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nsP1_protein

Euk-Vir

Eastern_equine_encephalitis_virus

nsP1_protein__NP_740649__Eastern_equine_encephalitis_virus__11021

Identity

Accession:
NP_740649 ↗
Protein ID:
nsP1_protein
Kingdom:
euk

Quality

70.1 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Alsuviricetes› Martellivirales› Togaviridae› Alphavirus› Eastern_equine_encephalitis_virus

TaxID: 11021

Cluster

View cluster (15 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 179-218_231-250
PDB
Domain cluster: representative
CATH (27)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
6epkA02 3.30.67.10 Alpha Beta › 2-Layer Sandwich › Viral Envelope Glycoprotein; domain 2 › Viral Envelope Glycoprotein, domain 2 0.68 43.0 4.07e-01 88.3% 54.9%
3pqhA01 2.20.220.20 Mainly Beta › Single Sheet › Glycosyl hydrolase fold › 0.64 38.0 3.90e-01 96.7% 60.0%
2gcjA01 2.30.29.150 Mainly Beta › Roll › PH-domain like › 0.63 39.0 3.02e-01 90.0% 28.4%
1a5yA00 3.90.190.10 Alpha Beta › Alpha-Beta Complex › Protein-Tyrosine Phosphatase; Chain A › Protein tyrosine phosphatase superfamily 0.61 49.0 3.11e-01 100.0% 18.3%
3pweA01 3.10.150.10 Alpha Beta › Roll › DNA Polymerase III; Chain A, domain 2 › DNA Polymerase III, subunit A, domain 2 0.61 42.0 3.36e-01 73.3% 83.7%
2q5fA02 2.60.200.30 Mainly Beta › Sandwich › Tumour Suppressor Smad4 › Probable inorganic polyphosphate/atp-NAD kinase; domain 2 0.59 52.0 4.05e-01 100.0% 97.0%
2m3xC02 2.40.10.360 Mainly Beta › Beta Barrel › Thrombin, subunit H › 0.58 36.0 3.49e-01 90.0% 53.6%
1ylxA00 3.30.70.1480 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › GK1464-like 0.58 48.0 4.06e-01 91.7% 78.8%
3nuhB02 3.30.300.370 Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › 0.56 41.0 3.38e-01 81.7% 57.0%
2jeuA02 2.170.200.10 Mainly Beta › Beta Complex › Regulatory Protein E2; Chain: A; Domain 2 › Papillomavirus E2 early protein domain 0.56 41.0 3.44e-01 78.3% 85.1%
5jp0A03 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.56 47.0 3.76e-01 96.7% 77.4%
6etzA02 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.55 45.0 4.15e-01 100.0% 89.3%
4g54A01 3.90.70.10 Alpha Beta › Alpha-Beta Complex › Cathepsin B; Chain A › Cysteine proteinases 0.54 41.0 3.28e-01 100.0% 40.0%
3l4eA00 3.40.50.880 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Class I glutamine amidotransferase (GATase) domain 0.54 39.0 2.71e-01 76.7% 99.0%
6o1wA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.54 48.0 3.13e-01 100.0% 89.0%
4uu4A00 2.60.450.10 Mainly Beta › Sandwich › lipopolysaccharide transport protein A fold › Lipopolysaccharide (LPS) transport protein A like domain 0.53 45.0 3.36e-01 91.7% 47.6%
2hq7B00 2.30.110.10 Mainly Beta › Roll › Pnp Oxidase; Chain A › Electron Transport, Fmn-binding Protein; Chain A 0.53 46.0 3.53e-01 100.0% 90.8%
3kenA00 3.40.850.10 Alpha Beta › 3-Layer(aba) Sandwich › Kinesin › Kinesin motor domain 0.52 42.0 2.77e-01 100.0% 56.5%
2zu2A01 2.40.10.10 Mainly Beta › Beta Barrel › Thrombin, subunit H › Trypsin-like serine proteases 0.52 38.0 3.31e-01 80.0% 67.3%
4bs9A02 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.52 46.0 3.19e-01 100.0% 63.9%
1cduA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.52 44.0 3.75e-01 95.0% 86.7%
4omfB02 3.10.450.750 Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › 0.52 33.0 3.68e-01 100.0% 85.1%
2r19A00 2.60.450.10 Mainly Beta › Sandwich › lipopolysaccharide transport protein A fold › Lipopolysaccharide (LPS) transport protein A like domain 0.52 43.0 3.29e-01 91.7% 49.6%
2petA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 41.0 3.55e-01 100.0% 89.6%
5e7gA01 2.60.40.10 Mainly Beta › Sandwich › Immunoglobulin-like › Immunoglobulins 0.51 43.0 3.96e-01 100.0% 91.7%
4m0hA01 2.60.120.1440 Mainly Beta › Sandwich › Jelly Rolls › 0.51 43.0 3.39e-01 100.0% 75.5%
3u7vA02 2.60.220.20 Mainly Beta › Sandwich › Chondroitinase Ac; Chain A, domain 3 › putative beta-Galactosidase from caulobacter crescentus 0.50 43.0 3.34e-01 100.0% 80.6%
ECOD (28)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4971247 331.10.2.0 ↗ a+b two layers › TBP-like › S-adenosylmethionine decarboxylase-related › Bacterial S-adenosylmethionine decarboxylase 0.61 38.0 3.46e-01 90.0% 46.3%
2773887 264.1.1.6 ↗ beta barrels › LigT-like › LigT-related › LigT-related › HVSL 0.60 43.0 2.97e-01 76.7% 96.8%
3397353 264.1.1.6 ↗ beta barrels › LigT-like › LigT-related › LigT-related › HVSL 0.60 43.0 3.11e-01 78.3% 98.9%
4307531 3600.1.1.4 ↗ alpha bundles › uncharacterized protein SYNW0670 › uncharacterized protein SYNW0670 › uncharacterized protein SYNW0670 › Exonuc_VII_L 0.59 39.0 3.20e-01 80.0% 37.3%
3625709 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.59 51.0 4.29e-01 100.0% 85.7%
4126991 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.57 41.0 3.63e-01 90.0% 52.2%
3244334 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.56 46.0 3.84e-01 98.3% 80.8%
4966592 11.1.4.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Prealbumin-like 0.56 39.0 4.12e-01 78.3% 80.0%
3697558 216.1.1.0 ↗ a+b two layers › UBC-like › UBC-like › UBC-like 0.56 42.0 3.51e-01 88.3% 46.7%
3994011 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.55 46.0 4.14e-01 93.3% 91.8%
3575305 5.1.11.0 ↗ beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 9-bladed 0.55 46.0 2.82e-01 90.0% 18.9%
3969126 3454.1.1.5 ↗ beta barrels › GspC HR domain/PilP-like › GspC HR domain/PilP-like › GspC HR domain/PilP-like › Y4YQ_C 0.55 45.0 4.42e-01 100.0% 83.1%
3274608 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.54 48.0 4.61e-01 100.0% 97.1%
4324895 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.54 47.0 2.64e-01 100.0% 9.2%
3250987 11.1.1.29 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like › TIG 0.54 46.0 3.41e-01 100.0% 49.1%
3482923 708.1.1.0 ↗ beta complex topology › ETN0001 domain-like › ETN0001 domain-like › NAC/WRKY/GCM/WOPR domain 0.54 44.0 3.70e-01 86.7% 66.3%
5082750 2484.3.1.1 ↗ mixed a+b and a/b › Ribonuclease H-like › Creatinase/prolidase N-terminal domain › Creatinase/prolidase N-terminal domain › Creatinase_N 0.54 41.0 3.25e-01 83.3% 60.8%
3592319 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.54 43.0 2.61e-01 100.0% 43.9%
4184608 2004.1.1.221 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › P-loop_TraG 0.54 48.0 2.85e-01 100.0% 69.7%
4594137 2004.1.1.0 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.54 48.0 2.85e-01 100.0% 70.6%
4865211 2.1.1.25 ↗ beta barrels › OB-fold › Nucleic acid-binding protein › Nucleic acid-binding protein › DNA_pol_B_exo1 0.52 33.0 3.79e-01 78.3% 88.6%
3697981 220.1.1.36 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like › PH_12 0.52 39.0 2.68e-01 80.0% 26.3%
5057476 2004.1.1.221 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › P-loop_TraG 0.52 45.0 2.80e-01 100.0% 79.0%
6336 331.13.1.1 ↗ a+b two layers › TBP-like › YwmB-like › YwmB-like › DUF1779 0.51 36.0 2.67e-01 80.0% 65.4%
4087108 4004.1.1.3 ↗ beta sandwiches › NAD kinase beta sandwich domain-like › NAD kinase beta sandwich domain-like › NAD kinase beta sandwich domain-like › NAD_kinase_C 0.51 41.0 3.20e-01 100.0% 59.4%
4955902 2004.1.1.76 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DUF87 0.50 45.0 2.76e-01 100.0% 82.5%
3255456 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.50 41.0 3.64e-01 100.0% 79.0%
3235968 2007.2.3.1 ↗ a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase 0.50 44.0 3.00e-01 100.0% 28.2%
D2 medium residues 1-54
PDB
Domain cluster: rep: guanine-7N-methyltransferase__NP_818933__Western_equine_encephalitis_virus__11039__D1-55
D3 medium residues 55-174_445-509
PDB
Domain cluster: rep: nsP1__NP_818995__Barmah_Forest_virus__11020__D49-179_262-299_450-478
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF01660.23 best Vmethyltransf 41.9 9.20e-11 71.4% 34.7%
CATH (1)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
4djaA01 3.40.50.620 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs 0.52 39.0 4.12e-01 82.2% 87.1%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3982330 2003.1.5.21 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › CMAS 0.61 40.0 3.16e-01 72.4% 34.0%
3199218 2003.1.1.5 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › ADH_zinc_N 0.57 34.0 4.00e-01 70.3% 83.1%
5050559 2004.1.1.49 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase 0.51 40.0 3.10e-01 81.1% 87.2%
D4 medium residues 251-317
PDB
D5 medium residues 318-402
PDB