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nonstructural_protein_NS2

Euk-Vir

Hepacivirus_N

nonstructural_protein_NS2__YP_009679008__Hepacivirus_N__2008773

Identity

Accession:: YP_009679008 ↗
Protein ID:: nonstructural_protein_NS2
Kingdom:: euk

Quality

70.3 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Hepacivirus› Hepacivirus_bovis

TaxID: 2008773

Cluster

Singleton — not in a non-trivial cluster

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 8-93

PDB

D2 medium residues 95-146

PDB

Domain cluster: representative

CATH (21)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2hd0A01	1.20.1280.150	Mainly Alpha › Up-down Bundle › Monooxygenase › Hepatitis C virus non-structural protein NS2, N-terminal domain	0.80	70.0	6.14e-01	98.1%	74.4%
3ne5B04	6.10.140.730	Special › Helix non-globular › Helix Hairpins ›	0.69	54.0	5.53e-01	88.5%	92.2%
1jgcA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.67	54.0	3.83e-01	90.4%	45.0%
5mmiJ02	1.10.10.250	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Ribosomal protein L11/L12, C-terminal domain	0.66	47.0	4.25e-01	75.0%	92.8%
1j5wA02	1.20.58.180	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Class II aaRS and biotin synthetases; domain 2	0.66	57.0	5.04e-01	100.0%	83.1%
1nfvA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.65	54.0	3.76e-01	92.3%	42.0%
2qqyA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.65	54.0	3.97e-01	92.3%	52.2%
2fjcB00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.65	53.0	3.76e-01	90.4%	48.1%
2yfaB01	1.20.1440.210	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) ›	0.64	50.0	3.89e-01	88.5%	92.4%
4a1nA02	6.10.250.1250	Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces ›	0.63	48.0	4.85e-01	98.1%	90.0%
2c2jA00	1.20.1260.10	Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle	0.62	53.0	3.79e-01	100.0%	82.4%
2gscC00	1.20.1440.60	Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence	0.61	54.0	4.24e-01	98.1%	63.6%
2xryA03	1.10.579.10	Mainly Alpha › Orthogonal Bundle › DNA Cyclobutane Dipyrimidine Photolyase, subunit A; domain 3 › DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3	0.61	49.0	3.70e-01	96.2%	44.0%
2rp4A00	6.10.280.60	Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Transcription factor p53, C-terminal domain	0.60	41.0	3.73e-01	71.2%	66.2%
1ps9A02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.60	46.0	3.38e-01	84.6%	49.0%
3fymA00	1.10.260.40	Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains	0.58	46.0	4.14e-01	96.2%	91.5%
1j77A00	1.20.910.10	Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like	0.58	45.0	3.20e-01	96.2%	59.3%
2d68A00	1.20.960.40	Mainly Alpha › Up-down Bundle › Mitochondrial Import Receptor Subunit Tom20; Chain A ›	0.57	42.0	3.77e-01	90.4%	56.0%
3d0cB00	3.20.20.70	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I	0.55	46.0	2.92e-01	100.0%	17.3%
3urgA01	6.10.140.400	Special › Helix non-globular › Helix Hairpins ›	0.54	44.0	4.29e-01	94.2%	85.0%
2zo4A02	1.10.10.10	Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	0.50	38.0	3.99e-01	82.7%	95.9%

ECOD (15)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3441253	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.90	62.0	4.74e-01	71.2%	35.2%
3426987	109.4.1.1260 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3, PPR_long	0.82	73.0	4.72e-01	96.2%	27.3%
3684686	109.4.1.1260 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR, PPR_2, PPR_3, PPR_long	0.79	70.0	4.09e-01	98.1%	15.0%
3770311	109.4.1.154 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › FA_FANCE	0.75	62.0	3.68e-01	92.3%	20.3%
4013705	109.4.1.2134 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR_3, TPR_24	0.74	67.0	4.26e-01	100.0%	26.0%
3340385	109.4.1.420 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR	0.72	62.0	4.48e-01	96.2%	40.7%
3658729	109.4.1.420 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › PPR	0.72	63.0	4.40e-01	100.0%	42.0%
4153913	375.1.1.0 ↗	few secondary structure elements › Rubredoxin-like › Rubredoxin-related › Rubredoxin-related	0.71	59.0	5.07e-01	100.0%	58.8%
3814836	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.69	60.0	4.25e-01	100.0%	38.1%
3237156	604.12.1.4 ↗	alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › ATG1-like_MIT1	0.68	57.0	4.31e-01	98.1%	77.0%
4154002	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.68	59.0	3.93e-01	100.0%	50.5%
3601001	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.65	53.0	3.66e-01	98.1%	38.5%
59817	109.4.1.0 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat	0.60	49.0	3.68e-01	98.1%	55.8%
5028412	148.1.3.20 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AAA_lid_2	0.53	41.0	2.98e-01	98.1%	27.9%
3348391	101.1.1.65 ↗	alpha arrays › HTH › HTH › Three-helical HTH › Myb_DNA-bind_4	0.52	42.0	3.55e-01	98.1%	87.0%

D3 medium residues 147-204

PDB

Domain cluster: representative

CATH (14)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2w42B02	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.56	45.0	3.14e-01	96.6%	82.7%
4iobA00	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.56	41.0	3.10e-01	82.8%	78.3%
2gwcA00	3.30.590.20	Alpha Beta › 2-Layer Sandwich › Creatine Kinase; Chain A, domain 2 ›	0.55	41.0	2.49e-01	82.8%	35.4%
3cueC00	3.30.450.70	Alpha Beta › 2-Layer Sandwich › Beta-Lactamase ›	0.55	40.0	3.08e-01	79.3%	67.1%
1hcfX00	2.60.40.10	Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins	0.55	41.0	3.44e-01	81.0%	49.5%
1m3qA01	3.30.310.40	Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein ›	0.54	40.0	3.53e-01	81.0%	77.5%
6vftD04	2.60.40.60	Mainly Beta › Sandwich › Immunoglobulin-like › Cadherins	0.54	40.0	3.34e-01	81.0%	45.2%
7e6gA01	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.54	40.0	3.12e-01	84.5%	83.9%
5xgbA02	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.53	40.0	2.94e-01	84.5%	70.4%
6vg1A04	2.60.40.60	Mainly Beta › Sandwich › Immunoglobulin-like › Cadherins	0.53	39.0	3.26e-01	81.0%	45.2%
6pwjA01	3.30.70.270	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Reverse transcriptase/Diguanylate cyclase domain	0.52	39.0	2.91e-01	84.5%	66.1%
2p4bB02	3.30.200.100	Alpha Beta › 2-Layer Sandwich › Phosphorylase Kinase; domain 1 › MucB/RseB, C-terminal domain	0.52	41.0	3.58e-01	93.1%	87.8%
3rfoA02	3.10.25.10	Alpha Beta › Roll › Methionyl-tRNA Fmet Formyltransferase; Chain A, domain 2 › Formyl transferase, C-terminal domain	0.51	41.0	3.49e-01	94.8%	72.4%
5ao2B02	3.30.70.2760	Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits ›	0.50	36.0	3.26e-01	81.0%	68.5%

ECOD (7)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3250056	1.1.7.0 ↗	beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C	0.61	45.0	3.57e-01	81.0%	52.8%
6702	244.1.1.4 ↗	a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › DAO	0.56	37.0	3.28e-01	81.0%	45.5%
3889949	11.1.1.97 ↗	beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › I-set	0.55	40.0	2.51e-01	77.6%	33.5%
3971371	304.48.1.14 ↗	a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › GGDEF	0.54	40.0	2.87e-01	82.8%	62.0%
5069298	2492.1.1.18 ↗	a+b three layers › Cytidine deaminase-like › Cytidine deaminase-like › Cytidine deaminase-like › Prok-JAB	0.52	43.0	3.12e-01	96.6%	90.3%
4428238	1.1.8.20 ↗	beta barrels › cradle loop barrel › RIFT-related › Aminomethyltransferase beta-barrel domain › Beta-barrel_CAF17_C	0.52	39.0	3.09e-01	82.8%	85.6%
1685099	1.1.7.51 ↗	beta barrels › cradle loop barrel › RIFT-related › Alanine racemase-C › NeqB_N	0.51	36.0	3.65e-01	77.6%	91.5%