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nsP4_protein

Euk-Vir

Eastern_equine_encephalitis_virus

nsP4_protein__NP_740652__Eastern_equine_encephalitis_virus__11021

Identity

Accession:
NP_740652 ↗
Protein ID:
nsP4_protein
Kingdom:
euk

Quality

80.8 mean pLDDT

Taxonomy

Orthornavirae› Kitrinoviricota› Alsuviricetes› Martellivirales› Togaviridae› Alphavirus› Eastern_equine_encephalitis_virus

TaxID: 11021

Cluster

View cluster (32 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 42-95
PDB
Domain cluster: rep: RNA-directed_RNA_polymerase_nsp4__YP_009020586__Madariaga_virus__1440170__D35-90
D2 medium residues 96-111_171-181_198-357_386-492
PDB
Domain cluster: rep: RNA-directed_RNA_polymerase__YP_009115492__Phomopsis_vexans_RNA_virus__1580605__D205-510
Pfam (3)
AccessionNameScoreE-valueQ covHMM cov
PF00978.27 best RdRP_2 160.9 7.00e-47 60.2% 36.6%
PF00978.27 RdRP_2 75.5 5.60e-21 37.1% 23.9%
PF02123.22 RdRP_4 23.2 4.30e-05 26.5% 10.5%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1mukA02 3.90.1850.10 Alpha Beta › Alpha-Beta Complex › RNA-directed RNA polymerase lambda-3 › RNA-directed RNA polymerase lambda-3 0.74 63.0 5.17e-01 89.1% 75.9%
2r7rA05 1.10.357.80 Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › 0.64 39.0 5.00e-01 71.4% 100.0%
ECOD (46)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
5366 304.48.1.15 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.81 72.0 6.39e-01 91.8% 87.2%
1875037 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.77 70.0 6.28e-01 94.6% 93.5%
3899435 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.77 67.0 5.77e-01 91.5% 77.3%
3877925 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.77 67.0 6.04e-01 90.8% 84.4%
3884315 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.76 68.0 5.20e-01 94.2% 93.4%
5364 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.76 69.0 6.19e-01 94.6% 92.2%
3753579 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.76 67.0 5.36e-01 91.8% 63.9%
3753267 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.76 66.0 5.75e-01 91.5% 78.2%
3789227 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 62.0 6.14e-01 85.0% 98.4%
4524063 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.75 66.0 5.11e-01 92.2% 87.9%
3920615 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.62e-01 91.5% 74.9%
1789314 304.48.1.8 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1 0.75 68.0 6.10e-01 94.6% 96.2%
3766919 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.75 67.0 5.01e-01 94.2% 91.9%
3938749 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 65.0 6.02e-01 90.8% 85.7%
4108146 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 54.0 5.14e-01 73.1% 78.3%
3927049 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.85e-01 91.8% 80.0%
3875601 141.1.1.0 ↗ alpha bundles › Terpenoid synthases › Terpenoid synthases › Terpenoid synthases 0.75 67.0 4.59e-01 94.2% 47.6%
3258406 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.21e-01 91.8% 60.4%
3928801 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 64.0 6.05e-01 89.5% 90.6%
3260077 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.93e-01 91.8% 87.7%
3273928 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.19e-01 91.8% 60.0%
217141 304.48.1.15 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_3 0.75 68.0 6.31e-01 94.6% 90.8%
3915025 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.75 66.0 4.94e-01 92.9% 57.4%
3878013 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.75 66.0 5.87e-01 91.8% 84.8%
3382764 626.1.1.0 ↗ alpha complex topology › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) › Formin homology 2 domain (FH2 domain) 0.74 58.0 4.33e-01 80.3% 43.0%
4875416 304.48.1.13 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › Flavi_NS5 0.74 67.0 6.02e-01 93.5% 89.0%
3265091 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 65.0 5.19e-01 91.8% 60.4%
3272030 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 65.0 5.86e-01 91.5% 85.8%
None — 0.74 66.0 5.06e-01 94.2% 92.2%
2994348 304.48.1.9 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RdRP_1,CoV_RPol_N 0.74 67.0 4.57e-01 94.6% 41.7%
3451410 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.74 65.0 5.44e-01 91.5% 72.1%
3574984 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.72 63.0 5.76e-01 90.8% 83.2%
4188583 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.72 63.0 5.54e-01 91.2% 77.1%
3691350 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 56.0 5.89e-01 80.6% 100.0%
4424453 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 62.0 4.97e-01 90.8% 58.7%
4330406 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.71 62.0 5.72e-01 91.8% 82.2%
3645993 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 62.0 5.62e-01 91.8% 83.1%
4456383 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.70 51.0 5.09e-01 72.8% 87.0%
3923013 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 57.0 5.40e-01 83.7% 86.1%
3655168 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.70 62.0 5.52e-01 92.5% 79.0%
3772920 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.68 59.0 5.89e-01 89.8% 99.7%
3454701 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.65 46.0 4.77e-01 72.1% 82.9%
3241316 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.63 56.0 5.34e-01 92.5% 92.2%
3997418 304.48.1.1 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like › RVT_1 0.61 54.0 5.21e-01 92.5% 83.3%
3479114 304.48.1.0 ↗ a+b two layers › Alpha-beta plaits › Adenylyl and guanylyl cyclase catalytic domain-like › Adenylyl and guanylyl cyclase catalytic domain-like 0.60 53.0 4.07e-01 92.9% 86.4%
None — 0.52 49.0 4.61e-01 99.3% 86.2%
D3 medium residues 112-148_182-197_515-614
PDB
Domain cluster: rep: replication_protein_2a__YP_006576519__Amazon_lily_mild_mottle_virus__1195163__D529-657
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00978.27 best RdRP_2 48.5 8.90e-13 60.1% 20.7%
D4 medium residues 358-385_493-514
PDB
Domain cluster: representative
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1gesA03 3.30.390.30 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › FAD/NAD-linked reductase, C-terminal dimerisation domain 0.55 37.0 3.01e-01 74.0% 72.6%
1novA00 2.60.120.20 Mainly Beta › Sandwich › Jelly Rolls › 0.53 42.0 2.61e-01 90.0% 96.1%
1kf6B01 3.10.20.30 Alpha Beta › Roll › Ubiquitin-like (UB roll) › Beta-grasp domain 0.51 36.0 2.92e-01 78.0% 73.1%
2xrcB03 3.10.250.10 Alpha Beta › Roll › Mac-2 Binding Protein › SRCR-like domain 0.50 37.0 3.12e-01 96.0% 40.6%
ECOD (3)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3957478 323.1.1.11 ↗ a+b complex topology › CoA-dependent acyltransferases › CoA-dependent acyltransferases › CoA-dependent acyltransferases › PapA_C 0.58 46.0 3.36e-01 92.0% 51.9%
4015832 230.1.1.0 ↗ a+b two layers › T-fold › Tetrahydrobiopterin biosynthesis enzymes-like › Tetrahydrobiopterin biosynthesis enzymes-like 0.53 40.0 3.24e-01 84.0% 66.7%
3798451 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.51 40.0 3.08e-01 96.0% 75.6%