←Back to structures
nonstructural_protein_NS2A
Euk-VirWest_Nile_virus
nonstructural_protein_NS2A__NP_776016__West_Nile_virus__11082
Identity
- Accession:
- NP_776016 ↗
- Protein ID:
- nonstructural_protein_NS2A
- Kingdom:
- euk
Quality
69.4
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
West_Nile_virus
TaxID: 11082
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 50-161
Domain cluster:
rep: NS2A__YP_009553730__Kampung_Karu_virus__2045186__D68-171
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01005.25 best | Flavi_NS2A | 39.3 | 9.00e-10 | 100.0% | 32.6% |
D2
high
residues 172-225
Domain cluster:
representative
CATH (40)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2wmmA01 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.84 | 56.0 | 5.91e-01 | 70.4% | 100.0% |
| 2xzmO02 | 1.10.287.10 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding | 0.79 | 57.0 | 5.22e-01 | 75.9% | 62.9% |
| 3jcuZ00 | 1.10.287.740 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre | 0.79 | 56.0 | 5.42e-01 | 75.9% | 96.7% |
| 6t0bc01 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.77 | 54.0 | 4.84e-01 | 75.9% | 56.4% |
| 7ymiZ01 | 1.10.287.740 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Photosystem II PsbZ, reaction centre | 0.76 | 54.0 | 5.28e-01 | 75.9% | 81.0% |
| 8hk0B03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.76 | 64.0 | 4.82e-01 | 98.1% | 61.6% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.75 | 52.0 | 4.75e-01 | 74.1% | 60.8% |
| 3pt1A02 | 1.20.930.60 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › | 0.73 | 51.0 | 3.95e-01 | 74.1% | 39.2% |
| 2fzlA02 | 6.10.140.1180 | Special › Helix non-globular › Helix Hairpins › | 0.73 | 49.0 | 4.72e-01 | 70.4% | 98.4% |
| 2js5A00 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.73 | 51.0 | 4.73e-01 | 75.9% | 67.6% |
| 7ae2A01 | 1.20.120.580 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like | 0.72 | 62.0 | 4.70e-01 | 100.0% | 86.1% |
| 7zmgL01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.71 | 62.0 | 5.44e-01 | 98.1% | 86.3% |
| 5hxgB00 | 1.10.4000.10 | Mainly Alpha › Orthogonal Bundle › Flagellar transcriptional activator fold › Flagellar transcriptional activator FlhD | 0.71 | 48.0 | 4.53e-01 | 70.4% | 81.5% |
| 3d36B02 | 1.10.287.130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Signal transduction histidine kinase, dimerisation/phosphotransfer (DHp) domain | 0.71 | 51.0 | 4.92e-01 | 77.8% | 90.2% |
| 2whnA00 | 1.20.81.30 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › Type II secretion system (T2SS), domain F | 0.70 | 51.0 | 4.07e-01 | 100.0% | 39.1% |
| 2avuB00 | 1.10.4000.10 | Mainly Alpha › Orthogonal Bundle › Flagellar transcriptional activator fold › Flagellar transcriptional activator FlhD | 0.69 | 48.0 | 3.83e-01 | 72.2% | 51.9% |
| 2jexA01 | 1.10.287.30 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 | 0.69 | 59.0 | 4.95e-01 | 100.0% | 97.9% |
| 3i2fA02 | 1.10.3020.10 | Mainly Alpha › Orthogonal Bundle › alpha-amino acid ester hydrolase ( Helical cap domain) › alpha-amino acid ester hydrolase ( Helical cap domain) | 0.67 | 46.0 | 3.87e-01 | 72.2% | 46.3% |
| 1zhcA00 | 6.10.280.50 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 48.0 | 4.39e-01 | 77.8% | 71.1% |
| 4okvE00 | 6.10.140.1890 | Special › Helix non-globular › Helix Hairpins › | 0.67 | 47.0 | 4.45e-01 | 74.1% | 78.5% |
| 4dveA00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.65 | 55.0 | 3.83e-01 | 98.1% | 47.1% |
| 1vgpA02 | 1.10.230.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450-Terp; domain 2 › Cytochrome P450-Terp, domain 2 | 0.65 | 45.0 | 3.67e-01 | 74.1% | 40.4% |
| 1e1dA02 | 1.20.1270.20 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.65 | 44.0 | 3.94e-01 | 75.9% | 47.6% |
| 2a2fX02 | 1.20.58.670 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain D | 0.63 | 44.0 | 3.39e-01 | 75.9% | 31.8% |
| 1un8A02 | 1.25.40.340 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › DhaL domain | 0.63 | 54.0 | 3.78e-01 | 100.0% | 29.7% |
| 1whuA00 | 1.10.10.400 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Polyribonucleotide nucleotidyltransferase, RNA-binding domain | 0.59 | 42.0 | 3.61e-01 | 81.5% | 53.8% |
| 3umbA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.59 | 44.0 | 3.94e-01 | 81.5% | 79.7% |
| 6wgyA02 | 1.10.230.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450-Terp; domain 2 › Cytochrome P450-Terp, domain 2 | 0.59 | 41.0 | 3.32e-01 | 72.2% | 38.6% |
| 1ig8A03 | 3.40.367.20 | Alpha Beta › 3-Layer(aba) Sandwich › Hexokinase; domain 1 › | 0.58 | 42.0 | 2.76e-01 | 81.5% | 37.7% |
| 2b61A02 | 1.10.1740.110 | Mainly Alpha › Orthogonal Bundle › Rna Polymerase Sigma Factor; Chain: A › | 0.57 | 46.0 | 3.93e-01 | 100.0% | 82.7% |
| 1u97A00 | 1.10.287.1130 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › CytochromE C oxidase copper chaperone | 0.57 | 41.0 | 3.93e-01 | 87.0% | 63.8% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.57 | 45.0 | 4.06e-01 | 87.0% | 78.7% |
| 1cm5A00 | 3.20.70.20 | Alpha Beta › Alpha-Beta Barrel › Anaerobic Ribonucleotide-triphosphate Reductase Large Chain › | 0.56 | 48.0 | 2.69e-01 | 100.0% | 26.7% |
| 3vkgA15 | 1.10.8.1220 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.56 | 44.0 | 3.81e-01 | 92.6% | 63.8% |
| 4ui9Y03 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.55 | 50.0 | 4.41e-01 | 100.0% | 96.2% |
| 3lcnB00 | 1.10.340.40 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Nuclear abundant poly(A) RNA-bind protein 2, N-terminal domain | 0.55 | 47.0 | 3.93e-01 | 100.0% | 54.6% |
| 3e1sA01 | 1.10.10.2220 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.52 | 40.0 | 3.51e-01 | 90.7% | 54.7% |
| 2gu0A02 | 3.30.428.20 | Alpha Beta › 2-Layer Sandwich › HIT family, subunit A › Rotavirus NSP2 fragment, C-terminal domain | 0.51 | 39.0 | 2.81e-01 | 83.3% | 45.3% |
| 5svlA01 | 1.10.287.940 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › atp-gated p2x4 ion channel | 0.51 | 39.0 | 3.63e-01 | 83.3% | 94.1% |
| 2xv4S03 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.51 | 45.0 | 3.79e-01 | 100.0% | 68.5% |
ECOD (20)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3708789 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.78 | 55.0 | 4.60e-01 | 75.9% | 76.8% |
| 4042824 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.77 | 55.0 | 4.85e-01 | 75.9% | 56.2% |
| 4032384 | 604.3.1.0 ↗ | alpha bundles › Spectrin repeat-like › BAG domain › BAG domain | 0.76 | 54.0 | 4.78e-01 | 75.9% | 56.2% |
| 5031591 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.75 | 67.0 | 5.64e-01 | 100.0% | 75.6% |
| 4961961 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.74 | 52.0 | 4.76e-01 | 75.9% | 64.0% |
| 3991595 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.74 | 52.0 | 4.35e-01 | 75.9% | 48.4% |
| 4995682 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.73 | 50.0 | 4.25e-01 | 72.2% | 70.0% |
| 3588414 | 2004.1.1.430 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ABC_tran, ABC_tran_Xtn | 0.69 | 50.0 | 2.83e-01 | 75.9% | 7.7% |
| 3531423 | 5106.1.1.14 ↗ | extended segments › PetG subunit of the cytochrome b6f complex › PetG subunit of the cytochrome b6f complex › PetG subunit of the cytochrome b6f complex › TMEM174 | 0.65 | 45.0 | 4.53e-01 | 75.9% | 78.2% |
| 4083064 | 192.6.1.0 ↗ | alpha bundles › Long alpha-hairpin › Epsilon subunit of F1F0-ATP synthase C-terminal domain › Epsilon subunit of F1F0-ATP synthase C-terminal domain | 0.65 | 45.0 | 4.60e-01 | 75.9% | 77.4% |
| 4042958 | 152.1.2.1 ↗ | alpha arrays › RPB6/omega subunit-like › RPB6/omega subunit-like › RNA polymerase omega subunit › RNA_pol_Rpb6 | 0.64 | 45.0 | 3.77e-01 | 74.1% | 83.2% |
| 4933491 | 3997.1.1.1 ↗ | alpha arrays › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › Helical insertion domain in magnesium chelatase catalytic subunit › CobN-Mg_chel | 0.63 | 47.0 | 3.33e-01 | 94.4% | 25.0% |
| 3927802 | 198.1.1.1 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like › SapB_2 | 0.63 | 45.0 | 4.00e-01 | 83.3% | 52.5% |
| 4567807 | 397.7.1.6 ↗ | few secondary structure elements › Toxic hairpin › Ribosome-inactivating protein luffin P1 › Ribosome-inactivating protein luffin P1 › PF29718 | 0.60 | 49.0 | 4.62e-01 | 90.7% | 80.0% |
| 3739112 | 375.1.1.26 ↗ | few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related › Rpr2 | 0.59 | 49.0 | 4.00e-01 | 98.1% | 90.0% |
| 3804465 | 109.4.1.1273 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_3 | 0.58 | 47.0 | 3.13e-01 | 96.3% | 21.8% |
| 5061090 | 4133.1.1.0 ↗ | alpha arrays › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like | 0.55 | 44.0 | 4.03e-01 | 94.4% | 67.1% |
| 3608662 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.54 | 43.0 | 3.85e-01 | 94.4% | 69.4% |
| 1175749 | 101.1.2.145 ↗ | alpha arrays › HTH › HTH › winged helix domain › HHH_4 | 0.52 | 40.0 | 3.61e-01 | 90.7% | 60.5% |
| 4171497 | 135.1.1.1 ↗ | alpha arrays › Transducin (alpha subunit), insertion domain › Transducin (alpha subunit), insertion domain › Transducin (alpha subunit), insertion domain › G-alpha | 0.51 | 40.0 | 3.28e-01 | 96.3% | 46.7% |