←Back to structures
nonstructural_protein_NS4A
Euk-VirDonggang_virus
nonstructural_protein_NS4A__YP_009259533__Donggang_virus__985683
Identity
- Accession:
- YP_009259533 ↗
- Protein ID:
- nonstructural_protein_NS4A
- Kingdom:
- euk
Quality
85.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Orthoflavivirus›
Donggang_virus
TaxID: 985683
Cluster
View cluster (21 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-74
Domain cluster:
rep: NS4A__YP_009553734__Kampung_Karu_virus__2045186__D2-69
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 47.8 | 2.00e-12 | 96.0% | 47.2% |
D2
medium
residues 75-126
Domain cluster:
rep: non-structural_protein_NS4a__NP_775521__Powassan_virus__11083__D77-126
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01350.22 best | Flavi_NS4A | 43.1 | 5.90e-11 | 100.0% | 36.1% |
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3lupA01 | 3.40.50.10170 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.88 | 61.0 | 4.21e-01 | 73.1% | 92.3% |
| 1mjtB01 | 3.90.340.10 | Alpha Beta › Alpha-Beta Complex › Nitric Oxide Synthase; Chain A, domain 1 › Nitric Oxide Synthase; Chain A, domain 1 | 0.86 | 64.0 | 4.67e-01 | 78.8% | 31.8% |
| 2g7zA01 | 3.40.50.10170 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.85 | 60.0 | 4.11e-01 | 73.1% | 91.6% |
| 3nctA00 | 3.40.50.11880 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Plasmid SOS inhibition protein | 0.85 | 62.0 | 4.44e-01 | 76.9% | 100.0% |
| 5z7cA01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.80 | 61.0 | 4.15e-01 | 84.6% | 24.4% |
| 1r1dA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.78 | 58.0 | 3.75e-01 | 84.6% | 17.4% |
| 3of4A00 | 3.40.109.10 | Alpha Beta › 3-Layer(aba) Sandwich › NADH Oxidase › NADH Oxidase | 0.78 | 61.0 | 4.05e-01 | 88.5% | 21.7% |
| 3qxzA02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.77 | 58.0 | 5.61e-01 | 82.7% | 78.3% |
| 4k7cA01 | 3.90.70.10 | Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases | 0.76 | 66.0 | 3.92e-01 | 98.1% | 12.9% |
| 3jamD02 | 3.30.1140.32 | Alpha Beta › 2-Layer Sandwich › Ribosomal protein S3 C-terminal domain › Ribosomal protein S3, C-terminal domain | 0.75 | 60.0 | 4.40e-01 | 86.5% | 79.7% |
| 4jcsA02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.73 | 53.0 | 5.07e-01 | 92.3% | 66.1% |
| 2pjqA01 | 1.10.472.50 | Mainly Alpha › Orthogonal Bundle › Cyclin A; domain 1 › HD-domain/PDEase-like | 0.73 | 51.0 | 4.30e-01 | 78.8% | 43.8% |
| 6lumD01 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.70 | 60.0 | 4.58e-01 | 100.0% | 77.6% |
| 4qmaA01 | 1.20.5.440 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › ATP synthase delta/epsilon subunit, C-terminal domain | 0.68 | 48.0 | 5.17e-01 | 86.5% | 100.0% |
| 1t07A00 | 1.10.3880.10 | Mainly Alpha › Orthogonal Bundle › YggX-like › Fe(II) trafficking protein YggX | 0.68 | 53.0 | 4.57e-01 | 86.5% | 77.8% |
| 6smyB02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.67 | 52.0 | 4.02e-01 | 86.5% | 38.3% |
| 1ufhA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.66 | 51.0 | 3.74e-01 | 88.5% | 30.3% |
| 3dkqA02 | 4.10.860.20 | Few Secondary Structures › Irregular › DNA Excision Repair, Uvrb; Chain A › Rabenosyn, Rab binding domain | 0.65 | 50.0 | 5.26e-01 | 82.7% | 100.0% |
| 1rr7A01 | 1.10.10.60 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like | 0.64 | 46.0 | 4.83e-01 | 80.8% | 84.8% |
| 2l35A00 | 1.10.287.770 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like | 0.63 | 54.0 | 5.13e-01 | 98.1% | 85.7% |
| 1tfeA02 | 1.10.286.20 | Mainly Alpha › Orthogonal Bundle › GTP Cyclohydrolase I; Chain A, domain 1 › | 0.63 | 45.0 | 4.73e-01 | 80.8% | 95.6% |
| 1l5jA03 | 3.40.1060.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aconitase; Domain 2 › Aconitase, Domain 2 | 0.62 | 46.0 | 3.23e-01 | 76.9% | 23.1% |
| 4asvA00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.62 | 45.0 | 4.05e-01 | 80.8% | 58.2% |
| 5kjpA02 | 1.10.12.10 | Mainly Alpha › Orthogonal Bundle › Lyase 2-enoyl-coa Hydratase; Chain A, domain 2 › Lyase 2-enoyl-coa Hydratase, Chain A, domain 2 | 0.62 | 44.0 | 4.37e-01 | 82.7% | 77.6% |
| 3fvvA02 | 1.20.1440.100 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › SG protein - dephosphorylation function | 0.61 | 46.0 | 4.07e-01 | 80.8% | 100.0% |
| 1b48A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.61 | 53.0 | 4.22e-01 | 100.0% | 56.9% |
| 3zdmB00 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.61 | 47.0 | 4.87e-01 | 86.5% | 88.0% |
| 2yevA02 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.61 | 51.0 | 4.52e-01 | 92.3% | 66.2% |
| 2ltuA00 | 1.10.8.10 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain | 0.61 | 41.0 | 3.95e-01 | 71.2% | 77.4% |
| 3m9vA01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.57 | 47.0 | 3.63e-01 | 98.1% | 43.3% |
| 3fk5A01 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.54 | 43.0 | 2.93e-01 | 90.4% | 31.8% |
ECOD (27)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3211845 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.98 | 73.0 | 8.28e-01 | 76.9% | 100.0% |
| 5058076 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.95 | 74.0 | 5.39e-01 | 80.8% | 35.0% |
| 3994704 | 108.1.1.0 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand | 0.91 | 65.0 | 5.98e-01 | 75.0% | 60.0% |
| 3937007 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.88 | 68.0 | 4.37e-01 | 82.7% | 20.0% |
| 3889409 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.88 | 69.0 | 4.46e-01 | 84.6% | 20.5% |
| 5053821 | 4953.1.1.0 ↗ | beta barrels › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like › L-aspartase C-terminal domain-like | 0.87 | 74.0 | 5.79e-01 | 90.4% | 47.0% |
| 3926800 | 3443.1.1.0 ↗ | alpha duplicates or obligate multimers › Get5 carboxyl domain › Get5 carboxyl domain › Get5 carboxyl domain | 0.86 | 72.0 | 6.80e-01 | 88.5% | 80.0% |
| 4198887 | 186.1.1.0 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N | 0.85 | 70.0 | 5.38e-01 | 92.3% | 42.9% |
| 3385053 | 5076.2.1.10 ↗ | alpha complex topology › Mitochondrial ADP/ATP carrier-like › Putative sulfate permease CysZ › Putative sulfate permease CysZ › PF29520 | 0.85 | 79.0 | 4.84e-01 | 100.0% | 31.9% |
| 3297889 | 10.12.1.1 ↗ | beta sandwiches › jelly-roll › Double-stranded beta-helix › Double-stranded beta-helix › cNMP_binding | 0.85 | 69.0 | 4.51e-01 | 88.5% | 22.4% |
| 4417274 | 2010.1.1.1 ↗ | a/b three-layered sandwiches › EDD domain › EDD domain › EDD domain › DegV | 0.84 | 60.0 | 4.12e-01 | 75.0% | 92.5% |
| 3165347 | 148.1.3.335 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain › AzlD | 0.84 | 68.0 | 6.03e-01 | 88.5% | 64.9% |
| 3483031 | 130.1.1.0 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif | 0.84 | 78.0 | 7.39e-01 | 100.0% | 90.0% |
| 3882597 | 4009.1.1.0 ↗ | alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins | 0.83 | 76.0 | 6.24e-01 | 100.0% | 60.0% |
| 3643105 | 6026.1.1.1 ↗ | alpha duplicates or obligate multimers › cwf21 domain › cwf21 domain › cwf21 domain › cwf21 | 0.80 | 71.0 | 5.01e-01 | 98.1% | 32.9% |
| 4564711 | 547.1.1.1 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer | 0.79 | 71.0 | 6.27e-01 | 100.0% | 82.7% |
| 4267174 | 614.1.1.24 ↗ | alpha duplicates or obligate multimers › L27 domain › L27 domain › L27 domain › GlutR_dimer | 0.78 | 70.0 | 6.20e-01 | 100.0% | 82.7% |
| 2647290 | 225.1.1.6 ↗ | a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_2 | 0.76 | 63.0 | 5.49e-01 | 96.2% | 61.3% |
| 5030164 | 101.11.1.0 ↗ | alpha arrays › HTH › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 › Polynucleotide phosphorylase/guanosine pentaphosphate synthase (PNPase/GPSI), domain 3 | 0.76 | 67.0 | 6.02e-01 | 98.1% | 74.3% |
| 2700815 | 4969.1.1.0 ↗ | alpha bundles › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I › thumb domain in bacteriophage RB69-like DNA polymerase I | 0.74 | 60.0 | 6.18e-01 | 90.4% | 95.8% |
| 4961801 | 2484.1.1.302 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Cas12f1-like_TNB | 0.69 | 57.0 | 3.94e-01 | 100.0% | 36.6% |
| 3175298 | 130.1.1.51 ↗ | alpha arrays › LEM/SAP HeH motif-like › LEM/SAP HeH motif › LEM/SAP HeH motif › Tho1_MOS11_C | 0.66 | 52.0 | 5.03e-01 | 86.5% | 95.0% |
| 3709588 | 632.15.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) | 0.65 | 52.0 | 4.54e-01 | 88.5% | 76.2% |
| 3861518 | 108.1.1.98 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_1, EF-hand_5, EF-hand_7 | 0.65 | 52.0 | 4.45e-01 | 90.4% | 56.7% |
| 3547115 | 108.1.1.29 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand › EF-hand_7 | 0.64 | 52.0 | 4.38e-01 | 90.4% | 56.7% |
| 4391428 | 4044.1.1.1 ↗ | alpha bundles › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Helical bundle domain in prismane-like proteins › Prismane | 0.64 | 52.0 | 3.84e-01 | 88.5% | 60.0% |
| 4630575 | 230.3.1.1 ↗ | a+b two layers › T-fold › Elongation factor Ts (EF-Ts), dimerisation domain › Elongation factor Ts (EF-Ts), dimerisation domain › EF_TS | 0.61 | 48.0 | 3.77e-01 | 92.3% | 61.6% |