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nonstructural_protein_NS2
Euk-VirNorway_rat_hepacivirus_1
nonstructural_protein_NS2__YP_009325396__Norway_rat_hepacivirus_1__1562038
Identity
- Accession:
- YP_009325396 ↗
- Protein ID:
- nonstructural_protein_NS2
- Kingdom:
- euk
Quality
80.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Norway_rat_hepacivirus_1
TaxID: 1562038
Cluster
View cluster (17 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 2-128
Domain cluster:
representative
CATH (43)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1cnt200 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.78 | 38.0 | 3.84e-01 | 79.5% | 46.2% |
| 3mq1A01 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.72 | 41.0 | 4.80e-01 | 77.2% | 78.3% |
| 1cxzB00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.71 | 42.0 | 5.00e-01 | 82.7% | 87.2% |
| 3r84A00 | 1.10.287.3490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.69 | 43.0 | 5.16e-01 | 76.4% | 96.3% |
| 2lm9A00 | 1.20.58.970 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.69 | 40.0 | 4.51e-01 | 78.0% | 75.0% |
| 2dq0A01 | 1.10.287.40 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain | 0.68 | 44.0 | 4.80e-01 | 74.8% | 77.6% |
| 3zgxA02 | 6.10.140.1720 | Special › Helix non-globular › Helix Hairpins › | 0.68 | 39.0 | 4.57e-01 | 73.2% | 79.1% |
| 4xvxA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 44.0 | 4.20e-01 | 83.5% | 57.1% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.66 | 43.0 | 5.03e-01 | 76.4% | 93.3% |
| 2gl2B00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.66 | 51.0 | 5.43e-01 | 80.3% | 100.0% |
| 2dw4A03 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.65 | 43.0 | 4.79e-01 | 72.4% | 84.2% |
| 4cqiA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.65 | 50.0 | 5.38e-01 | 89.0% | 96.3% |
| 2lw1A00 | 1.10.287.380 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain | 0.65 | 43.0 | 5.11e-01 | 86.6% | 100.0% |
| 1qsdA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 47.0 | 5.14e-01 | 88.2% | 96.1% |
| 3fppA03 | 6.10.140.1990 | Special › Helix non-globular › Helix Hairpins › | 0.63 | 38.0 | 4.48e-01 | 73.2% | 86.4% |
| 8ipqB01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.61 | 47.0 | 3.50e-01 | 78.7% | 95.9% |
| 2v0xA01 | 1.10.287.3160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 42.0 | 3.85e-01 | 70.9% | 78.0% |
| 3g67A00 | 1.10.287.950 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein | 0.60 | 49.0 | 4.08e-01 | 85.8% | 95.3% |
| 6q45G01 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.60 | 44.0 | 4.25e-01 | 77.2% | 87.7% |
| 7zo9A01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.60 | 48.0 | 3.55e-01 | 84.3% | 90.4% |
| 2bl2A00 | 1.20.120.610 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase | 0.60 | 37.0 | 3.48e-01 | 73.2% | 49.4% |
| 2rd0B00 | 1.10.287.1490 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 46.0 | 4.52e-01 | 82.7% | 84.2% |
| 6p6jB01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.58 | 47.0 | 3.49e-01 | 85.8% | 91.1% |
| 1i6zA00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.58 | 43.0 | 4.24e-01 | 90.6% | 72.6% |
| 7wivA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.58 | 46.0 | 3.49e-01 | 85.8% | 93.2% |
| 1x04A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.58 | 44.0 | 3.86e-01 | 83.5% | 52.0% |
| 4hteA02 | 1.20.58.1740 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 40.0 | 4.13e-01 | 70.1% | 92.3% |
| 3zdqA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.57 | 45.0 | 3.35e-01 | 84.3% | 86.8% |
| 3o6xA02 | 1.20.120.1560 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.57 | 45.0 | 4.28e-01 | 86.6% | 71.6% |
| 6yz2A01 | 1.20.120.350 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C | 0.57 | 43.0 | 4.49e-01 | 89.8% | 84.2% |
| 3k29A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.57 | 40.0 | 3.75e-01 | 73.2% | 78.9% |
| 2b5uA02 | 1.10.287.620 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix Hairpins | 0.57 | 45.0 | 4.17e-01 | 84.3% | 88.8% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.56 | 41.0 | 3.85e-01 | 84.3% | 61.6% |
| 2oexA02 | 1.20.140.50 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › alix/aip1 like domains | 0.55 | 45.0 | 3.96e-01 | 89.0% | 79.2% |
| 1y1uA01 | 1.20.1050.20 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › STAT transcription factor, all-alpha domain | 0.55 | 49.0 | 4.30e-01 | 99.2% | 84.6% |
| 3vkgA12 | 1.10.287.2610 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 40.0 | 3.37e-01 | 75.6% | 45.6% |
| 1quuA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 41.0 | 4.15e-01 | 97.6% | 81.7% |
| 4l8iB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.53 | 40.0 | 4.30e-01 | 88.2% | 90.2% |
| 3i9yA00 | 1.20.58.920 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 40.0 | 3.37e-01 | 82.7% | 70.3% |
| 6tqfA01 | 1.20.1560.10 | Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain | 0.52 | 43.0 | 3.04e-01 | 89.0% | 39.1% |
| 2y44A00 | 1.20.1260.80 | Mainly Alpha › Up-down Bundle › Ferritin › | 0.52 | 41.0 | 3.68e-01 | 85.8% | 67.9% |
| 5x9vA01 | 1.10.560.10 | Mainly Alpha › Orthogonal Bundle › GROEL; domain 1 › GroEL-like equatorial domain | 0.51 | 41.0 | 3.33e-01 | 85.0% | 74.3% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.51 | 37.0 | 3.59e-01 | 76.4% | 91.2% |
ECOD (46)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3918080 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.75 | 44.0 | 4.89e-01 | 80.3% | 73.0% |
| 3975940 | 601.4.1.6 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › TorS_sensor_domain | 0.69 | 43.0 | 4.05e-01 | 89.0% | 52.0% |
| 1276361 | 192.7.1.2 ↗ | alpha bundles › Long alpha-hairpin › tRNA-binding arm › tRNA-binding arm › Seryl_tRNA_N | 0.68 | 45.0 | 4.76e-01 | 74.8% | 73.3% |
| 3593427 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.68 | 56.0 | 5.21e-01 | 86.6% | 87.1% |
| 4033315 | 601.18.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 | 0.68 | 46.0 | 4.16e-01 | 70.1% | 50.3% |
| 3275656 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.65 | 43.0 | 4.09e-01 | 84.3% | 56.7% |
| 3742152 | 4177.1.1.0 ↗ | alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like | 0.64 | 45.0 | 3.67e-01 | 77.2% | 40.0% |
| 3858356 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.63 | 51.0 | 4.94e-01 | 87.4% | 92.4% |
| 5070735 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.63 | 45.0 | 4.00e-01 | 76.4% | 53.1% |
| 4932148 | 3755.4.1.0 ↗ | alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain | 0.62 | 44.0 | 4.45e-01 | 71.7% | 72.8% |
| 3385717 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.62 | 44.0 | 4.02e-01 | 73.2% | 61.2% |
| 3626504 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.62 | 48.0 | 3.96e-01 | 89.0% | 45.2% |
| 3693258 | 604.7.1.1 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA | 0.61 | 48.0 | 5.10e-01 | 91.3% | 99.1% |
| 4622994 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.60 | 48.0 | 3.54e-01 | 84.3% | 86.8% |
| 3975632 | 5086.1.1.92 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AprE | 0.60 | 41.0 | 3.60e-01 | 75.6% | 47.0% |
| 3498458 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 44.0 | 4.04e-01 | 76.4% | 63.0% |
| 3445974 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.60 | 48.0 | 3.65e-01 | 86.6% | 94.4% |
| 4523639 | 5086.1.1.92 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AprE | 0.60 | 41.0 | 3.56e-01 | 75.6% | 45.8% |
| 3456475 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.59 | 48.0 | 3.59e-01 | 86.6% | 93.9% |
| 4945254 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.59 | 48.0 | 3.53e-01 | 86.6% | 87.3% |
| 3453972 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.59 | 52.0 | 5.06e-01 | 97.6% | 87.1% |
| 4875104 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 47.0 | 3.48e-01 | 85.8% | 87.2% |
| 1313624 | 5086.1.1.92 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_AprE | 0.58 | 41.0 | 3.75e-01 | 72.4% | 92.8% |
| 3906208 | 604.7.1.12 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA_PH | 0.58 | 49.0 | 4.71e-01 | 91.3% | 97.9% |
| 3943905 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 47.0 | 3.42e-01 | 85.8% | 86.7% |
| 3987989 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.58 | 47.0 | 3.53e-01 | 86.6% | 93.1% |
| 5069236 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.57 | 39.0 | 3.59e-01 | 82.7% | 50.9% |
| 3284311 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.57 | 47.0 | 3.46e-01 | 86.6% | 89.7% |
| 3880244 | 603.2.1.24 ↗ | alpha bundles › STAT-like › STAT › STAT › TBCA_PH | 0.57 | 49.0 | 4.60e-01 | 94.5% | 97.4% |
| 4617696 | 1075.4.1.2 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane_2 | 0.56 | 47.0 | 3.41e-01 | 89.0% | 85.4% |
| 4487150 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.56 | 45.0 | 3.27e-01 | 84.3% | 36.5% |
| 3961356 | 1075.4.1.2 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane_2 | 0.56 | 46.0 | 3.27e-01 | 89.0% | 39.3% |
| 3659069 | 604.7.1.1 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA | 0.56 | 48.0 | 4.89e-01 | 94.5% | 100.0% |
| 3917262 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.56 | 45.0 | 4.42e-01 | 89.8% | 82.2% |
| 3701429 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.55 | 46.0 | 4.13e-01 | 90.6% | 86.9% |
| 4944553 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.55 | 43.0 | 3.28e-01 | 82.7% | 44.5% |
| 3988427 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.55 | 43.0 | 3.23e-01 | 83.5% | 40.0% |
| 3989648 | 1203.1.2.17 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › ABC_membrane | 0.54 | 42.0 | 3.58e-01 | 80.3% | 61.5% |
| 4021653 | 1075.4.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold | 0.54 | 42.0 | 3.14e-01 | 81.1% | 89.5% |
| 4024594 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.53 | 41.0 | 3.01e-01 | 81.9% | 37.4% |
| 5056762 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.53 | 44.0 | 3.27e-01 | 92.1% | 86.6% |
| 3715936 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.52 | 41.0 | 3.72e-01 | 85.0% | 62.3% |
| 3872051 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.52 | 46.0 | 3.95e-01 | 99.2% | 96.6% |
| 5008718 | 2004.1.1.198 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 | 0.52 | 41.0 | 2.82e-01 | 85.0% | 25.0% |
| 4821107 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.51 | 41.0 | 3.15e-01 | 88.2% | 88.7% |
| 4822553 | 1075.4.1.1 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane | 0.51 | 45.0 | 3.26e-01 | 100.0% | 66.7% |
D2
medium
residues 129-198
Domain cluster:
rep: nonstructural_protein_NS2__YP_009679008__Hepacivirus_N__2008773__D147-204