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nonstructural_protein_NS5

Euk-Vir

Langat_virus

nonstructural_protein_NS5__NP_740302__Langat_virus__11085

Identity

Accession:: NP_740302 ↗
Protein ID:: nonstructural_protein_NS5
Kingdom:: euk

Quality

85.5 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Flasuviricetes› Amarillovirales› Flaviviridae› Orthoflavivirus› Langat_virus

TaxID: 11085

Cluster

View cluster (51 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 733-886

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009268628__Hanko_virus__1125677__D698-878

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF20483.4 best	Flavi_NS5_thumb	186.0	6.90e-55	88.3%	81.1%

D2 medium residues 6-47_242-264

PDB

Domain cluster: representative

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1r6aA00	3.40.50.150	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Vaccinia Virus protein VP39	0.91	85.0	5.45e-01	100.0%	97.7%

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
5047779	2003.1.1.66 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › CoA_binding_2	0.56	27.0	2.19e-01	73.8%	20.8%
4933257	314.1.1.2 ↗	a+b three layers › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › Class II aaRS and biotin synthetases › tRNA-synt_2b	0.51	41.0	2.65e-01	90.8%	55.5%

D3 medium residues 48-63_99-143

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase__NP_775524__Powassan_virus__11083__D94-143

D4 medium residues 64-98_144-241

PDB

Domain cluster: rep: RNA-dependent_RNA_polymerase_NS5__YP_009329957__Saint_Louis_encephalitis_virus__11080__D147-245

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF01728.26 best	FtsJ	23.8	5.50e-05	67.7%	47.0%

D5 medium residues 265-321_342-364_389-479_574-597

PDB

Domain cluster: rep: NS5-like_protein__YP_009179403__Wuhan_flea_virus__1746071__D315-356_368-395_444-456_471-503_597-617

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	162.1	2.50e-47	49.2%	20.6%
PF00972.26	Flavi_NS5	46.1	3.90e-12	30.3%	12.0%
PF00972.26	Flavi_NS5	30.6	2.00e-07	14.4%	5.3%

D6 medium residues 365-388_480-501_544-573_598-610

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	36.5	3.30e-09	33.7%	5.8%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4nooB00	1.10.8.1160	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 ›	0.57	31.0	3.03e-01	92.1%	47.4%
5iduA01	1.10.540.10	Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain	0.56	45.0	4.14e-01	88.8%	96.7%
1kplA00	1.10.3080.10	Mainly Alpha › Orthogonal Bundle › Clc chloride channel › Clc chloride channel	0.53	43.0	2.84e-01	91.0%	81.2%
4l8jA04	1.10.287.470	Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin	0.52	27.0	3.17e-01	87.6%	71.2%
3hjlA02	1.10.220.30	Mainly Alpha › Orthogonal Bundle › Annexin V; domain 1 › Flagellar motor switch protein FliG, alpha-alpha superhelical domain	0.51	36.0	3.48e-01	85.4%	63.2%

ECOD (2)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
3499082	109.4.1.1224 ↗	alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_DOCK9	0.56	45.0	2.76e-01	86.5%	25.4%
4027154	621.1.1.0 ↗	alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain	0.56	38.0	3.71e-01	70.8%	84.0%

D7 medium residues 502-543_611-732

PDB

Domain cluster: rep: hypothetical_protein_2__YP_009337040__Changjiang_tombus-like_virus_21__1922815__D1-47_99-181

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00972.26 best	Flavi_NS5	123.6	1.20e-35	56.1%	20.4%
PF00972.26	Flavi_NS5	45.2	7.50e-12	26.2%	9.1%
PF20483.4	Flavi_NS5_thumb	37.7	2.80e-09	17.1%	17.1%