08e-01 | 76.3% | 84.6% |
| 3583169 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.68 | 51.0 | 5.09e-01 | 84.2% | 76.2% |
| 3999039 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.68 | 54.0 | 4.73e-01 | 88.2% | 57.4% |
| 3613914 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.68 | 51.0 | 5.21e-01 | 82.9% | 81.3% |
| 3391380 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.68 | 53.0 | 4.74e-01 | 84.2% | 81.9% |
| 4774281 | 1147.1.1.1 ↗ | alpha bundles › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › RNA polymerase II elongation factor ELL2 C-terminal domain › Occludin_ELL | 0.67 | 52.0 | 4.69e-01 | 85.5% | 78.0% |
| 4210642 | 3755.1.1.12 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › CheZ | 0.67 | 51.0 | 4.27e-01 | 81.6% | 50.0% |
| 5048976 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.67 | 52.0 | 4.14e-01 | 82.9% | 46.2% |
| 5038847 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.67 | 48.0 | 5.02e-01 | 81.6% | 84.3% |
| 3382780 | 2006.1.1.8 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › 5_nucleotid | 0.66 | 50.0 | 3.20e-01 | 78.9% | 17.7% |
| 3601853 | 604.7.1.0 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A | 0.66 | 51.0 | 4.14e-01 | 85.5% | 43.4% |
| 3935140 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.66 | 52.0 | 3.93e-01 | 84.2% | 40.0% |
| 3844040 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.66 | 50.0 | 5.37e-01 | 81.6% | 95.4% |
| 4174467 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.65 | 51.0 | 4.87e-01 | 84.2% | 75.6% |
| 5070059 | 3834.1.1.25 ↗ | alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain › DUF7121 | 0.65 | 54.0 | 3.73e-01 | 89.5% | 96.0% |
| 5084060 | 3755.3.1.637 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 | 0.65 | 51.0 | 4.04e-01 | 84.2% | 42.6% |
| 3253283 | 192.5.1.14 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat › HR1_TOCA | 0.65 | 55.0 | 5.08e-01 | 90.8% | 100.0% |
| 3964578 | 5094.1.1.1 ↗ | a+b duplicates or obligate multimers › OmpH-like › OmpH-like › OmpH-like › OmpH | 0.65 | 51.0 | 4.15e-01 | 84.2% | 55.7% |
| 4175809 | 5086.1.1.88 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_CyaD | 0.65 | 53.0 | 4.12e-01 | 89.5% | 42.4% |
| 3798426 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.64 | 44.0 | 4.57e-01 | 72.4% | 81.4% |
| 3696767 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.63 | 57.0 | 3.56e-01 | 98.7% | 56.2% |
| 3674276 | 603.1.1.161 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › DUF212 | 0.63 | 50.0 | 4.12e-01 | 88.2% | 46.4% |
| 3428852 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.63 | 49.0 | 4.03e-01 | 85.5% | 46.7% |
| 3201381 | 192.8.1.139 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain › Fung_rhodopsin | 0.63 | 43.0 | 4.35e-01 | 75.0% | 72.0% |
| 4958744 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.63 | 50.0 | 4.46e-01 | 86.8% | 83.6% |
| 3739924 | 6155.1.1.2 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter › PQ-loop | 0.61 | 42.0 | 3.82e-01 | 73.7% | 51.4% |
| 3974625 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.61 | 45.0 | 4.70e-01 | 78.9% | 87.1% |
| 3973899 | 5086.1.1.92 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AprE | 0.60 | 50.0 | 3.99e-01 | 89.5% | 48.3% |
| 3281879 | 101.1.2.48 ↗ | alpha arrays › HTH › HTH › winged helix domain › PadR | 0.59 | 48.0 | 3.62e-01 | 88.2% | 44.4% |
| 4528712 | 109.4.1.3083 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PF29810 | 0.58 | 45.0 | 3.17e-01 | 85.5% | 27.8% |
| 3736652 | 192.29.1.102 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Fung_rhodopsin | 0.58 | 43.0 | 4.32e-01 | 85.5% | 75.0% |
| 4176828 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.58 | 45.0 | 4.66e-01 | 86.8% | 100.0% |
| 3737838 | 109.4.1.25 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › DIL | 0.57 | 51.0 | 3.05e-01 | 100.0% | 96.8% |
D2
medium
residues 77-126
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 31.8 | 1.80e-07 | 100.0% | 34.7% |
CATH (41)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4ip8A00 | 1.10.132.110 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Serum amyloid A protein | 0.91 | 72.0 | 5.50e-01 | 84.0% | 77.1% |
| 4k7cA01 | 3.90.70.10 | Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases | 0.82 | 71.0 | 4.16e-01 | 96.0% | 12.2% |
| 3b9qA01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.82 | 62.0 | 5.09e-01 | 84.0% | 46.1% |
| 2dt8A01 | 3.40.50.10170 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.81 | 56.0 | 3.89e-01 | 72.0% | 93.3% |
| 3nctA00 | 3.40.50.11880 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Plasmid SOS inhibition protein | 0.81 | 58.0 | 4.13e-01 | 76.0% | 100.0% |
| 3lupA01 | 3.40.50.10170 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.81 | 58.0 | 3.99e-01 | 76.0% | 92.3% |
| 2xvtC00 | 1.10.150.510 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Receptor activity modifying family | 0.78 | 64.0 | 5.50e-01 | 90.0% | 65.8% |
| 1r1dA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.72 | 55.0 | 3.48e-01 | 86.0% | 16.9% |
| 4g3vA00 | 3.30.450.40 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › GAF domain | 0.71 | 52.0 | 3.64e-01 | 84.0% | 24.1% |
| 2cazD00 | 6.10.140.820 | Special › Helix non-globular › Helix Hairpins › | 0.71 | 61.0 | 5.80e-01 | 98.0% | 85.0% |
| 2nn4A00 | 1.10.287.760 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YqgQ-like | 0.70 | 52.0 | 4.91e-01 | 84.0% | 66.1% |
| 2bzbA00 | 4.10.280.10 | Few Secondary Structures › Irregular › MYOD Basic-Helix-Loop-Helix Domain, subunit B › Helix-loop-helix DNA-binding domain | 0.70 | 54.0 | 5.18e-01 | 90.0% | 75.8% |
| 6mh4A03 | 1.10.1740.10 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › RNA polymerase sigma factor, region 2, helix turn helix motif | 0.69 | 53.0 | 4.70e-01 | 92.0% | 55.7% |
| 4adnA01 | 1.20.1280.250 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.69 | 51.0 | 4.35e-01 | 82.0% | 50.6% |
| 2mqaA00 | 1.10.274.60 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, repetitive domain | 0.69 | 54.0 | 4.17e-01 | 92.0% | 38.4% |
| 1kblA05 | 1.20.80.30 | Mainly Alpha › Up-down Bundle › Acyl-CoA Binding Protein › | 0.68 | 54.0 | 4.45e-01 | 86.0% | 58.4% |
| 1l0oA00 | 3.30.565.10 | Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain | 0.68 | 57.0 | 4.23e-01 | 98.0% | 53.9% |
| 2l35A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.68 | 60.0 | 5.57e-01 | 100.0% | 84.1% |
| 5u1xA01 | 1.10.287.940 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › atp-gated p2x4 ion channel | 0.68 | 53.0 | 5.49e-01 | 92.0% | 100.0% |
| 1rr7A01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.67 | 46.0 | 4.77e-01 | 76.0% | 76.1% |
| 1z5zA02 | 1.20.120.850 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SWI2/SNF2 ATPases, N-terminal domain | 0.67 | 55.0 | 4.93e-01 | 98.0% | 69.7% |
| 5lbmA00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.67 | 55.0 | 4.83e-01 | 100.0% | 85.5% |
| 4qmaA01 | 1.20.5.440 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain | 0.66 | 47.0 | 4.99e-01 | 90.0% | 100.0% |
| 3dkqA02 | 4.10.860.20 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain | 0.66 | 52.0 | 5.33e-01 | 90.0% | 91.5% |
| 2yfaA02 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.66 | 55.0 | 4.31e-01 | 100.0% | 51.7% |
| 5o7oC01 | 3.30.310.280 | Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › | 0.65 | 55.0 | 4.25e-01 | 100.0% | 93.6% |
| 1t07A00 | 1.10.3880.10 | Mainly Alpha › Orthogonal Bundle › YggX-like › Fe(II) trafficking protein YggX | 0.65 | 49.0 | 4.25e-01 | 88.0% | 51.9% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.65 | 50.0 | 4.01e-01 | 96.0% | 41.6% |
| 2jaeA03 | 1.20.1440.240 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.64 | 55.0 | 4.41e-01 | 98.0% | 58.4% |
| 1e1dA02 | 1.20.1270.20 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.64 | 54.0 | 4.67e-01 | 98.0% | 75.0% |
| 2hh7A00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.64 | 54.0 | 4.65e-01 | 100.0% | 78.8% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.64 | 52.0 | 4.66e-01 | 94.0% | 67.6% |
| 1wp7A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.63 | 55.0 | 5.11e-01 | 100.0% | 85.9% |
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.63 | 50.0 | 5.09e-01 | 86.0% | 100.0% |
| 8cdaC01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.61 | 47.0 | 3.74e-01 | 90.0% | 44.4% |
| 1cbyA00 | 3.40.198.10 | Alpha Beta › 3-Layer(aba) Sandwich › Delta-endotoxin CytB › Delta-endotoxin CytB-like | 0.60 | 51.0 | 3.38e-01 | 100.0% | 43.2% |
| 1l5jA03 | 3.40.1060.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aconitase; Domain 2 › Aconitase, Domain 2 | 0.60 | 53.0 | 3.65e-01 | 100.0% | 45.1% |
| 2kwhA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.59 | 48.0 | 4.68e-01 | 96.0% | 82.1% |
| 1rajA01 | 4.10.880.10 | Few Secondary Structures › Irregular › Poliovirus 3D polymerase; domain 1 (Nucleotidyltransferase) › Poliovirus 3D polymerase Domain 1 (Nucleotidyltransferase) | 0.57 | 38.0 | 4.07e-01 | 70.0% | 84.1% |
| 3zdmB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.57 | 43.0 | 4.40e-01 | 88.0% | 86.0% |
| 3fk5A01 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.54 | 43.0 | 3.05e-01 | 100.0% | 67.7% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3889409 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.92 | 74.0 | 4.69e-01 | 88.0% | 20.0% |
| 3211845 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.91 | 68.0 | 7.51e-01 | 84.0% | 100.0% |
| 3590184 | 3711.1.1.0 ↗ | alpha bundles › LTXXQ motif family protein › LTXXQ motif family protein › LTXXQ motif family protein | 0.86 | 81.0 | 5.68e-01 | 100.0% | 38.5% |
| 3297889 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.86 | 68.0 | 4.40e-01 | 88.0% | 21.0% |
| 3966348 | 5058.1.1.16 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1 | 0.83 | 73.0 | 6.14e-01 | 100.0% | 62.4% |
| 3764064 | 4009.1.1.0 ↗ | alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins | 0.83 | 73.0 | 6.07e-01 | 98.0% | 57.6% |
| 4317794 | 5058.1.1.1 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1,MS_channel_1st | 0.82 | 73.0 | 5.72e-01 | 100.0% | 50.5% |
| 3385053 | 5076.2.1.10 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › PF29520 | 0.82 | 73.0 | 4.51e-01 | 100.0% | 51.9% |
| 3882597 | 4009.1.1.0 ↗ | alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins | 0.82 | 74.0 | 6.00e-01 | 100.0% | 57.8% |
| 3607406 | 6026.1.1.0 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain | 0.81 | 73.0 | 6.19e-01 | 100.0% | 62.5% |
| 5034026 | 5058.1.1.16 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st_1 | 0.79 | 71.0 | 5.53e-01 | 100.0% | 50.5% |
| 4970333 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.78 | 67.0 | 5.49e-01 | 100.0% | 61.1% |
| 5047182 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.78 | 68.0 | 6.30e-01 | 100.0% | 76.9% |
| 4309485 | 4229.1.1.2 ↗ | alpha bundles › Indolic compounds 2,3-dioxygenase-like › Indolic compounds 2,3-dioxygenase-like › Indolic compounds 2,3-dioxygenase-like › Trp_dioxygenase | 0.77 | 67.0 | 4.02e-01 | 100.0% | 16.3% |
| 3165347 | 148.1.3.335 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AzlD | 0.77 | 61.0 | 5.40e-01 | 88.0% | 63.5% |
| 4016157 | 6026.1.1.1 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › cwf21 | 0.77 | 67.0 | 4.93e-01 | 100.0% | 37.8% |
| 4506456 | 507.1.1.1 ↗ | alpha arrays › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB helicase N-terminal domain-related › DnaB | 0.74 | 56.0 | 4.08e-01 | 86.0% | 95.3% |
| 3645559 | 650.1.1.1 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain › DnaJ | 0.72 | 59.0 | 4.87e-01 | 98.0% | 51.1% |
| 3331809 | 375.1.9.23 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Zinc-nucleated domain of serine integrase › Sterile | 0.71 | 60.0 | 4.18e-01 | 100.0% | 28.6% |
| 2647290 | 225.1.1.6 ↗ | a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_2 | 0.71 | 61.0 | 5.30e-01 | 100.0% | 63.7% |
| 3491670 | 614.1.1.0 ↗ | alpha duplicates or obligate multimers › L27 domain › L27 domain › L27 domain | 0.70 | 56.0 | 5.54e-01 | 98.0% | 87.3% |
| 3175298 | 130.1.1.51 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › Tho1_MOS11_C | 0.70 | 54.0 | 5.16e-01 | 86.0% | 75.0% |
| 1487360 | 3929.1.1.1 ↗ | alpha bundles › THO1 C-terminal domain › THO1 C-terminal domain › THO1 C-terminal domain › Tho1_MOS11_C | 0.68 | 53.0 | 4.82e-01 | 86.0% | 74.6% |
| 4614833 | 102.1.1.83 ↗ | alpha arrays › HhH/H2TH › SAM/DNA-glycosylase › SAM domain-like › SHLD1_C | 0.66 | 51.0 | 4.48e-01 | 88.0% | 55.0% |
| 3274698 | 316.1.1.56 ↗ | a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › PF26128 | 0.66 | 53.0 | 3.52e-01 | 100.0% | 21.7% |
| 3713433 | 2004.1.1.73 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › MMR_HSR1 | 0.64 | 55.0 | 3.39e-01 | 100.0% | 45.2% |
| 3967173 | 7542.1.2.1 ↗ | a/b three-layered sandwiches › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain II › Aconitase | 0.62 | 49.0 | 3.55e-01 | 88.0% | 46.7% |
| 4006139 | 7542.1.2.0 ↗ | a/b three-layered sandwiches › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain › Aconitase iron-sulfur domain II | 0.62 | 49.0 | 3.52e-01 | 90.0% | 43.8% |