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nonstructural_protein_NS2

Euk-Vir

Non-primate_hepacivirus_NZP1

nonstructural_protein_NS2__YP_009664197__Non-primate_hepacivirus_NZP1__1605403

Identity

Accession:: YP_009664197 ↗
Protein ID:: nonstructural_protein_NS2
Kingdom:: euk

Quality

71.3 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Hepacivirus› Non-primate_hepacivirus_NZP1

TaxID: 1605403

Cluster

View cluster (17 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 108-158

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01538.24 best	HCV_NS2	43.8	3.20e-11	100.0%	25.6%

CATH (17)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hd0A01	1.20.1280.150	Mainly Alpha › Up-down Bundle › Monooxygenase › Hepatitis C virus non-structural protein NS2, N-terminal domain	0.90	83.0	7.05e-01	100.0%	65.4%
3rmqA02	6.10.140.1650	Special › Helix non-globular › Helix Hairpins ›	0.67	55.0	5.44e-01	100.0%	87.5%
5c8aA01	1.10.1240.10	Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain	0.66	55.0	4.94e-01	100.0%	89.7%
4n5qA00	1.25.40.20	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain	0.65	56.0	3.64e-01	100.0%	28.5%
3ne5B04	6.10.140.730	Special › Helix non-globular › Helix Hairpins ›	0.65	48.0	4.89e-01	84.3%	86.3%
1j5wA02	1.20.58.180	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2	0.62	51.0	4.50e-01	94.1%	81.8%
3onqA01	1.20.5.5100	Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces ›	0.61	46.0	4.92e-01	100.0%	100.0%
5z2mB00	1.25.40.20	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Ankyrin repeat-containing domain	0.61	50.0	3.85e-01	100.0%	48.9%
4a1nA02	6.10.250.1250	Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces ›	0.61	44.0	4.42e-01	92.2%	84.0%
7mqzA01	1.25.40.10	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain	0.61	49.0	3.30e-01	100.0%	22.8%
3kd4A02	3.10.620.30	Alpha Beta › Roll › C8orf32 fold ›	0.59	48.0	3.55e-01	100.0%	70.6%
2ra1A02	1.20.58.780	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	48.0	4.44e-01	96.1%	98.5%
5czdB00	1.10.1200.10	Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › ACP-like	0.57	44.0	3.95e-01	88.2%	83.1%
3c8cB02	3.30.450.20	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › PAS domain	0.57	45.0	3.66e-01	96.1%	97.3%
2ra1A03	1.20.58.770	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.55	43.0	4.14e-01	94.1%	87.3%
1v9dA01	1.20.58.630	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.51	42.0	3.65e-01	100.0%	88.4%
3fx3B02	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.50	41.0	3.52e-01	100.0%	57.9%

ECOD (15)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
185953	3427.1.1.1 ↗	beta barrels › Catalytic domain of hepatitis C virus NS2-3 protease › Catalytic domain of hepatitis C virus NS2-3 protease › Catalytic domain of hepatitis C virus NS2-3 protease › HCV_NS2	0.90	83.0	6.00e-01	100.0%	40.2%
3730605	109.4.1.883 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2	0.71	62.0	4.79e-01	100.0%	51.3%
4014760	558.1.1.0 ↗	alpha duplicates or obligate multimers › Lis-homology dimerization domain › Lis-homology dimerization domain › Lis-homology dimerization domain	0.71	48.0	4.78e-01	76.5%	67.3%
4013705	109.4.1.2134 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_3, TPR_24	0.71	60.0	3.94e-01	100.0%	26.4%
3692854	109.4.1.1356 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_2, PPR_3, PPR_long	0.70	60.0	4.41e-01	100.0%	38.6%
5009729	1030.1.1.0 ↗	alpha duplicates or obligate multimers › Crispr-associated protein Csm2 › Crispr-associated protein Csm2 › Crispr-associated protein Csm2	0.70	54.0	4.18e-01	86.3%	51.3%
4154002	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.67	56.0	3.82e-01	100.0%	51.4%
1103158	6119.1.1.2 ↗	alpha bundles › Helical bundle domain in CusB › Helical bundle domain in CusB › Helical bundle domain in CusB › PF25869	0.67	50.0	5.03e-01	84.3%	83.0%
3219715	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.66	56.0	4.91e-01	100.0%	97.5%
3411675	109.46.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2)	0.65	51.0	3.83e-01	86.3%	84.0%
3733653	109.3.1.2 ↗	alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2	0.64	53.0	3.52e-01	100.0%	28.6%
3574981	604.12.1.91 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › RSLD_CPSF6	0.62	50.0	4.60e-01	94.1%	85.7%
4966212	101.1.1.60 ↗	alpha arrays › HTH › HTH › Three-helical HTH › HTH_23	0.58	41.0	3.78e-01	84.3%	58.5%
2774009	109.4.1.1300 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8, TPR_16, TPR_19	0.56	43.0	3.97e-01	94.1%	64.8%
4972724	316.1.1.21 ↗	a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › Aminoglyc_resit	0.54	43.0	3.11e-01	100.0%	29.7%

D2 medium residues 173-216

PDB

Domain cluster: rep: putative_NS2_peptide__YP_009227301__Human_pegivirus_2__1729141__D193-239

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01538.24 best	HCV_NS2	35.3	1.40e-08	54.5%	12.3%