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nonstructural_protein_NS5A
Euk-VirNorway_rat_hepacivirus_2
nonstructural_protein_NS5A__YP_009325410__Norway_rat_hepacivirus_2__1562039
Identity
- Accession:
- YP_009325410 ↗
- Protein ID:
- nonstructural_protein_NS5A
- Kingdom:
- euk
Quality
56.2
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Norway_rat_hepacivirus_2
TaxID: 1562039
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 1-50
D2
medium
residues 51-107
Domain cluster:
rep: nonstructural_protein_NS5A__YP_009664181__Hepacivirus_K__2008770__D43-101
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08300.19 best | HCV_NS5a_1a | 26.4 | 8.30e-06 | 91.2% | 79.0% |
CATH (33)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3fqmA01 | 2.20.25.210 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C NS5A, domain 1B | 0.96 | 89.0 | 8.70e-01 | 100.0% | 91.8% |
| 1sgoA01 | 3.30.2280.10 | Alpha Beta › 2-Layer Sandwich › copper amine oxidase-like fold › Hypothetical protein (hspc210) | 0.64 | 46.0 | 3.67e-01 | 75.4% | 75.0% |
| 1i7dA03 | 2.70.20.10 | Mainly Beta › Distorted Sandwich › Topoisomerase I; domain 3 › Topoisomerase I, domain 3 | 0.63 | 50.0 | 3.79e-01 | 87.7% | 90.8% |
| 4obiA00 | 2.60.320.10 | Mainly Beta › Sandwich › mini-chromosome maintenance (MCM) complex, domain 2 › N-utilization substance G protein NusG, insert domain | 0.63 | 45.0 | 3.97e-01 | 77.2% | 90.8% |
| 4innA00 | 2.40.128.520 | Mainly Beta › Beta Barrel › Lipocalin › | 0.63 | 51.0 | 3.79e-01 | 89.5% | 82.9% |
| 4eg9A00 | 2.50.20.40 | Mainly Beta › Clam › outer membrane lipoprotein receptor (LolB), chain A › | 0.63 | 48.0 | 3.25e-01 | 84.2% | 86.1% |
| 2greF02 | 2.40.30.40 | Mainly Beta › Beta Barrel › Elongation Factor Tu (Ef-tu); domain 3 › Peptidase M42, domain 2 | 0.61 | 51.0 | 4.67e-01 | 94.7% | 83.3% |
| 1mi1A01 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.61 | 47.0 | 4.03e-01 | 91.2% | 97.1% |
| 6x6aA01 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.60 | 49.0 | 3.14e-01 | 91.2% | 39.1% |
| 3ld7A00 | 2.60.320.10 | Mainly Beta › Sandwich › mini-chromosome maintenance (MCM) complex, domain 2 › N-utilization substance G protein NusG, insert domain | 0.59 | 43.0 | 3.86e-01 | 82.5% | 88.5% |
| 3oe3C00 | 2.40.128.200 | Mainly Beta › Beta Barrel › Lipocalin › C-type lysozyme inhibitor | 0.58 | 42.0 | 3.72e-01 | 78.9% | 100.0% |
| 1p9rA01 | 3.30.450.90 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.58 | 47.0 | 3.78e-01 | 89.5% | 73.9% |
| 2k2jA00 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.57 | 46.0 | 3.76e-01 | 93.0% | 88.0% |
| 1lj5A02 | 2.30.39.10 | Mainly Beta › Roll › Alpha-1-antitrypsin; domain 1 › Alpha-1-antitrypsin, domain 1 | 0.57 | 46.0 | 3.44e-01 | 91.2% | 68.8% |
| 2r5vA01 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.56 | 48.0 | 3.59e-01 | 98.2% | 92.0% |
| 1tluA00 | 3.60.90.10 | Alpha Beta › 4-Layer Sandwich › S-adenosylmethionine decarboxylase › S-adenosylmethionine decarboxylase | 0.56 | 41.0 | 3.31e-01 | 78.9% | 70.1% |
| 5z6pA01 | 2.60.120.430 | Mainly Beta › Sandwich › Jelly Rolls › Galactose-binding lectin | 0.56 | 47.0 | 3.42e-01 | 100.0% | 56.7% |
| 3qijB03 | 2.30.29.30 | Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) | 0.55 | 44.0 | 3.87e-01 | 91.2% | 88.8% |
| 3r1kA03 | 3.30.1050.10 | Alpha Beta › 2-Layer Sandwich › Nonspecific Lipid-transfer Protein; Chain A › SCP2 sterol-binding domain | 0.55 | 47.0 | 4.04e-01 | 100.0% | 86.5% |
| 3bwxA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.54 | 43.0 | 2.81e-01 | 91.2% | 32.3% |
| 1lshA04 | 2.20.80.10 | Mainly Beta › Single Sheet › Lipovitellin-phosvitin complex, chain A, domain 4 › Lipovitellin-phosvitin complex, chain A, domain 4 | 0.54 | 36.0 | 2.40e-01 | 70.2% | 48.2% |
| 4adiA02 | 3.30.67.20 | Alpha Beta › 2-Layer Sandwich › Viral Envelope Glycoprotein; domain 2 › Rubella membrane glycoprotein E1, domain 2 | 0.53 | 41.0 | 3.60e-01 | 86.0% | 69.3% |
| 2o1uB01 | 3.30.565.10 | Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain | 0.53 | 45.0 | 3.26e-01 | 96.5% | 33.3% |
| 3ctkA01 | 3.40.420.10 | Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 | 0.53 | 43.0 | 3.18e-01 | 94.7% | 86.8% |
| 2af5A01 | 2.40.128.160 | Mainly Beta › Beta Barrel › Lipocalin › C1 set domains (antibody constant domain-like) | 0.53 | 35.0 | 3.66e-01 | 70.2% | 85.2% |
| 2e4mC00 | 2.80.10.50 | Mainly Beta › Trefoil › Trefoil (Acidic Fibroblast Growth Factor, subunit A) › | 0.53 | 42.0 | 3.28e-01 | 94.7% | 99.3% |
| 4hc5D00 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.53 | 36.0 | 2.82e-01 | 71.9% | 47.3% |
| 1mhmA00 | 3.60.90.10 | Alpha Beta › 4-Layer Sandwich › S-adenosylmethionine decarboxylase › S-adenosylmethionine decarboxylase | 0.52 | 38.0 | 2.59e-01 | 82.5% | 34.8% |
| 1xipA00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 43.0 | 2.66e-01 | 93.0% | 19.9% |
| 2yztA00 | 3.30.160.250 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.51 | 36.0 | 3.51e-01 | 75.4% | 97.0% |
| 3vpbE00 | 2.20.28.160 | Mainly Beta › Single Sheet › Rubrerythrin, domain 2 › | 0.51 | 35.0 | 3.55e-01 | 71.9% | 78.6% |
| 3mx7A00 | 2.40.128.180 | Mainly Beta › Beta Barrel › Lipocalin › | 0.51 | 40.0 | 3.52e-01 | 91.2% | 98.9% |
| 1ca1A02 | 2.60.60.20 | Mainly Beta › Sandwich › Lipoxygenase-1 › PLAT/LH2 domain | 0.50 | 42.0 | 3.41e-01 | 100.0% | 73.3% |
ECOD (19)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 119351 | 926.1.1.1 ↗ | few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1a | 0.96 | 89.0 | 8.06e-01 | 100.0% | 76.7% |
| 5024150 | 3740.1.1.2 ↗ | alpha arrays › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › DUF2099 | 0.66 | 53.0 | 3.51e-01 | 93.0% | 53.1% |
| 1144694 | 714.1.1.1 ↗ | beta sandwiches › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › NusG_II | 0.63 | 45.0 | 3.97e-01 | 77.2% | 90.8% |
| 3938353 | 9.13.1.0 ↗ | beta barrels › Lipocalins/Streptavidin › AOC barrel-like › AOC barrel-like | 0.61 | 43.0 | 3.66e-01 | 75.4% | 88.4% |
| 3265309 | 4026.1.1.0 ↗ | a+b three layers › a+b domain in Rap/Ran-GAP (Pfam 02145) › a+b domain in Rap/Ran-GAP (Pfam 02145) › a+b domain in Rap/Ran-GAP (Pfam 02145) | 0.61 | 48.0 | 3.59e-01 | 87.7% | 59.0% |
| 4931409 | 220.1.1.0 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like | 0.59 | 47.0 | 3.70e-01 | 91.2% | 90.0% |
| 3427234 | 219.1.1.0 ↗ | a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases | 0.56 | 48.0 | 3.18e-01 | 96.5% | 32.7% |
| 3616923 | 5084.1.1.0 ↗ | beta barrels › Outer membrane meander beta-barrels › OMPA-like › OMPA-like | 0.56 | 40.0 | 3.25e-01 | 78.9% | 65.8% |
| 141833 | 9.11.1.1 ↗ | beta barrels › Lipocalins/Streptavidin › YdhA-like › YdhA-like › MliC | 0.55 | 39.0 | 3.55e-01 | 78.9% | 100.0% |
| 3728136 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.54 | 46.0 | 3.74e-01 | 100.0% | 75.7% |
| 3205251 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.54 | 46.0 | 3.74e-01 | 100.0% | 79.1% |
| 3738905 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.53 | 46.0 | 3.90e-01 | 100.0% | 75.0% |
| 3922649 | 391.1.2.0 ↗ | few secondary structure elements › Fibronectin type I module-like › Fibronectin type I module-like › VWC domain-related | 0.53 | 44.0 | 4.25e-01 | 91.2% | 86.2% |
| 4003897 | 9.4.1.0 ↗ | beta barrels › Lipocalins/Streptavidin › D-aminopeptidase, middle and C-terminal domains › D-aminopeptidase, middle and C-terminal domains | 0.53 | 40.0 | 3.39e-01 | 91.2% | 48.0% |
| 3189294 | 884.1.1.0 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain | 0.52 | 45.0 | 3.54e-01 | 100.0% | 78.4% |
| 3624239 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.51 | 42.0 | 3.64e-01 | 93.0% | 66.7% |
| 5065884 | 2.1.1.15 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › tRNA_anti-codon | 0.51 | 35.0 | 2.78e-01 | 71.9% | 83.2% |
| 4965400 | 2.1.1.0 ↗ | beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein | 0.50 | 35.0 | 2.83e-01 | 75.4% | 63.3% |
| 4983823 | 1.1.1.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › acid protease | 0.50 | 39.0 | 3.13e-01 | 93.0% | 79.7% |
D3
medium
residues 114-199
D4
medium
residues 208-267