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nonstructural_protein_NS5A
Euk-VirHepacivirus_K
nonstructural_protein_NS5A__YP_009664181__Hepacivirus_K__2008770
Identity
- Accession:
- YP_009664181 ↗
- Protein ID:
- nonstructural_protein_NS5A
- Kingdom:
- euk
Quality
49.5
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Hepacivirus_macronycteridis
TaxID: 2008770
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 43-101
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08300.19 best | HCV_NS5a_1a | 30.0 | 6.50e-07 | 88.1% | 66.1% |
CATH (28)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3fqmA01 | 2.20.25.210 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C NS5A, domain 1B | 0.93 | 88.0 | 8.72e-01 | 100.0% | 96.7% |
| 4obiA00 | 2.60.320.10 | Mainly Beta › Sandwich › mini-chromosome maintenance (MCM) complex, domain 2 › N-utilization substance G protein NusG, insert domain | 0.64 | 46.0 | 4.14e-01 | 78.0% | 86.2% |
| 1sgoA01 | 3.30.2280.10 | Alpha Beta › 2-Layer Sandwich › copper amine oxidase-like fold › Hypothetical protein (hspc210) | 0.64 | 45.0 | 3.60e-01 | 72.9% | 74.1% |
| 3i8tA00 | 2.60.120.200 | Mainly Beta › Sandwich › Jelly Rolls › | 0.60 | 45.0 | 3.37e-01 | 79.7% | 62.1% |
| 4e4fA01 | 3.30.390.10 | Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain | 0.59 | 43.0 | 3.24e-01 | 76.3% | 84.4% |
| 1pzxA03 | 3.30.1180.10 | Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Tm841; Chain: A;domain 3 › | 0.59 | 46.0 | 3.62e-01 | 84.7% | 92.6% |
| 1p9rA01 | 3.30.450.90 | Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › | 0.59 | 46.0 | 3.71e-01 | 84.7% | 73.9% |
| 3r1kA03 | 3.30.1050.10 | Alpha Beta › 2-Layer Sandwich › Nonspecific Lipid-transfer Protein; Chain A › SCP2 sterol-binding domain | 0.57 | 49.0 | 4.27e-01 | 100.0% | 93.8% |
| 2dd7A00 | 2.40.155.10 | Mainly Beta › Beta Barrel › Green Fluorescent Protein › Green fluorescent protein | 0.57 | 48.0 | 3.41e-01 | 100.0% | 65.9% |
| 2r5vA01 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.56 | 46.0 | 3.51e-01 | 94.9% | 92.7% |
| 2p39A00 | 2.80.10.50 | Mainly Beta › Trefoil › Trefoil (Acidic Fibroblast Growth Factor, subunit A) › | 0.56 | 38.0 | 2.95e-01 | 72.9% | 88.0% |
| 3ow8C00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.55 | 49.0 | 3.07e-01 | 98.3% | 97.0% |
| 1mgpA02 | 3.30.1180.10 | Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Tm841; Chain: A;domain 3 › | 0.55 | 41.0 | 3.31e-01 | 83.1% | 95.0% |
| 2dt8A02 | 3.30.1180.10 | Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Tm841; Chain: A;domain 3 › | 0.55 | 42.0 | 3.30e-01 | 84.7% | 95.4% |
| 2cfuA03 | 3.30.1050.10 | Alpha Beta › 2-Layer Sandwich › Nonspecific Lipid-transfer Protein; Chain A › SCP2 sterol-binding domain | 0.54 | 46.0 | 3.65e-01 | 100.0% | 73.6% |
| 3mx7A00 | 2.40.128.180 | Mainly Beta › Beta Barrel › Lipocalin › | 0.54 | 41.0 | 3.65e-01 | 84.7% | 95.6% |
| 1dt9A02 | 3.30.420.60 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 | 0.54 | 43.0 | 3.50e-01 | 88.1% | 94.6% |
| 6cz7A01 | 2.20.25.90 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › ADC-like domains | 0.53 | 41.0 | 4.13e-01 | 86.4% | 87.1% |
| 3ei3A02 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.53 | 41.0 | 2.60e-01 | 86.4% | 21.4% |
| 1xipA00 | 2.130.10.10 | Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase | 0.52 | 42.0 | 2.65e-01 | 93.2% | 20.4% |
| 3ebwA01 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.52 | 39.0 | 3.12e-01 | 86.4% | 73.9% |
| 5jicA02 | 3.30.420.40 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain | 0.52 | 44.0 | 3.19e-01 | 98.3% | 100.0% |
| 3obwA02 | 3.30.420.60 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 | 0.52 | 42.0 | 3.38e-01 | 89.8% | 95.8% |
| 3wxmB02 | 3.30.420.60 | Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 | 0.51 | 41.0 | 3.28e-01 | 88.1% | 100.0% |
| 1ynjJ02 | 2.40.50.100 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain | 0.51 | 34.0 | 3.38e-01 | 83.1% | 64.5% |
| 2vhjA02 | 2.30.270.20 | Mainly Beta › Roll › duf1285 protein fold › | 0.51 | 38.0 | 3.78e-01 | 84.7% | 90.3% |
| 1zswA02 | 3.10.180.10 | Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 | 0.51 | 36.0 | 2.73e-01 | 76.3% | 56.0% |
| 1ca1A02 | 2.60.60.20 | Mainly Beta › Sandwich › Lipoxygenase-1 › PLAT/LH2 domain | 0.51 | 41.0 | 3.44e-01 | 100.0% | 74.2% |
ECOD (33)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 119351 | 926.1.1.1 ↗ | few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1a | 0.93 | 88.0 | 8.08e-01 | 100.0% | 80.8% |
| 5034583 | 1001.1.1.0 ↗ | a+b two layers › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 | 0.70 | 52.0 | 5.61e-01 | 88.1% | 94.0% |
| 6650 | 241.4.1.1 ↗ | a+b two layers › Type III secretory system chaperone-like › Hypothetical protein c14orf129, hspc210 › Hypothetical protein c14orf129, hspc210 › GSKIP_dom | 0.65 | 45.0 | 3.33e-01 | 71.2% | 58.3% |
| 1144694 | 714.1.1.1 ↗ | beta sandwiches › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › NusG_II | 0.64 | 46.0 | 4.14e-01 | 78.0% | 86.2% |
| 3718410 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.64 | 51.0 | 3.07e-01 | 86.4% | 97.3% |
| 3182004 | 11.1.4.1 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › Transthyretin | 0.61 | 52.0 | 3.96e-01 | 100.0% | 88.5% |
| 3417047 | 1.1.8.0 ↗ | beta barrels › cradle loop barrel › RIFT-related › Aminomethyltransferase beta-barrel domain | 0.60 | 49.0 | 4.79e-01 | 93.2% | 98.5% |
| 4514735 | 1049.2.1.4 ↗ | alpha duplicates or obligate multimers › Baseplate wedge protein gp7 helical domain-like › Baseplate wedge protein gp6 helical domain › Baseplate wedge protein gp6 helical domain › Baseplate_J | 0.60 | 50.0 | 3.61e-01 | 98.3% | 36.8% |
| 3719897 | 227.1.1.18 ↗ | a+b two layers › DNA clamp › DNA clamp › DNA clamp › DUF7881_C | 0.60 | 40.0 | 3.11e-01 | 84.7% | 32.0% |
| 3983524 | 274.1.1.13 ↗ | a+b two layers › Pili subunits › Pili subunits › Pili subunits › GspH | 0.59 | 45.0 | 3.34e-01 | 83.1% | 58.4% |
| 3811972 | 11.1.4.8 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › Pollen_Ole_e_1 | 0.58 | 49.0 | 3.91e-01 | 98.3% | 92.3% |
| 3832827 | 11.1.4.99 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like › PF30918 | 0.58 | 50.0 | 3.95e-01 | 100.0% | 93.1% |
| 4366164 | 2004.1.1.42 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE | 0.58 | 47.0 | 2.76e-01 | 86.4% | 30.4% |
| 4424238 | 220.1.1.127 ↗ | beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_GEF_YEL1 | 0.58 | 45.0 | 3.44e-01 | 89.8% | 70.3% |
| 3722582 | 708.1.2.6 ↗ | beta complex topology › ETN0001 domain-like › ETN0001 domain-like › Mss4-like › GFA | 0.58 | 41.0 | 3.17e-01 | 76.3% | 49.6% |
| 3728136 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.57 | 48.0 | 3.98e-01 | 100.0% | 82.6% |
| 3205251 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.55 | 47.0 | 3.89e-01 | 100.0% | 83.5% |
| 4425543 | 2484.1.1.38 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 | 0.55 | 44.0 | 3.41e-01 | 86.4% | 90.4% |
| 1936872 | 301.13.1.1 ↗ | a+b three layers › Bacillus chorismate mutase-like › DAK1/DegV C-terminal domain › DAK1/DegV C-terminal domain › DegV | 0.55 | 42.0 | 3.31e-01 | 84.7% | 96.9% |
| 3715799 | 5.1.5.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed | 0.55 | 41.0 | 2.46e-01 | 83.1% | 30.6% |
| 3599752 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.54 | 46.0 | 2.76e-01 | 93.2% | 30.4% |
| 3738905 | 884.1.1.1 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C | 0.54 | 47.0 | 4.02e-01 | 100.0% | 82.0% |
| 3189294 | 884.1.1.0 ↗ | a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain | 0.54 | 46.0 | 3.70e-01 | 100.0% | 82.4% |
| 3922649 | 391.1.2.0 ↗ | few secondary structure elements › Fibronectin type I module-like › Fibronectin type I module-like › VWC domain-related | 0.53 | 42.0 | 4.14e-01 | 86.4% | 86.2% |
| 4376478 | 330.1.1.0 ↗ | a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like | 0.53 | 37.0 | 3.25e-01 | 81.4% | 47.8% |
| 5047477 | 244.1.1.4 ↗ | a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD-linked reductases-C › FAD-linked reductases-C › DAO | 0.53 | 44.0 | 3.36e-01 | 98.3% | 43.9% |
| 4145162 | 5.1.11.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 9-bladed | 0.52 | 44.0 | 2.66e-01 | 93.2% | 15.2% |
| 3405373 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.52 | 45.0 | 2.78e-01 | 98.3% | 76.6% |
| 3169843 | 5.1.4.56 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › NUP214 | 0.52 | 43.0 | 2.63e-01 | 94.9% | 63.0% |
| 4020821 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.51 | 38.0 | 2.33e-01 | 81.4% | 15.0% |
| 3624239 | 304.9.1.0 ↗ | a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD | 0.51 | 40.0 | 3.52e-01 | 88.1% | 68.9% |
| 3939467 | 4026.1.1.0 ↗ | a+b three layers › a+b domain in Rap/Ran-GAP (Pfam 02145) › a+b domain in Rap/Ran-GAP (Pfam 02145) › a+b domain in Rap/Ran-GAP (Pfam 02145) | 0.50 | 36.0 | 3.01e-01 | 79.7% | 48.3% |
| 5038150 | 268.1.1.1 ↗ | a+b two layers › Sterol carrier protein-like › Sterol carrier protein, SCP-related › Sterol carrier protein, SCP-related › SCP2 | 0.50 | 43.0 | 3.63e-01 | 100.0% | 98.1% |
D2
medium
residues 109-188
Domain cluster:
rep: nonstructural_protein_NS5A__YP_009179227_nonstructural_protein_NS5A__Wenling_shark_virus__1746066__D111-203
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08301.19 best | HCV_NS5a_1b | 29.8 | 1.10e-06 | 90.0% | 60.8% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3fqmA02 | 2.20.25.220 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C virus NS5A, 1B domain | 0.91 | 86.0 | 8.40e-01 | 100.0% | 94.2% |
| 2kpiA01 | 2.20.25.10 | Mainly Beta › Single Sheet › N-terminal domain of TfIIb › | 0.62 | 30.0 | 3.96e-01 | 100.0% | 92.3% |
| 1pcfA00 | 2.30.31.10 | Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Transcriptional Coactivator Pc4; Chain A | 0.52 | 31.0 | 3.34e-01 | 98.8% | 69.7% |
| 3sreA00 | 2.120.10.30 | Mainly Beta › 6 Propeller › Neuraminidase › TolB, C-terminal domain | 0.51 | 35.0 | 2.39e-01 | 71.2% | 69.6% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 283055 | 926.1.1.2 ↗ | few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1b | 0.93 | 88.0 | 8.26e-01 | 100.0% | 86.2% |
| 3721757 | 386.1.1.0 ↗ | few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers | 0.67 | 34.0 | 3.81e-01 | 97.5% | 61.5% |
| 224047 | 6043.1.1.3 ↗ | a+b two layers › yfeY-like › yfeY-like › yfeY-like › CAP_assoc_N | 0.61 | 31.0 | 3.39e-01 | 100.0% | 56.1% |
| 4025709 | 79.1.1.0 ↗ | beta duplicates or obligate multimers › Phage tail fiber protein trimerization domain › Phage tail fiber protein trimerization domain › Phage tail fiber protein trimerization domain | 0.54 | 26.0 | 2.86e-01 | 97.5% | 52.3% |