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nonstructural_protein_NS2
Euk-VirHepacivirus_B
nonstructural_protein_NS2__YP_009678988__Hepacivirus_B__2008762
Identity
- Accession:
- YP_009678988 ↗
- Protein ID:
- nonstructural_protein_NS2
- Kingdom:
- euk
Quality
76.8
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Hepacivirus_platyrrhini
TaxID: 2008762
Cluster
View cluster (3 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 3-94
D2
medium
residues 99-150
Domain cluster:
representative
CATH (30)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2hd0A01 | 1.20.1280.150 | Mainly Alpha › Up-down Bundle › Monooxygenase › Hepatitis C virus non-structural protein NS2, N-terminal domain | 0.80 | 70.0 | 6.18e-01 | 100.0% | 67.9% |
| 1sxjE03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.70 | 61.0 | 5.03e-01 | 100.0% | 92.8% |
| 3lsjA02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.70 | 60.0 | 4.39e-01 | 100.0% | 62.7% |
| 1vqrD00 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.68 | 58.0 | 3.71e-01 | 98.1% | 20.7% |
| 1sz9C00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.68 | 58.0 | 4.33e-01 | 100.0% | 65.0% |
| 8carA01 | 1.50.10.10 | Mainly Alpha › Alpha/alpha barrel › Glycosyltransferase › | 0.67 | 56.0 | 3.40e-01 | 98.1% | 21.6% |
| 4jxtA00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.66 | 55.0 | 4.25e-01 | 100.0% | 70.8% |
| 1j5wA02 | 1.20.58.180 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2 | 0.65 | 56.0 | 4.94e-01 | 98.1% | 83.1% |
| 1vt0M05 | 6.10.280.90 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.64 | 44.0 | 3.94e-01 | 73.1% | 70.3% |
| 1uujA00 | 1.20.960.30 | Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A › | 0.63 | 43.0 | 3.80e-01 | 75.0% | 47.4% |
| 2lo6A00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.63 | 52.0 | 3.87e-01 | 100.0% | 66.9% |
| 5ab0C04 | 1.25.50.20 | Mainly Alpha › Alpha Horseshoe › Zincin-like fold › | 0.63 | 52.0 | 3.21e-01 | 96.2% | 16.0% |
| 1yhuB00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.63 | 51.0 | 3.92e-01 | 100.0% | 53.5% |
| 3fhnA01 | 6.10.280.210 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Dsl1p vesicle tethering complex, Tip20p subunit, domain A | 0.61 | 51.0 | 3.60e-01 | 100.0% | 38.6% |
| 1zeeA01 | 1.20.58.600 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.61 | 51.0 | 4.05e-01 | 100.0% | 58.5% |
| 1e5rB02 | 1.10.1720.10 | Mainly Alpha › Orthogonal Bundle › Proline Oxidase; Chain: A, Domain 2 › L-proline 3-hydroxylase, C-terminal domain | 0.60 | 49.0 | 4.35e-01 | 100.0% | 75.0% |
| 1iygA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.60 | 45.0 | 3.53e-01 | 100.0% | 34.6% |
| 2kxpA01 | 3.30.1140.60 | Alpha Beta › 2-Layer Sandwich › Ribosomal protein S3 C-terminal domain › F-actin capping protein, alpha subunit | 0.60 | 49.0 | 4.04e-01 | 100.0% | 86.9% |
| 1wrdA00 | 1.20.58.160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 51.0 | 4.22e-01 | 100.0% | 78.6% |
| 2bnxB01 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.60 | 47.0 | 3.18e-01 | 96.2% | 42.1% |
| 5cwkA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.59 | 49.0 | 3.57e-01 | 100.0% | 31.0% |
| 4od8D00 | 6.10.140.1880 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 46.0 | 4.70e-01 | 94.2% | 86.3% |
| 2dpmA02 | 1.10.1020.10 | Mainly Alpha › Orthogonal Bundle › Adenine-specific Methyltransferase; domain 2 › Adenine-specific Methyltransferase, Domain 2 | 0.59 | 46.0 | 3.77e-01 | 88.5% | 46.6% |
| 3hhwK01 | 1.10.3570.10 | Mainly Alpha › Orthogonal Bundle › Rhabdovirus nucleoprotein-like fold › Rhabdovirus nucleocapsid protein like domain | 0.59 | 44.0 | 3.18e-01 | 98.1% | 25.1% |
| 1cfzA00 | 3.40.50.1450 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HybD-like | 0.58 | 46.0 | 3.24e-01 | 84.6% | 98.1% |
| 2ds2D01 | 1.10.110.10 | Mainly Alpha › Orthogonal Bundle › Hydrophobic Seed Protein › Plant lipid-transfer and hydrophobic proteins | 0.57 | 46.0 | 4.49e-01 | 92.3% | 94.7% |
| 1qagA01 | 1.10.418.10 | Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Calponin-like domain | 0.56 | 46.0 | 3.72e-01 | 90.4% | 82.0% |
| 4s2rQ03 | 3.90.230.10 | Alpha Beta › Alpha-Beta Complex › Creatine Amidinohydrolase › Creatinase/methionine aminopeptidase superfamily | 0.56 | 41.0 | 2.66e-01 | 84.6% | 76.4% |
| 3k3oA02 | 1.20.58.1360 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.52 | 42.0 | 3.77e-01 | 100.0% | 83.3% |
| 2o4cA03 | 3.30.1370.170 | Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S8; Chain: A, domain 1 › Erythronate-4-phosphate dehydrogenase, dimerisation domain | 0.51 | 43.0 | 3.69e-01 | 100.0% | 93.2% |
ECOD (33)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3420666 | 109.4.1.1296 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_1, PPR_2, PPR_long, TPR_24 | 0.79 | 70.0 | 4.22e-01 | 100.0% | 17.4% |
| 3241639 | 109.4.1.1436 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_3, Rib_mS39_PPR | 0.78 | 69.0 | 3.85e-01 | 100.0% | 12.8% |
| 3823363 | 109.4.1.1371 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, Eplus_motif, E_motif | 0.75 | 66.0 | 3.89e-01 | 100.0% | 13.8% |
| 3647085 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.75 | 66.0 | 4.38e-01 | 100.0% | 27.6% |
| 3648151 | 109.4.1.1256 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3 | 0.74 | 67.0 | 4.87e-01 | 100.0% | 40.7% |
| 3671366 | 109.4.1.1271 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, TPR_24 | 0.74 | 64.0 | 3.58e-01 | 100.0% | 13.6% |
| 3257613 | 109.4.1.1260 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3, PPR_long | 0.73 | 64.0 | 5.12e-01 | 100.0% | 57.1% |
| 3464529 | 109.4.1.883 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR+PPR_2 | 0.72 | 63.0 | 3.84e-01 | 100.0% | 17.3% |
| 3442580 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.72 | 54.0 | 3.84e-01 | 86.5% | 64.6% |
| 3376709 | 138.1.1.11 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › RFC_C | 0.71 | 61.0 | 5.16e-01 | 100.0% | 90.0% |
| 3343787 | 109.4.1.1374 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, TPR_24 | 0.70 | 61.0 | 4.31e-01 | 100.0% | 45.6% |
| 3934545 | 109.4.1.70 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CID | 0.69 | 59.0 | 4.30e-01 | 100.0% | 50.0% |
| 4610045 | 109.4.1.207 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › HEAT_2 | 0.69 | 55.0 | 3.82e-01 | 100.0% | 25.1% |
| 3673343 | 138.1.1.0 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain | 0.69 | 57.0 | 4.63e-01 | 96.2% | 91.4% |
| 3630004 | 176.1.1.1 ↗ | alpha arrays › Annexin › Annexin › Annexin › Annexin | 0.68 | 58.0 | 5.23e-01 | 100.0% | 85.3% |
| 3274319 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.67 | 56.0 | 3.94e-01 | 100.0% | 33.2% |
| 3553046 | 109.4.1.875 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › CNOT1_1st | 0.67 | 56.0 | 4.07e-01 | 100.0% | 45.2% |
| 1712010 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.66 | 55.0 | 5.55e-01 | 98.1% | 100.0% |
| 3363864 | 170.1.1.15 ↗ | alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C › Retrotran_gag_2 | 0.66 | 56.0 | 4.63e-01 | 100.0% | 75.0% |
| 3313973 | 170.1.1.0 ↗ | alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C | 0.66 | 57.0 | 4.68e-01 | 100.0% | 75.0% |
| 3729461 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.65 | 56.0 | 4.04e-01 | 100.0% | 70.0% |
| 3372591 | 170.1.1.15 ↗ | alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C › Retrotran_gag_2 | 0.65 | 56.0 | 4.52e-01 | 100.0% | 74.3% |
| 3671771 | 109.4.1.420 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR | 0.63 | 54.0 | 4.26e-01 | 100.0% | 58.3% |
| 1556778 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.63 | 54.0 | 4.13e-01 | 100.0% | 43.7% |
| 3473786 | 109.4.1.1427 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_6, TPR_8, TPR_19 | 0.61 | 50.0 | 3.44e-01 | 96.2% | 26.0% |
| 3343428 | 170.1.1.0 ↗ | alpha bundles › Retrovirus capsid protein › Retrovirus capsid protein-C › Retrovirus capsid protein-C | 0.61 | 51.0 | 4.82e-01 | 96.2% | 92.3% |
| 3246574 | 109.4.1.257 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PDS5 | 0.60 | 50.0 | 3.12e-01 | 100.0% | 16.3% |
| 3632915 | 109.27.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › BACK domain › BACK domain | 0.60 | 51.0 | 4.68e-01 | 100.0% | 78.6% |
| 3997012 | 604.30.1.1 ↗ | alpha bundles › Spectrin repeat-like › Gamma-secretase subunit PEN-2 › Gamma-secretase subunit PEN-2 › PEN-2 | 0.60 | 52.0 | 4.30e-01 | 100.0% | 57.9% |
| 3422327 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.59 | 48.0 | 2.90e-01 | 100.0% | 22.1% |
| 3900684 | 109.4.1.1255 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Adaptin_N, Cnd1 | 0.59 | 48.0 | 3.64e-01 | 100.0% | 35.4% |
| 3230694 | 1065.1.1.5 ↗ | alpha bundles › SPX domain › SPX domain › SPX domain › DUF19 | 0.59 | 50.0 | 3.68e-01 | 100.0% | 45.3% |
| 2992201 | 6171.1.1.1 ↗ | alpha bundles › C-terminal helical domain in Jumonji domain-containing histone demethylases › C-terminal helical domain in Jumonji domain-containing histone demethylases › C-terminal helical domain in Jumonji domain-containing histone demethylases › JHD | 0.57 | 48.0 | 3.84e-01 | 96.2% | 67.3% |
D3
medium
residues 164-207
Domain cluster:
rep: putative_NS2_peptide__YP_009227301__Human_pegivirus_2__1729141__D193-239