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nonstructural_protein_NS-2

Euk-Vir

Culex_pipiens_densovirus

nonstructural_protein_NS-2__YP_002887626__Culex_pipiens_densovirus__185638

Identity

Accession:
YP_002887626 ↗
Protein ID:
nonstructural_protein_NS-2
Kingdom:
euk

Quality

65.6 mean pLDDT

Cluster

Singleton — not in a non-trivial cluster

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-120
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF27719.1 best Parvo_NS2 61.9 8.00e-17 99.2% 40.0%
CATH (35)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4m0mA03 1.20.1270.430 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.63 41.0 4.85e-01 72.0% 98.7%
6i3mE01 1.20.120.420 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 0.61 44.0 4.20e-01 74.6% 80.3%
1yjgA00 1.20.120.240 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Lipoprotein, type 6 0.61 46.0 4.22e-01 79.7% 82.2%
1dqeA00 1.10.238.20 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › Pheromone/general odorant binding protein domain 0.60 39.0 3.73e-01 82.2% 56.9%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 40.0 4.29e-01 73.7% 82.4%
4m0mA04 1.20.1270.440 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 42.0 4.29e-01 77.1% 94.0%
2scpA00 1.10.238.10 Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand 0.57 43.0 3.89e-01 82.2% 67.2%
1oahA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.57 44.0 4.16e-01 82.2% 73.2%
2j9wB00 1.20.120.1130 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Vps28 C-terminal domain 0.56 39.0 4.22e-01 79.7% 84.8%
3b5oA00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.56 46.0 3.76e-01 90.7% 89.1%
1v4aA01 1.10.4050.10 Mainly Alpha › Orthogonal Bundle › Nucleotidyltransferase substrate binding subunit/domain fold › Glutamine synthase adenylyltransferase GlnE 0.56 32.0 3.39e-01 100.0% 60.6%
1tdpA00 1.20.1440.50 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like 0.55 35.0 3.62e-01 72.0% 66.7%
2hszA02 1.10.150.240 Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 0.55 35.0 4.20e-01 79.7% 100.0%
2l81A00 1.20.120.830 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Serine-rich domain 0.55 42.0 3.64e-01 78.8% 77.8%
1u8vB03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 42.0 3.42e-01 80.5% 73.2%
7sbeA01 1.10.132.70 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › 0.54 43.0 3.54e-01 85.6% 84.8%
1rjgA00 3.40.50.150 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39 0.54 40.0 3.04e-01 78.0% 95.2%
4akfA01 3.40.1090.10 Alpha Beta › 3-Layer(aba) Sandwich › Cytosolic phospholipase A2 catalytic domain › Cytosolic phospholipase A2 catalytic domain 0.54 41.0 3.01e-01 82.2% 45.9%
1xzpA02 1.20.120.430 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 0.53 39.0 3.48e-01 75.4% 87.3%
2zs0A00 1.10.490.10 Mainly Alpha › Orthogonal Bundle › Globin-like › Globins 0.53 43.0 4.11e-01 88.1% 85.7%
2w9yA00 1.20.120.1100 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.53 43.0 4.09e-01 85.6% 91.2%
3buxB01 1.20.930.20 Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Adaptor protein Cbl, N-terminal domain 0.53 38.0 3.74e-01 74.6% 87.6%
3fbzA01 1.20.58.800 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.53 37.0 3.96e-01 78.0% 84.3%
6pd2A01 3.90.550.10 Alpha Beta › Alpha-Beta Complex › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A › Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A 0.53 37.0 2.95e-01 72.0% 85.5%
3m9vA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 38.0 3.50e-01 77.1% 77.1%
4akgA16 1.10.8.720 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Region D6 of dynein motor 0.52 40.0 3.68e-01 85.6% 73.9%
2vm6A00 1.10.437.10 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › Blc2-like 0.52 41.0 3.90e-01 86.4% 95.8%
3pntA01 1.10.10.1660 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Nicotine adenine dinucleotide glycohydrolase, helical linker domain 0.51 27.0 3.17e-01 83.9% 74.7%
3bjbD00 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 37.0 3.35e-01 78.0% 63.2%
5jfqB00 1.10.600.10 Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase 0.51 38.0 2.83e-01 77.1% 96.4%
1wgwA00 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.51 34.0 3.64e-01 72.0% 80.8%
4akgA06 1.10.8.710 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Dynein motor, AAA1 domain, small subdomain 0.51 35.0 3.68e-01 72.9% 78.5%
2k3qA00 1.10.274.70 Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain 0.51 38.0 3.89e-01 81.4% 89.8%
3n00A00 1.10.565.10 Mainly Alpha › Orthogonal Bundle › Retinoid X Receptor › Retinoid X Receptor 0.51 43.0 3.74e-01 93.2% 95.1%
4agsB04 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.51 35.0 3.41e-01 71.2% 94.0%
ECOD (37)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4940075 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.65 39.0 4.71e-01 70.3% 90.0%
3286912 632.18.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 0.62 38.0 4.21e-01 71.2% 75.8%
4374650 601.54.1.0 alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 0.62 44.0 4.06e-01 74.6% 63.9%
5014074 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.62 42.0 4.81e-01 74.6% 95.3%
1097268 633.19.1.1 alpha bundles › Bromodomain-like › Hypothetical protein lpg2422 helical bundle domain › Hypothetical protein lpg2422 helical bundle domain › DUF6842 0.61 42.0 4.77e-01 75.4% 97.6%
3697275 192.29.1.104 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF4149 0.61 45.0 3.96e-01 78.0% 80.4%
3475282 108.1.1.0 alpha arrays › EF-hand › EF-hand-related › EF-hand 0.60 41.0 4.71e-01 94.1% 97.6%
3785508 632.15.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.60 33.0 4.07e-01 71.2% 85.3%
3770817 601.1.2.47 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › MARVEL 0.60 42.0 4.11e-01 72.9% 75.4%
3864123 633.21.1.10 alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › MARVEL 0.60 42.0 4.11e-01 72.9% 75.4%
5046322 632.11.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.59 36.0 4.26e-01 70.3% 90.0%
4298601 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.58 42.0 3.20e-01 74.6% 93.1%
1097270 633.19.1.1 alpha bundles › Bromodomain-like › Hypothetical protein lpg2422 helical bundle domain › Hypothetical protein lpg2422 helical bundle domain › DUF6842 0.58 42.0 4.35e-01 74.6% 90.7%
3523264 633.23.1.22 alpha bundles › Bromodomain-like › Claudin › Claudin › MARVEL 0.58 42.0 4.06e-01 74.6% 76.9%
4982105 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.57 34.0 4.06e-01 70.3% 90.7%
5043412 1025.1.1.0 alpha bundles › Stonustoxin helical domain › Stonustoxin helical domain › Stonustoxin helical domain 0.57 41.0 4.20e-01 73.7% 85.2%
3620303 101.1.1.66 alpha arrays › HTH › HTH › Three-helical HTH › Myb_DNA-bind_5 0.56 27.0 3.38e-01 76.3% 74.3%
3454663 131.2.1.0 alpha complex topology › PDEase-like › Poly A polymerase C-terminal region-like › Poly A polymerase C-terminal region-like 0.56 43.0 3.15e-01 83.1% 46.3%
4303951 601.54.1.0 alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 0.56 40.0 3.93e-01 73.7% 74.4%
3613513 5059.1.1.0 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.56 45.0 3.42e-01 88.1% 73.4%
3897485 633.1.1.0 alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.56 45.0 4.60e-01 89.0% 96.5%
3499218 632.1.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.55 39.0 4.04e-01 72.0% 77.3%
4360987 601.4.1.34 alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › SHR3_chaperone 0.55 41.0 3.57e-01 77.1% 82.3%
3291137 7002.1.1.8 alpha duplicates or obligate multimers › TM trimerization region of envelope glycoprotein B › TM trimerization region of envelope glycoprotein B › TM trimerization region of envelope glycoprotein B › DUF1206 0.55 43.0 3.85e-01 83.9% 88.5%
3606235 604.7.1.0 alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A 0.54 33.0 2.90e-01 71.2% 42.4%
3097451 4963.1.2.1 alpha complex topology › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal additional helical subdomain in reovirus polymerase lambda3 › N-terminal domain in vesicular stomatitis virus RNA polymerase L › Mononeg_RNA_pol 0.54 42.0 2.97e-01 83.1% 94.1%
3974601 601.3.1.0 alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain 0.54 38.0 3.94e-01 78.0% 78.2%
3190417 632.22.1.0 alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.54 40.0 4.13e-01 77.1% 90.9%
3209235 4177.2.1.0 alpha duplicates or obligate multimers › BAR/IMD domain-like › Inhibitor of kappaB kinase beta dimerization domain › Inhibitor of kappaB kinase beta dimerization domain 0.54 40.0 3.07e-01 78.0% 69.6%
3463325 219.1.1.0 a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.52 45.0 3.52e-01 94.1% 83.9%
3443112 150.3.1.33 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › DUF594 0.52 43.0 3.41e-01 89.8% 94.5%
3250479 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.52 38.0 3.08e-01 75.4% 73.2%
3237525 101.1.1.290 alpha arrays › HTH › HTH › Three-helical HTH › PBC 0.52 36.0 3.58e-01 72.0% 94.4%
3453588 101.1.10.1 alpha arrays › HTH › HTH › Cyclin-like › Cyclin_N 0.51 41.0 3.33e-01 86.4% 50.0%
4946129 5001.1.1.0 alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like 0.51 41.0 3.34e-01 87.3% 94.5%
3600021 5059.1.1.0 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.51 42.0 3.00e-01 90.7% 77.5%
3264752 4044.1.1.0 alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins 0.51 36.0 3.39e-01 73.7% 89.0%
D2 high residues 149-256
PDB