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nonstructural_protein_NS2

Euk-Vir

Hepacivirus_I

nonstructural_protein_NS2__YP_009679028__Hepacivirus_I__2008768

Identity

Accession:
YP_009679028 ↗
Protein ID:
nonstructural_protein_NS2
Kingdom:
euk

Quality

76.9 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Hepacivirus› Hepacivirus_rhabdomysis

TaxID: 2008768

Cluster

View cluster (17 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 3-90
PDB
Domain cluster: representative
CATH (21)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3jsbA01 1.20.1440.300 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › RNA-directed RNA polymerase L, helical domain 0.64 38.0 4.02e-01 87.5% 65.4%
3bt5A00 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.64 55.0 4.70e-01 98.9% 94.0%
2v0oB00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.62 48.0 3.45e-01 85.2% 74.5%
7c1iA01 1.20.120.160 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain 0.61 40.0 3.88e-01 90.9% 58.0%
7wz5A01 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.59 46.0 3.96e-01 87.5% 60.9%
1b5lA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.59 46.0 3.94e-01 87.5% 60.5%
4akvA02 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.57 46.0 3.62e-01 87.5% 90.5%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 46.0 4.36e-01 90.9% 74.5%
2rbdA01 1.20.1260.10 Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle 0.56 49.0 4.17e-01 98.9% 90.7%
2f2gA00 1.20.910.10 Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like 0.56 46.0 3.60e-01 95.5% 74.4%
1yfmA01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.56 45.0 4.07e-01 90.9% 63.5%
2xq9A02 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.55 48.0 4.30e-01 96.6% 85.1%
1br0A00 1.20.58.70 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.54 39.0 3.59e-01 77.3% 78.3%
1x04A00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 46.0 3.59e-01 95.5% 83.5%
2b5dX01 3.20.110.10 Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain 0.54 46.0 3.01e-01 96.6% 69.8%
1sj8A02 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.53 43.0 3.87e-01 87.5% 70.5%
1yisA01 1.10.275.10 Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) 0.53 42.0 4.05e-01 90.9% 73.8%
1cnt200 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.52 40.0 3.58e-01 88.6% 57.7%
7uzqK01 1.10.3430.10 Mainly Alpha › Orthogonal Bundle › Ammonium transporter fold › Ammonium transporter AmtB like domains 0.51 44.0 2.93e-01 96.6% 27.2%
3tp3A02 1.10.357.10 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 0.51 43.0 3.67e-01 97.7% 56.1%
4c3eM00 1.20.120.1350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Pneumovirus matrix protein 2 (M2), zinc-binding domain 0.50 39.0 3.29e-01 85.2% 48.4%
ECOD (40)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3624023 5059.1.1.0 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.71 63.0 5.59e-01 100.0% 75.4%
3575542 601.2.1.5 ↗ alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes › Ctr 0.64 45.0 4.17e-01 73.9% 74.6%
3227781 5059.1.1.0 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.64 48.0 4.51e-01 81.8% 70.0%
3288703 150.1.1.5 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › DUF305 0.63 55.0 4.61e-01 96.6% 94.2%
3270728 5001.1.1.81 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › THH1_TOM1-3_dom 0.63 51.0 3.59e-01 88.6% 35.1%
3738138 180.1.1.1 ↗ alpha bundles › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › Acid phosphatase/Vanadium-dependent haloperoxidase › PAP2 0.63 49.0 3.97e-01 84.1% 84.1%
4029967 633.1.1.0 ↗ alpha bundles › Bromodomain-like › Bromodomain › Bromodomain 0.63 49.0 4.46e-01 100.0% 63.5%
4942070 5050.1.1.87 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › LPG_synthase_TM 0.61 50.0 3.72e-01 92.0% 47.2%
3593123 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.61 46.0 4.54e-01 83.0% 85.3%
3237805 3447.1.1.5 ↗ alpha bundles › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Isoprenylcysteine carboxyl methyltransferase (ICMT) › Steroid_dh 0.60 51.0 3.95e-01 96.6% 43.3%
352056 5057.1.1.1 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neur_chan_memb 0.59 47.0 4.24e-01 87.5% 87.1%
4600241 3883.1.1.1 ↗ alpha bundles › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-alcohol phosphotransferase helical bundle domain › CDP-OH_P_transf 0.58 43.0 3.34e-01 78.4% 49.7%
4982105 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.57 42.0 4.45e-01 86.4% 90.7%
3645353 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.56 43.0 4.35e-01 89.8% 81.1%
3793286 4177.1.1.2 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR 0.56 45.0 3.51e-01 87.5% 88.5%
4071531 1188.1.1.3 ↗ alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Mntp 0.56 50.0 3.94e-01 100.0% 83.8%
3450026 633.4.1.1 ↗ alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI 0.56 47.0 3.80e-01 90.9% 54.6%
3337263 198.1.1.0 ↗ alpha arrays › Saposin-like › Saposin-like › Saposin-like 0.56 42.0 4.17e-01 80.7% 92.2%
3454208 632.15.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) 0.56 44.0 4.62e-01 87.5% 95.0%
4994150 632.18.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › hypothetical protein PA2901 › hypothetical protein PA2901 0.55 46.0 4.48e-01 89.8% 83.2%
3419489 632.7.1.27 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › Rx_N 0.55 45.0 3.94e-01 89.8% 69.6%
3971653 5050.1.1.0 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.55 40.0 3.20e-01 78.4% 88.9%
3466653 192.29.1.101 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › Rx_N 0.54 45.0 4.13e-01 89.8% 69.6%
5028219 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.54 44.0 4.45e-01 94.3% 87.8%
3500901 4177.1.1.2 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR 0.54 46.0 3.59e-01 94.3% 91.6%
3503725 4177.1.1.2 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › BAR 0.54 45.0 3.53e-01 94.3% 87.5%
3475323 174.1.1.0 ↗ few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.54 44.0 3.82e-01 88.6% 65.2%
3235535 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.54 44.0 4.12e-01 90.9% 76.4%
3228302 601.1.2.0 ↗ alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) 0.53 45.0 4.09e-01 93.2% 70.8%
5044068 632.11.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like 0.53 42.0 4.18e-01 87.5% 87.4%
3233827 5057.1.1.0 ↗ alpha bundles › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore › Neurotransmitter-gated ion-channel transmembrane pore 0.52 47.0 4.21e-01 98.9% 85.0%
3925056 5059.1.1.4 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › Nuc_sug_transp 0.52 43.0 3.04e-01 95.5% 87.8%
3937465 148.1.3.0 ↗ alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.52 41.0 3.14e-01 87.5% 72.1%
3931107 632.7.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain 0.51 43.0 3.85e-01 94.3% 78.5%
3255232 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.51 44.0 3.20e-01 95.5% 70.0%
3802240 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.51 42.0 4.07e-01 89.8% 92.0%
3932046 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.51 40.0 3.99e-01 86.4% 95.6%
4374650 601.54.1.0 ↗ alpha bundles › Four-helical up-and-down bundle › low CO2-inducible protein LCI1 › low CO2-inducible protein LCI1 0.51 43.0 3.55e-01 92.0% 53.5%
3935633 1203.1.2.1 ↗ alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 › ASD2 0.50 46.0 3.59e-01 100.0% 76.2%
3906133 633.21.1.4 ↗ alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › Cg6151-P 0.50 43.0 3.96e-01 94.3% 75.7%
D2 medium residues 159-203
PDB
Domain cluster: rep: nonstructural_protein_NS2__YP_009679008__Hepacivirus_N__2008773__D147-204