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nonstructural_protein_NS4B
Euk-VirNon-primate_hepacivirus_NZP1
nonstructural_protein_NS4B__YP_009664200__Non-primate_hepacivirus_NZP1__1605403
Identity
- Accession:
- YP_009664200 ↗
- Protein ID:
- nonstructural_protein_NS4B
- Kingdom:
- euk
Quality
59.4
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Non-primate_hepacivirus_NZP1
TaxID: 1605403
Cluster
View cluster (26 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 46-125
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF01001.25 best | HCV_NS4b | 85.1 | 7.10e-24 | 100.0% | 41.7% |
CATH (53)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2pmrA00 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.74 | 45.0 | 4.69e-01 | 97.5% | 65.8% |
| 7ru9C01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.72 | 57.0 | 3.96e-01 | 88.7% | 25.8% |
| 4kb2A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.71 | 49.0 | 4.49e-01 | 72.5% | 89.9% |
| 5wp3B00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.70 | 51.0 | 4.74e-01 | 77.5% | 93.1% |
| 3qyqA00 | 3.20.20.70 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Aldolase class I | 0.69 | 60.0 | 4.07e-01 | 93.8% | 29.3% |
| 4it4A02 | 1.20.58.80 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit | 0.69 | 54.0 | 5.21e-01 | 83.7% | 86.8% |
| 4gpkF02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.68 | 55.0 | 3.89e-01 | 92.5% | 28.7% |
| 1sz9C00 | 1.25.40.90 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.68 | 57.0 | 4.80e-01 | 100.0% | 54.3% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.68 | 49.0 | 4.24e-01 | 78.8% | 89.5% |
| 3vwaA03 | 1.25.10.10 | Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant | 0.67 | 57.0 | 3.88e-01 | 96.2% | 26.5% |
| 2yvkA01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.66 | 55.0 | 4.56e-01 | 93.8% | 73.6% |
| 2a0uB01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.65 | 54.0 | 4.35e-01 | 91.3% | 61.3% |
| 1nzeA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.65 | 53.0 | 4.70e-01 | 87.5% | 79.5% |
| 8h6rA01 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.65 | 53.0 | 5.29e-01 | 91.3% | 98.8% |
| 3u8vA00 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.65 | 53.0 | 5.25e-01 | 87.5% | 86.7% |
| 3d7iB00 | 1.20.1290.10 | Mainly Alpha › Up-down Bundle › AhpD-like › AhpD-like | 0.65 | 55.0 | 5.18e-01 | 97.5% | 76.5% |
| 4gywA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.64 | 48.0 | 4.40e-01 | 88.7% | 60.0% |
| 2i0mA01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.64 | 48.0 | 4.40e-01 | 80.0% | 87.7% |
| 3zsuA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.63 | 51.0 | 4.49e-01 | 87.5% | 75.4% |
| 2icwG02 | 1.10.10.530 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › mam-mhc complex, Chain D, Domain 2 | 0.63 | 45.0 | 4.35e-01 | 75.0% | 71.9% |
| 4hehA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.62 | 53.0 | 5.29e-01 | 96.2% | 92.8% |
| 2xs6A00 | 1.10.555.10 | Mainly Alpha › Orthogonal Bundle › Phosphatidylinositol 3-kinase; Chain A › Rho GTPase activation protein | 0.62 | 51.0 | 4.20e-01 | 96.2% | 83.7% |
| 1sumB02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.62 | 52.0 | 4.65e-01 | 95.0% | 87.3% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.62 | 47.0 | 4.44e-01 | 82.5% | 95.9% |
| 6xssA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.62 | 44.0 | 4.76e-01 | 85.0% | 87.0% |
| 3sbtB02 | 1.25.40.550 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Aar2, C-terminal domain-like | 0.61 | 53.0 | 4.31e-01 | 98.8% | 56.1% |
| 1kz7A01 | 1.20.900.10 | Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain | 0.61 | 52.0 | 4.05e-01 | 100.0% | 80.3% |
| 2vwaA00 | 1.20.58.1330 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Plasmodium falciparum UIS3 membrane protein | 0.61 | 47.0 | 4.48e-01 | 86.3% | 94.9% |
| 2c2lA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.61 | 48.0 | 3.98e-01 | 82.5% | 66.9% |
| 1c02A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.61 | 50.0 | 3.99e-01 | 92.5% | 72.3% |
| 4g1tA02 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.59 | 37.0 | 4.07e-01 | 85.0% | 83.6% |
| 6a3kA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.59 | 49.0 | 4.21e-01 | 92.5% | 81.4% |
| 2x6hA01 | 1.25.40.70 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) | 0.58 | 49.0 | 3.91e-01 | 100.0% | 47.3% |
| 3ubcA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.58 | 51.0 | 4.31e-01 | 96.2% | 67.2% |
| 1cpqA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.58 | 46.0 | 3.96e-01 | 87.5% | 80.6% |
| 3mx3A01 | 1.25.40.390 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 44.0 | 3.40e-01 | 85.0% | 35.9% |
| 4x5mA00 | 1.20.1280.290 | Mainly Alpha › Up-down Bundle › Monooxygenase › | 0.57 | 41.0 | 4.06e-01 | 75.0% | 86.0% |
| 1bbhA00 | 1.20.120.10 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c/b562 | 0.57 | 47.0 | 4.07e-01 | 92.5% | 82.4% |
| 2ondA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.57 | 49.0 | 3.35e-01 | 97.5% | 38.0% |
| 2n1rA00 | 1.10.150.90 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Immunodeficiency lentiviruses, gag gene matrix protein p17 | 0.57 | 43.0 | 3.69e-01 | 82.5% | 58.2% |
| 1f5oA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.56 | 48.0 | 3.99e-01 | 97.5% | 64.4% |
| 1wn0A00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.56 | 46.0 | 3.96e-01 | 91.3% | 58.8% |
| 1gcvA00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.56 | 48.0 | 4.02e-01 | 96.2% | 66.4% |
| 2chpA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.56 | 45.0 | 3.72e-01 | 90.0% | 93.9% |
| 2ig3A00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.55 | 48.0 | 4.15e-01 | 97.5% | 66.1% |
| 4nwpD00 | 1.20.1200.10 | Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like | 0.55 | 47.0 | 3.97e-01 | 100.0% | 71.8% |
| 2kckA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.55 | 46.0 | 4.15e-01 | 92.5% | 90.2% |
| 7qocA01 | 1.10.3210.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af1432 › Hypothetical protein af1432 | 0.55 | 46.0 | 3.65e-01 | 98.8% | 48.7% |
| 2c2uA00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.55 | 44.0 | 3.48e-01 | 90.0% | 77.5% |
| 3n4eA01 | 3.30.390.10 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain | 0.55 | 48.0 | 4.39e-01 | 96.2% | 93.3% |
| 2wyhB04 | 1.20.1270.50 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Glycoside hydrolase family 38, central domain | 0.52 | 38.0 | 3.53e-01 | 77.5% | 84.2% |
| 2g5gX02 | 1.10.8.760 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Haem-binding uptake, Tiki superfamily, ChaN, domain 2 | 0.52 | 32.0 | 3.63e-01 | 77.5% | 84.7% |
| 2fzfA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.50 | 41.0 | 3.42e-01 | 92.5% | 81.3% |
ECOD (26)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4959895 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.75 | 67.0 | 4.28e-01 | 100.0% | 23.5% |
| 3678928 | 3352.1.1.0 ↗ | alpha bundles › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain › STT3/PglB/AglB transmembrane domain | 0.74 | 65.0 | 3.82e-01 | 100.0% | 13.9% |
| 3971983 | 3758.2.1.0 ↗ | alpha bundles › Bacterial hemolysins-like › Biopolymer transport protein ExbB › Biopolymer transport protein ExbB | 0.72 | 50.0 | 3.44e-01 | 72.5% | 48.0% |
| 3733744 | 608.1.1.1 ↗ | alpha arrays › AhpD-like › AhpD-like › AhpD-like › CMD | 0.69 | 61.0 | 5.22e-01 | 98.8% | 95.4% |
| 3183250 | 4121.1.1.0 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like | 0.68 | 52.0 | 3.33e-01 | 81.2% | 26.8% |
| 3172910 | 603.1.1.99 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins › PF27021 | 0.65 | 50.0 | 4.59e-01 | 82.5% | 92.4% |
| 4428893 | 601.18.1.2 ↗ | alpha bundles › Four-helical up-and-down bundle › Oxygen-evolving enhancer protein 3 › Oxygen-evolving enhancer protein 3 › SMBP | 0.65 | 52.0 | 5.05e-01 | 86.3% | 84.4% |
| 3391534 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.64 | 55.0 | 4.03e-01 | 100.0% | 36.6% |
| 5002387 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.64 | 48.0 | 3.34e-01 | 82.5% | 37.2% |
| 4668212 | 604.5.1.2 ↗ | alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › PhoU | 0.63 | 52.0 | 3.97e-01 | 90.0% | 85.3% |
| 2672135 | 5000.3.1.1 ↗ | alpha arrays › Toxins' membrane translocation domains › Bcl-2 inhibitors of programmed cell death › Bcl-2 inhibitors of programmed cell death › Bcl-2 | 0.63 | 54.0 | 4.30e-01 | 96.2% | 47.2% |
| 3213744 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.63 | 52.0 | 4.15e-01 | 96.2% | 69.1% |
| 4963832 | 5069.1.1.107 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › Exosortase_EpsH | 0.62 | 54.0 | 3.63e-01 | 92.5% | 98.1% |
| 5027495 | 192.12.1.0 ↗ | alpha bundles › Long alpha-hairpin › Transcriptional repressor TraM › Transcriptional repressor TraM | 0.62 | 42.0 | 4.15e-01 | 70.0% | 88.2% |
| 3538757 | 109.4.1.192 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_8 | 0.62 | 51.0 | 3.75e-01 | 92.5% | 33.8% |
| 3506555 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.59 | 50.0 | 4.52e-01 | 93.8% | 70.9% |
| 3463576 | 3684.1.1.2 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 | 0.59 | 50.0 | 3.74e-01 | 97.5% | 94.5% |
| 2389382 | 150.1.1.1 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Ferritin | 0.59 | 44.0 | 3.55e-01 | 80.0% | 80.2% |
| 3713694 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.59 | 47.0 | 3.77e-01 | 87.5% | 70.6% |
| 3354384 | 601.3.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain | 0.57 | 47.0 | 4.02e-01 | 91.3% | 57.0% |
| 4960871 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.57 | 47.0 | 3.45e-01 | 96.2% | 58.0% |
| 4883379 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.56 | 45.0 | 3.75e-01 | 91.3% | 50.3% |
| 3769912 | 109.4.1.83 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Suf | 0.56 | 47.0 | 4.10e-01 | 100.0% | 87.4% |
| 4992256 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.55 | 42.0 | 4.02e-01 | 86.3% | 94.9% |
| 4670461 | 632.7.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Heat shock protein 70kD (HSP70), C-terminal subdomain › Heat shock protein 70kD (HSP70), C-terminal subdomain › HSP70 | 0.53 | 36.0 | 3.20e-01 | 98.8% | 48.7% |
| 4927417 | 4121.1.1.1 ↗ | a+b three layers › CorA soluble domain-like › CorA soluble domain-like › CorA soluble domain-like › CorA | 0.50 | 42.0 | 3.14e-01 | 100.0% | 80.0% |
D2
high
residues 129-249