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nonstructural_protein_NS2B
Euk-VirZika_virus
nonstructural_protein_NS2B__YP_009430303__Zika_virus__64320
Identity
- Accession:
- YP_009430303 ↗
- Protein ID:
- nonstructural_protein_NS2B
- Kingdom:
- euk
Quality
68.7
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Zika_virus
TaxID: 64320
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 4-49_81-129
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01002.24 best | Flavi_NS2B | 29.5 | 8.60e-07 | 48.4% | 33.9% |
CATH (25)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2vx2G02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.74 | 40.0 | 5.14e-01 | 94.7% | 92.7% |
| 1z5zA02 | 1.20.120.850 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SWI2/SNF2 ATPases, N-terminal domain | 0.66 | 47.0 | 5.25e-01 | 88.4% | 93.4% |
| 4adnA01 | 1.20.1280.250 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.62 | 46.0 | 4.83e-01 | 96.8% | 89.4% |
| 3b9qA01 | 1.20.120.140 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain | 0.61 | 48.0 | 4.95e-01 | 100.0% | 92.1% |
| 2wl8C00 | 1.20.120.900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pex19, mPTS binding domain | 0.59 | 38.0 | 3.68e-01 | 95.8% | 56.9% |
| 3nkzA00 | 1.20.58.380 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Flagellar protein flit. | 0.59 | 44.0 | 4.43e-01 | 80.0% | 82.5% |
| 7eu3E01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 41.0 | 4.29e-01 | 77.9% | 80.5% |
| 4tkrA00 | 1.10.1760.20 | Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 › | 0.58 | 50.0 | 4.12e-01 | 98.9% | 65.0% |
| 2crbA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.58 | 41.0 | 4.10e-01 | 81.1% | 72.2% |
| 6o0aA01 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.57 | 44.0 | 3.77e-01 | 81.1% | 77.9% |
| 7c1iA01 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.57 | 45.0 | 4.42e-01 | 92.6% | 78.0% |
| 4cybD00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.57 | 43.0 | 3.53e-01 | 80.0% | 80.1% |
| 7d3uC01 | 1.10.287.3510 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.56 | 41.0 | 4.03e-01 | 77.9% | 76.6% |
| 6vmsR00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.56 | 50.0 | 3.63e-01 | 100.0% | 48.9% |
| 4xpwA00 | 1.20.120.50 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Hemerythrin-like | 0.56 | 48.0 | 4.35e-01 | 96.8% | 83.2% |
| 4cgrB00 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.56 | 48.0 | 3.91e-01 | 98.9% | 64.9% |
| 3pvuA02 | 1.10.167.10 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 | 0.55 | 41.0 | 4.40e-01 | 85.3% | 92.5% |
| 8jpdG01 | 1.10.167.10 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 | 0.55 | 41.0 | 3.62e-01 | 88.4% | 53.1% |
| 1q0gA00 | 1.20.120.400 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nickel-containing superoxide dismutase | 0.54 | 45.0 | 4.24e-01 | 92.6% | 84.6% |
| 1dtoA01 | 1.10.287.30 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › E2 (early) protein, N terminal domain, subdomain 1 | 0.53 | 40.0 | 3.91e-01 | 80.0% | 98.0% |
| 2xl4A00 | 1.20.120.1420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › LntA helical domain | 0.53 | 45.0 | 3.89e-01 | 92.6% | 78.9% |
| 2b1eA01 | 1.20.58.1150 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 35.0 | 3.73e-01 | 80.0% | 76.7% |
| 2jx0A00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.52 | 43.0 | 3.95e-01 | 92.6% | 86.3% |
| 3l8rA00 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.51 | 39.0 | 3.87e-01 | 81.1% | 86.3% |
| 1iq0A03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.50 | 42.0 | 3.92e-01 | 90.5% | 81.0% |
ECOD (19)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3613310 | 2004.1.1.30 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Helicase_C | 0.70 | 58.0 | 4.08e-01 | 88.4% | 87.0% |
| 4978586 | 604.9.1.0 ↗ | alpha bundles › Spectrin repeat-like › Ribosomal protein S20 › Ribosomal protein S20 | 0.66 | 42.0 | 4.06e-01 | 81.1% | 56.4% |
| 4032867 | 601.1.1.11 ↗ | alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › EcsB | 0.65 | 50.0 | 4.39e-01 | 81.1% | 62.1% |
| 3973079 | 5065.1.1.0 ↗ | alpha bundles › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold › Type II ABC importer transmembrane domain fold | 0.65 | 58.0 | 4.11e-01 | 100.0% | 39.0% |
| 5020952 | 605.1.1.356 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › DUF2178 | 0.64 | 56.0 | 5.19e-01 | 100.0% | 92.0% |
| 3748894 | 6155.1.1.0 ↗ | alpha duplicates or obligate multimers › TOG superfamily › SWEET transporter › SWEET transporter | 0.63 | 49.0 | 4.12e-01 | 83.2% | 55.8% |
| 3445635 | 3718.1.1.23 ↗ | alpha bundles › Flagellar protein fliT › Flagellar protein fliT › Flagellar protein fliT › ALMT | 0.63 | 47.0 | 4.45e-01 | 78.9% | 69.6% |
| 3477809 | 1005.1.1.0 ↗ | alpha arrays › Cell-shape determining Csd6 N-terminal dimerization domain › Cell-shape determining Csd6 N-terminal dimerization domain › Cell-shape determining Csd6 N-terminal dimerization domain | 0.61 | 43.0 | 4.69e-01 | 83.2% | 93.3% |
| 3266671 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.57 | 43.0 | 4.22e-01 | 81.1% | 73.3% |
| 4104105 | 5076.2.1.9 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › Choline_transpo | 0.56 | 51.0 | 3.62e-01 | 100.0% | 54.5% |
| 3591396 | 3866.1.1.0 ↗ | extended segments › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25 › Mitochondrial 54S ribosomal protein L25 | 0.54 | 42.0 | 4.25e-01 | 81.1% | 85.3% |
| 3188597 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.54 | 41.0 | 4.26e-01 | 80.0% | 87.8% |
| 4984545 | 601.7.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain | 0.53 | 42.0 | 4.29e-01 | 92.6% | 88.9% |
| 3239393 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.53 | 44.0 | 4.20e-01 | 91.6% | 87.3% |
| 3466653 | 192.29.1.101 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Rx_N | 0.53 | 47.0 | 4.42e-01 | 98.9% | 90.4% |
| 4944640 | 604.6.1.0 ↗ | alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain | 0.52 | 40.0 | 3.88e-01 | 81.1% | 83.8% |
| 4999706 | 2003.1.5.66 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 | 0.52 | 38.0 | 2.91e-01 | 77.9% | 74.2% |
| 3934161 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.51 | 41.0 | 3.16e-01 | 86.3% | 69.8% |
| 3974503 | 601.4.1.4 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › PilJ | 0.50 | 42.0 | 4.09e-01 | 96.8% | 93.3% |