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non-structural_protein_NS4b
Euk-VirYellow_fever_virus
non-structural_protein_NS4b__NP_776008__Yellow_fever_virus__11089
Identity
- Accession:
- NP_776008 ↗
- Protein ID:
- non-structural_protein_NS4b
- Kingdom:
- euk
Quality
84.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Yellow_fever_virus
TaxID: 11089
Cluster
View cluster (29 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 37-154
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01349.23 best | Flavi_NS4B | 227.8 | 2.00e-67 | 100.0% | 47.6% |
CATH (15)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4bwrA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.68 | 34.0 | 2.26e-01 | 78.0% | 12.2% |
| 6cgvM01 | 1.20.120.1500 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pre-hexon-linking protein IIIa | 0.58 | 33.0 | 3.17e-01 | 77.1% | 47.0% |
| 2rdcA00 | 1.10.287.800 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › protein ne1242 | 0.58 | 42.0 | 4.04e-01 | 74.6% | 91.7% |
| 1kmiZ02 | 1.10.287.500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.57 | 35.0 | 3.37e-01 | 92.4% | 52.2% |
| 2lvfA00 | 1.10.110.10 | Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins | 0.55 | 33.0 | 3.38e-01 | 75.4% | 60.5% |
| 2pkeA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.55 | 28.0 | 3.41e-01 | 78.0% | 75.6% |
| 1j77A00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.53 | 38.0 | 3.22e-01 | 76.3% | 44.2% |
| 2v7kA02 | 1.20.58.480 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 41.0 | 3.40e-01 | 83.1% | 63.1% |
| 3zevB00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.52 | 44.0 | 3.29e-01 | 92.4% | 68.1% |
| 1mhyD00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.52 | 46.0 | 3.05e-01 | 100.0% | 89.4% |
| 3zbhA00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.51 | 33.0 | 3.71e-01 | 76.3% | 84.4% |
| 6e1kA01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 35.0 | 3.59e-01 | 92.4% | 73.2% |
| 3sk9A00 | 1.10.3210.30 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › | 0.51 | 41.0 | 3.35e-01 | 88.1% | 92.6% |
| 1zvuA03 | 1.10.268.10 | Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 | 0.51 | 35.0 | 3.34e-01 | 79.7% | 60.0% |
| 1y1uA01 | 1.20.1050.20 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › STAT transcription factor, all-alpha domain | 0.51 | 38.0 | 3.20e-01 | 78.0% | 53.3% |
ECOD (50)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3428503 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.66 | 53.0 | 4.32e-01 | 86.4% | 77.3% |
| 5027934 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.65 | 52.0 | 4.43e-01 | 85.6% | 83.2% |
| 3699262 | 1002.1.1.1 ↗ | alpha complex topology › Fluoride ion channel › Fluoride ion channel › Fluoride ion channel › CRCB | 0.64 | 47.0 | 4.57e-01 | 81.4% | 69.0% |
| 3884038 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.63 | 50.0 | 4.08e-01 | 87.3% | 69.1% |
| 4628161 | 1002.1.1.1 ↗ | alpha complex topology › Fluoride ion channel › Fluoride ion channel › Fluoride ion channel › CRCB | 0.62 | 45.0 | 4.61e-01 | 78.8% | 77.4% |
| 4213823 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 50.0 | 4.27e-01 | 87.3% | 79.0% |
| 3456226 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.62 | 50.0 | 3.88e-01 | 86.4% | 65.8% |
| 4992292 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.61 | 48.0 | 4.20e-01 | 83.9% | 85.6% |
| 3692811 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.61 | 50.0 | 4.03e-01 | 87.3% | 76.9% |
| 4999046 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.61 | 49.0 | 4.17e-01 | 87.3% | 80.0% |
| 4024694 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.61 | 49.0 | 4.12e-01 | 87.3% | 79.5% |
| 4954997 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.61 | 49.0 | 4.15e-01 | 87.3% | 79.0% |
| 5009687 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 49.0 | 4.00e-01 | 87.3% | 71.8% |
| 5015634 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.60 | 48.0 | 4.16e-01 | 87.3% | 82.1% |
| 5009698 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 49.0 | 4.17e-01 | 87.3% | 82.6% |
| 3882736 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 47.0 | 4.03e-01 | 83.9% | 80.0% |
| 3192460 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 48.0 | 3.76e-01 | 87.3% | 60.0% |
| 3590361 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 48.0 | 4.08e-01 | 87.3% | 81.0% |
| 5003187 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.60 | 48.0 | 3.77e-01 | 86.4% | 62.0% |
| 3984959 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 47.0 | 4.03e-01 | 84.7% | 80.5% |
| 3689860 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 48.0 | 3.75e-01 | 87.3% | 62.4% |
| 3952372 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 47.0 | 4.02e-01 | 86.4% | 79.0% |
| 3216672 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.59 | 49.0 | 4.13e-01 | 87.3% | 79.5% |
| 3284119 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 48.0 | 4.10e-01 | 89.0% | 82.5% |
| 3736810 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 47.0 | 3.79e-01 | 87.3% | 64.9% |
| 3390139 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.59 | 48.0 | 4.00e-01 | 89.8% | 78.2% |
| 3202766 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 47.0 | 3.74e-01 | 87.3% | 62.7% |
| 3417088 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.59 | 49.0 | 4.02e-01 | 89.8% | 79.5% |
| 3932094 | 5050.1.1.8 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FPN1 | 0.59 | 48.0 | 3.87e-01 | 87.3% | 76.9% |
| 3929509 | 5050.1.1.11 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UNC-93 | 0.59 | 48.0 | 3.96e-01 | 90.7% | 74.2% |
| 3783257 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.58 | 47.0 | 3.82e-01 | 87.3% | 70.4% |
| 4320634 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.58 | 36.0 | 2.72e-01 | 90.7% | 25.6% |
| 3285842 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 45.0 | 3.95e-01 | 84.7% | 82.1% |
| 3181677 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.58 | 47.0 | 3.67e-01 | 87.3% | 63.9% |
| 4817062 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 45.0 | 3.19e-01 | 84.7% | 37.9% |
| 3990207 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.57 | 47.0 | 3.84e-01 | 89.0% | 75.5% |
| 4443875 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.57 | 46.0 | 3.73e-01 | 87.3% | 68.7% |
| 5038347 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.57 | 47.0 | 4.02e-01 | 90.7% | 85.6% |
| 3288129 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.55 | 44.0 | 3.82e-01 | 86.4% | 83.0% |
| 4127216 | 547.1.1.1 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer | 0.55 | 38.0 | 3.91e-01 | 73.7% | 73.9% |
| 5003145 | 2006.1.1.18 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › HAD-like › HAD_2 | 0.54 | 39.0 | 3.26e-01 | 77.1% | 85.2% |
| 3763261 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.53 | 36.0 | 2.91e-01 | 91.5% | 36.4% |
| 3397538 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.53 | 44.0 | 3.52e-01 | 90.7% | 83.8% |
| 4216519 | 2003.1.1.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains | 0.53 | 37.0 | 2.82e-01 | 77.1% | 32.1% |
| 4048104 | 109.4.1.1151 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HIR3_helical | 0.52 | 39.0 | 2.44e-01 | 78.8% | 20.9% |
| 3560229 | 3291.1.1.230 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › TBCA_PH | 0.52 | 37.0 | 3.57e-01 | 75.4% | 100.0% |
| 4940643 | 1079.1.1.0 ↗ | alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA | 0.52 | 42.0 | 3.51e-01 | 90.7% | 88.4% |
| 3918480 | 5050.1.1.32 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Acatn | 0.51 | 44.0 | 3.57e-01 | 100.0% | 73.3% |
| 3638722 | 1075.1.2.23 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › PF28681 | 0.51 | 40.0 | 3.21e-01 | 84.7% | 64.5% |
| 3415351 | 192.5.1.0 ↗ | alpha bundles › Long alpha-hairpin › HR1 repeat › HR1 repeat | 0.51 | 40.0 | 4.11e-01 | 84.7% | 93.9% |
D2
medium
residues 155-245
Domain cluster:
rep: nonstructural_protein_NS4B__YP_009328360_nonstructural_protein_NS4B__New_Mapoon_virus__499854__D161-238
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01349.23 best | Flavi_NS4B | 162.1 | 2.30e-47 | 98.9% | 37.9% |