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nonstructural_protein_NS5A

Euk-Vir

Hepacivirus_B

nonstructural_protein_NS5A__YP_009678992__Hepacivirus_B__2008762

Identity

Accession:
YP_009678992 ↗
Protein ID:
nonstructural_protein_NS5A
Kingdom:
euk

Quality

57.0 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 111-194
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08301.19 best HCV_NS5a_1b 86.6 2.20e-24 100.0% 81.4%
CATH (6)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3fqmA02 2.20.25.220 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C virus NS5A, 1B domain 0.86 78.0 7.75e-01 100.0% 94.2%
2kpiA01 2.20.25.10 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › 0.63 29.0 3.94e-01 100.0% 92.3%
3nvoA01 3.30.460.20 Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › CorA soluble domain-like 0.61 33.0 2.80e-01 100.0% 32.8%
4aeeA05 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.51 35.0 3.87e-01 100.0% 91.0%
2cswA01 2.60.200.20 Mainly Beta › Sandwich › Tumour Suppressor Smad4 › 0.50 36.0 3.24e-01 77.4% 98.4%
3zxkA02 2.60.120.200 Mainly Beta › Sandwich › Jelly Rolls › 0.50 35.0 2.69e-01 73.8% 72.2%
ECOD (7)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
283055 926.1.1.2 few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1b 0.87 79.0 7.59e-01 100.0% 86.2%
3721757 386.1.1.0 few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers 0.67 33.0 3.74e-01 97.6% 61.5%
4993636 4312.1.1.15 a+b two layers › RelE-like › RelE-like › RelE-like › DUF4258 0.65 33.0 3.58e-01 98.8% 57.1%
224047 6043.1.1.3 a+b two layers › yfeY-like › yfeY-like › yfeY-like › CAP_assoc_N 0.62 32.0 3.49e-01 100.0% 59.1%
1157731 6043.1.1.3 a+b two layers › yfeY-like › yfeY-like › yfeY-like › CAP_assoc_N 0.55 28.0 2.87e-01 100.0% 45.6%
5015019 12.1.1.0 beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain 0.51 34.0 3.84e-01 100.0% 98.3%
3597350 73.1.1.0 beta sandwiches › SMAD/FHA domain › SMAD/FHA domain › SMAD/FHA domain 0.50 32.0 3.29e-01 100.0% 66.3%
D2 medium residues 50-104
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF08300.19 best HCV_NS5a_1a 38.6 1.30e-09 90.9% 74.2%
CATH (38)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3fqmA01 2.20.25.210 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C NS5A, domain 1B 0.97 90.0 8.68e-01 100.0% 88.5%
3fqmA02 2.20.25.220 Mainly Beta › Single Sheet › N-terminal domain of TfIIb › Hepatitis C virus NS5A, 1B domain 0.68 56.0 4.85e-01 92.7% 59.3%
1sgoA01 3.30.2280.10 Alpha Beta › 2-Layer Sandwich › copper amine oxidase-like fold › Hypothetical protein (hspc210) 0.66 49.0 3.83e-01 78.2% 76.9%
4obiA00 2.60.320.10 Mainly Beta › Sandwich › mini-chromosome maintenance (MCM) complex, domain 2 › N-utilization substance G protein NusG, insert domain 0.61 44.0 3.88e-01 78.2% 75.9%
2pn1A03 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.60 47.0 3.58e-01 83.6% 97.5%
4gniA03 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.60 51.0 4.27e-01 90.9% 97.7%
1txdA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.59 47.0 3.80e-01 94.5% 76.9%
2pvpA02 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.59 45.0 3.24e-01 81.8% 68.5%
1pzxA03 3.30.1180.10 Alpha Beta › 2-Layer Sandwich › Hypothetical Protein Tm841; Chain: A;domain 3 › 0.58 49.0 3.75e-01 92.7% 92.6%
1p9rA01 3.30.450.90 Alpha Beta › 2-Layer Sandwich › Beta-Lactamase › 0.57 48.0 3.81e-01 92.7% 73.9%
4za3A01 3.40.420.10 Alpha Beta › 3-Layer(aba) Sandwich › Ricin (A subunit); domain 1 › Ricin (A subunit), domain 1 0.57 50.0 3.60e-01 100.0% 87.1%
3r1kA03 3.30.1050.10 Alpha Beta › 2-Layer Sandwich › Nonspecific Lipid-transfer Protein; Chain A › SCP2 sterol-binding domain 0.57 49.0 4.15e-01 100.0% 84.4%
1uc8A03 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.57 44.0 3.67e-01 83.6% 81.9%
4ecnA02 2.60.40.3540 Mainly Beta › Sandwich › Immunoglobulin-like › Domain of unknown function DUF4458 0.57 47.0 3.77e-01 100.0% 87.7%
3oe3C00 2.40.128.200 Mainly Beta › Beta Barrel › Lipocalin › C-type lysozyme inhibitor 0.56 44.0 3.85e-01 87.3% 97.7%
5i47B03 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.56 43.0 3.54e-01 81.8% 85.3%
2r5vA01 3.10.180.10 Alpha Beta › Roll › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1 › 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1 0.55 45.0 3.43e-01 98.2% 92.0%
1a9xA06 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.55 44.0 3.05e-01 90.9% 55.2%
2qq6A01 3.30.390.10 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › Enolase-like, N-terminal domain 0.55 40.0 3.24e-01 81.8% 98.3%
3agkA02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.54 46.0 3.59e-01 96.4% 93.5%
2af5A01 2.40.128.160 Mainly Beta › Beta Barrel › Lipocalin › C1 set domains (antibody constant domain-like) 0.54 38.0 3.84e-01 72.7% 85.2%
1xipA00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.54 46.0 2.76e-01 92.7% 23.2%
1dt9A02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.54 46.0 3.65e-01 96.4% 94.6%
3o4lD01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 37.0 3.13e-01 76.4% 55.8%
4aezA00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.53 45.0 2.71e-01 90.9% 18.4%
2o1uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.53 45.0 3.21e-01 96.4% 33.3%
5yxkA00 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.53 41.0 3.45e-01 94.5% 60.0%
2hesX00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.52 44.0 2.75e-01 92.7% 26.0%
4j87A00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.52 44.0 2.71e-01 92.7% 28.8%
2rfrA00 3.10.450.50 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 42.0 3.01e-01 87.3% 89.0%
3fehA02 2.30.29.30 Mainly Beta › Roll › PH-domain like › Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) 0.52 39.0 3.27e-01 94.5% 78.2%
2pm6D01 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.52 43.0 2.75e-01 92.7% 26.1%
1t6cA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.52 45.0 3.44e-01 96.4% 98.4%
3vpbE00 2.20.28.160 Mainly Beta › Single Sheet › Rubrerythrin, domain 2 › 0.51 36.0 3.60e-01 90.9% 75.0%
4iwxA03 3.30.470.20 Alpha Beta › 2-Layer Sandwich › D-amino Acid Aminotransferase; Chain A, domain 1 › ATP-grasp fold, B domain 0.51 42.0 3.38e-01 92.7% 69.4%
1k8kC00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.51 45.0 2.76e-01 100.0% 95.5%
3wxmB02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.51 42.0 3.36e-01 96.4% 100.0%
1mdaH00 2.130.10.10 Mainly Beta › 7 Propeller › Methylamine Dehydrogenase; Chain H › YVTN repeat-like/Quinoprotein amine dehydrogenase 0.51 39.0 2.46e-01 90.9% 90.8%
ECOD (51)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
119351 926.1.1.1 few secondary structure elements › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV NS5A domain I subdomains › HCV_NS5a_1a 0.97 90.0 8.05e-01 100.0% 74.0%
5034583 1001.1.1.0 a+b two layers › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 › Formate dehydrogenase/DMSO reductase, domain 1 0.69 54.0 5.62e-01 96.4% 94.0%
5024150 3740.1.1.2 alpha arrays › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › F420-reducing hydrogenase subunit beta › DUF2099 0.66 54.0 3.55e-01 94.5% 53.1%
3719189 5.1.5.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed 0.64 49.0 3.12e-01 90.9% 18.3%
3718410 5.1.4.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.64 55.0 3.28e-01 94.5% 97.3%
1144694 714.1.1.1 beta sandwiches › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › N-utilization substance G protein NusG, insert domain › NusG_II 0.61 44.0 3.88e-01 78.2% 75.9%
4938517 5.1.3.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed 0.60 49.0 3.03e-01 89.1% 83.3%
3967995 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.59 49.0 2.90e-01 90.9% 21.3%
4370678 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.59 49.0 2.95e-01 90.9% 25.4%
141833 9.11.1.1 beta barrels › Lipocalins/Streptavidin › YdhA-like › YdhA-like › MliC 0.58 43.0 3.80e-01 81.8% 100.0%
3809440 226.1.1.20 a+b two layers › POZ domain › POZ domain › POZ domain › PF30468, PF30469 0.58 49.0 3.72e-01 92.7% 45.6%
4366164 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.57 49.0 2.85e-01 92.7% 20.7%
5014898 5.1.4.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.57 47.0 2.72e-01 87.3% 17.5%
3994860 5.1.4.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.57 49.0 2.97e-01 94.5% 91.9%
4965457 206.1.3.21 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp › RimK 0.57 44.0 2.91e-01 81.8% 44.3%
3682049 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.57 48.0 3.00e-01 92.7% 22.4%
3631132 5.1.5.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 8-bladed › WD40 0.57 49.0 2.90e-01 92.7% 18.7%
3843979 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.57 47.0 2.84e-01 90.9% 20.8%
4978331 331.10.2.0 a+b two layers › TBP-like › S-adenosylmethionine decarboxylase-related › Bacterial S-adenosylmethionine decarboxylase 0.57 40.0 3.76e-01 76.4% 92.9%
3989004 2004.1.1.42 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › T2SSE 0.56 47.0 2.92e-01 92.7% 28.4%
3427234 219.1.1.0 a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.56 47.0 3.11e-01 96.4% 31.4%
3681619 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.56 50.0 3.17e-01 100.0% 94.1%
5028042 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.55 37.0 2.95e-01 70.9% 82.5%
3727382 2484.1.1.21 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › BcrAD_BadFG 0.55 49.0 3.27e-01 100.0% 95.9%
3229789 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.55 49.0 3.02e-01 100.0% 85.8%
3514681 7089.1.1.0 a+b two layers › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD › Methane monooxygenase hydroxylase, MmoD 0.55 40.0 3.93e-01 85.5% 70.0%
3788355 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.55 45.0 2.66e-01 89.1% 21.2%
None 0.55 43.0 2.64e-01 85.5% 80.6%
3414236 5.1.4.94 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Det1 0.55 47.0 2.69e-01 94.5% 45.5%
1954221 2.26.1.1 beta barrels › OB-fold › Arcadin-1 › Arcadin-1 › Arcadin_1 0.54 43.0 3.86e-01 85.5% 73.3%
3728136 884.1.1.1 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › CobW_C 0.54 46.0 3.71e-01 100.0% 76.5%
3927181 5.1.4.377 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Beta-prop_WDR35_TULP_N 0.54 42.0 2.53e-01 85.5% 67.8%
5036959 206.1.3.0 a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › ATP-grasp 0.54 41.0 2.91e-01 94.5% 26.1%
4029737 5.1.4.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.53 44.0 2.51e-01 96.4% 8.1%
3922649 391.1.2.0 few secondary structure elements › Fibronectin type I module-like › Fibronectin type I module-like › VWC domain-related 0.53 45.0 4.28e-01 92.7% 84.6%
3585489 5.1.4.6 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40,ANAPC4_WD40 0.53 45.0 2.70e-01 92.7% 20.1%
3624239 304.9.1.0 a+b two layers › Alpha-beta plaits › RNA-binding domain, RBD › RNA-binding domain, RBD 0.53 44.0 3.80e-01 94.5% 65.6%
4984946 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.53 36.0 2.90e-01 70.9% 83.5%
3941131 5.1.4.36 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › MMS1_N 0.53 43.0 2.71e-01 94.5% 20.6%
3618164 5.1.4.298 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › Beta-prop_ELP1_1st, Beta-prop_ELP1_2nd 0.53 39.0 2.29e-01 87.3% 16.6%
4974931 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.53 36.0 2.87e-01 70.9% 50.8%
3221147 5.1.4.1 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 0.52 44.0 2.70e-01 92.7% 23.0%
3463325 219.1.1.0 a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.52 43.0 2.87e-01 96.4% 34.1%
5042381 2004.1.1.198 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23 0.52 42.0 2.61e-01 98.2% 34.4%
5055765 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.52 34.0 2.81e-01 70.9% 52.2%
4965400 2.1.1.0 beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein 0.51 35.0 2.82e-01 70.9% 80.8%
3189294 884.1.1.0 a+b two layers › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain › Hypothetical protein YjiA, C-terminal domain 0.51 44.0 3.44e-01 100.0% 77.6%
3422058 5.1.3.144 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › b-prop_At3g26010-like 0.50 39.0 2.66e-01 94.5% 39.2%
3599752 5.1.4.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed 0.50 42.0 2.53e-01 94.5% 38.2%
3670446 5.1.3.0 beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed 0.50 43.0 2.62e-01 92.7% 25.9%
3823805 76.1.1.0 beta duplicates or obligate multimers › beta-Prism I › beta-Prism I › beta-Prism I 0.50 38.0 3.16e-01 89.1% 43.6%