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nonstructural_protein_NS2A
Euk-VirSaint_Louis_encephalitis_virus
nonstructural_protein_NS2A__YP_009329951__Saint_Louis_encephalitis_virus__11080
Identity
- Accession:
- YP_009329951 ↗
- Protein ID:
- nonstructural_protein_NS2A
- Kingdom:
- euk
Quality
71.0
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
St._Louis_encephalitis_virus
TaxID: 11080
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 8-125
Domain cluster:
rep: nonstructural_protein_NS2A__NP_733808__dengue_virus_type_I__11053__D7-117
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01005.25 best | Flavi_NS2A | 81.2 | 1.40e-22 | 95.8% | 50.2% |
D2
medium
residues 126-223
Domain cluster:
representative
CATH (32)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1w53A00 | 1.10.1240.30 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain | 0.70 | 50.0 | 5.37e-01 | 82.7% | 88.1% |
| 2hjmA01 | 1.20.120.460 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › protein pf1176 like | 0.69 | 44.0 | 4.70e-01 | 71.4% | 73.3% |
| 1q6aA00 | 1.10.1240.30 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › KaiA/RbsU domain | 0.67 | 48.0 | 4.72e-01 | 74.5% | 72.9% |
| 3zh9B03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.66 | 50.0 | 4.56e-01 | 78.6% | 81.0% |
| 1paqA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.64 | 55.0 | 4.67e-01 | 93.9% | 92.5% |
| 4gyvE00 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.64 | 44.0 | 3.44e-01 | 72.4% | 85.6% |
| 4l6rA02 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.62 | 54.0 | 3.81e-01 | 94.9% | 43.2% |
| 4r78A02 | 3.90.1200.10 | Alpha Beta › Alpha-Beta Complex › Aminoglycoside 3'-phosphotransferase; Chain: A, domain 2 › Aminoglycoside phosphotransferase (APH), C-terminal lobe | 0.61 | 49.0 | 3.90e-01 | 84.7% | 63.9% |
| 3lwjA00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.61 | 45.0 | 3.66e-01 | 77.6% | 93.3% |
| 1kf6C00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.61 | 41.0 | 3.82e-01 | 70.4% | 86.9% |
| 3ajmB02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.59 | 37.0 | 3.34e-01 | 84.7% | 45.9% |
| 1qv9A02 | 6.10.140.120 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 41.0 | 4.08e-01 | 81.6% | 68.0% |
| 4mndA02 | 1.20.120.1760 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › CDP-alcohol phosphotransferase transmembrane (TM) domain | 0.58 | 44.0 | 3.54e-01 | 79.6% | 50.3% |
| 1a1vA03 | 1.10.820.10 | Mainly Alpha › Orthogonal Bundle › RNA Helicase; Chain A, domain 3 › RNA Helicase Chain A , domain 3 | 0.58 | 45.0 | 3.85e-01 | 83.7% | 86.3% |
| 3juiA00 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 49.0 | 4.16e-01 | 96.9% | 88.5% |
| 7d1tA01 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.57 | 42.0 | 3.48e-01 | 78.6% | 71.4% |
| 1d9cA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.57 | 43.0 | 4.02e-01 | 86.7% | 63.6% |
| 3mzoB00 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.57 | 48.0 | 3.85e-01 | 96.9% | 80.0% |
| 2gnoA03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.56 | 42.0 | 4.24e-01 | 83.7% | 79.0% |
| 3ripA02 | 1.20.120.1900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain | 0.55 | 49.0 | 3.59e-01 | 100.0% | 83.9% |
| 5zr4A01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.55 | 39.0 | 3.90e-01 | 74.5% | 100.0% |
| 4yvoA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.54 | 44.0 | 4.11e-01 | 87.8% | 78.2% |
| 2oezA02 | 1.10.3900.10 | Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like | 0.53 | 40.0 | 3.41e-01 | 96.9% | 47.9% |
| 1gqeA01 | 1.20.58.410 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Release factor | 0.53 | 43.0 | 4.06e-01 | 83.7% | 84.1% |
| 3ay5A02 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.53 | 48.0 | 4.03e-01 | 100.0% | 90.9% |
| 4ezbA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.52 | 38.0 | 3.64e-01 | 78.6% | 85.5% |
| 3gw7A00 | 1.10.3210.50 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › | 0.52 | 44.0 | 3.55e-01 | 98.0% | 94.9% |
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.52 | 44.0 | 3.09e-01 | 93.9% | 74.9% |
| 2wdqC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.51 | 39.0 | 3.67e-01 | 80.6% | 75.2% |
| 2ff4A02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.51 | 42.0 | 3.53e-01 | 92.9% | 79.1% |
| 8hdlA01 | 1.10.600.10 | Mainly Alpha › Orthogonal Bundle › Farnesyl Diphosphate Synthase › Farnesyl Diphosphate Synthase | 0.51 | 41.0 | 3.11e-01 | 87.8% | 65.1% |
| 2v57A00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.51 | 42.0 | 3.57e-01 | 92.9% | 94.2% |
ECOD (15)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4492735 | 4982.1.1.1 ↗ | alpha arrays › KaiA/RbsU domain-like › KaiA/RbsU domain › KaiA/RbsU domain › KaiA | 0.71 | 49.0 | 4.45e-01 | 71.4% | 56.9% |
| 3256824 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.63 | 50.0 | 3.62e-01 | 85.7% | 58.9% |
| 3287705 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 43.0 | 3.28e-01 | 71.4% | 80.4% |
| 3517672 | 601.1.1.7 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Talin_IBS2B | 0.57 | 44.0 | 3.76e-01 | 80.6% | 88.7% |
| 5078378 | 601.7.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain › HepT-like | 0.55 | 43.0 | 3.73e-01 | 80.6% | 68.3% |
| 3705915 | 3615.1.1.0 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain | 0.55 | 44.0 | 4.16e-01 | 99.0% | 72.5% |
| 4944467 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.54 | 48.0 | 3.05e-01 | 100.0% | 43.5% |
| 3269138 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.54 | 47.0 | 3.52e-01 | 100.0% | 37.6% |
| 3419521 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 39.0 | 3.72e-01 | 77.6% | 87.0% |
| 3956517 | 5069.1.3.3 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Fumarate_red_D | 0.53 | 40.0 | 3.78e-01 | 80.6% | 79.2% |
| 4944304 | 109.4.1.198 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_12 | 0.52 | 48.0 | 2.99e-01 | 100.0% | 32.6% |
| 3649512 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.52 | 39.0 | 2.97e-01 | 83.7% | 78.9% |
| 3458540 | 3755.4.1.17 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Rx_N | 0.51 | 40.0 | 3.85e-01 | 83.7% | 100.0% |
| 3944446 | 5069.1.3.1 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Sdh_cyt | 0.51 | 35.0 | 3.79e-01 | 71.4% | 91.8% |
| 4497855 | 5069.1.3.2 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Fumarate reductase respiratory complex transmembrane subunits › Fumarate_red_C | 0.51 | 36.0 | 3.35e-01 | 72.4% | 69.9% |