←Back to structures
nonstructural_protein_NS5B
Euk-VirNorway_rat_hepacivirus_2
nonstructural_protein_NS5B__YP_009325411__Norway_rat_hepacivirus_2__1562039
Identity
- Accession:
- YP_009325411 ↗
- Protein ID:
- nonstructural_protein_NS5B
- Kingdom:
- euk
Quality
88.6
mean pLDDT
Taxonomy
Orthornavirae›
Kitrinoviricota›
Flasuviricetes›
Amarillovirales›
Flaviviridae›
Hepacivirus›
Norway_rat_hepacivirus_2
TaxID: 1562039
Cluster
View cluster (450 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 366-549
Domain cluster:
rep: NS5B_RNA-dependent_RNA_polymerase__YP_009272656__Hepatitis_C_virus_genotype_5__33746__D391-472_498-585
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 51.3 | 1.10e-13 | 77.2% | 25.5% |
CATH (8)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1khdA01 | 1.20.970.10 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C | 0.58 | 33.0 | 4.27e-01 | 80.4% | 100.0% |
| 7qihA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.57 | 29.0 | 3.75e-01 | 78.8% | 86.1% |
| 2q7fA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.56 | 30.0 | 3.00e-01 | 79.3% | 47.9% |
| 2xppA00 | 1.20.930.10 | Mainly Alpha › Up-down Bundle › Transcription Elongation Factor S-II; Chain A › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 | 0.56 | 39.0 | 4.47e-01 | 88.6% | 97.1% |
| 2c2lA01 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.55 | 30.0 | 3.49e-01 | 88.6% | 71.4% |
| 4i98C01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.54 | 23.0 | 3.47e-01 | 79.3% | 94.7% |
| 1e8yA03 | 1.25.40.70 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Phosphatidylinositol 3-kinase, accessory domain (PIK) | 0.52 | 33.0 | 3.33e-01 | 93.5% | 60.8% |
| 2lniA00 | 1.25.40.10 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Tetratricopeptide repeat domain | 0.51 | 29.0 | 3.35e-01 | 87.0% | 74.4% |
ECOD (5)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 150973 | 4967.1.1.5 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › RdRP_3 | 0.89 | 85.0 | 8.00e-01 | 100.0% | 88.9% |
| 3781 | 4967.1.1.0 ↗ | alpha bundles › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases › helical bundle domain in reverse transcriptase-like polymerases | 0.72 | 66.0 | 6.53e-01 | 100.0% | 94.2% |
| 4375416 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.55 | 40.0 | 3.81e-01 | 88.6% | 62.7% |
| 4549695 | 611.3.1.1 ↗ | alpha bundles › N-cbl like › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Conserved domain common to transcription factors TFIIS, elongin A, CRSP70 › Med26 | 0.54 | 39.0 | 3.86e-01 | 88.6% | 68.5% |
| 3801526 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.53 | 34.0 | 3.18e-01 | 70.1% | 50.6% |
D2
medium
residues 62-81_175-188_223-306
Domain cluster:
rep: nonstructural_protein_NS5B__YP_009179227_nonstructural_protein_NS5B__Wenling_shark_virus__1746066__D171-191_226-287
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 71.1 | 1.10e-19 | 72.9% | 17.3% |
D3
medium
residues 82-143_155-174
Domain cluster:
representative
CATH (1)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4paaA01 | 3.50.50.60 | Alpha Beta › 3-Layer(bba) Sandwich › FAD/NAD(P)-binding domain › FAD/NAD(P)-binding domain | 0.53 | 39.0 | 2.85e-01 | 79.3% | 89.0% |
ECOD (22)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5366 | 304.48.1.15 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 | 0.82 | 75.0 | 4.72e-01 | 100.0% | 24.1% |
| 3918122 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.80 | 73.0 | 4.59e-01 | 100.0% | 23.8% |
| 4330406 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.74 | 66.0 | 4.29e-01 | 100.0% | 23.8% |
| 1827765 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 65.0 | 4.44e-01 | 100.0% | 28.9% |
| 3589612 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.73 | 65.0 | 4.31e-01 | 100.0% | 27.3% |
| 3945039 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.72 | 64.0 | 4.28e-01 | 100.0% | 25.5% |
| 4004424 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.71 | 63.0 | 4.09e-01 | 100.0% | 23.2% |
| 4497954 | 304.48.1.73 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1, RVT_N | 0.71 | 63.0 | 4.24e-01 | 100.0% | 28.4% |
| 5078830 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.70 | 60.0 | 4.18e-01 | 95.1% | 32.5% |
| 5018572 | 304.48.1.72 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_N | 0.69 | 63.0 | 4.82e-01 | 100.0% | 46.1% |
| 5002351 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.69 | 60.0 | 3.95e-01 | 100.0% | 23.2% |
| 4138932 | 304.48.1.72 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_N | 0.69 | 62.0 | 4.17e-01 | 100.0% | 28.7% |
| 5029718 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 57.0 | 3.78e-01 | 100.0% | 23.2% |
| 4937067 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 57.0 | 4.01e-01 | 100.0% | 30.2% |
| 4872037 | 304.48.1.1 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 | 0.66 | 56.0 | 3.95e-01 | 100.0% | 29.7% |
| 4418134 | 5054.1.1.7 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › KdpA | 0.62 | 44.0 | 2.70e-01 | 75.6% | 48.8% |
| 3304359 | 304.48.1.70 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Intron_maturas2 | 0.59 | 52.0 | 3.20e-01 | 100.0% | 16.0% |
| 3446024 | 304.48.1.70 ↗ | a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Intron_maturas2 | 0.57 | 51.0 | 3.11e-01 | 100.0% | 18.8% |
| 4959825 | 5054.1.1.7 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › KdpA | 0.52 | 41.0 | 2.59e-01 | 90.2% | 69.0% |
| 3664519 | 5051.1.1.6 ↗ | alpha complex topology › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Sodium:neurotransmitter symporter family (SNF)-like › Aa_trans | 0.52 | 43.0 | 2.81e-01 | 100.0% | 50.5% |
| 4944480 | 242.1.1.0 ↗ | a+b two layers › Homing endonucleases-like › Homing endonucleases › Homing endonucleases | 0.50 | 39.0 | 3.58e-01 | 84.1% | 90.9% |
| 5001537 | 3281.1.1.1 ↗ | alpha complex topology › Sodium/proton antiporter subunits-like › Sodium/proton antiporter subunits-like › NADH-quinone oxidoreductase subunit L (NuoL)-related › Proton_antipo_M | 0.50 | 43.0 | 2.67e-01 | 98.8% | 83.5% |
D4
medium
residues 189-222_307-364
Domain cluster:
rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00998.29 best | RdRP_3 | 36.3 | 4.00e-09 | 64.1% | 11.1% |
| PF00998.29 | RdRP_3 | 28.3 | 1.00e-06 | 38.0% | 6.8% |